The New York Yankees signed Peguero as an international free agent on July 2,2015.[1] Peguero spent the 2016 season with the Dominican Summer League Yankees. He went 2–7 with a 4.39 ERA and 43 strikeouts. Peguero was assigned to the Gulf Coast League Yankees to begin the 2017 season. After making 7 appearances,going 1–1 with an ERA of 3.00 with 5 strikeouts for the GCL Yankees,he was optioned back to the DSL Yankees,where he struggled to an 0–3 record with a 8.76 ERA with 16 strikeouts through 3 starts. Peguero spent the entire 2018 season with the GCL Yankees,where he made 9 appearances,going 0–3 with a 6.25 ERA and 23 strikeouts. Peguero spent the 2019 season with the Pulaski Yankees. He made 15 appearances for Pulaski,going 2–2 with a 4.19 ERA and 29 strikeouts. Peguero did not play in 2020 due to the COVID-19 pandemic. He began the 2021 season with the High-A Hudson Valley Renegades. He made 15 appearances for Hudson Valley,going 3–1 with a 2.51 ERA and 40 strikeouts. On July 6,2021,Peguero was assigned to the Double-A Somerset Patriots.[2] In 6 appearances for Somerset,he went 1–0 with a 1.50 ERA and 17 strikeouts.
Los Angeles Angels
On July 30,2021,Peguero and Janson Junk were traded to the Los Angeles Angels in exchange for Andrew Heaney.[3] The Angels assigned him to the Double-A Rocket City Trash Pandas,where he made four appearances,going 1–1 with an 8.44 ERA and eight strikeouts. On August 19,he was promoted to the Triple-A Salt Lake Bees. Peguero only made one appearance for Salt Lake,pitching two scoreless innings. On August 25,the Angels selected Peguero's contract.[4][5] He made his major-league debut on August 26 against the Baltimore Orioles,getting two outs and giving up five runs.[6] On September 17,Peguero was removed from the 40-man roster and returned to Triple-A.[7]
Peguero was re-selected to the 40-man roster following the season on November 19,2021,to be protected from the Rule 5 draft.[8] Peguero made 13 appearances for the Angels in 2022,struggling to a 6.75 ERA with 12 strikeouts in 17.1 innings pitched. He spent the rest of his time with Triple-A Salt Lake,where he registered a 4–1 record and 2.84 ERA with 50 strikeouts and 5 saves in 38 appearances.[9]
Milwaukee Brewers
On November 22,2022,the Angels traded Peguero,Janson Junk,and Adam Seminaris to the Milwaukee Brewers for Hunter Renfroe.[10] Peguero was optioned to the Triple-A Nashville Sounds to begin the 2023 season.[11] He made his Brewers debut against the Boston Red Sox on April 23,where he threw 1+1⁄3 innings while giving up one hit and striking out two. Peguero made 59 total appearances for Milwaukee during the year, posting a 4-5 record and 3.38 ERA with 54 strikeouts and one save across 61+1⁄3 innings pitched.[12]
Peguero made 52 appearances out of the bullpen for the Brewers during the 2024 season, registering a 7-4 record and 2.98 ERA with 47 strikeouts and two saves across 51+1⁄3 innings pitched.[13]
Peguero pitched in six contests for Milwaukee in 2025, recording a 4.91 ERA with five strikeouts across 7+1⁄3 innings pitched. He was designated for assignment on July 31, 2025.[14]
Chicago White Sox
On August 3, 2025, Peguero was claimed off waivers by the Chicago White Sox.[15] He made two appearances (one start) for Chicago, but struggled to a 13.50 ERA with three strikeouts over two innings of work. On October 13, Peguero was removed from the 40-man roster and sent outright to the Triple-A Charlotte Knights.[16] He elected free agency on November 6.[17]
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