COVID-19 pandemic

Last updated

COVID‑19 pandemic
COVID-19 Outbreak World Map per Capita.svg
Confirmed cases per 100,000 population
as of 25 October 2020
  •   >3,000
  •   1,000–3,000
  •   300–1,000
  •   100–300
  •   30–100
  •   0–30
  •   None or no data
Total cases per country
COVID-19 Outbreak World Map.svg
As of 25 October 2020
  •   >1,000,000
  •   100,000–999,999
  •   10,000–99,999
  •   1,000–9,999
  •   100–999
  •   1–99
  •   None or no data
Deaths per capita
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Per million population
as of 11 October 2020
Daily new cases
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Daily new cases as of 28 September 2020
(7 day rolling average)
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Clockwise from top:
Disease Coronavirus disease 2019 (COVID‑19)
Virus strain Severe acute respiratory syndrome
coronavirus 2
(SARS‑CoV‑2) [lower-alpha 1]
SourcePossibly via bats, pangolins, or both [1] [2]
Location Worldwide
First outbreakWuhan, China [3]
Index case Wuhan, Hubei, China
30°37′11″N114°15′28″E / 30.61972°N 114.25778°E / 30.61972; 114.25778
Arrival dateBetween 6 October 2019 and 11 December 2019 [4]
Date31 December 2019 (2019-12-31) [3] – present
(10 months, 3 weeks and 4 days)
Confirmed cases42,990,032 [5]
Active cases12,876,203 [5] (28.1% of confirmed cases as of 24 September)
Suspected casesThe WHO estimated in October 2020 that 10% of the global population (c. 770 million) has been infected. [6]
Recovered28,960,204 [5]
Deaths
1,153,625 [5]
Territories
189 [5]
Suspected cases have not been confirmed as being due to this strain by laboratory tests, although some other strains may have been ruled out.

The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first identified in December 2019 in Wuhan, China. [3] The outbreak was declared a Public Health Emergency of International Concern in January 2020 and a pandemic in March 2020. As of 26 October 2020, more than 42.9 million cases have been confirmed, with more than 1.15 million deaths attributed to COVID-19. [5]

Contents

COVID-19 spreads most often when people are physically close. [lower-alpha 2] It spreads very easily and sustainably through the air, primarily via small droplets or aerosols , as an infected person breathes, coughs, sneezes, sings, or speaks. [9] [10] It may also be transmitted via contaminated surfaces , although this has not been conclusively demonstrated. [10] [11] [12] Airborne transmission from aerosol formation is suspected to be the main mode of transmission. [13] It can spread from an infected person for up to two days before they display symptoms, and from people who are asymptomatic . [10] People remain infectious for seven to twelve days in moderate cases, and up to two weeks in severe cases. [10] [14]

Common symptoms include fever, cough, fatigue, breathing difficulties, and loss of smell and taste. Complications may include pneumonia and acute respiratory distress syndrome. The incubation period is typically around five days but may range from one to 14 days. [14] There are several vaccine candidates in development, although none have completed clinical trials. There is no known specific antiviral medication, so primary treatment is currently symptomatic. [15]

Recommended preventive measures include hand washing, covering one's mouth when sneezing or coughing, social distancing, wearing a face mask in public, ventilation and air-filtering, disinfecting surfaces, and monitoring and self-isolation for people exposed or symptomatic. Authorities worldwide have responded by implementing travel restrictions, lockdowns, workplace hazard controls, and facility closures. Many places have also worked to increase testing capacity and trace contacts of the infected.

The pandemic has caused global social and economic disruption, including the largest global recession since the Great Depression. [16] It has led to the postponement or cancellation of sporting, religious, political, and cultural events, [17] widespread supply shortages exacerbated by panic buying, famines affecting hundreds of millions of people, [18] and decreased emissions of pollutants and greenhouse gases. Educational institutions have been partially or fully closed, with many switching to online schooling. Misinformation about the pandemic has circulated through social media and mass media. There have been incidents of xenophobia and discrimination against Chinese people and against those perceived as being Chinese or as being from areas with high infection rates. [19]

Epidemiology

For country-level data, see:
732-bar-chart.svg
Cases
42,990,032
Deaths
1,153,625
As of 26 October 2020 [5]

Background

Although it is still unknown exactly where the outbreak first started, several early infected people had visited Huanan Seafood Wholesale Market, located in Wuhan, Hubei, China. [20] On 11 February 2020, the World Health Organization named the disease "COVID-19", short for coronavirus disease 2019. [21] [22] The virus that caused the outbreak is known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly discovered virus closely related to bat coronaviruses, [23] pangolin coronaviruses, [24] [25] and SARS-CoV. [26] The scientific consensus is that COVID-19 has a natural origin. [27] [28] The probable bat-to-human infection may have been among people processing bat carcasses and guano in the production of traditional Chinese medicines. [29]

The earliest known person with symptoms was later discovered to have fallen ill on 1 December 2019, and that person did not have visible connections with the later wet market cluster. [30] [31] Of the early cluster of cases reported that month, two-thirds were found to have a link with the market. [32] [33] [34] There are several theories about when and where the very first case (the so-called patient zero) originated. [35] On 13 March 2020, an unverified report from the South China Morning Post (SCMP) suggested a case traced back to 17 November 2019 (a 55-year-old person from Hubei) may have been the first person infected. [36] [37] Phylogenic estimates in genetic studies conducted in early 2020 indicate that SARS-CoV-2 likely passed onto humans sometime between 6 October 2019 and 11 December 2019. [4]

The Huanan Seafood Wholesale Market in March 2020, after it was closed down. Huanan Seafood Wholesale Market.png
The Huanan Seafood Wholesale Market in March 2020, after it was closed down.

Cases

Official case counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols. [38] [39] Many countries, early on, had official policies to not test those with only mild symptoms. [40] [41] An analysis of the early phase of the outbreak up to 23 January estimated 86 percent of COVID-19 infections had not been detected, and that these undocumented infections were the source for 79 percent of documented cases. [42] Several other studies, using a variety of methods, have estimated that numbers of infections in many countries are likely to be considerably greater than the reported cases. [43] [44]

On 9 April 2020, preliminary results found that 15 percent of people tested in Gangelt, the centre of a major infection cluster in Germany, tested positive for antibodies. [45] Screening for COVID-19 in pregnant women in New York City, and blood donors in the Netherlands, has also found rates of positive antibody tests that may indicate more infections than reported. [46] [47] Seroprevalence based estimates are conservative as some studies shown that persons with mild symptoms do not have detectable antibodies. [48] Some results (such as the Gangelt study) have received substantial press coverage without first passing through peer review. [49]

Analysis by age in China indicates that a relatively low proportion of cases occur in individuals under 20. [50] It was not clear whether this was because young people were less likely to be infected, or less likely to develop serious symptoms and seek medical attention and be tested. [51] A retrospective cohort study in China found that children and adults were just as likely to be infected. [52]

Initial estimates of the basic reproduction number (R0) for COVID-19 in January were between 1.4 and 2.5, [53] but a subsequent analysis concluded that it may be about 5.7 (with a 95 percent confidence interval of 3.8 to 8.9). [54] R0 can vary across populations and is not to be confused with the effective reproduction number (commonly just called R), which takes into account effects such as social distancing and herd immunity. By mid-May 2020, the effective R was close to or below 1.0 in many countries, meaning the spread of the disease in these areas at that time was stable or decreasing. [55]

Deaths

Deceased in a 16 m (53 ft) "mobile morgue" outside a hospital in Hackensack, New Jersey COVID19 deceased in Hackensack NJ April 27.jpg
Deceased in a 16 m (53 ft) "mobile morgue" outside a hospital in Hackensack, New Jersey

Official deaths from COVID-19 generally refer to people who died after testing positive according to protocols. This may ignore deaths of people who die without having been tested. [57] Conversely, deaths of people who had underlying conditions may lead to over-counting. [58] Comparison of statistics for deaths for all causes versus the seasonal average indicates excess mortality in many countries. [59] [60] This may include deaths due to strained healthcare systems and bans on elective surgery. [61] The first confirmed death was in Wuhan on 9 January 2020. [62] The first reported death outside of China occurred on 1 February in the Philippines, [63] and the first reported death outside Asia was in the United States on 6 February. [64]

More than 95% of the people who contract COVID-19 recover. Otherwise, the time between symptoms onset and death usually ranges from 6 to 41 days, typically about 14 days. [65] As of 26 October 2020, more than 1.15 million [5] deaths had been attributed to COVID-19. In China, as of 14 June, about 80% of deaths were recorded in those over 60, and 75% had pre-existing health conditions including cardiovascular disease and diabetes. [66] Individuals of any age with underlying health conditions are at increased risk of severe illness. [67]

On 24 March 2020, the Centers for Disease Control and Prevention (CDC) changed criteria for attributing deaths to COVID-19 to include those marked "probable"/"likely." The CDC said, "It is not likely that [the National Center for Health Statistics (NCHS)] will follow up on these cases" and that while the "underlying cause depends upon what and where conditions are reported on the death certificate, … the rules for coding and selection of the ... cause of death are expected to result in COVID–19 being the underlying cause more often than not." [68]

On 16 April, the World Health Organisation (WHO) created two codes for classifying deaths: UO7.1, "confirmed by laboratory testing irrespective of severity of clinical signs or symptoms"; and UO7.2, "diagnosed clinically or epidemiologically but laboratory testing is inconclusive or not available". The WHO "recognized that in many countries detail as to the laboratory confirmation… will not be reported [and] recommended, for mortality purposes only, to code COVID-19 provisionally to code U07.1 unless it is stated as 'probable' or 'suspected'." [69] [70] It was also noted that the WHO "does not distinguish" between infection by SARS-CoV-2 and COVID-19. [71]

In August 2020, the CDC reported that in the United States 94% of COVID-19 death certificates listed at least one comorbidity. [72] The reported comorbidities include symptoms caused by COVID-19 infection which contributed to the fatality in addition to pre-existing health conditions. [73] On 92% of American death certificates listing COVID-19 as a cause of death, COVID-19 was listed as “the condition that began the chain of events that ultimately led to the person’s death”. [74]

Multiple measures are used to quantify mortality. [75] These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, [76] [77] [78] time since the initial outbreak, and population characteristics, such as age, sex, and overall health. [79] Countries like Belgium include deaths from suspected cases of COVID-19, regardless of whether the person was tested, resulting in higher numbers compared to countries that include only test-confirmed cases. [80]

The death-to-case ratio reflects the number of deaths attributed to COVID-19 divided by the number of diagnosed cases within a given time interval. Based on Johns Hopkins University statistics, the global death-to-case ratio is

Infection fatality ratio (IFR)

The most important metric in assessing death rate is infection fatality ratio (IFR), [82] [lower-alpha 3] which is deaths attributed to disease divided by individuals infected (including all asymptomatic and undiagnosed) to-date. [84] In March, a peer-reviewed analysis of pre-serology data from mainland China yielded an overall IFR of 0.66% (with age-bracketed values ranging from 0.00161% for 0–9 years to 0.595% for 50–59 years to 7.8% for > 80 years). [85]

In April, an IFR range of 0.12–1.08% was derived from non-peer-reviewed serology surveys, with the upper bound characterized as much more credible and the range indicated as from 3 to 27 times deadlier than influenza (0.04%). [86]

In July, the CDC adopted the IFR as a "more directly measurable parameter for disease severity for COVID-19" and computed an overall 'best estimate' for planning purposes for the U.S. of 0.65%. [87] [88] In September, the CDC computed an age-bracketed ‘best estimate’ for the U.S. of 0.003% for 0–19 years; 0.02% for 20–49 years; 0.5% for 50–69 years; and 5.4% for 70+ years. [89] [lower-alpha 4]

In August, the WHO reported serology testing for three locations in Europe (with some data through 2 June) that showed IFR overall estimates converging at approximately 0.5-1%. [83] A systematic review article in The BMJ advised that "caution is warranted … using serological tests for … epidemiological surveillance" and called for higher quality studies assessing accuracy with reference to a standard of "RT-PCR performed on at least two consecutive specimens, and, when feasible, includ[ing] viral cultures." [91] [92] CEBM researchers have called for in-hospital 'case definition' to record "CT lung findings and associated blood tests" [93] and for the WHO to produce a "protocol to standardise the use and interpretation of PCR" with continuous re-calibration. [94]

In September, a Bulletin of the World Health Organization article by John Ioannides estimated global IFR inferred from seroprevalence data at 0.23% [lower-alpha 5] overall and 0.05% for people < 70 years, much lower than estimates made earlier in the pandemic. Ioannides criticized prior "average IFR … irresponsibly circulated widely in media and social media" as "probably extremely flawed as they depended on erroneous modeling assumptions, and/or focused only on selecting mostly studies from countries high death burden (that indeed have higher IFRs), and/or were done by inexperienced authors who used overtly wrong meta-analysis methods in a situation where there is extreme between-study heterogeneity. [95] As the data for his analysis was drawn "predominantly from hard-hit epicenters", Ioannides indicates that even lower "average values of 0.15–0.25% … and 0.03–0.04% for <70 years) as of October 2020 are plausible." [95] [96] He also notes that in European countries with a large numbers of cases and deaths [97] and in the U.S., [98] "many, and in many cases most, deaths occurred in nursing homes”. [99]

On 6 October, Dr. Mike Ryan, director of the WHO's Health Emergencies Programme announced "Our current best estimates tell us that about 10% of the global population may have been infected by this virus." [100] Also in October, the Centre for Evidence-Based Medicine (CEBM) reported a 'presumed estimate' of global IFR at between 0.10% to 0.35%, noting that this will vary between populations due to differences in demographics. [101] These researchers noted a decrease in IFR in England over time; [102] [lower-alpha 6] and, for the UK and Italy (the two Europeans nations worst hit by COVID-19), attribute the rise in daily cases, stability in daily deaths, and shift of cases to a younger population to waning viral circulation, misapplication of testing, and misinterpretation of test results rather than to prevention, treatment, or virus mutation. [103]

Case fatality ratio (CFR)

Another metric in assessing death rate is the case fatality ratio (CFR), [lower-alpha 7] which is deaths attributed to disease divided by individuals diagnosed to-date. This metric can be misleading because of delay between symptom onset and death and because testing focuses on individuals with symptoms (and particularly on those manifesting more severe symptoms). [71] On 4 August, WHO indicated "at this early stage of the pandemic, most estimates of fatality ratios have been based on cases detected through surveillance and calculated using crude methods, giving rise to widely variable estimates of CFR by country – from less than 0.1% to over 25%." [83]

Transmission

COVID-19 spreads from person to person mainly through the respiratory route after an infected person coughs, sneezes, sings, talks or breathes. A new infection occurs when virus-containing particles exhaled by an infected person, either respiratory droplets or aerosols, get into the mouth, nose, or eyes of other people who are in close contact with the infected person. [105] [106] Respiratory droplets may evaporate into droplet nuclei, which remain suspended in the air for longer periods of time, causing airborne transmission particularly in crowded and inadequately ventilated indoor spaces, such as restaurants, nightclubs or choirs. [106] [107] It also can occur in the healthcare setting, with certain aerosol-generating medical procedures performed on COVID-19 patients. [107]

Kissing, physical intimacy and other forms of direct contact can easily transmit the virus and thus lead to COVID-19 in people exposed to such contact. [107] [108] It may be possible that a person can get COVID-19 through indirect contact by touching a contaminated surface or object, and then touching their own mouth, nose, or possibly their eyes, [107] though this is not thought to be the main way the virus spreads. [106] There currently is no significant evidence of COVID-19 virus transmission through feces, urine, breast milk, food, wastewater, drinking water, animal disease vectors, or from mother to baby during pregnancy, although research is ongoing and caution is advised. [107] [108] [ needs update ]

It can transmit when people are symptomatic, also for up to two days prior to developing symptoms, and even if a person never shows symptoms. [106] [109] People remain infectious in moderate cases for 7-12 days, and up to two weeks in severe cases. [109] In October 2020, medical scientists reported evidence of reinfection in one patient.

Signs and symptoms

Symptoms of COVID-19 Symptoms of coronavirus disease 2019 4.0.svg
Symptoms of COVID-19

Symptoms of COVID-19 can be relatively non-specific; the two most common symptoms are fever (88 percent) and dry cough (68 percent). Less common symptoms include fatigue, respiratory sputum production (phlegm), loss of the sense of smell, loss of taste, shortness of breath, muscle and joint pain, sore throat, headache, chills, vomiting, coughing out blood, diarrhea, and rash. [111] [112] [113]

Among those who develop symptoms, approximately one in five may become more seriously ill and have difficulty breathing. [114] Emergency symptoms include difficulty breathing, persistent chest pain or pressure, sudden confusion, difficulty waking, and bluish face or lips; immediate medical attention is advised if these symptoms are present. [113] Further development of the disease can lead to complications including pneumonia, acute respiratory distress syndrome, sepsis, septic shock, and kidney failure. [112]

Cause

Virology

Illustration of SARSr-CoV virion Coronavirus virion structure.svg
Illustration of SARSr-CoV virion

SARS-CoV-2 is a Baltimore class IV [115] positive-sense single-stranded RNA virus [116] that is contagious in humans. [117] As described by the U.S. National Institutes of Health, it is the successor to SARS-CoV-1, [118] [119] the strain that caused the 2002–2004 SARS outbreak.

Epidemiological studies estimate each infection results in 5.7 new ones when no members of the community are immune and no preventive measures taken. [120] The virus primarily spreads between people through close contact and via respiratory droplets produced from coughs or sneezes. [121] [122] It mainly enters human cells by binding to the receptor angiotensin converting enzyme 2 (ACE2). [123] [124] [125] [126]

Diagnosis

Demonstration of a swab for COVID-19 testing Infektionsschutzzentrum im Rautenstrauch-Joest-Museum, Koln-6313 (cropped).jpg
Demonstration of a swab for COVID-19 testing

COVID-19 can provisionally be diagnosed on the basis of symptoms and confirmed using reverse transcription polymerase chain reaction (RT-PCR) testing of infected secretions or CT imaging of the chest. [127] [128]

On 29 September, a letter in Lancet highlighted the increasing likelihood of overestimating of COVID-19 incidence as more asymptomatic people are included in RT-PCR testing with consequent "misdirection of policies regarding lockdowns and school closures," noting that the false-positive rate in the UK is currently unknown, with "preliminary estimates … somewhere between 0·8% and 4·0%". [129] [130] The letter called for "stricter standards … in laboratory testing, … and pretest probability assessments … [including] symptoms, previous medical history of COVID-19 or presence of antibodies, any potential exposure to COVID-19, and likelihood of an alternative diagnosis." [131]

Viral testing

The standard test for presence of SARS-CoV-2 uses RNA testing of respiratory secretions collected using a nasopharyngeal swab, though it is possible to test other samples. This test uses real-time rRT-PCR which detects the presence of viral RNA fragments. [132] As this test detects RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." [133] Positive tests have been shown not to correlate with future excess deaths. [134]

A number of laboratories and companies have developed serological tests, which detect antibodies produced by the body in response to infection. [135] Several have been evaluated by Public Health England and approved for use in the UK. [136]

On 22 June 2020, UK health secretary Matt Hancock announced the country would conduct a new "spit test" for COVID-19 on 14,000 key workers and their families in Southampton, having them spit in a pot, which was collected by Southampton University, with results expected within 48 hours. Hancock said the test was easier than using swabs and could enable people to conduct it at home. [137]

The University of Oxford's CEBM has pointed to mounting evidence [138] [139] that "a good proportion of 'new' mild cases and people re-testing positives after quarantine or discharge from hospital are not infectious, but are simply clearing harmless virus particles which their immune system has efficiently dealt with" and have called for "an international effort to standardize and periodically calibrate testing" [140] On 7 September, the UK government issued "guidance for procedures to be implemented in laboratories to provide assurance of positive SARS-CoV-2 RNA results during periods of low prevalence, when there is a reduction in the predictive value of positive test results." [141]

In October 2020, the US diplomats and security officials raised a warning for Las Vegas against the use of Chinese test kits donated by the United Arab Emirates. In partnership with Group 42, Nevada was receiving donations of hundreds of thousands of test kits costing from between $15 million to $20 million, which raised concerns around patient privacy and test accuracy. Earlier, there were doubts that UAE's Group 42 could get access to US citizens through tests data. [142] [143]

Imaging

A CT scan of a person with COVID-19 shows lesions (bright regions) in the lungs. COVID19CTPneumonia.jpg
A CT scan of a person with COVID-19 shows lesions (bright regions) in the lungs.

Characteristic imaging features on chest radiographs and computed tomography (CT) of people who are symptomatic include asymmetric peripheral ground-glass opacities without pleural effusions. [144] Many groups have created COVID-19 datasets that include imagery such as the Italian Radiological Society which has compiled an international online database of imaging findings for confirmed cases. [145] Due to overlap with other infections such as adenovirus, imaging without confirmation by rRT-PCR is of limited specificity in identifying COVID-19. [144] A large study in China compared chest CT results to PCR and demonstrated that though imaging is less specific for the infection, it is faster and more sensitive. [128]

Prevention

Infographic by the U.S. Centers for Disease Control and Prevention (CDC), describing how to stop the spread of germs Stop the Spread of Germs updated (English).pdf
Infographic by the U.S. Centers for Disease Control and Prevention (CDC), describing how to stop the spread of germs

Strategies for preventing transmission of the disease include social distancing, wearing of masks, washing hands, avoiding touching the eyes, nose, or mouth with unwashed hands, and coughing or sneezing into a tissue, and putting the tissue directly into a waste container. [146] [147] [148] [149]

Social distancing

Social distancing measures on public ground Kastro, Kavala.jpg
Social distancing measures on public ground

Social distancing (also known as physical distancing) includes infection control actions intended to slow the spread of the disease by minimising close contact between individuals. Methods include quarantines; travel restrictions; and the closing of schools, workplaces, stadiums, theatres, or shopping centres. Individuals may apply social distancing methods by staying at home, limiting travel, avoiding crowded areas, using no-contact greetings, and physically distancing themselves from others. [147] [150] [151] Many governments are now mandating or recommending social distancing in regions affected by the outbreak. [152] [153] Non-cooperation with distancing measures in some areas has contributed to the further spread of the pandemic. [154]

The maximum gathering size recommended by U.S. government bodies and health organisations was swiftly reduced from 250 people (if there were no known COVID-19 spread in a region) to 50 people, and later to 10. [155] On 22 March 2020, Germany banned public gatherings of more than two people. [156] A Cochrane review found that early quarantine with other public health measures are effective in limiting the pandemic, but the best manner of adopting and relaxing policies are uncertain, as local conditions vary. [151]

Older adults and those with underlying medical conditions such as diabetes, heart disease, respiratory disease, hypertension, and compromised immune systems face increased risk of serious illness and complications and have been advised by the CDC to stay home as much as possible in areas of community outbreak. [157] [158]

In late March 2020, the WHO and other health bodies began to replace the use of the term "social distancing" with "physical distancing", to clarify that the aim is to reduce physical contact while maintaining social connections, either virtually or at a distance. The use of the term "social distancing" had led to implications that people should engage in complete social isolation, rather than encouraging them to stay in contact through alternative means. [159] [160] Some authorities have issued sexual health guidelines for the pandemic, which include recommendations to have sex only with someone you live with, and who does not have the virus or symptoms of the virus. [161] [162]

Face masks and respiratory hygiene

The CDC and WHO advise that masks reduce the spread of coronavirus by asymptomatic and pre-symptomatic individuals (Taiwan President Tsai Ing-wen pictured wearing a surgical mask) 04.02 Zong Tong Shi Cha [Zhong Yang Liu Xing Yi Qing Zhi Hui Zhong Xin ]  49726568957 66543b616e o.jpg
The CDC and WHO advise that masks reduce the spread of coronavirus by asymptomatic and pre-symptomatic individuals (Taiwan President Tsai Ing-wen pictured wearing a surgical mask)

The CDC and WHO recommend individuals wear non-medical face coverings in public settings where there is an increased risk of transmission and where social distancing measures are difficult to maintain. [163] [164] [165] This recommendation is meant to reduce the spread of the disease by asymptomatic and pre-symtomatic individuals and is complementary to established preventive measures such as social distancing. [164] [166] Face coverings limit the volume and travel distance of expiratory droplets dispersed when talking, breathing, and coughing. [164] [166] Many countries and local jurisdictions encourage or mandate the use of face masks or cloth face coverings by members of the public to limit the spread of the virus. [167] [168]

Masks are also strongly recommended for those who may have been infected and those taking care of someone who may have the disease. [169] When not wearing a mask, the CDC recommends covering the mouth and nose with a tissue when coughing or sneezing and recommends using the inside of the elbow if no tissue is available. [146] Proper hand hygiene after any cough or sneeze is encouraged. [146] Healthcare professionals interacting directly with COVID-19 patients are advised to use respirators at least as protective as NIOSH-certified N95 or equivalent, in addition to other personal protective equipment. [170]

Self-isolation

Without pandemic containment measures--such as social distancing, vaccination, and use of face masks--pathogens can spread exponentially. This graphic shows how early adoption of containment measures tends to protect wider swaths of the population. 20200609 Effect of pandemic containment measures.gif
Without pandemic containment measures—such as social distancing, vaccination, and use of face masks—pathogens can spread exponentially. This graphic shows how early adoption of containment measures tends to protect wider swaths of the population.

Self-isolation at home has been recommended for those diagnosed with COVID-19 and those who suspect they have been infected. Health agencies have issued detailed instructions for proper self-isolation. [172] [173]

Many governments have mandated or recommended self-quarantine for entire populations. [174] [175] The strongest self-quarantine instructions have been issued to those in high-risk groups. [176] Those who may have been exposed to someone with COVID-19 and those who have recently travelled to a country or region with the widespread transmission have been advised to self-quarantine for 14 days from the time of last possible exposure. [114] [177] [178]

Ventilation and air filtration

The CDC recommends ventilation in public spaces to help clear out infectious aerosols, as well several others, including those regarding air filtration. [179] [180]

Hand washing

Hand hygiene is extremely important to prevent the spread of SARS-CoV-2. [181] The CDC recommends that people wash hands often with soap and water for at least twenty seconds, especially after going to the toilet or when hands are visibly dirty; before eating; and after blowing one's nose, coughing, or sneezing. This is because outside the human body, the virus is killed by household soap, which bursts its protective bubble. [182] In addition, soap and water disrupts the sticky bond between pathogens and human skin which causes the coronavirus pathogen to slide off the hands/body. [183] CDC has recommended using an alcohol-based hand sanitiser with at least 60 percent alcohol by volume when soap and water are not readily available. [146] The WHO advises people to avoid touching the eyes, nose, or mouth with unwashed hands. [147] [184] It is not clear whether washing hands with ash, if soap is not available, is effective at reducing the spread of viral infections. [185]

Surface cleaning

Surfaces may be decontaminated with a number of solutions (within one minute of exposure to the disinfectant for a stainless steel surface), including 62–71 percent ethanol, 50–100 percent isopropanol, 0.1 percent sodium hypochlorite, 0.5 percent hydrogen peroxide, and 0.2–7.5 percent povidone-iodine. Other solutions, such as benzalkonium chloride and chlorhexidine gluconate, are less effective. [186] Ultraviolet germicidal irradiation may also be used. [179] The CDC recommends that if a COVID-19 case is suspected or confirmed at a facility such as an office or day care, all areas such as offices, bathrooms, common areas, shared electronic equipment like tablets, touch screens, keyboards, remote controls, and ATM machines used by the ill persons should be disinfected. [187]

Vaccine

Previous work to develop a vaccine against SARS and MERS established knowledge about the structure and function of coronaviruses which accelerated development during early 2020 of varied technology platforms for a COVID‑19 vaccine. [188] As of October 2020, there were 321 vaccine candidates in development, a 2.5 fold increase since April. However, no candidate has completed vaccine trials to prove its safety and efficacy. [189] In October, some 44 vaccine candidates were in clinical research: namely 34 in Phase I–II trials and 10 in Phase II–III trials. [189] [190] [191] [192]

Mitigation

Screening, containment and mitigation

Goals of mitigation include delaying and reducing peak burden on healthcare (flattening the curve) and lessening overall cases and health impact. Moreover, progressively greater increases in healthcare capacity (raising the line) such as by increasing bed count, personnel, and equipment, help to meet increased demand. 20200410 Flatten the curve, raise the line - pandemic (English).gif
Goals of mitigation include delaying and reducing peak burden on healthcare ( flattening the curve ) and lessening overall cases and health impact. Moreover, progressively greater increases in healthcare capacity ( raising the line ) such as by increasing bed count, personnel, and equipment, help to meet increased demand.
Mitigation attempts that are inadequate in strictness or duration--such as premature relaxation of distancing rules or stay-at-home orders--can allow a resurgence after the initial surge and mitigation. 20200409 Pandemic resurgence - effect of inadequate mitigation.gif
Mitigation attempts that are inadequate in strictness or duration—such as premature relaxation of distancing rules or stay-at-home orders—can allow a resurgence after the initial surge and mitigation.

Strategies in the control of an outbreak are screening, containment (or suppression), and mitigation. Screening is done with a device such as a thermometer to detect the elevated body temperature associated with fevers caused by the coronavirus. [197] Containment is undertaken in the early stages of the outbreak and aims to trace and isolate those infected as well as introduce other measures to stop the disease from spreading. When it is no longer possible to contain the disease, efforts then move to the mitigation stage: measures are taken to slow the spread and mitigate its effects on the healthcare system and on society. A combination of both containment and mitigation measures may be undertaken at the same time. [198] Suppression requires more extreme measures so as to reverse the pandemic by reducing the basic reproduction number to less than 1. [199]

Part of managing an infectious disease outbreak is trying to delay and decrease the epidemic peak, known as flattening the epidemic curve. [193] This decreases the risk of health services being overwhelmed and provides more time for vaccines and treatments to be developed. [193] Non-pharmaceutical interventions that may manage the outbreak include personal preventive measures such as hand hygiene, wearing face masks, and self-quarantine; community measures aimed at physical distancing such as closing schools and cancelling mass gathering events; community engagement to encourage acceptance and participation in such interventions; as well as environmental measures such surface cleaning. [200]

More drastic actions aimed at containing the outbreak were taken in China once the severity of the outbreak became apparent, such as quarantining entire cities and imposing strict travel bans. [201] Other countries also adopted a variety of measures aimed at limiting the spread of the virus. South Korea introduced mass screening and localised quarantines and issued alerts on the movements of infected individuals. Singapore provided financial support for those infected who quarantined themselves and imposed large fines for those who failed to do so. Taiwan increased face mask production and penalised hoarding of medical supplies. [202]

Simulations for Great Britain and the United States show that mitigation (slowing but not stopping epidemic spread) and suppression (reversing epidemic growth) have major challenges. Optimal mitigation policies might reduce peak healthcare demand by two-thirds and deaths by half, but still result in hundreds of thousands of deaths and overwhelmed health systems. Suppression can be preferred but needs to be maintained for as long as the virus is circulating in the human population (or until a vaccine becomes available), as transmission otherwise quickly rebounds when measures are relaxed. Long-term intervention to suppress the pandemic has considerable social and economic costs. [199]

Contact tracing

Mandatory traveller information collection for use in COVID-19 contact tracing at New York City's LaGuardia Airport in August 2020

Contact tracing is an important method for health authorities to determine the source of infection and to prevent further transmission. [203] The use of location data from mobile phones by governments for this purpose has prompted privacy concerns, with Amnesty International and more than a hundred other organisations issuing a statement calling for limits on this kind of surveillance. [204]

Several mobile apps have been implemented or proposed for voluntary use, and as of 7 April 2020 more than a dozen expert groups were working on privacy-friendly solutions such as using Bluetooth to log a user's proximity to other cellphones. [204] (Users are alerted if they have been near someone who subsequently tests positive.) [204]

On 10 April 2020, Google and Apple jointly announced an initiative for privacy-preserving contact tracing based on Bluetooth technology and cryptography. [205] [206] The system is intended to allow governments to create official privacy-preserving coronavirus tracking apps, with the eventual goal of integration of this functionality directly into the iOS and Android mobile platforms. [207] In Europe and in the U.S., Palantir Technologies is also providing COVID-19 tracking services. [208]

Health care

An army-constructed field hospital outside Ostra sjukhuset (Eastern hospital) in Gothenburg, Sweden, contains temporary intensive care units for COVID-19 patients. Ostra Sjukhuset COVID-19 Faltsjukhus.jpg
An army-constructed field hospital outside Östra sjukhuset (Eastern hospital) in Gothenburg, Sweden, contains temporary intensive care units for COVID-19 patients.

Increasing capacity and adapting healthcare for the needs of COVID-19 patients is described by the WHO as a fundamental outbreak response measure. [209] The ECDC and the European regional office of the WHO have issued guidelines for hospitals and primary healthcare services for shifting of resources at multiple levels, including focusing laboratory services towards COVID-19 testing, cancelling elective procedures whenever possible, separating and isolating COVID-19 positive patients, and increasing intensive care capabilities by training personnel and increasing the number of available ventilators and beds. [209] [210] In addition, in an attempt to maintain physical distancing, and to protect both patients and clinicians, in some areas non-emergency healthcare services are being provided virtually. [211] [212] [213]

Due to capacity limitations in the standard supply chains, some manufacturers are 3D printing healthcare material such as nasal swabs and ventilator parts. [214] [215] In one example, when an Italian hospital urgently required a ventilator valve, and the supplier was unable to deliver in the timescale required, a local startup received legal threats due to alleged patent infringement after reverse-engineering and printing the required hundred valves overnight. [216] [217] [218] On 23 April 2020, NASA reported building, in 37 days, a ventilator which is currently undergoing further testing. NASA is seeking fast-track approval. [219] [220]

Treatment

An exhausted anaesthesiologist in Pesaro, Italy, March 2020 Covid-19 San Salvatore 09.jpg
An exhausted anaesthesiologist in Pesaro, Italy, March 2020

Antiviral medications are under investigation for COVID-19, though none have yet been shown to be clearly effective on mortality in published randomised controlled trials. [221] However, remdesivir may affect the time it takes to recover from the virus. [222] Emergency use authorisation for remdesivir was granted in the U.S. on 1 May, for people hospitalised with severe COVID-19. [223] The interim authorisation was granted considering the lack of other specific treatments, and that its potential benefits appear to outweigh the potential risks. [223] [224]

Taking over-the-counter cold medications, [225] drinking fluids, and resting may help alleviate symptoms. [146] Depending on the severity, oxygen therapy, intravenous fluids, and breathing support may be required. [226] The safety and effectiveness of convalescent plasma as a treatment option requires further research. [227]

Other trials are investigating whether existing medications can be used effectively against COVID-19 or the immune reaction to it. [221] [228] On 16 June, the RECOVERY Trial group released a statement that their preliminary results show low dose dexamethasone reduces mortality in patients receiving respiratory support, [229] though previous reviews had suggested the use of steroids may worsen outcomes. [230] Demand for dexamethasone surged after publication of the preprint. [231] On 2 September, the WHO recommended treatment with systemic steroids for patients with severe and critical symptoms, but continued to advise against their use for other patients. [232]

A study of major hospitals in the U.S. found that abnormal liver tests occurred in most hospitalized patients with COVID-19 and may be associated with poorer clinical outcomes. [233] Tocilizumab was significantly associated in the relationship between the drugs used to treat the disease and abnormal liver tests, which prompted studies to determine whether abnormal results were due to coronavirus or drug-induced liver injury, according to Michael Nathanson, director of the Yale Liver Center and co-author of the study. [234]

History

2019

COVID-19 pandemic
Cumulative per capita confirmed COVID-19 cases
Desc-i.svg
Interactive timeline map of confirmed cases per million people
(drag circle to adjust; may not work on mobile devices)

Based on the retrospective analysis, starting from December, the number of coronavirus cases in Hubei gradually increased, reaching 60 by 20 December and at least 266 by 31 December. [36] That same day, the WHO received reports of a cluster of viral pneumonia cases of an unknown cause in Wuhan, [235] and an investigation was launched at the start of January 2020. [236]

According to official Chinese sources, these early cases were mostly linked to the Huanan Seafood Wholesale Market, which also sold live animals. [237] However, in May 2020, George Gao, the director of the Chinese Center for Disease Control and Prevention, said animal samples collected from the seafood market had tested negative for the virus, indicating the market was not the source of the initial outbreak. [238]

On 24 December, Wuhan Central Hospital sent a bronchoalveolar lavage fluid (BAL) sample from an unresolved clinical case to sequencing company Vision Medicals. On 27 and 28 December, Vision Medicals informed the Wuhan Central Hospital and the Chinese CDC of the results of the test, showing a new coronavirus. [239] A pneumonia cluster of unknown cause was observed on 26 December and treated by the doctor Zhang Jixian in Hubei Provincial Hospital, who informed the Wuhan Jianghan CDC on 27 December. [240]

On 30 December 2019, a test report addressed to Wuhan Central Hospital, from company CapitalBio Medlab, stated that there was an erroneous positive result for SARS, causing a group of doctors at Wuhan Central Hospital to alert their colleagues and relevant hospital authorities of the result. Eight of those doctors, including Li Wenliang (who was also punished on 3 January), [241] were later admonished by the police for spreading false rumours; and another doctor, Ai Fen, was reprimanded by her superiors for raising the alarm. [242] That evening, the Wuhan Municipal Health Commission issued a notice to various medical institutions about "the treatment of pneumonia of unknown cause". [243] The next day, the Wuhan Municipal Health Commission made the first public announcement of a pneumonia outbreak of unknown cause, confirming 27 cases [235] [244] [245] —enough to trigger an investigation. [236]

2020

Chinese medics in the city of Huanggang, Hubei on 20 March 2020 2020-3-20 Huang Gang Song Bie Shan Dong Yuan E Yi Liao Dui Huang Mei Xi Da Ju Yuan .jpg
Chinese medics in the city of Huanggang, Hubei on 20 March 2020

During the early stages of the outbreak, the number of cases doubled approximately every seven and a half days. [246] In early and mid-January 2020, the virus spread to other Chinese provinces, helped by the Chinese New Year migration and Wuhan being a transport hub and major rail interchange. [247] On 20 January, China reported nearly 140 new cases in one day, including two people in Beijing and one in Shenzhen. [248] A retrospective official study published in March found that 6,174 people had already developed symptoms by 20 January (most of them would be diagnosed later) [249] and more may have been infected. [250] A report in The Lancet on 24 January indicated human transmission, strongly recommended personal protective equipment for health workers, and said testing for the virus was essential due to its "pandemic potential". [32] [251]

On 30 January, with 7,818 confirmed cases across 19 countries, the WHO declared the outbreak a Public Health Emergency of International Concern (PHEIC), [252] [253] and then a pandemic on 11 March 2020 [254] [255] as Italy, Iran, South Korea, and Japan reported increasing numbers of cases. Later that month, the number of cases outside of China quickly surpassed the number of cases inside China. [256]

On 31 January 2020, Italy had its first confirmed cases, two tourists from China. [257] As of 13 March 2020, the WHO considered Europe the active centre of the pandemic. [258] On 19 March 2020, Italy overtook China as the country with the most reported deaths. [259] By 26 March, the United States had overtaken China and Italy with the highest number of confirmed cases in the world. [260] Research on coronavirus genomes indicates the majority of COVID-19 cases in New York came from European travellers, rather than directly from China or any other Asian country. [261] Retesting of prior samples found a person in France who had the virus on 27 December 2019 [262] [263] and a person in the United States who died from the disease on 6 February 2020. [264]

On 11 June 2020, after 55 days without a locally transmitted case being officially reported, [265] the city of Beijing reported a single COVID-19 case, followed by two more cases on 12 June. [266] As of 15 June 79 cases were officially confirmed. [267] Most of these patients went to Xinfadi Wholesale Market. [265] [268]

On 29 June 2020, WHO warned that the spread of the virus is still accelerating as countries reopen their economies, although many countries have made progress in slowing down the spread. [269]

On 15 July 2020, one COVID-19 case was officially reported in Dalian in more than three months. The patient did not travel outside the city in the 14 days before developing symptoms, nor did he have contact with people from "areas of attention." [270]

In October 2020, the WHO stated, at a special meeting of WHO leaders, that one in ten people around the world may have been infected with COVID-19. At the time, that translated to 780 million people being infected, while only 35 million infections had been confirmed. [271]

As of 26 October 2020, more than 42.9 million cases have been reported worldwide; more than 1.15 million people have died and more than 28.9 million have recovered. [5]

National responses

A total of 189 [5] countries and territories have had at least one case of COVID-19 so far. Due to the pandemic in Europe, many countries in the Schengen Area have restricted free movement and set up border controls. [272] National reactions have included containment measures such as quarantines and curfews (known as stay-at-home orders, shelter-in-place orders, or lockdowns). [273] The WHO's recommendation on curfews and lockdowns is that they should be short-term measures to reorganize, regroup, rebalance resources, and protect health workers who are exhausted. To achieve a balance between restrictions and normal life, the long-term responses to the pandemic should consist of strict personal hygiene, effective contact tracing, and isolating when ill. [274]

By 26 March, 1.7 billion people worldwide were under some form of lockdown, [275] which increased to 3.9 billion people by the first week of April—more than half the world's population. [276] [277]

By late April, around 300 million people were under lockdown in nations of Europe, including but not limited to Italy, Spain, France, and the United Kingdom, while around 200 million people were under lockdown in Latin America. [278] Nearly 300 million people, or about 90 percent of the population, were under some form of lockdown in the United States, [279] around 100 million people in the Philippines, [278] about 59 million people in South Africa, [280] and 1.3 billion people have been under lockdown in India. [281] [282] On 21 May 100,000 new infections occurred worldwide, the most since the start of the pandemic, while overall 5 million cases were surpassed. [283]

Asia

As of 19 May 2020, cases have been reported in all Asian countries except for Turkmenistan and North Korea, although these countries likely also have cases. [284] [285] Despite being the first area of the world hit by the outbreak, the early wide-scale response of some Asian states, particularly Mongolia, [286] South Korea, [287] Taiwan, [288] and Vietnam, [289] has allowed them to fare comparatively well.

China

A temporary hospital constructed in Wuhan in February Ta Zi Hu Ti Yu Zhong Xin Gai Zao De Fang Cang Yi Yuan 07.jpg
A temporary hospital constructed in Wuhan in February

As of 14 July 2020, there are 83,545 cases confirmed in China excluding 114 asymptomatic cases, 62 of which were imported, under medical observation; asymtomatic cases have not been reported prior to 31 March 2020 with 4,634 deaths and 78,509 recoveries, [290] meaning there are only 402 cases. Hubei has the most cases, followed by Xinjiang. [291]

India

Indian officials conducting temperature checks at the Ratha Yatra Hindu festival on 23 June Thermal Screening of Sebayats.jpg
Indian officials conducting temperature checks at the Ratha Yatra Hindu festival on 23 June

The first case of COVID-19 in India originated from China and was reported on 30 January 2020. India ordered a nationwide lockdown for the entire population starting 24 March, [292] with a phased unlock beginning 1 June. Six cities account for around half of all reported cases in the country—Mumbai, Delhi, Ahmedabad, Chennai, Pune and Kolkata. [293]

As of September 2020, India had the largest number of confirmed cases in Asia; [294] and the second-highest number of confirmed cases in the world, [295] behind the United States, [296] with the number of total confirmed cases breaching the 100,000 mark on 19 May, [297] 1,000,000 on 16 July [298] and 5,000,000 confirmed cases on 16 September 2020. [299] On 30 August, India surpassed the US record for the most cases in a single day, with more than 78,000 cases, [300] and set a new record on 16 September, with almost 98,000 cases reported that day.

On 10 June, India's recoveries exceeded active cases for the first time. [301] As of 30 August, India's case fatality rate is relatively low at 2.3%, against the global 4.7%. [302]

Iran

Disinfection of Tehran Metro trains against coronavirus. Similar measures have also been taken in other countries. Disinfection of Tehran subway wagons against coronavirus 2020-02-26 09.jpg
Disinfection of Tehran Metro trains against coronavirus. Similar measures have also been taken in other countries.

Iran reported its first confirmed cases of SARS-CoV-2 infections on 19 February in Qom, where, according to the Ministry of Health and Medical Education, two people had died that day. [304] [305] Early measures announced by the government included the cancellation of concerts and other cultural events, [306] sporting events, [307] Friday prayers, [308] and closures of universities, higher education institutions, and schools. [309] Iran allocated 5 trillion rials (equivalent to US$120,000,000) to combat the virus. [310] President Hassan Rouhani said on 26 February there were no plans to quarantine areas affected by the outbreak, and only individuals would be quarantined. [311] Plans to limit travel between cities were announced in March, [312] although heavy traffic between cities ahead of the Persian New Year Nowruz continued. [313] Shia shrines in Qom remained open to pilgrims until 16 March. [314] [315]

Iran became a centre of the spread of the virus after China during February. [316] [317] More than ten countries had traced their cases back to Iran by 28 February, indicating the outbreak may have been more severe than the 388 cases reported by the Iranian government by that date. [317] [318] The Iranian Parliament was shut down, with 23 of its 290 members reported to have had tested positive for the virus on 3 March. [319] On 15 March, the Iranian government reported a hundred deaths in a single day, the most recorded in the country since the outbreak began. [320] At least twelve sitting or former Iranian politicians and government officials had died from the disease by 17 March. [321] By 23 March, Iran was experiencing fifty new cases every hour and one new death every ten minutes due to coronavirus. [322] According to a WHO official, there may be five times more cases in Iran than what is being reported. It is also suggested that U.S. sanctions on Iran may be affecting the country's financial ability to respond to the viral outbreak. [323] On 20 April, Iran reopened shopping malls and other shopping areas across the country. [324] After reaching a low in new cases in early May, a new peak was reported on 4 June, raising fear of a second wave. [325] On 18 July, President Rouhani estimated that 25 million Iranians had already become infected, which is considerably higher than the official count. [326] Leaked data suggest that 42,000 people had died with COVID-19 symptoms by 20 July, nearly tripling the 14,405 officially reported by that date. [327]

South Korea

A drive-through test centre at the Gyeongju Public Health Centre Coronavirus Check by Drive-Through.jpg
A drive-through test centre at the Gyeongju Public Health Centre

COVID-19 was confirmed to have spread to South Korea on 20 January 2020 from China. The nation's health agency reported a significant increase in confirmed cases on 20 February, [328] largely attributed to a gathering in Daegu of the Shincheonji Church of Jesus. [328] [329] Shincheonji devotees visiting Daegu from Wuhan were suspected to be the origin of the outbreak. [330] [331] By 22 February, among 9,336 followers of the church, 1,261 or about 13 percent reported symptoms. [332] South Korea declared the highest level of alert on 23 February 2020. [333] On 29 February, more than 3,150 confirmed cases were reported. [334] All South Korean military bases were quarantined after tests showed three soldiers had the virus. [330] Airline schedules were also changed. [335] [336]

South Korea introduced what was considered the largest and best-organised programme in the world to screen the population for the virus, isolate any infected people, and trace and quarantine those who contacted them. [287] [337] Screening methods included mandatory self-reporting of symptoms by new international arrivals through mobile application, [338] drive-through testing for the virus with the results available the next day, [339] and increasing testing capability to allow up to 20,000 people to be tested every day. [340] Despite some early criticisms of President Moon Jae-in's response to the crisis, [341] South Korea's programme is considered a success in controlling the outbreak without quarantining entire cities. [287] [342] [343]

On 23 March, it was reported that South Korea had the lowest one-day case total in four weeks. [340] On 29 March it was reported that beginning 1 April all new overseas arrivals will be quarantined for two weeks. [344] Per media reports on 1 April, South Korea has received requests for virus testing assistance from 121 different countries. [345] Persistent local groups of infections in the greater Seoul area continued to be found, which led to Korea's CDC director saying in June that the country had entered a second wave of infections, [346] although a WHO official disagreed with that assessment. [347]

Europe

Cases of COVID-19 per 100,000 residents in Europe. The numbers are not comparable, as the testing strategy differs among countries and time periods. COVID-19 outbreak Europe per capita cases map.svg
Cases of COVID-19 per 100,000 residents in Europe. The numbers are not comparable, as the testing strategy differs among countries and time periods.

As of 13 March 2020, when the number of new cases became greater than those in China, the World Health Organization (WHO) began to consider Europe the active centre of the pandemic. [348] [349] Cases by country across Europe had doubled over periods of typically 3 to 4 days, with some countries (mostly those at earlier stages of detection) showing doubling every 2 days. [350]

As of 17 March, all countries within Europe had a confirmed case of COVID-19, with Montenegro being the last European country to report at least one case. [351] At least one death has been reported in all European countries, apart from the Vatican City.

As of 18 March, more than 250 million people were in lockdown in Europe. [352]

As of 24 May, 68 days since its first recorded case, Montenegro became the first COVID-19-free country in Europe, [353] [354] but this situation lasted only 44 days before a newly imported case was identified there. [355]

On 21 August, it was reported the COVID-19 cases were climbing among younger individuals across Europe. [356]

France

Although it was originally thought the pandemic reached France on 24 January 2020, when the first COVID-19 case in Europe was confirmed in Bordeaux, it was later discovered that a person near Paris had tested positive for the virus on 27 December 2019 after retesting old samples. [262] [263] A key event in the spread of the disease in the country was the annual assembly of the Christian Open Door Church between 17 and 24 February in Mulhouse, which was attended by about 2,500 people, at least half of whom are believed to have contracted the virus. [357] [358]

On 13 March, Prime Minister Édouard Philippe ordered the closure of all non-essential public places, [359] and on 16 March, French President Emmanuel Macron announced mandatory home confinement, a policy which was extended at least until 11 May. [360] [361] [362] As of 14 September, France has reported more than 402,000 confirmed cases, 30,000 deaths, and 90,000 recoveries, [363] ranking fourth in number of confirmed cases. [364] In April, there were riots in some Paris suburbs. [365] On 18 May, it was reported that schools in France had to close again after reopening, due to COVID-19 case flare-ups. [366]

Italy

The outbreak was confirmed to have spread to Italy on 31 January, when two Chinese tourists tested positive for SARS-CoV-2 in Rome. [257] Cases began to rise sharply, which prompted the Italian government to suspend all flights to and from China and declare a state of emergency. [367] An unassociated cluster of COVID-19 cases was later detected, starting with 16 confirmed cases in Lombardy on 21 February. [368]

Civil Protection volunteers conduct health checks at the Guglielmo Marconi Airport in Bologna on 5 February. Emergenza coronavirus (49496308758).jpg
Civil Protection volunteers conduct health checks at the Guglielmo Marconi Airport in Bologna on 5 February.

On 22 February, the Council of Ministers announced a new decree-law to contain the outbreak, including quarantining more than 50,000 people from eleven different municipalities in northern Italy. [369] Prime Minister Giuseppe Conte said, "In the outbreak areas, entry and exit will not be provided. Suspension of work activities and sports events has already been ordered in those areas." [370] [371]

On 4 March, the Italian government ordered the full closure of all schools and universities nationwide as Italy reached a hundred deaths. All major sporting events were to be held behind closed doors until April, [372] but on 9 March all sport was suspended completely for at least one month. [373] On 11 March, Prime Minister Conte ordered stoppage of nearly all commercial activity except supermarkets and pharmacies. [374] [375]

On 6 March, the Italian College of Anaesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI) published medical ethics recommendations regarding triage protocols. [376] [377] [378] On 19 March, Italy overtook China as the country with the most coronavirus-related deaths in the world after reporting 3,405 fatalities from the pandemic. [379] [380] On 22 March, it was reported that Russia had sent nine military planes with medical equipment to Italy. [381] As of 14 September, there were 287,753 confirmed cases, 35,610 deaths, and 213,634 recoveries in Italy, with the majority of those cases occurring in the Lombardy region. [256] A CNN report indicated that the combination of Italy's large elderly population and inability to test all who have the virus to date may be contributing to the high fatality rate. [382] On 19 April, it was reported that the country had its lowest deaths at 433 in seven days and some businesses are asking for a loosening of restrictions after six weeks of lockdown. [383] On 13 October 2020, the Italian government again issued restrictive rules to contain a rise in infections. [384]

Spain

Residents of Valencia, Spain, maintaining social distancing while queueing 2020-03-Detalls i consequencies del COVID-19 al Pais Valencia 14.jpg
Residents of Valencia, Spain, maintaining social distancing while queueing

The virus was first confirmed to have spread to Spain on 31 January 2020, when a German tourist tested positive for SARS-CoV-2 in La Gomera, Canary Islands. [385] Post-hoc genetic analysis has shown that at least 15 strains of the virus had been imported, and community transmission began by mid-February. [386] By 13 March, cases had been confirmed in all 50 provinces of the country.

A lockdown was imposed on 14 March 2020. [387] On 29 March, it was announced that, beginning the following day, all non-essential workers were ordered to remain at home for the next 14 days. [388] By late March, the Community of Madrid has recorded the most cases and deaths in the country. Medical professionals and those who live in retirement homes have experienced especially high infection rates. [389] On 25 March, the official death toll in Spain surpassed that of mainland China. [390] On 2 April, 950 people died of the virus in a 24-hour period—at the time, the most by any country in a single day. [391] On 17 May, the daily death toll announced by the Spanish government fell below 100 for the first time, [392] and 1 June was the first day without deaths by coronavirus. [393] The state of alarm ended on 21 June. [394] However, the number of cases increased again in July in a number of cities including Barcelona, Zaragoza and Madrid, which led to reimposition of some restrictions but no national lockdown. [395] [396] [397] [398]

Studies have suggested that the number of infections and deaths may have been underestimated due to lack of testing and reporting, and many people with only mild or no symptoms were not tested. [399] [400] Reports in May suggested that, based on a sample of more than 63,000 people, the number of infections may be ten times higher than the number of confirmed cases by that date, and Madrid and several provinces of Castilla–La Mancha and Castile and León were the most affected areas with a percentage of infection greater than 10%. [401] [402] There may also be as many as 15,815 more deaths according to the Spanish Ministry of Health monitoring system on daily excess mortality (Sistema de Monitorización de la Mortalidad Diaria - MoMo). [403] On 6 July 2020, the results of a Government of Spain nationwide seroprevalence study showed that about two million people, or 5.2% of the population, could have been infected during the pandemic. [404] [405] Spain is the second country in Europe (behind Russia) to record half a million cases. [406] On 21 October, Spain passed 1 million COVID-19 cases, with 1,005,295 infections and 34,366 deaths reported as of 21 October a third of which occurred in Madrid. [407]

Sweden

Sweden differed from most other European countries in that it mostly remained open. [408] Per the Swedish Constitution, the Public Health Agency of Sweden has autonomy which prevents political interference and the agency's policy favoured forgoing a lockdown. The Swedish strategy focused on measures that could be put in place over a longer period of time, based on the assumption that the virus would start spreading again after a shorter lockdown. [409] [410] The New York Times said that, as of May 2020, the outbreak had been far deadlier there but the economic impact had been reduced as Swedes have continued to go to work, restaurants, and shopping. [408] [411] On 19 May, it was reported that the country had in the week of 12–19 May the highest per capita deaths in Europe, 6.25 deaths per million per day. [412] In the end of June, Sweden no longer had excess mortality. [413]

United Kingdom

The "Wee Annie" statue in Gourock, Scotland, was given a face mask during the pandemic. Wee Annie, Kempock Street, face mask.jpg
The "Wee Annie" statue in Gourock, Scotland, was given a face mask during the pandemic.

Devolution in the United Kingdom meant that each of the four countries of the UK had its own different response to COVID-19, and the UK government, on behalf of England, moved quicker to lift restrictions. [414] The UK government started enforcing social distancing and quarantine measures on 18 March 2020 [415] [416] and was criticised[ by whom? ] for a perceived lack of intensity in its response to concerns faced by the public. [417] [418] On 16 March, Prime Minister Boris Johnson advised against non-essential travel and social contact, suggesting people work from home and avoid venues such as pubs, restaurants, and theatres. [419] [420] On 20 March, the government announced that all leisure establishments to close as soon as possible, [421] and promised to prevent unemployment. [422] On 23 March, Johnson banned gatherings of multiple people and restricting non-essential travel and outdoor activity. Unlike previous measures, these restrictions were enforceable by police through fines and dispersal of gatherings. Most unessential businesses were ordered to close. [423]

On 24 April it was reported that a promising vaccine trial had begun in England; the government pledged more than £50 million towards research. [424] A number of temporary critical care hospitals were built. [425] The first operating was the 4000-bed NHS Nightingale Hospital London, constructed for over nine days. [426] On 4 May, it was announced that it would be placed on standby and remaining patients transferred to other facilities; [427] 51 patients had been treated in the first three weeks. [428]

On 16 April it was reported that the UK would have first access to the Oxford vaccine, due to a prior contract; should the trial be successful, some 30 million doses in the UK would be available. [429]

North America

The first cases in North America were reported in the United States in January 2020. Cases were reported in all North American countries after Saint Kitts and Nevis confirmed a case on 25 March, and in all North American territories after Bonaire confirmed a case on 16 April. [430]

Canada reported 117,658 cases and 3,842 deaths on 30 July, while Mexico reported 416,179 cases and 46,000 deaths. [431] The most cases by state is Texas with about 17,279 deaths and over 849,000 confirmed cases.

United States

The hospital ship USNS Comfort arrives in Manhattan on 30 March. USNS Comfort New York City 2020.jpg
The hospital ship USNS Comfort arrives in Manhattan on 30 March.

As of October 2020, there were more than 8,600,000 cases and 220,000 COVID-19-related deaths in the U.S., representing 20% of the world's known COVID-19 deaths, and the most deaths of any country. [432] As of October 20, the U.S. death rate had reached 670 per million people, the eleventh-highest rate globally, and ninth-highest if European microstates are excluded. [433] [434]

The first American case was reported on January 20, and the U.S. outbreak was officially declared a public health emergency on January 31. Some restrictions were placed on flights arriving from China, [435] [436] but the initial U.S. response to the pandemic was otherwise slow, in terms of preparing the healthcare system, stopping other travel, and testing for the virus. [437] [438] [439] [lower-alpha 8] Meanwhile, President Donald Trump downplayed the threat posed by the virus and claimed the outbreak was under control. [441]

The first known American deaths occurred in February, but were not known to be caused by COVID-19 until April. [442] By the end of March, cases had been confirmed in all fifty U.S. states, the District of Columbia, and all inhabited U.S. territories except American Samoa. [443] [444]

On March 13, President Trump declared a national emergency. [445] The Trump administration largely waited until mid-March to start purchasing large quantities of medical equipment. [446] In late March, the administration started to use the Defense Production Act to direct industries to produce medical equipment. [447] By April 17, the federal government approved disaster declarations for all states and territories. A second rise in infections began in June 2020, following relaxed restrictions in several states. [448]

State and local responses to the outbreak have included prohibitions and cancellation of large-scale gatherings (including festivals and sporting events), stay-at-home orders, and the closure of schools. [449] Disproportionate numbers of cases have been observed among Black and Latino populations, [450] [451] [452] and there were reported incidents of xenophobia and racism against Asian Americans. [453] Clusters of infections and deaths have occurred in many areas. [lower-alpha 9]

South America

Argentina was among the Latin American countries that earned the best grades for their response to the pandemic. Alberto Fernandez toma la promesa a alumnos de todo el pais (20 de junio de 2020).jpg
Argentina was among the Latin American countries that earned the best grades for their response to the pandemic.
The pandemic was confirmed to have reached South America on 26 February 2020 when Brazil confirmed a case in São Paulo . [457] By 3 April, all countries and territories in South America had recorded at least one case. [458]

On October 19, the highest number of cases and deaths was registered in Brazil, [459] followed by Argentina and Colombia in the number of confirmed cases. [460]

On 13 May, it was reported that Latin America and the Caribbean had reported over 400,000 cases of infection with 23,091 deaths. On 22 May, citing especially the rapid increase of infections in Brazil, the WHO declared that South America is presently the epicentre of the coronavirus pandemic. [461] [462]

As of 20 September, South America has about 7.5 million confirmed cases and 238,000 deaths, surpassing the United States with about 6.9 million cases and 200,000 deaths. Due to a dearth of testing and medical facilities, it is believed that the outbreak in the former is far larger than the official numbers show. [463]

Brazil

The National Congress of Brazil, projecting the words "Solidariedade Salva Vidas," meaning "Solidarity Saves Lives." Congresso Nacional - Projecao "Solidariedade Salva Vidas" (49799764871).jpg
The National Congress of Brazil, projecting the words "Solidariedade Salva Vidas," meaning "Solidarity Saves Lives."

On 20 May it was reported that Brazil had a record 1,179 deaths in a single day, for a total of almost 18,000 fatalities. With a total number of almost 272,000 cases, Brazil became the country with the third-highest number of cases, following Russia and the United States. [464] On 25 May, Brazil exceeded the number of reported cases in Russia when they reported that 11,687 new cases had been confirmed over the previous 24 hours, bringing the total number to over 374,800, with more than 23,400 deaths. President Jair Bolsonaro has created a great deal of controversy referring to the virus as a "little flu" and frequently speaking out against preventive measures such as lockdowns and quarantines. His attitude towards the outbreak has so closely matched that of U.S. President Donald Trump he has been called the "Trump of the Tropics". [465] Bolsonaro later tested positive for the virus. [466]

In June 2020, the government of Brazil attempted to conceal the actual figures of the COVID-19 active cases and deaths, as it stopped publishing the total number of infections and deaths. On 5 June, Brazil's health ministry took down the official website reflecting the total numbers of infections and deaths. The website was live on 6 June, with only the number of infections of the previous 24 hours. The last official numbers reported about 615,000 infections and over 34,000 deaths. [467] On 15 June, it was reported that the worldwide cases had jumped from seven to eight million in one week, citing Latin America, specifically Brazil as one of the countries where cases are surging, in this case, towards 1 million cases. [468]

Africa

U.S. Air Force airmen unload a C-17 aircraft carrying approximately 1,800 kg (4,000 lb) of medical supplies in Niamey, Niger 23 April 2020. Air Forces Africa delivers medical supplies to Ghana (49829156488).jpg
U.S. Air Force airmen unload a C-17 aircraft carrying approximately 1,800 kg (4,000 lb) of medical supplies in Niamey, Niger 23 April 2020.

According to Michael Yao, WHO's head of emergency operations in Africa, early detection is vital because the continent's health systems "are already overwhelmed by many ongoing disease outbreaks". [469] [470] Advisers say that a strategy based on testing could allow African countries to minimise lockdowns that inflict enormous hardship on those who depend on income earned day by day to be able to feed themselves and their families. Even in the best scenario, the United Nations says 74 million test kits and 30,000 ventilators will be needed by the continent's 1.3 billion people in 2020. [471] The number of infections exceeded a million by 6 August, with five countries making up over 75% of the total confirmed cases: South Africa, Algeria, Egypt, Ghana, and Nigeria. [472] It is, however, believed that there is widespread under-reporting in other African countries with poorer health care systems, [473] and some countries such as Tanzania failed to provide useful statistics. The mortality rates of COVID-19 cases in African countries are relatively low compared to Europe due to the younger age of their populations. [472]

Cases have been confirmed in all African countries, with Lesotho the last country to report its first coronavirus case on 13 May 2020. [474] There have been no reported cases in the British Overseas Territory of Saint Helena, Ascension and Tristan da Cunha. [475]

Oceania

The pandemic was confirmed to have reached Oceania on 25 January 2020 with the first confirmed case reported in Melbourne, Victoria, Australia. [476] It has since spread elsewhere in the region, [477] although many small Pacific island nations have thus far avoided the outbreak by closing their international borders. Nine Oceania sovereign states have yet to report a case: Kiribati, the Marshall Islands, the Federated States of Micronesia, Nauru, Palau, Samoa, Tonga, Tuvalu, and Vanuatu. The most recent country to report a case was the Solomon Islands on 3 October 2020.

On 19 May 2020, Australia filed a motion with the UN for an inquiry into the origins of the virus, and the response of the UN and governments. More than 100 countries supported this motion, and it was passed unanimously. [478] [479]

International responses

Travel restrictions

As a result of the pandemic, many countries and regions imposed quarantines, entry bans, or other restrictions, either for citizens, recent travellers to affected areas, [480] or for all travellers. [481] Together with a decreased willingness to travel, this had a negative economic and social impact on the travel sector. Concerns have been raised over the effectiveness of travel restrictions to contain the spread of COVID-19. [482] A study in Science found that travel restrictions had only modestly affected the initial spread of COVID-19, unless combined with infection prevention and control measures to considerably reduce transmissions. [483] Researchers concluded that "travel restrictions are most useful in the early and late phase of an epidemic" and "restrictions of travel from Wuhan unfortunately came too late". [484]

The European Union rejected the idea of suspending the Schengen free travel zone and introducing border controls with Italy, [485] [486] a decision which has been criticised by some European politicians. [487] [488]

Evacuation of foreign citizens

Ukraine evacuates Ukrainian and foreign citizens from Wuhan, China. Ukraine evacuates Ukrainian and foreign citizens from Wuhan 16.jpg
Ukraine evacuates Ukrainian and foreign citizens from Wuhan, China.

Owing to the effective lockdown of Wuhan and Hubei, several countries evacuated their citizens and diplomatic staff from the area, primarily through chartered flights of the home nation, with Chinese authorities providing clearance. Canada, the United States, Japan, India, [489] Sri Lanka, Australia, France, Argentina, Germany, and Thailand were among the first to plan the evacuation of their citizens. [490] Brazil and New Zealand also evacuated their own nationals and some other people. [491] [492] On 14 March, South Africa repatriated 112 South Africans who tested negative for the virus from Wuhan, while four who showed symptoms were left behind to mitigate risk. [493] Pakistan said it would not evacuate citizens from China. [494]

On 15 February, the U.S. announced it would evacuate Americans aboard the cruise ship Diamond Princess , [495] and on 21 February, Canada evacuated 129 Canadian passengers from the ship. [496] In early March, the Indian government began evacuating its citizens from Iran. [497] [498] On 20 March, the United States began to partially withdraw its troops from Iraq due to the pandemic. [499]

United Nations response measures

The United Nations response to the pandemic has been led by its Secretary-General and can be divided into formal resolutions at the General Assembly and at the Security Council (UNSC), and operations via its specialized agencies.

In June 2020, the Secretary-General launched its 'UN Comprehensive Response to COVID-19'. [500] The United Nations Conference on Trade and Development (UNSC) has been criticized for a slow coordinated response, especially regarding the UN's global ceasefire, which aims to open up humanitarian access to the world's most vulnerable in conflict zones. [501]

WHO response measures

The WHO is a leading organisation involved in the global coordination for mitigating the pandemic.

WHO has spearheaded several initiatives like the COVID-19 Solidarity Response Fund to raise money for the pandemic response, the UN COVID-19 Supply Chain Task Force, and the solidarity trial for investigating potential treatment options for the disease.

In responding to the outbreak, WHO has had to deal with political conflicts between member states, in particular between the United States and China. [502] On May 19, WHO agreed to an independent investigation into its handling of the pandemic. On August 27, WHO announced the setting up of an independent expert Review Committee to examine aspects of the international treaty that governs preparedness and response to health emergencies.

Protests against governmental measures

In several countries, protests have risen against governmental restrictive responses to the COVID-19 pandemic.

Impact

Economics

A stock index chart shows the 2020 stock market crash Stock-indices-2020crash.svg
A stock index chart shows the 2020 stock market crash

The outbreak is a major destabilising threat to the global economy. Agathe Demarais of the Economist Intelligence Unit has forecast that markets will remain volatile until a clearer image emerges on potential outcomes. One estimate from an expert at Washington University in St. Louis gave a $300+ billion impact on the world's supply chain that could last up to two years. [503] Global stock markets fell on 24 February due to a significant rise in the number of COVID-19 cases outside China. [504] [505] On 27 February, due to mounting worries about the coronavirus outbreak, U.S. stock indexes posted their sharpest falls since 2008, with the Dow falling 1,191 points (the largest one-day drop since the financial crisis of 2007–08) [506] and all three major indexes ending the week down more than 10 percent. [507] On 28 February, Scope Ratings GmbH affirmed China's sovereign credit rating but maintained a Negative Outlook. [508] Stocks plunged again due to coronavirus fears, the largest fall being on 16 March. [509]

Lloyd's of London has estimated that the global insurance industry will absorb losses of US$204 billion, exceeding the losses from the 2017 Atlantic Hurricane season and 9/11, suggesting the COVID-19 pandemic will likely go down in history as the costliest disaster ever in human history. [510]

A highway sign on the Gardiner Expressway in Toronto discouraging non-essential travel COVID-19 highway sign in Toronto, March 2020 (cropped).jpg
A highway sign on the Gardiner Expressway in Toronto discouraging non-essential travel

Tourism is one of the worst affected sectors due to travel bans, closing of public places including travel attractions, and advice of governments against travel. Numerous airlines have cancelled flights due to lower demand, and British regional airline Flybe collapsed. [511] The cruise line industry was hard hit, [512] and several train stations and ferry ports have also been closed. [513] International mail between some countries stopped or was delayed due to reduced transportation between them or suspension of domestic service. [514]

The retail sector has been impacted globally, with reductions in store hours or temporary closures. [515] Visits to retailers in Europe and Latin America declined by 40 percent. North America and Middle East retailers saw a 50–60 percent drop. [516] This also resulted in a 33–43 percent drop in foot traffic to shopping centres in March compared to February. Shopping mall operators around the world imposed additional measures, such as increased sanitation, installation of thermal scanners to check the temperature of shoppers, and cancellation of events. [517]

"Those who can, put something in; those who can't, help yourself." Bologna, April 2020. Food basket Covid.jpg
"Those who can, put something in; those who can't, help yourself." Bologna, April 2020.

Hundreds of millions of jobs could be lost globally. [518] [519] More than 40 million Americans lost their jobs and filed unemployment insurance claims. [520] The economic impact and mass unemployment caused by the pandemic has raised fears of a mass eviction crisis, [521] [522] with an analysis by the Aspen Institute indicating between 30 and 40 million Americans are at risk for eviction by the end of 2020. [523] [524] According to a report by the Yelp, about 60% of U.S. businesses that have closed since the start of the pandemic will stay shut permanently. [525]

According to a United Nations Economic Commission for Latin America estimate, the pandemic-induced recession could leave 14–22 million more people in extreme poverty in Latin America than would have been in that situation without the pandemic. [526] According to the World Bank, up to 100 million more people globally could fall into extreme poverty due to the shutdowns. [527] [528] The International Labour Organization (ILO) informed that the income generated in first nine months of 2020 from work across the world dropped by 10.7 per cent, or $3.5 trillion, amidst the coronavirus outbreak. [529]

Supply shortages

Coronavirus fears have led to panic buying of essentials across the world, including toilet paper, dried and instant noodles, bread, rice, vegetables, disinfectant, and rubbing alcohol. Ntuc super store, Singapore (49505410793).jpg
Coronavirus fears have led to panic buying of essentials across the world, including toilet paper, dried and instant noodles, bread, rice, vegetables, disinfectant, and rubbing alcohol.

The outbreak has been blamed for several instances of supply shortages, stemming from globally increased usage of equipment to fight outbreaks, panic buying (which in several places led to shelves being cleared of grocery essentials such as food, toilet paper, and bottled water), and disruption to the factory and logistic operations. [530] The spread of panic buying has been found to stem from perceived threat, perceived scarcity, fear of the unknown, coping behaviour and social psychological factors (e.g. social influence and trust). [531] The technology industry, in particular, has warned of delays to shipments of electronic goods. [532] According to the WHO director-general Tedros Adhanom, demand for personal protection equipment has risen a hundredfold, leading to prices up to twenty times the normal price and also delays in the supply of medical items of four to six months. [533] [534] It has also caused a shortage of personal protective equipment worldwide, with the WHO warning that this will endanger health workers. [535]

The impact of the coronavirus outbreak was worldwide. The virus created a shortage of precursors (raw material) used in the manufacturing of fentanyl and methamphetamine. The Yuancheng Group, headquartered in Wuhan, is one of the leading suppliers. [536] Price increases and shortages in these illegal drugs have been noticed on the street of the UK. [537] U.S. law enforcement also told the New York Post Mexican drug cartels were having difficulty in obtaining precursors. [538]

The pandemic has disrupted global food supplies and threatens to trigger a new food crisis. [539] [540] David Beasley, head of the World Food Programme (WFP), said "we could be facing multiple famines of biblical proportions within a short few months." [541] Senior officials at the United Nations estimated in April 2020 that an additional 130 million people could starve, for a total of 265 million by the end of 2020. [18] [541] [542]

Oil and other energy markets

In early February 2020, Organization of the Petroleum Exporting Countries (OPEC) "scrambled" after a steep decline in oil prices due to lower demand from China. [543] On Monday, 20 April, the price of West Texas Intermediate (WTI) went negative and fell to a record low (minus $37.63 a barrel) due to traders' offloading holdings so as not to take delivery and incur storage costs. [544] June prices were down but in the positive range, with a barrel of West Texas trading above $20. [544]

Culture

Closed entrance to the Shah Abdol-Azim Shrine in Ray, Iran 3404926 syh khrwn br zndgy shhry.jpg
Closed entrance to the Shah Abdol-Azim Shrine in Ray, Iran

The performing arts and cultural heritage sectors have been profoundly affected by the pandemic, impacting organisations' operations as well as individuals—both employed and independent—globally. Arts and culture sector organisations attempted to uphold their (often publicly funded) mission to provide access to cultural heritage to the community, maintain the safety of their employees and the public, and support artists where possible. By March 2020, across the world and to varying degrees, museums, libraries, performance venues, and other cultural institutions had been indefinitely closed with their exhibitions, events and performances cancelled or postponed. [545] In response there were intensive efforts to provide alternative services through digital platforms. [546] [547] [548]

An American Catholic military chaplain prepares for a live-streamed Mass in an empty chapel at Offutt Air Force Base in March 2020. Religious service live-streaming during the 2020 coronavirus pandemic.jpg
An American Catholic military chaplain prepares for a live-streamed Mass in an empty chapel at Offutt Air Force Base in March 2020.

Holy Week observances in Rome, which occur during the last week of the Christian penitential season of Lent, were cancelled. [547] Many dioceses have recommended older Christians stay home rather than attend Mass on Sundays; services have been made available via radio, online live streaming and television, though some congregations have made provisions for drive-in worship. [549] [550] [547] With the Roman Catholic Diocese of Rome closing its churches and chapels and St. Peter's Square emptied of Christian pilgrims, [547] other religious bodies also cancelled in-person services and limited public gatherings in churches, mosques, synagogues, temples and gurdwaras. [547] Iran's Health Ministry announced the cancellation of Friday prayers in areas affected by the outbreak and shrines were later closed, [308] [315] while Saudi Arabia banned the entry of foreign pilgrims as well as its residents to holy sites in Mecca and Medina. [551] [552] The 2020 Hajj was limited to around 1,000 selected pilgrims, in contrast to the usual number of over 2 million. [553]

The pandemic has caused the most significant disruption to the worldwide sporting calendar since the Second World War. Most major sporting events have been cancelled or postponed, including the 2019–20 UEFA Champions League, [554] 2019–20 Premier League, [555] UEFA Euro 2020, 2019–20 NBA season, [556] and 2019–20 NHL season. [557] The outbreak disrupted plans for the 2020 Summer Olympics in Tokyo, Japan, which were originally scheduled to start at 24 July 2020, and were postponed by the International Olympic Committee to 23 July 2021. [558] [559] [560]

The entertainment industry has also been affected, with many music groups suspending or cancelling concert tours. [561] [562] The Eurovision Song Contest, which was due to be held in Rotterdam, the Netherlands in May, was cancelled; however, the Netherlands was retained as host for 2021. [563] [564] Many large theatres such as those on Broadway also suspended all performances. [565] Some artists have explored ways to continue to produce and share work over the internet as an alternative to traditional live performance, such as live streaming concerts [566] or creating web-based "festivals" for artists to perform, distribute, and publicise their work. [567] Online, numerous COVID-19-themed Internet memes have spread as many turn to humour and distraction amid the uncertainty. [568]

Politics

The pandemic has affected the political systems of multiple countries, causing suspensions of legislative activities, [569] isolations or deaths of multiple politicians, [570] and rescheduling of elections due to fears of spreading the virus. [571] Starting in late May, large-scale protests against police brutality in at least 200 U.S. cities and later worldwide in response to the killing of George Floyd raised concerns of a resurgence of the virus. [572]

Although they have broad support among epidemiologists, social distancing measures have been politically controversial in many countries. Intellectual opposition to social distancing has come primarily from writers of other fields, although there are a few heterodox epidemiologists. [573]

On 23 March 2020, United Nations Secretary-General António Manuel de Oliveira Guterres issued an appeal for a global ceasefire in response to the pandemic; [574] [575] 172 UN Member States and Observers signed a non-binding statement in support of the appeal in June, [576] and the UN Security Council passed a resolution supporting it in July. [577] [578]

China

Chinese Communist Party general secretary Xi Jinping (left) with State Council Premier Li Keqiang Xi jinping and Li keqiang.jpg
Chinese Communist Party general secretary Xi Jinping (left) with State Council Premier Li Keqiang

The Chinese government has been criticised by the United States government, [579] UK Minister for the Cabinet Office Michael Gove, [580] and others [581] for its handling of the pandemic. A number of provincial-level administrators of the Communist Party of China were dismissed over their handling of the quarantine measures in China, a sign of discontent with their response to the outbreak. Some commentators believed this move was intended to protect Chinese Communist Party general secretary Xi Jinping from the controversy. [582] The U.S. intelligence community says China intentionally under-reported its number of coronavirus cases. [583] The Chinese government maintains it has acted swiftly and transparently. [584] [585]

Italy

In early March, the Italian government criticised the European Union's lack of solidarity with coronavirus-affected Italy [586] [587] —Maurizio Massari, Italy's ambassador to the EU, said "only China responded bilaterally", not the EU. [588] On 22 March, after a phone call with Italian Prime Minister Giuseppe Conte, Russian president Vladimir Putin had the Russian army send military medics, disinfection vehicles, and other medical equipment to Italy. [589] President of Lombardy Attilio Fontana and Italian Foreign Minister Luigi Di Maio expressed their gratitude for the aid. [590] Russia also sent a cargo plane with medical aid to the United States. [591] Kremlin spokesman Dmitry Peskov said "when offering assistance to U.S. colleagues, [Putin] assumes that when U.S. manufacturers of medical equipment and materials gain momentum, they will also be able to reciprocate if necessary." [592] In early April, Norway and EU states like Romania and Austria started to offer help by sending medical personnel and disinfectant, [593] and Ursula von der Leyen offered an official apology to the country. [594]

United States

Several hundred anti-lockdown protesters rallied at the Ohio Statehouse 20 April. Open Ohio Rally IMG 0910 (49799974031).jpg
Several hundred anti-lockdown protesters rallied at the Ohio Statehouse 20 April.

The outbreak prompted calls for the United States to adopt social policies common in other wealthy countries, including universal health care, universal child care, paid sick leave, and higher levels of funding for public health. [596] [597] [598] Political analysts anticipated it may negatively affect Donald Trump's chances of re-election. [599] [600] Beginning in mid-April 2020, there were protests in several U.S. states against government-imposed business closures and restricted personal movement and association. [601] Simultaneously, protests ensued by essential workers in the form of a general strike. [602] In early October 2020, Donald Trump and many other government officials were diagnosed with COVID-19, further disrupting the country's politics. [603] The president, while still infected with the novel coronavirus, returned to the Oval Office on 7 October 2020. White House chief of staff Mark Meadows had previously ensured safety precautions to accommodate the president's request to return to work as soon as possible. Meadows claimed that the staffers and personnel working in direct contact with the president wore "full PPE, masks, goggles, and the like." [604]

Other countries

The planned NATO "Defender 2020" military exercise in Germany, Poland, and the Baltic states, the largest NATO war exercise since the end of the Cold War, will be held on a reduced scale. [605] [606] The Campaign for Nuclear Disarmament's general secretary Kate Hudson criticised the exercise, saying "it jeopardises the lives not only of the troops from the U.S. and the many European countries participating but the inhabitants of the countries in which they are operating." [607]

The Iranian government has been heavily affected by the virus, with about two dozen parliament members and fifteen current or former political figures infected. [318] [608] Iran's President Hassan Rouhani wrote a public letter to world leaders asking for help on 14 March 2020, saying they were struggling to fight the outbreak due to a lack of access to international markets from the United States sanctions against Iran. [609] Saudi Arabia, which launched a military intervention in Yemen in March 2015, declared a ceasefire. [610]

Diplomatic relations between Japan and South Korea worsened due to the pandemic. [611] South Korea criticised Japan's "ambiguous and passive quarantine efforts" after Japan announced anyone coming from South Korea would be placed in quarantine for two weeks at government-designated sites. [612] South Korean society was initially polarised on President Moon Jae-in's response to the crisis; many Koreans signed petitions either calling for Moon's impeachment or praising his response. [341]

Some countries have passed emergency legislation in response to the pandemic. Some commentators have expressed concern that it could allow governments to strengthen their grip on power. [613] [614] In the Philippines, lawmakers granted president Rodrigo Duterte temporary emergency powers during the pandemic. [615] In Hungary, the parliament voted to allow the prime minister, Viktor Orbán, to rule by decree indefinitely, suspend parliament as well as elections, and punish those deemed to have spread false information about the virus and the government's handling of the crisis. [616] In some countries, including Egypt, [617] Turkey, [618] and Thailand, [615] opposition activists and government critics have been arrested for allegedly spreading fake news about the COVID-19 pandemic. [619]

Agriculture and food systems

The COVID-19 pandemic has disrupted agricultural and food systems worldwide. [620] COVID-19 hit at a time when hunger or undernourishment was once again on the rise in the world, with an estimated 690 million people already going hungry in 2019. [621] Based on the latest UN estimates, the economic recession triggered by the pandemic may lead to another 83 million people, and possibly as many as 132 million, going hungry in 2020. [621] [622] [623] [624] This is mainly due to a lack of access to food – linked to falling incomes, lost remittances and, in some cases, a rise in food prices. In countries that already suffer from high levels of acute food insecurity, it is no longer an issue of access to food alone, but increasingly also one of food production. [620] [621]

Famine

The pandemic, alongside lockdowns and travel restrictions, has prevented movement of aid and greatly impacted food production. As a result, several famines are forecast, which the United Nations called a crisis "of biblical proportions," [625] or "hunger pandemic." [626] It is estimated that without intervention 30 million people may die of hunger, with Oxfam reporting that "12,000 people per day could die from COVID-19 linked hunger" by the end of 2020. [627] [625] [628] This pandemic, in conjunction with the 2019-20 locust infestations and several ongoing armed conflicts, is predicted to form the worst series of famines since the Great Chinese Famine, affecting between 10 and 20 percent of the global population in some way. [629] 55 countries are reported to be at risk, with three dozen succumbing to crisis-level famines or above in the worst-case scenario. [630] 265 million people are forecast to be in famine conditions, an increase of 125 million due to the coronavirus pandemic. [627]

Education

The pandemic has severely impacted educational systems globally. Most governments have temporarily closed educational institutions, with many switching to online education. As of 30 September 2020, approximately 1.077 billion learners are currently affected due to school closures in response to the pandemic. According to UNICEF monitoring, 53 countries are currently implementing nationwide closures and 27 are implementing local closures, impacting about 61.6 percent of the world's student population. 72 countries' schools are currently open. [631]

School closures impact not only students, teachers, and families but have far-reaching economic and societal consequences. School closures in response to the pandemic have shed light on various social and economic issues, including student debt, digital learning, food insecurity, and homelessness, as well as access to childcare, health care, housing, internet, and disability services. The impact has been more severe for disadvantaged children and their families, causing interrupted learning, compromised nutrition, childcare problems, and consequent economic cost to families who cannot work.

Other health issues

The pandemic has had many impacts on global health beyond those caused by the COVID-19 disease itself. It has led to a reduction in hospital visits for other reasons. There have been 38 per cent fewer hospital visits for heart attack symptoms in the United States and 40 per cent fewer in Spain. [632] The head of cardiology at the University of Arizona said, "My worry is some of these people are dying at home because they're too scared to go to the hospital." [633] There is also concern that people with strokes and appendicitis are not seeking timely treatment. [633] Shortages of medical supplies have impacted people with various conditions. [634]

In several countries there has been a marked reduction of spread of sexually transmitted infections, including HIV/AIDS, attributable to COVID-19 quarantines, social distancing measures, and recommendations to not engage in casual sex. [635] [636] Similarly, in some places, rates of transmission of influenza and other respiratory viruses significantly decreased during the pandemic. [637] [638] [639]

The pandemic has also negatively impacted mental health globally, including increased loneliness resulting from social distancing. [640]

Environment and climate

Images from the NASA Earth Observatory show a stark drop in pollution in Wuhan, when comparing NO2 levels in early 2019 (top) and early 2020 (bottom). Pollutant Drops in wuhan china due to virus.png
Images from the NASA Earth Observatory show a stark drop in pollution in Wuhan, when comparing NO2 levels in early 2019 (top) and early 2020 (bottom).

The worldwide disruption caused by the pandemic has resulted in numerous impacts on the environment and the climate. The global reduction in modern human activity such as the considerable decline in planned travel [642] was coined anthropause [643] and has caused many regions to experience a large drop in air pollution and water pollution. [644] In China, lockdowns and other measures resulted in a 25 percent reduction in carbon emissions [645] and 50 percent reduction in nitrogen oxides emissions, [646] which one Earth systems scientist estimated may have saved at least 77,000 lives over two months. [647] [648] Other positive impacts on the environment include governance-system-controlled investments towards a sustainable energy transition and other goals related to environmental protection such as the European Union's seven-year €1 trillion budget proposal and €750 billion recovery plan "Next Generation EU" which seeks to reserve 25% of EU spending for climate-friendly expenditure. [649] [650] [651]

However, the outbreak has also provided cover for illegal activities such as deforestation of the Amazon rainforest [652] [653] and poaching in Africa, [654] [655] hindered environmental diplomacy efforts, [656] and created economic fallout that some predict will slow investment in green energy technologies. [657]

Xenophobia and racism

Since the start of the outbreak, heightened prejudice, xenophobia, and racism have been documented around the world toward people of Chinese and East Asian descent. [658] [659] [660] Reports from February (when most cases were confined to China) documented racist sentiments expressed in groups worldwide about Chinese people 'deserving' the virus. [661] [662] [663] Chinese people and other Asian in the United Kingdom and United States have reported increasing levels of racist abuse and assaults. [664] [665] [666] U.S. President Donald Trump has been criticised for referring to the coronavirus as the "Chinese Virus" and "Kung Flu", which has been widely condemned as racist and xenophobic. [667] [668] [669] On 14 March, an Asian family, including a two-year-old girl, was attacked at knifepoint in Texas in what the FBI has called a COVID-19 related hate crime. [670]

Following the progression of the outbreak to new hotspot countries, people from Italy (the first country in Europe to experience a serious outbreak of COVID-19) were also subjected to suspicion and xenophobia, [671] [672] as were people from hotspots in other countries. Discrimination against Muslims in India escalated after public health authorities identified an Islamic missionary (Tablighi Jamaat) group's gathering in New Delhi in early March 2020 as a source of spread. [673] Paris has seen riots break out over police treatment of ethnic minorities during the coronavirus lockdown. [674] Racism and xenophobia towards southern and south east Asians increased in the Arab states of the Persian Gulf. [675] [676] [677] South Korea's LGBTQ community was blamed by some for the spread of COVID-19 in Seoul. [678] [679] In China, some people of African descent were evicted from their homes and told to leave China within 24 hours, due to disinformation that they and other foreigners were spreading the virus. [680] This racism and xenophobia was criticised by foreign governments and diplomatic corps and the Chinese ambassador to Zimbabwe. [681]

Information dissemination

Ongoing COVID-19 research is indexed and searchable in the NIH COVID-19 Portfolio. [682] Some newspaper agencies removed their online paywalls for some or all of their coronavirus-related articles and posts, [683] while scientific publishers made scientific papers related to the outbreak available with open access. [684] Some scientists chose to share their results quickly on preprint servers such as bioRxiv. [685]

Misinformation

U.S. president Donald Trump suggested at a press briefing on 23 April that disinfectant injections or exposure to ultraviolet light might help treat COVID-19. There is no evidence that either could be a viable method. [686] (1:05 min)

The pandemic has resulted in misinformation and conspiracy theories about the scale of the pandemic and the origin, prevention, diagnosis, and treatment of the disease. False information, including intentional disinformation, has been spread through social media, text messaging, and mass media, including the tabloid media, conservative media, and state media of countries such as China, Iran, and Turkmenistan. It has also been reportedly spread by covert operations backed by states such as Saudi Arabia, and China to generate panic and sow distrust in other countries. In some countries, such as India, Bangladesh, and Ethiopia, journalists have been arrested for allegedly spreading fake news about the pandemic.

Misinformation has been propagated by celebrities, politicians (including heads of state in countries such as the United States, Iran, and Brazil), and other prominent public figures. Commercial scams have claimed to offer at-home tests, supposed preventives, and "miracle" cures. Several religious groups have claimed their faith will protect them from the virus. Some people have claimed the virus is a bioweapon accidentally or purposefully leaked from a laboratory, a population control scheme, the result of a spy operation, or the side effect of 5G upgrades to cellular networks.

The World Health Organization has declared an "infodemic" of incorrect information about the virus, which poses risks to global health.

See also

Notes

  1. In summary, this article is about the coronavirus pandemic, which is caused by the disease COVID‑19, which in turn is caused by the virus SARS‑CoV‑2.
  2. Known as "close contact" which is variously defined, including within ~1.8 metres (six feet) by the US Centers for Disease Control and Prevention (CDC), and being face to face for a cumulative total of 15 minutes, [7] or sharing an enclosed space for a prolonged period such as two hours, by the Australian Health Department. [8] [9]
  3. Some refer to this as 'infection fatality rate'; however the term 'ratio' is more accurate as this is not per unit time. [83]
  4. This CDC best estimate (current as of 10 September) was derived from a paper in PLOS Medicine that estimated a range of IFR across several areas in Europe, from 0.5% (95% CrI 0.4%–0.6%) in Switzerland to 1.4% (95% CrI 1.1%–1.6%) in Lombardy, Italy (based on data through mid-to-late April). [90] Regarding the differences across the regions, the European researchers noted "the importance of local factors … including demographic characteristics" and "the lower degree of preparedness and health service capacity in northern Italy, which in Europe was affected first by the SARS-CoV-2 epidemic." [90]
  5. The overall value was corrected from 0.27% to account for "the fact that only one or two types of antibodies (among IgG, IgM, IgA) might have been used” in testing.
  6. One set of national statistics for England (ONS) shows a decrease in IFR from 2.63% to 0.49%; another (MRC) from 0.69% to 0.30%, both over eight weeks ending 4 August.
  7. Some refer to 'fatality rate'; however 'fatality ratio' is more accurate as this is not per unit time. [83]
  8. A lack of mass testing obscured the extent of the outbreak. [440]
  9. Examples of areas in which clusters have occurred include urban areas, nursing homes, long-term care facilities, group homes for the intellectually disabled, [454] detention centers (including prisons), meatpacking plants, churches, and navy ships. [455]

Related Research Articles

Severe acute respiratory syndrome coronavirus 2 Virus strain that causes coronavirus disease 2019 (COVID-19)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Colloquially known as simply the coronavirus, it was previously referred to by its provisional name, 2019 novel coronavirus (2019-nCoV), and has also been called human coronavirus 2019. The World Health Organization declared the outbreak a Public Health Emergency of International Concern on 30 January 2020, and a pandemic on 11 March 2020.

Coronavirus disease 2019 Infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2

Coronavirus disease 2019 (COVID-19) is a contagious respiratory and vascular disease. It is caused by becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a specific type of coronavirus. Common symptoms include fever, cough, fatigue, shortness of breath or breathing difficulties, and loss of smell and taste. The incubation period, which is the time between becoming infected with the virus and showing symptoms, may range from one to fourteen days. While most people have mild symptoms, some people develop acute respiratory distress syndrome (ARDS) possibly precipitated by cytokine storm, multi-organ failure, septic shock, and blood clots. Longer-term damage to organs has been observed, and there is concern about a significant number of patients who have recovered from the acute phase of the disease but continue to experience a range of effects—including severe fatigue, memory loss and other cognitive issues, low grade fever, muscle weakness, breathlessness, and other symptoms—for months afterwards.

COVID-19 pandemic in the United States Ongoing viral pandemic in the United States

The COVID-19 pandemic in the United States is part of the worldwide pandemic of coronavirus disease 2019. As of October 2020, there were more than 8,600,000 cases and 220,000 COVID-19-related deaths in the U.S., representing 20% of the world's known COVID-19 deaths, and the most deaths of any country. As of October 20, the U.S. death rate had reached 670 per million people, the eleventh-highest rate globally, and ninth-highest if European microstates are excluded.

COVID-19 pandemic in Europe Ongoing viral pandemic in Europe

As of 13 March 2020, when the number of new cases became greater than those in China, the World Health Organization (WHO) began to consider Europe the active centre of the COVID-19 pandemic. Cases by country across Europe had doubled over periods of typically 3 to 4 days, with some countries showing doubling every 2 days.

COVID-19 pandemic in Asia Ongoing COVID-19 viral pandemic in Asia

The COVID-19 pandemic began in Asia in Wuhan, Hubei, China, and has spread widely through the continent. As of 8 June 2020, at least one case of COVID-19 had been reported in every country in Asia except North Korea and Turkmenistan.

COVID-19 pandemic in North America Ongoing COVID-19 viral pandemic in North America

The first cases of the COVID-19 pandemic of coronavirus disease 2019 in North America were reported in the United States in January 2020. Cases were reported in all North American countries after Saint Kitts and Nevis confirmed a case on 25 March, and in all North American territories after Bonaire confirmed a case on 16 April.

COVID-19 pandemic in Egypt Ongoing COVID-19 viral pandemic in Egypt

The COVID-19 pandemic in Egypt is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The virus was confirmed to have reached Egypt on 14 February 2020.

National responses to the COVID-19 pandemic Internal responses of the nations of the world

In response to the COVID-19 pandemic, national responses have been varied, and have included containment measures such as lockdowns, quarantines, and curfews. As of 26 October 2020, more than 42.9 million cases of COVID-19 have been reported in more than 189 countries and territories, resulting in more than 1.15 million deaths. More than 28.9 million people have recovered from the virus. The most affected countries in terms of confirmed cases are the United States, Brazil, India, Russia, South Africa, Peru, Mexico, Chile, the United Kingdom, and Iran.

COVID-19 pandemic in South America Ongoing COVID-19 viral pandemic in South America

The COVID-19 pandemic was confirmed to have reached South America on 26 February 2020 when Brazil confirmed a case in São Paulo. By 3 April, all countries and territories in South America had recorded at least one case.

The COVID-19 pandemic in Djibouti is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The virus spread to Djibouti in March 2020. It is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2. Model-based simulations for Djibouti indicate that the 95% confidence interval for the time-varying reproduction number R t has been stable around 1.0 since August 2020.

The COVID-19 pandemic in Madagascar is part of the ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On 20 March 2020, the first case in Madagascar was confirmed in Antananarivo.

COVID-19 pandemic in Guatemala Ongoing COVID-19 viral pandemic in Guatemala

The COVID-19 pandemic in Guatemala is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The virus was confirmed to have reached Guatemala in March 2020.

The COVID-19 pandemic was confirmed to have reached Eritrea on 21 March 2020.

The COVID-19 pandemic in The Gambia is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The virus was confirmed to have reached The Gambia in March 2020.

The COVID-19 pandemic in Mozambique is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The virus was confirmed to have reached Mozambique in March 2020.

The COVID-19 pandemic was confirmed to have reached Rwanda in March 2020.

COVID-19 pandemic in South Asia Epidemiology of COVID-19 pandemic in Southern Asia

Countries and territories in South Asia have been affected by the COVID-19 pandemic. The first South Asian country to report a confirmed case was Nepal, which documented its first case on 23 January 2020, in a man who had returned from China on 5 January. As of 2 July, at least one case of COVID-19 has been reported in every country in South Asia. Afghanistan, Bangladesh, Pakistan and Maldives have implemented lockdowns, Sri Lanka has responded with quarantine curfews while India and Nepal have declared a country-wide lockdown. Countries have also instituted various levels of restrictions on international travel, some countries have completely sealed off their land borders and grounded most international flights.

World Health Organizations response to the COVID-19 pandemic

The World Health Organization is a leading organization involved in the global coordination for mitigating the COVID-19 pandemic, within the broader United Nations response to the pandemic caused by the emergence of severe acute respiratory syndrome coronavirus 2 in late 2019.

The ongoing COVID-19 pandemic was confirmed to have reached Lesotho on 13 May 2020.

Science diplomacy is the collaborative efforts by local and global entities to solve global issues using science and technology as a base. In science diplomacy, collaboration takes place to advance science but science can also be used to facilitate diplomatic relations. This allows even conflicting nations to come together through science to find solutions to global issues. Global organizations, researchers, public health officials, countries, government officials, and clinicians have previously worked together to create effective measures of infection control and subsequent treatment. They continue to do so through sharing of resources, research data, ideas, and by putting into effect laws and regulations that can further advance scientific research. Without the collaborative efforts of such entities, the world would not have the vaccines and treatments we now possess for diseases that were once considered deadly such as tuberculosis, tetanus, polio, influenza, etc. Historically, science diplomacy has proved successful in diseases such as SARS, Ebola, Zika and continues to be relevant during the COVID-19 pandemic today.

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