This article is about the history of human medicine. For the book, see A History of Medicine.
This article may be too long to read and navigate comfortably. Consider splitting content into sub-articles, condensing it, or adding subheadings. Please discuss this issue on the article's talk page.(November 2024)
A 12th-century manuscript of the Hippocratic Oath in Greek, one of the most famous aspects of classical medicine that carried into later eras
The history of medicine is both a study of medicine throughout history as well as a multidisciplinary field of study that seeks to explore and understand medical practices, both past and present, throughout human societies.[1]
The history of medicine is the study and documentation of the evolution of medical treatments, practices, and knowledge over time. Medical historians often draw from other humanities fields of study including economics, health sciences, sociology, and politics to better understand the institutions, practices, people, professions, and social systems that have shaped medicine. When a period which predates or lacks written sources regarding medicine, information is instead drawn from archaeological sources.[1][2] This field tracks the evolution of human societies' approach to health, illness, and injury ranging from prehistory to the modern day, the events that shape these approaches, and their impact on populations.
Early medical traditions include those of Babylon, China, Egypt and India. Invention of the microscope was a consequence of improved understanding, during the Renaissance. Prior to the 19th century, humorism (also known as humoralism) was thought to explain the cause of disease but it was gradually replaced by the germ theory of disease, leading to effective treatments and even cures for many infectious diseases. Military doctors advanced the methods of trauma treatment and surgery. Public health measures were developed especially in the 19th century as the rapid growth of cities required systematic sanitary measures. Advanced research centers opened in the early 20th century, often connected with major hospitals. The mid-20th century was characterized by new biological treatments, such as antibiotics. These advancements, along with developments in chemistry, genetics, and radiography led to modern medicine. Medicine was heavily professionalized in the 20th century, and new careers opened to women as nurses (from the 1870s) and as physicians (especially after 1970).
Prehistoric medicine is a field of study focused on understanding the use of medicinal plants, healing practices, illnesses, and wellness of humans before written records existed.[4] Although styled prehistoric "medicine", prehistoric healthcare practices were vastly different from what we understand medicine to be in the present era and more accurately refers to studies and exploration of early healing practices.
This period extends across the first use of stone tools by early humans c. 3.3million years ago[5] to the beginning of writing systems and subsequent recorded history c. 5000 years ago.
As human populations were once scattered across the world, forming isolated communities and cultures that sporadically interacted, a range of archaeological periods have been developed to account for the differing contexts of technology, sociocultural developments, and uptake of writing systems throughout early human societies.[6][7] Prehistoric medicine is then highly contextual to the location and people in question,[8] creating an ununiform period of study to reflect various degrees of societal development.
Without written records, insights into prehistoric medicine comes indirectly from interpreting evidence left behind by prehistoric humans. One branch of this includes the archaeology of medicine; a discipline that uses a range of archaeological techniques from observing illness in human remains, plant fossils, to excavations to uncover medical practices.[3][9] There is evidence of healing practices within Neanderthals[10] and other early human species. Prehistoric evidence of human engagement with medicine include the discovery of psychoactive plant sources such as psilocybin mushrooms in c. 6000 BCESahara[11] to primitive dental care in c. 10,900 BCE (13,000 BP) Riparo Fredian[12] (present-day Italy)[13] and c. 7000 BCEMehrgarh (present-day Pakistan).[14][15]
Anthropology is another academic branch that contributes to understanding prehistoric medicine in uncovering the sociocultural relationships, meaning, and interpretation of prehistoric evidence.[16] The overlap of medicine as both a root to healing the body as well as the spiritual throughout prehistoric periods highlights the multiple purposes that healing practices and plants could potentially have.[17][18][19] From proto-religions to developed spiritual systems, relationships of humans and supernatural entities, from Gods to shamans, have played an interwoven part in prehistoric medicine.[20][21]
Ancient history covers time between c. 3000 BCE to c. 500 CE, starting from evidenced development of writing systems to the end of the classical era and beginning of the post-classical period. This periodisation presents history as if it were the same everywhere, however it is important to note that socioculture and technological developments could differ locally from settlement to settlement as well as globally from one society to the next.[22]
Ancient medicine covers a similar period of time and presented a range of similar healing theories from across the world connecting nature, religion, and humans within ideas of circulating fluids and energy.[23] Although prominent scholars and texts detailed well-defined medical insights, their real-world applications were marred by knowledge destruction and loss,[24] poor communication, localised reinterpretations, and subsequent inconsistent applications.[25]
Ancient Mesopotamian medicine
A cuneiform terracotta tablet describing a medicinal recipe for poisoning (c. 18th centuryBCE). Discovered in Nippur, Iraq.
The Sumerians developed one of the earliest known writing systems in the 3rd millennium BCE, and created numerous cuneiform clay tablets regarding their civilisation. These included detailed accounts of drug prescriptions and operations, as well as exorcisms. These were administered and carried out by highly defined professionals including bârû (seers), âs[h]ipu (exorcists), and asû (physician-priests).[31] An example of an early, prescription-like medication appeared in Sumerian during the Third Dynasty of Ur (c. 2112 BCE – c. 2004 BCE).[32]
Following the conquest of the Sumerian civilisation by the Akkadian Empire and the empire's eventual collapse from a number of social and environmental factors,[33] the Babylonian civilisation began to dominate the region. Examples of Babylonian Medicine include the extensive Babylonian medical text, the Diagnostic Handbook, written by the ummânū, or chief scholar, Esagil-kin-apli of Borsippa,[34]:99[35] in the middle of the 11th century BCE during the reign of the Babylonian king Adad-apla-iddina (1069–1046BCE).[36]
This medical treatise devoted great attention to the practice of diagnosis, prognosis, physical examination, and remedies. The text contains a list of medical symptoms and often detailed empirical observations along with logical rules used in combining observed symptoms on the body of a patient with their diagnosis and prognosis.[34]:97–98 Here, clearly developed rationales were developed to understand the causes of disease and injury, supported by theories, agreed upon at the time, of elements we might now understand as natural causes, supernatural magic and religious explanations.[35]
Most known and recovered artefacts from the ancient Mesopotamian civilisations centre on the neo-Assyrian (c. 900 – 600 BCE) and neo-Babylonian (c. 600 – 500 BCE) periods, as the last empires ruled by native Mesopotamian rulers.[37] These discoveries include a huge array of medical clay tablets from this period, although damage to the clay documents creates large gaps in our understanding of medical practices.[38]
Throughout the civilisations of Mesopotamia there are a wide range of medical innovations, including evidenced practices of prophylaxis, measures to prevent the spread of disease,[28] accounts of stroke,[citation needed] and an awareness of mental illnesses.[39]
Herodotus described the Egyptians as "the healthiest of all men, next to the Libyans",[42] because of the dry climate and the notable public health system that they possessed. According to him, "the practice of medicine is so specialized among them that each physician is a healer of one disease and no more." Although Egyptian medicine, to a considerable extent, dealt with the supernatural,[43] it eventually developed a practical use in the fields of anatomy, public health, and clinical diagnostics.
Medical information in the Edwin Smith Papyrus may date to a time as early as 3000BCE.[44]Imhotep in the 3rd dynasty is sometimes credited with being the founder of ancient Egyptian medicine and with being the original author of the Edwin Smith Papyrus, detailing cures, ailments and anatomical observations. This papyrus is regarded as a copy of several earlier works and was written c. 1600BCE. It is an ancient textbook on surgery almost completely devoid of magical thinking and describes in exquisite detail the examination, diagnosis, treatment, and prognosis of numerous ailments.[45]
The Kahun Gynaecological Papyrus[46] treats women's complaints, including problems with conception. Thirty-four cases detailing diagnosis and[47] treatment survive, although some of them are mere fragments.[48] Dating to 1800BCE, it is the oldest surviving medical text of any kind.
Medical institutions, referred to as Houses of Life, are known to have been established in ancient Egypt as early as 2200 BCE.[49]
The Ebers Papyrus is the oldest written text mentioning enemas. Many medications were administered by enemas and one of the many types of medical specialists was an Iri, the Shepherd of the Anus.[50]
The earliest known physician is also credited to ancient Egypt: Hesy-Ra, "Chief of Dentists and Physicians" for King Djoser in the 27th centuryBCE.[51] Also, the earliest known woman physician, Peseshet, practiced in Ancient Egypt at the time of the 4th dynasty. Her title was "Lady Overseer of the Lady Physicians."[52]
Medical and healing practices in early Chinese dynasties were heavily shaped by the practice of traditional Chinese medicine (TCM).[53] Starting around the Zhou dynasty, parts of this system were being developed and are demonstrated in early writings on herbs in Classic of Changes (Yi Jing) and Classic of Poetry (Shi Jing).[54][55]
China also developed a large body of traditional medicine. Much of the philosophy of traditional Chinese medicine derived from empirical observations of disease and illness by Taoist physicians and reflects the classical Chinese belief that individual human experiences express causative principles effective in the environment at all scales. These causative principles, whether material, essential, or mystical, correlate as the expression of the natural order of the universe.
The foundational text of Chinese medicine is the Huangdi Neijing, (or Yellow Emperor's Inner Canon), written 5th century to 3rd century BCE.[56] Near the end of the 2nd century CE, during the Han dynasty, Zhang Zhongjing, wrote a Treatise on Cold Damage, which contains the earliest known reference to the Neijing Suwen. The Jin dynasty practitioner and advocate of acupuncture and moxibustion, Huangfu Mi (215–282), also quotes the Yellow Emperor in his Jiayi jing, c. 265. During the Tang dynasty, the Suwen was expanded and revised and is now the best extant representation of the foundational roots of traditional Chinese medicine. Traditional Chinese medicine that is based on the use of herbal medicine, acupuncture, massage and other forms of therapy has been practiced in China for thousands of years.
Critics say that TCM theory and practice have no basis in modern science, and TCM practitioners do not agree on what diagnosis and treatments should be used for any given person.[57] A 2007 editorial in the journal Nature wrote that TCM "remains poorly researched and supported, and most of its treatments have no logical mechanism of action."[58] It also described TCM as "fraught with pseudoscience".[58] A review of the literature in 2008 found that scientists are "still unable to find a shred of evidence" according to standards of science-based medicine for traditional Chinese concepts such as qi, meridians, and acupuncture points,[59] and that the traditional principles of acupuncture are deeply flawed.[60] There are concerns over a number of potentially toxic plants, animal parts, and mineral Chinese compounds,[61] as well as the facilitation of disease. Trafficked and farm-raised animals used in TCM are a source of several fatal zoonotic diseases.[62] There are additional concerns over the illegal trade and transport of endangered species including rhinoceroses and tigers, and the welfare of specially farmed animals, including bears.[63]
The Atharvaveda, a sacred text of Hinduism dating from the middle Vedic age (c. 1200–900 BCE),[64] is one of the first Indian texts dealing with medicine. It is a text filled with magical charms, spells, and incantations used for various purposes, such as protection against demons, rekindling love, ensuring childbirth, and achieving success in battle, trade, and even gambling. It also includes numerous charms aimed at curing diseases and several remedies from medicinal herbs, overall making it a key source of medical knowledge during the Vedic period. The use of herbs to treat ailments would later form a large part of Ayurveda.[5]
Ayurveda, meaning the "complete knowledge for long life" is another medical system of India. Its two most famous texts (samhitas) belong to the schools of Charaka and Sushruta. The Samhitas represent later revised versions (recensions) of their original works. The earliest foundations of Ayurveda were built on a synthesis of traditional herbal practices together with a massive addition of theoretical conceptualizations, new nosologies and new therapies dating from about 600 BCE onwards, and coming out of the communities of thinkers which included the Buddha and others.[65][66]
According to the compendium of Charaka, the Charakasamhitā, health and disease are not predetermined and life may be prolonged by human effort. The compendium of Suśruta, the Suśrutasamhitā defines the purpose of medicine to cure the diseases of the sick, protect the healthy, and to prolong life. Both these ancient compendia include details of the examination, diagnosis, treatment, and prognosis of numerous ailments. The Suśrutasamhitā is notable for describing procedures on various forms of surgery, including rhinoplasty, the repair of torn ear lobes, perineal lithotomy, cataract surgery, and several other excisions and other surgical procedures. Most remarkable was Susruta's surgery specially the rhinoplasty for which he is called father of plastic surgery. Susruta also described more than 125 surgical instruments in detail. Also remarkable is Sushruta's penchant for scientific classification: His medical treatise consists of 184 chapters, 1,120 conditions are listed, including injuries and illnesses relating to aging and mental illness.[clarification needed]
The Ayurvedic classics mention eight branches of medicine: kāyācikitsā (internal medicine), śalyacikitsā (surgery including anatomy), śālākyacikitsā (eye, ear, nose, and throat diseases), kaumārabhṛtya (pediatrics with obstetrics and gynaecology), bhūtavidyā (spirit and psychiatric medicine), agada tantra (toxicology with treatments of stings and bites), rasāyana (science of rejuvenation), and vājīkaraṇa (aphrodisiac and fertility). Apart from learning these, the student of Āyurveda was expected to know ten arts that were indispensable in the preparation and application of his medicines: distillation, operative skills, cooking, horticulture, metallurgy, sugar manufacture, pharmacy, analysis and separation of minerals, compounding of metals, and preparation of alkalis. The teaching of various subjects was done during the instruction of relevant clinical subjects. For example, the teaching of anatomy was a part of the teaching of surgery, embryology was a part of training in pediatrics and obstetrics, and the knowledge of physiology and pathology was interwoven in the teaching of all the clinical disciplines.[clarification needed]
Even today Ayurvedic treatment is practiced, but it is considered pseudoscientific because its premises are not based on science, some ayurvedic medicines have been found to contain toxic substances.[67][68] Both the lack of scientific soundness in the theoretical foundations of ayurveda and the quality of research have been criticized.[67][69][70][71]
The theory of humors was derived from ancient medical works, dominated Western medicine until the 19th century, and is credited to Greek philosopher and surgeon Galen of Pergamon (129 – c.216 CE).[72] In Greek medicine, there are thought to be four humors, or bodily fluids that are linked to illness: blood, phlegm, yellow bile, and black bile.[73] Early scientists believed that food is digested into blood, muscle, and bones, while the humors that were not blood were then formed by indigestible materials that are left over. An excess or shortage of any one of the four humors is theorized to cause an imbalance that results in sickness; the aforementioned statement was hypothesized by sources before Hippocrates.[73] Hippocrates (c.400 BCE) deduced that the four seasons of the year and four ages of man that affect the body in relation to the humors.[72] The four ages of man are childhood, youth, prime age, and old age.[73] Black bile is associated with autumn, phlegm with winter, blood with spring, and yellow bile with summer.[74]
In De temperamentis, Galen linked what he called temperaments, or personality characteristics, to a person's natural mixture of humors. He also said that the best place to check the balance of temperaments was in the palm of the hand. A person that is considered to be phlegmatic is said to be an introvert, even-tempered, calm, and peaceful.[73] This person would have an excess of phlegm, which is described as a viscous substance or mucous.[75] Similarly, a melancholic temperament related to being moody, anxious, depressed, introverted, and pessimistic.[73] A melancholic temperament is caused by an excess of black bile, which is sedimentary and dark in colour.[75] Being extroverted, talkative, easygoing, carefree, and sociable coincides with a sanguine temperament, which is linked to too much blood.[73] Finally, a choleric temperament is related to too much yellow bile, which is actually red in colour and has the texture of foam; it is associated with being aggressive, excitable, impulsive, and also extroverted.
There are numerous ways to treat a disproportion of the humors. For example, if someone was suspected to have too much blood, then the physician would perform bloodletting as a treatment. Likewise, if a person believed to have too much phlegm should feel better after expectorating, and someone with too much yellow bile would purge.[75] Another factor to be considered in the balance of humors is the quality of air where one resides, such as the climate and elevation. Also, the standard of food and drink, balance of sleeping and waking, exercise and rest, retention and evacuation are important. Moods such as anger, sadness, joy, and love can affect the balance. During that time, the importance of balance was demonstrated by the fact that women lose blood monthly during menstruation, and have a lesser occurrence of gout, arthritis, and epilepsy than men do.[75] Galen also hypothesized that there are three faculties. The natural faculty affects growth and reproduction and is produced in the liver. Animal or vital faculty controls respiration and emotion, coming from the heart. In the brain, the psychic faculty commands the senses and thoughts.[75] The structure of bodily functions is related to the humors as well. Greek physicians understood that food was cooked in the stomach; this is where the nutrients are extracted. The best, most potent and pure nutrients from food are reserved for blood, which is produced in the liver and carried through veins to organs. Blood enhanced with pneuma, which means wind or breath, is carried by the arteries.[73] The path that blood take is as follows: venous blood passes through the vena cava and is moved into the right ventricle of the heart; then, the pulmonary artery takes it to the lungs.[75] Later, the pulmonary vein then mixes air from the lungs with blood to form arterial blood, which has different observable characteristics.[73] After leaving the liver, half of the yellow bile that is produced travels to the blood, while the other half travels to the gallbladder. Similarly, half of the black bile produced gets mixed in with blood, and the other half is used by the spleen.[75]
People
Around 800 BCE Homer in the Iliad gives descriptions of wound treatment by the two sons of Asklepios, the admirable physicians Podaleirius and Machaon and one acting doctor, Patroclus. Because Machaon is wounded and Podaleirius is in combat Eurypylus asks Patroclus to "cut out the arrow-head, and wash the dark blood from my thigh with warm water, and sprinkle soothing herbs with power to heal on my wound".[76] Asklepios, like Imhotep, came to be associated as a god of healing over time.
View of the Askleipion of Kos, the best preserved instance of an Asklepieion.
Temples dedicated to the healer-god Asclepius, known as Asclepieia (Ancient Greek: Ἀσκληπιεῖα, sing. Ἀσκληπιεῖον, Asclepieion), functioned as centers of medical advice, prognosis, and healing.[77] At these shrines, patients would enter a dream-like state of induced sleep known as enkoimesis (ἐγκοίμησις) not unlike anesthesia, in which they either received guidance from the deity in a dream or were cured by surgery.[78] Asclepeia provided carefully controlled spaces conducive to healing and fulfilled several of the requirements of institutions created for healing.[77] In the Asclepeion of Epidaurus, three large marble boards dated to 350 BCE preserve the names, case histories, complaints, and cures of about 70 patients who came to the temple with a problem and shed it there. Some of the surgical cures listed, such as the opening of an abdominal abscess or the removal of traumatic foreign material, are realistic enough to have taken place, but with the patient in a state of enkoimesis induced with the help of soporific substances such as opium.[78]Alcmaeon of Croton wrote on medicine between 500 and 450 BCE. He argued that channels linked the sensory organs to the brain, and it is possible that he discovered one type of channel, the optic nerves, by dissection.[79]
Hippocrates of Kos (c.460–c.370 BCE), considered the "father of modern medicine."[80] The Hippocratic Corpus is a collection of around seventy early medical works from ancient Greece strongly associated with Hippocrates and his students. Most famously, the Hippocratics invented the Hippocratic Oath for physicians. Contemporary physicians swear an oath of office which includes aspects found in early editions of the Hippocratic Oath.
Hippocrates and his followers were first to describe many diseases and medical conditions. Though humorism (humoralism) as a medical system predates 5th-century Greek medicine, Hippocrates and his students systematized the thinking that illness can be explained by an imbalance of blood, phlegm, black bile, and yellow bile.[81] Hippocrates is given credit for the first description of clubbing of the fingers, an important diagnostic sign in chronic suppurative lung disease, lung cancer and cyanotic heart disease. For this reason, clubbed fingers are sometimes referred to as "Hippocratic fingers".[82] Hippocrates was also the first physician to describe the Hippocratic face in Prognosis. Shakespeare famously alludes to this description when writing of Falstaff's death in Act II, Scene iii. of Henry V.[83] Hippocrates began to categorize illnesses as acute, chronic, endemic and epidemic, and use terms such as, "exacerbation, relapse, resolution, crisis, paroxysm, peak, and convalescence."[84][85]
The Greek Galen (c. 129–216CE) was one of the greatest physicians of the ancient world, as his theories dominated all medical studies for nearly 1500 years.[86] His theories and experimentation laid the foundation for modern medicine surrounding the heart and blood. Galen's influence and innovations in medicine can be attributed to the experiments he conducted, which were unlike any other medical experiments of his time. Galen strongly believed that medical dissection was one of the essential procedures in truly understanding medicine. He began to dissect different animals that were anatomically similar to humans, which allowed him to learn more about the internal organs and extrapolate the surgical studies to the human body.[86] In addition, he performed many audacious operations—including brain and eye surgeries—that were not tried again for almost two millennia. Through the dissections and surgical procedures, Galen concluded that blood is able to circulate throughout the human body, and the heart is most similar to the human soul.[86][87] In Ars medica ("Arts of Medicine"), he further explains the mental properties in terms of specific mixtures of the bodily organs.[88][89] While much of his work surrounded the physical anatomy, he also worked heavily in humoral physiology.
Galen's medical work was regarded as authoritative until well into the Middle Ages. He left a physiological model of the human body that became the mainstay of the medieval physician's university anatomy curriculum. Although he attempted to extrapolate the animal dissections towards the model of the human body, some of Galen's theories were incorrect. This caused his model to suffer greatly from stasis and intellectual stagnation.[90] Greek and Roman taboos caused dissection of the human body to usually be banned in ancient times, but in the Middle Ages it changed.[91][92]
In 1523 Galen's On the Natural Faculties was published in London. In the 1530s Belgian anatomist and physician Andreas Vesalius launched a project to translate many of Galen's Greek texts into Latin. Vesalius's most famous work, De humani corporis fabrica was greatly influenced by Galenic writing and form.
Hippocrates (c. 460–370 BCE). Known as the "father of medicine".
Galen (129–216 CE), known for his wide insights into anatomy.
Herophilus and Erasistratus
The plinthios brochos as described by Greek physician Heraklas, a sling for binding a fracturedjaw. These writings were preserved in one of Oribasius' collections.
Herophilus of Chalcedon, the renowned Alexandrian physician, was one of the pioneers of human anatomy. Though his knowledge of the anatomical structure of the human body was vast, he specialized in the aspects of neural anatomy.[96] Thus, his experimentation was centered around the anatomical composition of the blood-vascular system and the pulsations that can be analyzed from the system.[96] Furthermore, the surgical experimentation he administered caused him to become very prominent throughout the field of medicine, as he was one of the first physicians to initiate the exploration and dissection of the human body.[97]
The banned practice of human dissection was lifted during his time within the scholastic community. This brief moment in the history of Greek medicine allowed him to further study the brain, which he believed was the core of the nervous system.[97] He also distinguished between veins and arteries, noting that the latter pulse and the former do not. Thus, while working at the medical school of Alexandria, Herophilus placed intelligence in the brain based on his surgical exploration of the body, and he connected the nervous system to motion and sensation. In addition, he and his contemporary, Erasistratus of Chios, continued to research the role of veins and nerves. After conducting extensive research, the two Alexandrians mapped out the course of the veins and nerves across the human body. Erasistratus connected the increased complexity of the surface of the human brain compared to other animals to its superior intelligence. He sometimes employed experiments to further his research, at one time repeatedly weighing a caged bird, and noting its weight loss between feeding times.[98] In Erasistratus' physiology, air enters the body, is then drawn by the lungs into the heart, where it is transformed into vital spirit, and is then pumped by the arteries throughout the body. Some of this vital spirit reaches the brain, where it is transformed into animal spirit, which is then distributed by the nerves.[98]
The Roman army physician Dioscorides (c.40–90 CE), was a Greek botanist and pharmacologist. He wrote the encyclopedia De Materia Medica describing over 600 herbal cures, forming an influential pharmacopoeia which was used extensively for the following 1,500 years.[103]
Early Christians in the Roman Empire incorporated medicine into their theology, ritual practices, and metaphors.[104]
Byzantine medicine encompasses the common medical practices of the Byzantine Empire from about 400 CE to 1453 CE. Byzantine medicine was notable for building upon the knowledge base developed by its Greco-Roman predecessors. In preserving medical practices from antiquity, Byzantine medicine influenced Islamic medicine as well as fostering the Western rebirth of medicine during the Renaissance.
Byzantine physicians often compiled and standardized medical knowledge into textbooks. Their records tended to include both diagnostic explanations and technical drawings. The Medical Compendium in Seven Books, written by the leading physician Paul of Aegina, survived as a particularly thorough source of medical knowledge. This compendium, written in the late seventh century, remained in use as a standard textbook for the following 800 years.
Late antiquity ushered in a revolution in medical science, and historical records often mention civilian hospitals (although battlefield medicine and wartime triage were recorded well before Imperial Rome). Constantinople stood out as a center of medicine during the Middle Ages, which was aided by its crossroads location, wealth, and accumulated knowledge.
The first ever known example of separating conjoined twins occurred in the Byzantine Empire in the 10th century. The next example of separating conjoined twins would be recorded many centuries later in Germany in 1689.[105][106]
The Byzantine Empire's neighbors, the Persian Sassanid Empire, also made their noteworthy contributions mainly with the establishment of the Academy of Gondeshapur, which was "the most important medical center of the ancient world during the 6th and 7th centuries."[107] In addition, Cyril Elgood, British physician and a historian of medicine in Persia, commented that thanks to medical centers like the Academy of Gondeshapur, "to a very large extent, the credit for the whole hospital system must be given to Persia."[108]
The Islamic civilization rose to primacy in medical science as its physicians contributed significantly to the field of medicine, including anatomy, ophthalmology, pharmacology, pharmacy, physiology, and surgery. Islamic civilization's contribution to these fields within medicine was a gradual process that took hundreds of years. During the time of the first great Muslim dynasty, the Umayyad Caliphate (661–750 CE), these fields were in their very early stages of development, and not much progress was made.[109] One reason for the limited advancement in medicine during the Umayyad Caliphate was the Caliphate's focus on expansion after the death of Muhammad (632 CE).[110] The focus on expansionism redirected resources from other fields, such as medicine. The priority on these factors led a large percentage of the population to believe that God will provide cures for their illnesses and diseases because of the attention on spirituality.[110]
There were also many other areas of interest during that time before there was a rising interest in the field of medicine. Abd al-Malik ibn Marwan, the fifth caliph of the Umayyad, developed governmental administration, adopted Arabic as the main language, and focused on many other areas.[111] However, this rising interest in Islamic medicine grew significantly when the Abbasid Caliphate (750–1258 CE) overthrew the Umayyad Caliphate in 750 CE.[112] This change in dynasty from the Umayyad Caliphate to the Abbasid Caliphate served as a turning point towards scientific and medical developments. A large contributor to this was that under Abbasid rule much of the Greek legacy was transmitted into Arabic which by then, was the main language of Islamic nations.[110] Because of this, many Islamic physicians were heavily influenced by the works of Greek scholars of Alexandria and Egypt and were able to further expand on those texts to produce new medical pieces of knowledge.[113] This period of time is also known as the Islamic Golden Age where there was a period of development and flourishment of technology, commerce, and sciences including medicine. Additionally, during this time the creation of the first Islamic Hospital in 805 CE by the Abbasid caliph Harun al-Rashid in Baghdad was recounted as a glorious event of the Golden Age.[109] This hospital in Baghdad contributed immensely to Baghdad's success and also provided educational opportunities for Islamic physicians. During the Islamic Golden Age, there were many famous Islamic physicians that paved the way for medical advancements and understandings. However, this would not be possible without the influence from many different areas of the world that influenced the Arabs.
Arabic manuscript, Anatomy of the Eye, by al-Mutadibih, 1200 CE
Muslims were influenced by ancient Indian, Persian, Greek, Roman and Byzantine medical practices, and helped them to develop it further.[114]Galen & Hippocrates were pre-eminent authorities. The translation of 129 of Galen's works into Arabic by the Nestorian Christian Hunayn ibn Ishaq and his assistants, and in particular Galen's insistence on a rational systematic approach to medicine, set the template for Islamic medicine, which rapidly spread throughout the Arab Empire.[115] Its most famous physicians included the Persian polymaths Muhammad ibn Zakarīya al-Rāzi and Avicenna, who wrote more than 40 works on health, medicine, and well-being. Taking leads from Greece and Rome, Islamic scholars kept both the art and science of medicine alive and moving forward.[116] Persian polymath Avicenna has also been called the "father of medicine".[117] He wrote The Canon of Medicine which became a standard medical text at many medieval European universities,[118] considered one of the most famous books in the history of medicine.[119]The Canon of Medicine presents an overview of the contemporary medical knowledge of the medieval Islamic world, which had been influenced by earlier traditions including Greco-Roman medicine (particularly Galen),[120]Persian medicine, Chinese medicine and Indian medicine. Persian physician al-Rāzi[121] was one of the first to question the Greek theory of humorism, which nevertheless remained influential in both medieval Western and medieval Islamic medicine.[122] Some volumes of al-Rāzi's work Al-Mansuri, namely "On Surgery" and "A General Book on Therapy", became part of the medical curriculum in European universities.[123] Additionally, he has been described as a doctor's doctor,[124] the father of pediatrics,[125][126] and a pioneer of ophthalmology. For example, he was the first to recognize the reaction of the eye's pupil to light.[citation needed]
In addition to contributions to humanity's understanding of human anatomy, Islamicate scientists and scholars, physicians specifically, played an invaluable role in the development of the modern hospital system, creating the foundations on which more contemporary medical professionals would build models of public health systems in Europe and elsewhere.[127] During the time of the Safavid empire (16th–18th centuries) in Iran and the Mughal empire (16th–19th centuries) in India, Muslim scholars radically transformed the institution of the hospital, creating an environment in which rapidly developing medical knowledge of the time could be passed among students and teachers from a wide range of cultures.[128] There were two main schools of thought with patient care at the time. These included humoral physiology from the Persians and Ayurvedic practice. After these theories were translated from Sanskrit to Persian and vice-versa, hospitals could have a mix of culture and techniques. This allowed for a sense of collaborative medicine.[citation needed] Hospitals became increasingly common during this period as wealthy patrons commonly founded them. Many features that are still in use today, such as an emphasis on hygiene, a staff fully dedicated to the care of patients, and separation of individual patients from each other were developed in Islamicate hospitals long before they came into practice in Europe.[129] At the time, the patient care aspects of hospitals in Europe had not taken effect. European hospitals were places of religion rather than institutions of science. As was the case with much of the scientific work done by Islamicate scholars, many of these novel developments in medical practice were transmitted to European cultures hundreds of years after they had long been used throughout the Islamicate world. Although Islamicate scientists were responsible for discovering much of the knowledge that allows the hospital system to function safely today, European scholars who built on this work still receive the majority of the credit historically.[127]
Before the development of scientific medical practices in the Islamicate empires, medical care was mainly performed by religious figures such as priests.[127] Without a profound understanding of how infectious diseases worked and why sickness spread from person to person, these early attempts at caring for the ill and injured often did more harm than good. Contrarily, with the development of new and safer practices by scholars and physicians in hospitals of the Islamic world, ideas vital for the effective care of patients were developed, learned, and transmitted widely. Hospitals developed novel "concepts and structures" which are still in use today: separate wards for male and female patients, pharmacies, medical record-keeping, and personal and institutional sanitation and hygiene.[127] Much of this knowledge was recorded and passed on through Islamicate medical texts, many of which were carried to Europe and translated for the use of European medical workers. The Tasrif, written by surgeon Abu Al-Qasim Al-Zahrawi, was translated into Latin; it became one of the most important medical texts in European universities during the Middle Ages and contained useful information on surgical techniques and spread of bacterial infection.[127]
The hospital was a typical institution included in the majority of Muslim cities, and although they were often physically attached to religious institutions, they were not themselves places of religious practice.[128] Rather, they served as facilities in which education and scientific innovation could flourish. If they had places of worship, they were secondary to the medical side of the hospital. Islamicate hospitals, along with observatories used for astronomical science, were some of the most important points of exchange for the spread of scientific knowledge. Undoubtedly, the hospital system developed in the Islamicate world played an invaluable role in the creation and evolution of the hospitals we as a society know and depend on today.
13th-century illustration showing the veins. Bodleian Library, Oxford.
After 400 CE, the study and practice of medicine in the Western Roman Empire went into deep decline. Medical services were provided, especially for the poor, in the thousands of monastic hospitals that sprang up across Europe, but the care was rudimentary and mainly palliative.[130] Most of the writings of Galen and Hippocrates were lost to the West, with the summaries and compendia of St. Isidore of Seville being the primary channel for transmitting Greek medical ideas.[131] The Carolingian Renaissance brought increased contact with Byzantium and a greater awareness of ancient medicine,[132] but only with the Renaissance of the 12th century and the new translations coming from Muslim and Jewish sources in Spain, and the fifteenth-century flood of resources after the fall of Constantinople did the West fully recover its acquaintance with classical antiquity.
Greek and Roman taboos had meant that dissection was usually banned in ancient times, but in the Middle Ages it changed: medical teachers and students at Bologna began to open human bodies, and Mondino de Luzzi (c.1275–1326) produced the first known anatomy textbook based on human dissection.[91][92]
Wallis identifies a prestige hierarchy with university educated physicians on top, followed by learned surgeons; craft-trained surgeons; barber surgeons; itinerant specialists such as dentist and oculists; empirics; and midwives.[133]
Institutions
The first medical schools were opened in the 9th century, most notably the Schola Medica Salernitana at Salerno in southern Italy. The cosmopolitan influences from Greek, Latin, Arabic, and Hebrew sources gave it an international reputation as the Hippocratic City. Students from wealthy families came for three years of preliminary studies and five of medical studies. The medicine, following the laws of Federico II, that he founded in 1224 the university and improved the Schola Salernitana, in the period between 1200 and 1400, it had in Sicily (so-called Sicilian Middle Ages) a particular development so much to create a true school of Jewish medicine.[134]
As a result of which, after a legal examination, was conferred to a Jewish Sicilian woman, Virdimura, wife of another physician Pasquale of Catania, the historical record of before woman officially trained to exercise of the medical profession.[135]
At the University of Bologna the training of physicians began in 1219. The Italian city attracted students from across Europe. Taddeo Alderotti built a tradition of medical education that established the characteristic features of Italian learned medicine and was copied by medical schools elsewhere.Turisanus (d. 1320) was his student.[136]
The University of Padua was founded about 1220 by walkouts from the University of Bologna, and began teaching medicine in 1222. It played a leading role in the identification and treatment of diseases and ailments, specializing in autopsies and the inner workings of the body.[137] Starting in 1595, Padua's famous anatomical theatre drew artists and scientists studying the human body during public dissections. The intensive study of Galen led to critiques of Galen modeled on his own writing, as in the first book of Vesalius's De humani corporis fabrica.Andreas Vesalius held the chair of Surgery and Anatomy (explicator chirurgiae) and in 1543 published his anatomical discoveries in De Humani Corporis Fabrica. He portrayed the human body as an interdependent system of organ groupings. The book triggered great public interest in dissections and caused many other European cities to establish anatomical theatres.[138]
By the thirteenth century, the medical school at Montpellier began to eclipse the Salernitan school. In the 12th century, universities were founded in Italy, France, and England, which soon developed schools of medicine. The University of Montpellier in France and Italy's University of Padua and University of Bologna were leading schools. Nearly all the learning was from lectures and readings in Hippocrates, Galen, Avicenna, and Aristotle. In later centuries, the importance of universities founded in the late Middle Ages gradually increased, e.g. Charles University in Prague (established in 1348), Jagiellonian University in Kraków (1364), University of Vienna (1365), Heidelberg University (1386) and University of Greifswald (1456).
In England, there were but three small hospitals after 1550. Pelling and Webster estimate that in London in the 1580 to 1600 period, out of a population of nearly 200,000 people, there were about 500 medical practitioners. Nurses and midwives are not included. There were about 50 physicians, 100 licensed surgeons, 100 apothecaries, and 250 additional unlicensed practitioners. In the last category about 25% were women.[139] All across England—and indeed all of the world—the vast majority of the people in city, town or countryside depended for medical care on local amateurs with no professional training but with a reputation as wise healers who could diagnose problems and advise sick people what to do—and perhaps set broken bones, pull a tooth, give some traditional herbs or brews or perform a little magic to cure what ailed them.
The Renaissance brought an intense focus on scholarship to Christian Europe. A major effort to translate the Arabic and Greek scientific works into Latin emerged. Europeans gradually became experts not only in the ancient writings of the Romans and Greeks, but in the contemporary writings of Islamic scientists. During the later centuries of the Renaissance came an increase in experimental investigation, particularly in the field of dissection and body examination, thus advancing our knowledge of human anatomy.[140]
Animalcules: In 1677 Antonie van Leeuwenhoek identified "animalcules", which we now know as microorganisms, within their paper "letter on the protozoa".[141]
At the University of Bologna the curriculum was revised and strengthened in 1560–1590.[143] The representative professor was Julius Caesar Aranzi (Arantius) (1530–1589). He became Professor of Anatomy and Surgery at the University of Bologna in 1556, where he established anatomy as a major branch of medicine for the first time. Aranzi combined anatomy with a description of pathological processes, based largely on his own research, Galen, and the work of his contemporary Italians. Aranzi discovered the 'Nodules of Aranzio' in the semilunar valves of the heart and wrote the first description of the superior levator palpebral and the coracobrachialis muscles. His books (in Latin) covered surgical techniques for many conditions, including hydrocephalus, nasal polyp, goitre and tumours to phimosis, ascites, haemorrhoids, anal abscess and fistulae.[144]
People
Woman
Catholic women played large roles in health and healing in medieval and early modern Europe.[145] A life as a nun was a prestigious role; wealthy families provided dowries for their daughters, and these funded the convents, while the nuns provided free nursing care for the poor.[146]
The Catholic elites provided hospital services because of their theology of salvation that good works were the route to heaven. The Protestant reformers rejected the notion that rich men could gain God's grace through good works—and thereby escape purgatory—by providing cash endowments to charitable institutions. They also rejected the Catholic idea that the poor patients earned grace and salvation through their suffering.[147] Protestants generally closed all the convents[148] and most of the hospitals, sending women home to become housewives, often against their will.[149] On the other hand, local officials recognized the public value of hospitals, and some were continued in Protestant lands, but without monks or nuns and in the control of local governments.[150]
In London, the crown allowed two hospitals to continue their charitable work, under nonreligious control of city officials.[151] The convents were all shut down but Harkness finds that women—some of them former nuns—were part of a new system that delivered essential medical services to people outside their family. They were employed by parishes and hospitals, as well as by private families, and provided nursing care as well as some medical, pharmaceutical, and surgical services.[152]
Meanwhile, in Catholic lands such as France, rich families continued to fund convents and monasteries, and enrolled their daughters as nuns who provided free health services to the poor. Nursing was a religious role for the nurse, and there was little call for science.[153]
Asia
China
In the 18th century, during the Qing dynasty, there was a proliferation of popular books as well as more advanced encyclopedias on traditional medicine. Jesuit missionaries introduced Western science and medicine to the royal court, although the Chinese physicians ignored them.[154]
India
Unani medicine, based on Avicenna's Canon of Medicine (ca. 1025), was developed in India throughout the Medieval and Early Modern periods. Its use continued, especially in Muslim communities, during the Indian Sultanate and Mughal periods. Unani medicine is in some respects close to Ayurveda and to Early Modern European medicine. All share a theory of the presence of the elements (in Unani, as in Europe, they are considered to be fire, water, earth, and air) and humors in the human body. According to Unani physicians, these elements are present in different humoral fluids and their balance leads to health and their imbalance leads to illness.[155]
Sanskrit medical literature of the Early Modern period included innovative works such as the Compendium of Śārṅgadhara (Skt. Śārṅgadharasaṃhitā, ca. 1350) and especially The Illumination of Bhāva (Bhāvaprakāśa, by Bhāvamiśra, ca. 1550). The latter work also contained an extensive dictionary of materia medica, and became a standard textbook used widely by ayurvedic practitioners in north India up to the present day (2024). Medical innovations of this period included pulse diagnosis, urine diagnosis, the use of mercury and china root to treat syphilis, and the increasing use of metallic ingredients in drugs.[156]
By the 18th century CE, Ayurvedic medical therapy was still widely used among most of the population. Muslim rulers built large hospitals in 1595 in Hyderabad, and in Delhi in 1719, and numerous commentaries on ancient texts were written.[157]
During the Age of Enlightenment, the 18th century, science was held in high esteem and physicians upgraded their social status by becoming more scientific. The health field was crowded with self-trained barber-surgeons, apothecaries, midwives, drug peddlers, and charlatans.
Across Europe medical schools relied primarily on lectures and readings. The final year student would have limited clinical experience by trailing the professor through the wards. Laboratory work was uncommon, and dissections were rarely done because of legal restrictions on cadavers. Most schools were small, and only Edinburgh Medical School, Scotland, with 11,000 alumni, produced large numbers of graduates.[158][159]
In the Spanish Empire, the viceregal capital of Mexico City was a site of medical training for physicians and the creation of hospitals. Epidemic disease had decimated indigenous populations starting with the early sixteenth-century Spanish conquest of the Aztec empire, when a black auxiliary in the armed forces of conqueror Hernán Cortés, with an active case of smallpox, set off a virgin land epidemic among indigenous peoples, Spanish allies and enemies alike. Aztec emperor Cuitlahuac died of smallpox.[160][161] Disease was a significant factor in the Spanish conquest elsewhere as well.[162]
Mexico City epidemic of 1737, with elites calling on the Virgin of Guadalupe
Medical education instituted at the Royal and Pontifical University of Mexico chiefly served the needs of urban elites. Male and female curanderos or lay practitioners, attended to the ills of the popular classes. The Spanish crown began regulating the medical profession just a few years after the conquest, setting up the Royal Tribunal of the Protomedicato, a board for licensing medical personnel in 1527. Licensing became more systematic after 1646 with physicians, druggists, surgeons, and bleeders requiring a license before they could publicly practice.[163] Crown regulation of medical practice became more general in the Spanish empire.[164]
Elites and the popular classes alike called on divine intervention in personal and society-wide health crises, such as the epidemic of 1737. The intervention of the Virgin of Guadalupe was depicted in a scene of dead and dying Indians, with elites on their knees praying for her aid. In the late eighteenth century, the crown began implementing secularizing policies on the Iberian peninsula and its overseas empire to control disease more systematically and scientifically.[165][166][167]
Spanish Quest for Medicinal Spices
Botanical medicines also became popular during the 16th, 17th, and 18th Centuries. Spanish pharmaceutical books during this time contain medicinal recipes consisting of spices, herbs, and other botanical products. For example, nutmeg oil was documented for curing stomach ailments and cardamom oil was believed to relieve intestinal ailments.[168] During the rise of the global trade market, spices and herbs, along with many other goods, that were indigenous to different territories began to appear in different locations across the globe. Herbs and spices were especially popular for their utility in cooking and medicines. As a result of this popularity and increased demand for spices, some areas in Asia, like China and Indonesia, became hubs for spice cultivation and trade.[169] The Spanish Empire also wanted to benefit from the international spice trade, so they looked towards their American colonies.
The Spanish American colonies became an area where the Spanish searched to discover new spices and indigenous American medicinal recipes. The Florentine Codex, a 16th-century ethnographic research study in Mesoamerica by the Spanish Franciscan friarBernardino de Sahagún, is a major contribution to the history of Nahua medicine.[170] The Spanish did discover many spices and herbs new to them, some of which were reportedly similar to Asian spices. A Spanish physician by the name of Nicolás Monardes studied many of the American spices coming into Spain. He documented many of the new American spices and their medicinal properties in his survey Historia medicinal de las cosas que se traen de nuestras Indias Occidentales. For example, Monardes describes the "Long Pepper" (Pimienta luenga), found along the coasts of the countries that are now known Panama and Colombia, as a pepper that was more flavorful, healthy, and spicy in comparison to the Eastern black pepper.[168] The Spanish interest in American spices can first be seen in the commissioning of the Libellus de Medicinalibus Indorum Herbis, which was a Spanish-American codex describing indigenous American spices and herbs and describing the ways that these were used in natural Aztec medicines. The codex was commissioned in the year 1552 by Francisco de Mendoza, the son of Antonio de Mendoza, who was the first Viceroy of New Spain.[168] Francisco de Mendoza was interested in studying the properties of these herbs and spices, so that he would be able to profit from the trade of these herbs and the medicines that could be produced by them.
Francisco de Mendoza recruited the help of Monardez in studying the traditional medicines of the indigenous people living in what was then the Spanish colonies. Monardez researched these medicines and performed experiments to discover the possibilities of spice cultivation and medicine creation in the Spanish colonies. The Spanish transplanted some herbs from Asia, but only a few foreign crops were successfully grown in the Spanish Colonies. One notable crop brought from Asia and successfully grown in the Spanish colonies was ginger, as it was considered Hispaniola's number 1 crop at the end of the 16th Century.[168] The Spanish Empire did profit from cultivating herbs and spices, but they also introduced pre-Columbian American medicinal knowledge to Europe. Other Europeans were inspired by the actions of Spain and decided to try to establish a botanical transplant system in colonies that they controlled, however, these subsequent attempts were not successful.[169]
United Kingdom and the British Empire
18th-century medical remedies collected by a British Gentry family
The London Dispensary opened in 1696, the first clinic in the British Empire to dispense medicines to poor sick people. The innovation was slow to catch on, but new dispensaries were open in the 1770s. In the colonies, small hospitals opened in Philadelphia in 1752, New York in 1771, and Boston (Massachusetts General Hospital) in 1811.[171]
Guy's Hospital, the first great British hospital with a modern foundation, opened in 1721 in London, with funding from businessman Thomas Guy. It had been preceded by St Bartholomew's Hospital and St Thomas's Hospital, both medieval foundations. In 1821 a bequest of £200,000 by William Hunt in 1829 funded expansion for an additional hundred beds at Guy's. Samuel Sharp (1709–78), a surgeon at Guy's Hospital from 1733 to 1757, was internationally famous; his A Treatise on the Operations of Surgery (1st ed., 1739), was the first British study focused exclusively on operative technique.[172]
In 1847 in Vienna, Ignaz Semmelweis (1818–1865), dramatically reduced the death rate of new mothers (due to childbed fever) by requiring physicians to clean their hands before attending childbirth, yet his principles were marginalized and attacked by professional peers.[174] At that time most people still believed that infections were caused by foul odors called miasmas.
Louis Pasteur experimenting on bacteria, c.1870Statue of Robert Koch, father of medical bacteriology, at Robert-Koch-Platz (Robert Koch square) in Berlin
French scientist Louis Pasteur confirmed Schwann's fermentation experiments in 1857 and afterwards supported the hypothesis that yeast were microorganisms. Moreover, he suggested that such a process might also explain contagious disease. In 1860, Pasteur's report on bacterial fermentation of butyric acid motivated fellow Frenchman Casimir Davaine to identify a similar species (which he called bacteridia) as the pathogen of the deadly disease anthrax. Others dismissed "bacteridia" as a mere byproduct of the disease. British surgeon Joseph Lister, however, took these findings seriously and subsequently introduced antisepsis to wound treatment in 1865.
German physician Robert Koch, noting fellow German Ferdinand Cohn's report of a spore stage of a certain bacterial species, traced the life cycle of Davaine's bacteridia, identified spores, inoculated laboratory animals with them, and reproduced anthrax—a breakthrough for experimental pathology and germ theory of disease. Pasteur's group added ecological investigations confirming spores' role in the natural setting, while Koch published a landmark treatise in 1878 on the bacterial pathology of wounds. In 1881, Koch reported discovery of the "tubercle bacillus", cementing germ theory and Koch's acclaim.
Upon the outbreak of a cholera epidemic in Alexandria, Egypt, two medical missions went to investigate and attend the sick, one was sent out by Pasteur and the other led by Koch.[176] Koch's group returned in 1883, having successfully discovered the cholera pathogen.[176] In Germany, however, Koch's bacteriologists had to vie against Max von Pettenkofer, Germany's leading proponent of miasmatic theory.[177] Pettenkofer conceded bacteria's casual involvement, but maintained that other, environmental factors were required to turn it pathogenic, and opposed water treatment as a misdirected effort amid more important ways to improve public health.[177] The massive cholera epidemic in Hamburg in 1892 devastated Pettenkoffer's position, and yielded German public health to "Koch's bacteriology".[177]
On losing the 1883 rivalry in Alexandria, Pasteur switched research direction, and introduced his third vaccine—rabies vaccine—the first vaccine for humans since Jenner's for smallpox.[176] From across the globe, donations poured in, funding the founding of Pasteur Institute, the globe's first biomedical institute, which opened in 1888.[176] Along with Koch's bacteriologists, Pasteur's group—which preferred the term microbiology—led medicine into the new era of "scientific medicine" upon bacteriology and germ theory.[176] Accepted from Jakob Henle, Koch's steps to confirm a species' pathogenicity became famed as "Koch's postulates". Although his proposed tuberculosis treatment, tuberculin, seemingly failed, it soon was used to test for infection with the involved species. In 1905, Koch was awarded the Nobel Prize in Physiology or Medicine, and remains renowned as the founder of medical microbiology.[178]
Nursing
The breakthrough to professionalization based on knowledge of advanced medicine was led by Florence Nightingale in England. She resolved to provide more advanced training than she saw on the Continent. At Kaiserswerth, where the first German nursing schools were founded in 1836 by Theodor Fliedner, she said, "The nursing was nil and the hygiene horrible."[179] Britain's male doctors preferred the old system, but Nightingale won out and her Nightingale Training School opened in 1860 and became a model. The Nightingale solution depended on the patronage of upper-class women, and they proved eager to serve. Royalty became involved. In 1902 the wife of the British king took control of the nursing unit of the British army, became its president, and renamed it after herself as the Queen Alexandra's Royal Army Nursing Corps; when she died the next queen became president. Today its Colonel in Chief is Sophie, Countess of Wessex, the daughter-in-law of Queen Elizabeth II. In the United States, upper-middle-class women who already supported hospitals promoted nursing. The new profession proved highly attractive to women of all backgrounds, and schools of nursing opened in the late 19th century. Nurses were soon a part of large hospitals, where they provided a steady stream of low-paid idealistic workers. The International Red Cross began operations in numerous countries in the late 19th century, promoting nursing as an ideal profession for middle-class women.[180]
Statistical methods
"Diagram of the causes of mortality in the army in the East" by Florence Nightingale.
A major breakthrough in epidemiology came with the introduction of statistical maps and graphs. They allowed careful analysis of seasonality issues in disease incidents, and the maps allowed public health officials to identify critical loci for the dissemination of disease. John Snow in London developed the methods. In 1849, he observed that the symptoms of cholera, which had already claimed around 500 lives within a month, were vomiting and diarrhoea. He concluded that the source of contamination must be through ingestion, rather than inhalation as was previously thought. It was this insight that resulted in the removal of The Pump On Broad Street, after which deaths from cholera plummeted. English nurse Florence Nightingale pioneered analysis of large amounts of statistical data, using graphs and tables, regarding the condition of thousands of patients in the Crimean War to evaluate the efficacy of hospital services. Her methods proved convincing and led to reforms in military and civilian hospitals, usually with the full support of the government.[181][182][183]
By the late 19th and early 20th century English statisticians led by Francis Galton, Karl Pearson and Ronald Fisher developed the mathematical tools such as correlations and hypothesis tests that made possible much more sophisticated analysis of statistical data.[184]
During the U.S. Civil War the Sanitary Commission collected enormous amounts of statistical data, and opened up the problems of storing information for fast access and mechanically searching for data patterns. The pioneer was John Shaw Billings (1838–1913). A senior surgeon in the war, Billings built the Library of the Surgeon General's Office (now the National Library of Medicine), the centerpiece of modern medical information systems.[185] Billings figured out how to mechanically analyze medical and demographic data by turning facts into numbers and punching the numbers onto cardboard cards that could be sorted and counted by machine. The applications were developed by his assistant Herman Hollerith; Hollerith invented the punch card and counter-sorter system that dominated statistical data manipulation until the 1970s. Hollerith's company became International Business Machines (IBM) in 1911.[186]
The Quaker-run York Retreat, founded in 1796, gained international prominence as a centre for moral treatment and a model of asylum reform following the publication of Samuel Tuke's Description of the Retreat (1813).
Until the nineteenth century, the care of the insane was largely a communal and family responsibility rather than a medical one. The vast majority of the mentally ill were treated in domestic contexts with only the most unmanageable or burdensome likely to be institutionally confined.[187] This situation was transformed radically from the late eighteenth century as, amid changing cultural conceptions of madness, a new-found optimism in the curability of insanity within the asylum setting emerged.[188] Increasingly, lunacy was perceived less as a physiological condition than as a mental and moral one[189] to which the correct response was persuasion, aimed at inculcating internal restraint, rather than external coercion.[190] This new therapeutic sensibility, referred to as moral treatment, was epitomised in French physician Philippe Pinel's quasi-mythological unchaining of the lunatics of the Bicêtre Hospital in Paris[191] and realised in an institutional setting with the foundation in 1796 of the Quaker-run York Retreat in England.[47]
Patient, Surrey County Lunatic Asylum, c.1850–58. The asylum population in England and Wales rose from 1,027 in 1827 to 74,004 in 1900.
From the early nineteenth century, as lay-led lunacy reform movements gained influence,[192] ever more state governments in the West extended their authority and responsibility over the mentally ill.[193] Small-scale asylums, conceived as instruments to reshape both the mind and behaviour of the disturbed,[194] proliferated across these regions.[195] By the 1830s, moral treatment, together with the asylum itself, became increasingly medicalised[196] and asylum doctors began to establish a distinct medical identity with the establishment in the 1840s of associations for their members in France, Germany, the United Kingdom and America, together with the founding of medico-psychological journals.[47] Medical optimism in the capacity of the asylum to cure insanity soured by the close of the nineteenth century as the growth of the asylum population far outstripped that of the general population.[a][197] Processes of long-term institutional segregation, allowing for the psychiatric conceptualisation of the natural course of mental illness, supported the perspective that the insane were a distinct population, subject to mental pathologies stemming from specific medical causes.[194] As degeneration theory grew in influence from the mid-nineteenth century,[198] heredity was seen as the central causal element in chronic mental illness,[199] and with national asylum systems overcrowded and insanity apparently undergoing an inexorable rise, the focus of psychiatric therapeutics shifted from a concern with treating the individual to maintaining the racial and biological health of national populations.[200]
Emil Kraepelin (1856–1926), the founder of modern scientific psychiatry, psychopharmacology and psychiatric genetics.
Emil Kraepelin (1856–1926) introduced new medical categories of mental illness, which eventually came into psychiatric usage despite their basis in behavior rather than pathology or underlying cause. Shell shock among frontline soldiers exposed to heavy artillery bombardment was first diagnosed by British Army doctors in 1915. By 1916, similar symptoms were also noted in soldiers not exposed to explosive shocks, leading to questions as to whether the disorder was physical or psychiatric.[202] In the 1920s surrealist opposition to psychiatry was expressed in a number of surrealist publications. In the 1930s several controversial medical practices were introduced including inducing seizures (by electroshock, insulin or other drugs) or cutting parts of the brain apart (leucotomy or lobotomy). Both came into widespread use by psychiatry, but there were grave concerns and much opposition on grounds of basic morality, harmful effects, or misuse.[203]
In the 1950s new psychiatric drugs, notably the antipsychotic chlorpromazine, were designed in laboratories and slowly came into preferred use. Although often accepted as an advance in some ways, there was some opposition, due to serious adverse effects such as tardive dyskinesia. Patients often opposed psychiatry and refused or stopped taking the drugs when not subject to psychiatric control. There was also increasing opposition to the use of psychiatric hospitals, and attempts to move people back into the community on a collaborative user-led group approach ("therapeutic communities") not controlled by psychiatry. Campaigns against masturbation were done in the Victorian era and elsewhere. Lobotomy was used until the 1970s to treat schizophrenia. This was denounced by the anti-psychiatric movement in the 1960s and later.
Women
It was very difficult for women to become doctors in any field before the 1970s. Elizabeth Blackwell became the first woman to formally study and practice medicine in the United States. She was a leader in women's medical education. While Blackwell viewed medicine as a means for social and moral reform, her student Mary Putnam Jacobi (1842–1906) focused on curing disease. At a deeper level of disagreement, Blackwell felt that women would succeed in medicine because of their humane female values, but Jacobi believed that women should participate as the equals of men in all medical specialties using identical methods, values and insights.[204] Although the majority of medical doctors in the Soviet Union were women, they were paid less than the male dominated factory workers.[205]
Because of the social custom that men and women should not be near to one another, the women of China were reluctant to be treated by male doctors. The missionaries sent women doctors such as Dr. Mary Hannah Fulton (1854–1927). Supported by the Foreign Missions Board of the Presbyterian Church (US) she in 1902 founded the first medical college for women in China, the Hackett Medical College for Women, in Guangzhou.[207]
Japan
A doctor checks a patient's pulse in Meiji-era Japan.
European ideas of modern medicine were spread widely through the world by medical missionaries, and the dissemination of textbooks. Japanese elites enthusiastically embraced Western medicine after the Meiji Restoration of the 1860s. However they had been prepared by their knowledge of the Dutch and German medicine, for they had some contact with Europe through the Dutch. Highly influential was the 1765 edition of Hendrik van Deventer's pioneer work Nieuw Ligt ("A New Light") on Japanese obstetrics, especially on Katakura Kakuryo's publication in 1799 of Sanka Hatsumo ("Enlightenment of Obstetrics").[208][209] A cadre of Japanese physicians began to interact with Dutch doctors, who introduced smallpox vaccinations. By 1820 Japanese ranpô medical practitioners not only translated Dutch medical texts, they integrated their readings with clinical diagnoses. These men became leaders of the modernization of medicine in their country. They broke from Japanese traditions of closed medical fraternities and adopted the European approach of an open community of collaboration based on expertise in the latest scientific methods.[210]
Kitasato Shibasaburō (1853–1931) studied bacteriology in Germany under Robert Koch. In 1891 he founded the Institute of Infectious Diseases in Tokyo, which introduced the study of bacteriology to Japan. He and French researcher Alexandre Yersin went to Hong Kong in 1894, where; Kitasato confirmed Yersin's discovery that the bacterium Yersinia pestis is the agent of the plague. In 1897 he isolated and described the organism that caused dysentery. He became the first dean of medicine at Keio University, and the first president of the Japan Medical Association.[211][212]
Japanese physicians immediately recognized the values of X-Rays. They were able to purchase the equipment locally from the Shimadzu Company, which developed, manufactured, marketed, and distributed X-Ray machines after 1900.[213] Japan not only adopted German methods of public health in the home islands, but implemented them in its colonies, especially Korea and Taiwan, and after 1931 in Manchuria.[214] A heavy investment in sanitation resulted in a dramatic increase of life expectancy.[215]
Europe
The practice of medicine changed in the face of rapid advances in science, as well as new approaches by physicians. Hospital doctors began much more systematic analysis of patients' symptoms in diagnosis.[216] Among the more powerful new techniques were anaesthesia, and the development of both antiseptic and aseptic operating theatres.[217] Effective cures were developed for certain endemic infectious diseases. However, the decline in many of the most lethal diseases was due more to improvements in public health and nutrition than to advances in medicine.[citation needed]
Medicine was revolutionized in the 19th century and beyond by advances in chemistry, laboratory techniques, and equipment. Old ideas of infectious disease epidemiology were gradually replaced by advances in bacteriology and virology.[142]
The Russian Orthodox Church sponsored seven orders of nursing sisters in the late 19th century. They ran hospitals, clinics, almshouses, pharmacies, and shelters as well as training schools for nurses. In the Soviet era (1917–1991), with the aristocratic sponsors gone, nursing became a low-prestige occupation based in poorly maintained hospitals.[218]
Places
France
Paris (France) and Vienna were the two leading medical centers on the Continent in the era 1750–1914.
In the 1770s–1850s Paris became a world center of medical research and teaching. The "Paris School" emphasized that teaching and research should be based in large hospitals and promoted the professionalization of the medical profession and the emphasis on sanitation and public health. A major reformer was Jean-Antoine Chaptal (1756–1832), a physician who was Minister of Internal Affairs. He created the Paris Hospital, health councils, and other bodies.[219]
Louis Pasteur (1822–1895) was one of the most important founders of medical microbiology. He is remembered for his remarkable breakthroughs in the causes and preventions of diseases. His discoveries reduced mortality from puerperal fever, and he created the first vaccines for rabies and anthrax. His experiments supported the germ theory of disease. He was best known to the general public for inventing a method to treat milk and wine to prevent it from causing sickness, a process that came to be called pasteurization. He is regarded as one of the three main founders of microbiology, together with Ferdinand Cohn and Robert Koch. He worked chiefly in Paris and in 1887 founded the Pasteur Institute there to perpetuate his commitment to basic research and its practical applications. As soon as his institute was created, Pasteur brought together scientists with various specialties. The first five departments were directed by Emile Duclaux (general microbiology research) and Charles Chamberland (microbe research applied to hygiene), as well as a biologist, Ilya Ilyich Mechnikov (morphological microbe research) and two physicians, Jacques-Joseph Grancher (rabies) and Emile Roux (technical microbe research). One year after the inauguration of the Institut Pasteur, Roux set up the first course of microbiology ever taught in the world, then entitled Cours de Microbie Technique (Course of microbe research techniques). It became the model for numerous research centers around the world named "Pasteur Institutes."[220][221]
Vienna
The First Viennese School of Medicine, 1750–1800, was led by the Dutchman Gerard van Swieten (1700–1772), who aimed to put medicine on new scientific foundations—promoting unprejudiced clinical observation, botanical and chemical research, and introducing simple but powerful remedies. When the Vienna General Hospital opened in 1784, it at once became the world's largest hospital and physicians acquired a facility that gradually developed into the most important research centre.[222] Progress ended with the Napoleonic wars and the government shutdown in 1819 of all liberal journals and schools; this caused a general return to traditionalism and eclecticism in medicine.[223]
Vienna was the capital of a diverse empire and attracted not just Germans but Czechs, Hungarians, Jews, Poles and others to its world-class medical facilities. After 1820 the Second Viennese School of Medicine emerged with the contributions of physicians such as Carl Freiherr von Rokitansky, Josef Škoda, Ferdinand Ritter von Hebra, and Ignaz Philipp Semmelweis. Basic medical science expanded and specialization advanced. Furthermore, the first dermatology, eye, as well as ear, nose, and throat clinics in the world were founded in Vienna. The textbook Lehre von den Augenkrankheiten of ophthalmologistGeorg Joseph Beer (1763–1821) combined practical research and philosophical speculations, and became the standard reference work for decades.[224]
In the American Civil War (1861–65), as was typical of the 19th century, more soldiers died of disease than in battle, and even larger numbers were temporarily incapacitated by wounds, disease and accidents.[225][226] Conditions were poor in the Confederacy, where doctors and medical supplies were in short supply.[227] The war had a dramatic long-term impact on medicine in the U.S., from surgical technique to hospitals to nursing and to research facilities. Weapon development—particularly the appearance of Springfield Model 1861, mass-produced and much more accurate than muskets—led to generals underestimating the risks of long range rifle fire; risks exemplified in the death of John Sedgwick and the disastrous Pickett's Charge. The rifles could shatter bone forcing amputation and longer ranges meant casualties were sometimes not quickly found. Evacuation of the wounded from Second Battle of Bull Run took a week.[228] As in earlier wars, untreated casualties sometimes survived unexpectedly due to maggots debriding the wound—an observation which led to the surgical use of maggots—still a useful method in the absence of effective antibiotics.
The hygiene of the training and field camps was poor, especially at the beginning of the war when men who had seldom been far from home were brought together for training with thousands of strangers. First came epidemics of the childhood diseases of chicken pox, mumps, whooping cough, and, especially, measles. Operations in the South meant a dangerous and new disease environment, bringing diarrhea, dysentery, typhoid fever, and malaria. There were no antibiotics, so the surgeons prescribed coffee, whiskey, and quinine. Harsh weather, bad water, inadequate shelter in winter quarters, poor policing of camps, and dirty camp hospitals took their toll.[229]
This was a common scenario in wars from time immemorial, and conditions faced by the Confederate army were even worse. The Union responded by building army hospitals in every state. What was different in the Union was the emergence of skilled, well-funded medical organizers who took proactive action, especially in the much enlarged United States Army Medical Department,[230] and the United States Sanitary Commission, a new private agency.[231] Numerous other new agencies also targeted the medical and morale needs of soldiers, including the United States Christian Commission as well as smaller private agencies.[232]
The U.S. Army learned many lessons and in August 1886, it established the Hospital Corps.
The ABO blood group system was discovered in 1901 by Karl Landsteiner at the University of Vienna. Landsteiner experimented on his staff, mixing their various blood components together, and found that some people's blood agglutinated (clumped together) with other blood, while some did not. This then lead him identifying three blood groups, ABC, which would later be renamed to ABO.[236] The less frequently found blood group AB was discovered later in 1902 by Alfred Von Decastello and Adriano Sturli.[237] In 1937 Landsteiner and Alexander S. Wiener further discovered the Rh factor (misnamed from early thinking that this blood group was similar to that found in rhesus monkeys) whose antigens further determine blood reaction between people.[237] This was demonstrated in a 1939 case study by Phillip Levine and Rufus Stetson where a mother who had recently given birth had reacted to their partner's blood, highlighting the Rh factor.[238]
In 1958, Arne Larsson in Sweden became the first patient to depend on an artificial cardiac pacemaker. He died in 2001 at age 86, having outlived its inventor, the surgeon, and 26 pacemakers.
As infectious diseases have become less lethal, and the most common causes of death in developed countries are now tumors and cardiovascular diseases, these conditions have received increased attention in medical research.
Starting in World War II, DDT was used as insecticide to combat insect vectors carrying malaria, which was endemic in most tropical regions of the world.[240][241][242] The first goal was to protect soldiers, but it was widely adopted as a public health device. In Liberia, for example, the United States had large military operations during the war and the U.S. Public Health Service began the use of DDT for indoor residual spraying (IRS) and as a larvicide, with the goal of controlling malaria in Monrovia, the Liberian capital. In the early 1950s, the project was expanded to nearby villages. In 1953, the World Health Organization (WHO) launched an antimalaria program in parts of Liberia as a pilot project to determine the feasibility of malaria eradication in tropical Africa. However these projects encountered a spate of difficulties that foreshadowed the general retreat from malaria eradication efforts across tropical Africa by the mid-1960s.[243]
Pandemics
1918 influenza pandemic (1918-1920)
The 1918 influenza pandemic was a global pandemic in the early 20th century that occurred between 1918 and 1920. Sometimes known as Spanish Flu due to popular opinion at the time thinking the flu originated from Spain, this pandemic caused close to 50 million deaths around the world.[244] Spreading at the end of World War I.[245]
Public health
Public health measures became particularly important during the 1918 flu pandemic, which killed at least 50 million people around the world.[246] It became an important case study in epidemiology.[247] Bristow shows there was a gendered response of health caregivers to the pandemic in the United States. Male doctors were unable to cure the patients, and they felt like failures. Women nurses also saw their patients die, but they took pride in their success in fulfilling their professional role of caring for, ministering, comforting, and easing the last hours of their patients, and helping the families of the patients cope as well.
Most countries have seen a tremendous increase in life expectancy since 1945. However, in southern Africa, the HIV epidemic beginning around 1990 has eroded national health.
Tobacco smoking as a cause of lung cancer was first researched in the 1920s, but was not widely supported by publications until the 1950s.
Surgery
Cardiac surgery was revolutionized in 1948 as open-heart surgery was introduced for the first time since 1925. In 1954 Joseph Murray, J. Hartwell Harrison and others accomplished the first kidney transplantation. Transplantations of other organs, such as heart, liver and pancreas, were also introduced during the later 20th century. The first partial face transplant was performed in 2005, and the first full one in 2010. By the end of the 20th century, microtechnology had been used to create tiny robotic devices to assist microsurgery using micro-video and fiber-optic cameras to view internal tissues during surgery with minimally invasive practices.[248]Laparoscopic surgery was broadly introduced in the 1990s. Natural orifice surgery has followed.
War
Mexican Revolution (1910-1920)
During the 19th century, large-scale wars were attended with medics and mobile hospital units which developed advanced techniques for healing massive injuries and controlling infections rampant in battlefield conditions. During the Mexican Revolution (1910–1920), General Pancho Villa organized hospital trains for wounded soldiers. Boxcars marked Servicio Sanitario ("sanitary service") were re-purposed as surgical operating theaters and areas for recuperation, and staffed by up to 40 Mexican and U.S. physicians. Severely wounded soldiers were shuttled back to base hospitals.[249]
World War I (1914-1918)
Medicine during the First World War - Medical Transport.
From 1917 to 1932, the American Red Cross moved into Europe with a battery of long-term child health projects. It built and operated hospitals and clinics, and organized antituberculosis and antityphus campaigns. A high priority involved child health programs such as clinics, better baby shows, playgrounds, fresh air camps, and courses for women on infant hygiene. Hundreds of U.S. doctors, nurses, and welfare professionals administered these programs, which aimed to reform the health of European youth and to reshape European public health and welfare along American lines.[250][251][252]
World War II (1939-1945)
American combat surgery during the Pacific War, 1943
The advances in medicine made a dramatic difference for Allied troops, while the Germans and especially the Japanese and Chinese suffered from a severe lack of newer medicines, techniques and facilities. Harrison finds that the chances of recovery for a badly wounded British infantryman were as much as 25 times better than in the First World War. The reason was that:
"By 1944 most casualties were receiving treatment within hours of wounding, due to the increased mobility of field hospitals and the extensive use of aeroplanes as ambulances. The care of the sick and wounded had also been revolutionized by new medical technologies, such as active immunization against tetanus, sulphonamide drugs, and penicillin."[253]
The War spurred the usage of Roentgen's X-ray, and the electrocardiograph, for the monitoring of internal bodily functions. This was followed in the inter-war period by the development of the first anti-bacterial agents such as the sulpha antibiotics.
Nazi and Japanese medical research
Unethical human subject research, and killing of patients with disabilities, peaked during the Nazi era, with Nazi human experimentation and Aktion T4 during the Holocaust as the most significant examples. Many of the details of these and related events were the focus of the Doctors' Trial. Subsequently, principles of medical ethics, such as the Nuremberg Code, were introduced to prevent a recurrence of such atrocities.[255] After 1937, the Japanese Army established programs of biological warfare in China. In Unit 731, Japanese doctors and research scientists conducted large numbers of vivisections and experiments on human beings, mostly Chinese victims.[256]
Institutions
World Health Organization
Smallpox vaccination in Niger, 1969. A decade later, this was the first infectious disease to be eradicated.
The discovery of penicillin in the 20th century by Alexander Fleming provided a vital line of defence against bacterical infections that, without them, often cause patients to suffer prelonged recovery periods and highly increased chances of death. Its discovery and application within medicine allowed previously impossible treatments to take place, including cancer treatments, organ transplants, to open heart surgery.[257] Throughout the 20th century, though, their overprescribed use to humans,[258] as well as to animals that need them due to the conditions of intensive animal farming,[259] has led to the development of antibiotic resistant bacteria.[257]
Robotics
Medical personnel place sterilized covers on the arms of the daVinci Xi surgical system, a minimally-invasive robotic surgery system, at the William Beaumont Army Medical Center.
HIV First death
A Ukrainian monument to the HIV pandemic.COVID-19 swab testing in Rwanda (2021).
The early 21st century, facilitated by extensive global connections, international travel, and unprecedented human disruption of ecological systems,[260][261] has been defined by a number of noval as well as continuing global pandemics from the 20th century.[262]
Past
The SARS 2002 to 2004 outbreak affected a number of countries around the world and killed hundreds. This outbreak gave rise to a number of lessons learnt from viral infection control, including more effective isolation room protocols to better hand washing techniques for medical staff.[263] A mutated strain of SARS would go on to develop into COVID-19, causing the future COVID-19 pandemic. A significant influenza strain, H1N1, caused a further pandemic between 2009 and 2010. Known as swine flu, due to its indirect source from pigs, it went on to infect over 700 million people.[264]
The outbreak of COVID-19, starting in 2019, and subsequent declaration of the COVID-19 pandemic by the WHO[270] is a major pandemic event within the early 21st century. Causing global disruptions, millions of infections and deaths, the pandemic has caused suffering throughout communities. The pandemic has also seen some of the largest logistical organisations of goods, medical equipment, medical professionals, and military personnel since World War II that highlights its far-reaching impact.[271][272]
Personalised medicine
The rise of personalised medicine in the 21st century has generated the possibility to develop diagnosis and treatments based on the individual characteristics of a person, rather than through generic practices that defined 20th century medicine. Areas like DNA sequencing, genetic mapping, gene therapy, imaging protocols, proteomics, stem cell therapy, and wireless health monitoring devices[273] are all rising innovations that can help medical professionals fine tune treatment to the individual.[274][275]
Women have always served as healers and midwives since ancient times. However, the professionalization of medicine forced them increasingly to the sidelines. As hospitals multiplied they relied in Europe on orders of Roman Catholic nun-nurses, and German Protestant and Anglican deaconesses in the early 19th century. They were trained in traditional methods of physical care that involved little knowledge of medicine.
↑ England and Wales had nine county and borough asylums in 1827 with an average capacity of a little over 100 patients, but by 1890 there were 66 such asylums containing on average 800 patients each;[b] the total number of patients so confined increased from 1,027 in 1827 to 74,004 in 1900.[c] Similarly, in Germany, between 1852 and 1898 the asylum population increased seven-fold from 11,622 to 74,087 patients during a period when the total population had only grown by ten per cent.[d] In America the asylum population had risen to almost 250,000 on the eve of the First World War.[e]
Scull A (2005). Most Solitary of Afflictions: Madness And Society in Britain, 1700–1900. Yale University Press. p.281. ISBN978-0-300-10754-8.
Jones K (1993). Asylums and after: a revised history of the mental health services: from the early 18th century to the 1990s. Athlone Press. p.116. ISBN978-0-485-12091-2.
Wright D (April 1997). "Getting out of the asylum: understanding the confinement of the insane in the nineteenth century". Social History of Medicine. 10 (1): 137–155. doi:10.1093/shm/10.1.137. PMID11619188.
Related Research Articles
Aelius Galenus or Claudius Galenus, often anglicized as Galen or Galen of Pergamon, was a Roman and Greek physician, surgeon, and philosopher. Considered to be one of the most accomplished of all medical researchers of antiquity, Galen influenced the development of various scientific disciplines, including anatomy, physiology, pathology, pharmacology, and neurology, as well as philosophy and logic.
Hippocrates of Kos, also known as Hippocrates II, was a Greek physician and philosopher of the classical period who is considered one of the most outstanding figures in the history of medicine. He is traditionally referred to as the "Father of Medicine" in recognition of his lasting contributions to the field, such as the use of prognosis and clinical observation, the systematic categorization of diseases, and the formulation of humoral theory. The Hippocratic school of medicine revolutionized ancient Greek medicine, establishing it as a discipline distinct from other fields with which it had traditionally been associated, thus establishing medicine as a profession.
Medicine is the science and practice of caring for patients, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.
Pediatrics also spelled paediatrics, is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, pediatrics covers many of their youth until the age of 18. The American Academy of Pediatrics recommends people seek pediatric care through the age of 21, but some pediatric subspecialists continue to care for adults up to 25. Worldwide age limits of pediatrics have been trending upward year after year. A medical doctor who specializes in this area is known as a pediatrician, or paediatrician. The word pediatrics and its cognates mean "healer of children", derived from the two Greek words: παῖς and ἰατρός. Pediatricians work in clinics, research centers, universities, general hospitals and children's hospitals, including those who practice pediatric subspecialties.
Veterinary medicine is the branch of medicine that deals with the prevention, management, diagnosis, and treatment of disease, disorder, and injury in non-human animals. The scope of veterinary medicine is wide, covering all animal species, both domesticated and wild, with a wide range of conditions that can affect different species.
The history of anatomy extends from the earliest examinations of sacrificial victims to the sophisticated analyses of the body performed by modern anatomists and scientists. Written descriptions of human organs and parts can be traced back thousands of years to ancient Egyptian papyri, where attention to the body was necessitated by their highly elaborate burial practices.
Bloodletting is the withdrawal of blood from a patient to prevent or cure illness and disease. Bloodletting, whether by a physician or by leeches, was based on an ancient system of medicine in which blood and other bodily fluids were regarded as "humours" that had to remain in proper balance to maintain health. It is the most common medical practice performed by surgeons from antiquity until the late 19th century, a span of over 2,000 years. In Europe, the practice continued to be relatively common until the end of the 19th century. The practice has now been abandoned by modern-style medicine for all except a few very specific medical conditions. In the beginning of the 19th century, studies had begun to show the harmful effects of bloodletting.
Ayurveda is an alternative medicine system with historical roots in the Indian subcontinent. It is heavily practiced throughout India and Nepal, where as much as 80% of the population report using ayurveda. The theory and practice of ayurveda is pseudoscientific and toxic metals such as lead are used as ingredients in many ayurvedic medicines.
Humorism, the humoral theory, or humoralism, was a system of medicine detailing a supposed makeup and workings of the human body, adopted by Ancient Greek and Roman physicians and philosophers.
In the Middle Ages, the medicine of Western Europe was composed of a mixture of existing ideas from antiquity. In the Early Middle Ages, following the fall of the Western Roman Empire, standard medical knowledge was based chiefly upon surviving Greek and Roman texts, preserved in monasteries and elsewhere. Medieval medicine is widely misunderstood, thought of as a uniform attitude composed of placing hopes in the church and God to heal all sicknesses, while sickness itself exists as a product of destiny, sin, and astral influences as physical causes. But, especially in the second half of the medieval period, medieval medicine became a formal body of theoretical knowledge and was institutionalized in universities. Medieval medicine attributed illnesses, and disease, not to sinful behavior, but to natural causes, and sin was connected to illness only in a more general sense of the view that disease manifested in humanity as a result of its fallen state from God. Medieval medicine also recognized that illnesses spread from person to person, that certain lifestyles may cause ill health, and some people have a greater predisposition towards bad health than others.
Medical astrology or astrological medicine is an ancient applied branch of astrology based mostly on melothesia, the association of various parts of the body, diseases, and drugs with the nature of the sun, moon, planets, and the twelve astrological signs. The underlying basis for medical astrology is considered to be a pseudoscience as there is no scientific basis for its core beliefs.
The Hippocratic Corpus, or Hippocratic Collection, is a collection of around 60 early Ancient Greek medical works strongly associated with the physician Hippocrates and his teachings. The Hippocratic Corpus covers many diverse aspects of medicine, from Hippocrates' medical theories to what he devised to be ethical means of medical practice, to addressing various illnesses. Even though it is considered a singular corpus that represents Hippocratic medicine, they vary in content, age, style, methods, and views practiced; therefore, authorship is largely unknown. Hippocrates began Western society's development of medicine, through a delicate blending of the art of healing and scientific observations. What Hippocrates was sharing from within his collection of works was not only how to identify symptoms of disease and proper diagnostic practices, but more essentially, he was alluding to his personable form of art, "The art of true living and the art of fine medicine combined." The Hippocratic Corpus became the foundation upon which Western medical practice was built.
In the history of medicine, "Islamic medicine" Also known as "Arabian medicine" is the science of medicine developed in the Middle East, and usually written in Arabic, the lingua franca of Islamic civilization.
Byzantine medicine encompasses the common medical practices of the Byzantine Empire from c. 400 AD to 1453 AD. Byzantine medicine was notable for building upon the knowledge base developed by its Greco-Roman predecessors. In preserving medical practices from antiquity, Byzantine medicine influenced Islamic medicine and fostered the Western rebirth of medicine during the Renaissance. The concept of the hospital appeared in Byzantine Empire as an institution to offer medical care and possibility of a cure for the patients because of the ideals of Christian charity.
Ancient Greek medicine was a compilation of theories and practices that were constantly expanding through new ideologies and trials. The Greek term for medicine was iatrikē. Many components were considered in ancient Greek medicine, intertwining the spiritual with the physical. Specifically, the ancient Greeks believed health was affected by the humors, geographic location, social class, diet, trauma, beliefs, and mindset. Early on the ancient Greeks believed that illnesses were "divine punishments" and that healing was a "gift from the Gods". As trials continued wherein theories were tested against symptoms and results, the pure spiritual beliefs regarding "punishments" and "gifts" were replaced with a foundation based in the physical, i.e., cause and effect.
Medicine in ancient Rome was highly influenced by ancient Greek medicine, but also developed new practices through knowledge of the Hippocratic Corpus combined with use of the treatment of diet, regimen, along with surgical procedures. This was most notably seen through the works of two of the prominent Greek physicians, Dioscorides and Galen, who practiced medicine and recorded their discoveries. This is contrary to two other physicians like Soranus of Ephesus and Asclepiades of Bithynia, who practiced medicine both in outside territories and in ancient Roman territory, subsequently. Dioscorides was a Roman army physician, Soranus was a representative for the Methodic school of medicine, Galen performed public demonstrations, and Asclepiades was a leading Roman physician. These four physicians all had knowledge of medicine, ailments, and treatments that were healing, long lasting and influential to human history.
Surgery is the branch of medicine that deals with the physical manipulation of a bodily structure to diagnose, prevent, or cure an ailment. Ambroise Paré, a 16th-century French surgeon, stated that to perform surgery is, "To eliminate that which is superfluous, restore that which has been dislocated, separate that which has been united, join that which has been divided and repair the defects of nature."
The practice and study of medicine in Persia has a long and prolific history. The Iranian academic centers like Gundeshapur University were a breeding ground for the union among great scientists from different civilizations. These centers successfully followed their predecessors’ theories and greatly extended their scientific research through history. Persians were the first establishers of modern hospital system.
The history of dermatology concerns the development of the practice of researching, defining and treating skin diseases, from ancient times to the present. The field has its origin in the earliest forms of medicine, later becoming a distinct field with its own specialised practitioners and researchers.
The history of cancer describes the development of the field of oncology and its role in the history of medicine.
1 2 Martkoplishvili I, Kvavadze E (2015-05-26). "Some popular medicinal plants and diseases of the Upper Palaeolithic in Western Georgia". Journal of Ethnopharmacology. 166: 42–52. doi:10.1016/j.jep.2015.03.003. PMID25769538.
↑ Riga A, Dori I, Vierin S, Boschian G, Tozzi C, Willman JC, Moggi-Cecchi J (2018). "At the upper Palaeolithic – Mesolithic boundary: revision of the human remains from Riparo Fredian (Molazzana, Lucca, Italy)". Alpine and Mediterranean Quaternary. 31 (1): 49–57. doi:10.26382/AMQ.2018.04.
↑ Oxilia G, Fiorillo F, Boschin F, Boaretto E, Apicella SA, Matteucci C, etal. (July 2017). "The dawn of dentistry in the late upper Paleolithic: An early case of pathological intervention at Riparo Fredian". American Journal of Physical Anthropology. 163 (3): 446–461. doi:10.1002/ajpa.23216. hdl:11585/600517. PMID28345756.
↑ Ferngren, Gary B. (2017). "Medicine and Spirituality: A Historical Perspective". In Balboni, Michael; Peteet, John (eds.). Spirituality and Religion Within the Culture of Medicine: From Evidence to Practice Get access Arrow. pp.305–324. doi:10.1093/med/9780190272432.003.0019. ISBN978-0-19-027243-2.
↑ Teppone M (July 2019). "Medicine has always been "Modern" and "Scientific" from ancient times to the present day". Journal of Integrative Medicine. 17 (4): 229–237. doi:10.1016/j.joim.2019.03.008. PMID30967348. S2CID106409698.
↑ Robson E (2008-06-28). "Mesopotamian Medicine and Religion: Current Debates, New Perspectives". Religion Compass. 2 (4): 455–483. doi:10.1111/j.1749-8171.2008.00082.x.
1 2 McIntosh JR (2005). Ancient Mesopotamia: New Perspectives. Santa Barbara, California, Denver, Colorado, and Oxford, England: ABC-CLIO. pp.273–76. ISBN978-1-57607-966-9.
↑ Abusch T (2002). Mesopotamian Witchcraft: Towards a History and Understanding of Babylonian Witchcraft Beliefs and Literature. Leiden, The Netherlands: Brill. p.56. ISBN978-90-04-12387-8.
1 2 Horstmanshoff HF, Van Tilburg CR, Stol M (2004). Magic and Rationality in Ancient Near Eastern and Graeco-Roman Medicine. Leiden: Brill. ISBN978-90-04-13666-3.
↑ Selin H, Shapiro H, eds. (2003). Medicine Across Cultures: History and Practice of Medicine in Non-Western Cultures. Dordrecht: Springer Science & Business Media. p.35. ISBN978-0-306-48094-2.
↑ "The Shambhala Guide to Traditional Chinese Medicine. Daniel Reid, 1996. U.S. $12.00, Canada $16.95, ISBN 1-57062-141-1. Available from Shambhala Publications, Inc., Horticultural Hall, 300 Massachusetts Avenue, Boston, MA 02115". Complementary Health Practice Review. 3 (2): 147. 1997-07-01. doi:10.1177/153321019700300253. S2CID208272511.
↑ Unschuld PU (2003). Huang Di Nei Jing Su Wen: nature, knowledge, imagery in an ancient Chinese medical text, with an appendix, the doctrine of the five periods and six qi in the Huang Di Nei Jing Su Wen. Berkeley: University of California Press. ISBN978-0-520-92849-7.
1 2 "Hard to swallow". Nature. 448 (7150): 105–6. July 2007. Bibcode:2007Natur.448S.105.. doi:10.1038/448106a. PMID17625521. Constructive approaches to divining the potential usefulness of traditional therapies are to be welcomed. But it seems problematic to apply a brand new technique, largely untested in the clinic, to test the veracity of traditional Chinese medicine, when the field is so fraught with pseudoscience. In the meantime, claims made on behalf of an uncharted body of knowledge should be treated with the customary skepticism that is the bedrock of both science and medicine.
↑ Beall, Jeffrey (2018). "Scientific soundness and the problem of predatory journals". In Kaufman, Allison B.; Kaufman, James C. (eds.). Pseudoscience: The Conspiracy Against Science. MIT Press. p.293. ISBN978-0-262-03742-6. Archived from the original on 7 September 2023. Retrieved 11 September 2020. Ayurveda, a traditional Indian medicine, is the subject of more than a dozen, with some of these 'scholarly' journals devoted to Ayurveda alone..., others to Ayurveda and some other pseudoscience.... Most current Ayurveda research can be classified as 'tooth fairy science,' research that accepts as its premise something not scientifically known to exist.... Ayurveda is a long-standing system of beliefs and traditions, but its claimed effects have not been scientifically proven. Most Ayurveda researchers might as well be studying the tooth fairy. The German publisher Wolters Kluwer bought the Indian open-access publisher Medknow in 2011....It acquired its entire fleet of journals, including those devoted to pseudoscience topics such as An International Quarterly Journal of Research in Ayurveda.
1 2 Syros V (2013). "Galenic Medicine and Social Stability in Early Modern Florence and the Islamic Empires". Journal of Early Modern History. 17 (2): 161–213. doi:10.1163/15700658-12342361– via Academic Search Premier.
1 2 3 4 5 6 7 8 Stelmack RM, Stalikas A (1991). "Galen and the Humor Theory of Temperament". University of Ottawa. 12: 255–63 – via Science Direct.
↑ Siegel RE (1968). Galen's System of Physiology and Medicine: an analysis of his doctrines and observations on bloodflow, respiration, humors and internal diseases. Basel: S. Karger. ISBN978-3-8055-1016-5.
↑ Longrigg J (1993). Greek Rational Medicine: Philosophy and Medicine from Alcmaeon to the Alexandrians. Psychology Press. ISBN978-0-415-02594-2.
↑ Galen (2000). On the Natural Faculties, Books I, II, and III. Harvard: Loeb Classical Library.
1 2 Vallance JT (April 1993). "Herophilus: The Art of Medicine in Early Alexandria". Ancient Philosophy. 13 (1): 237–241. doi:10.5840/ancientphil199313163.
↑ "Greek Medicine". US National Institutes of Health. 16 September 2002. Archived from the original on 9 November 2013. Retrieved 29 August 2014.
↑ Crislip, Andrew T. (2015). "New Perspectives on Health and Disability in Late Ancient Judaism and Christianity: A Response". Journal of Late Antiquity. 8 (2): 405–409. doi:10.1353/jla.2015.0017. S2CID162654188. ProjectMUSE605034.
↑ Cambridge History of Iran Volume 4. Cambridge University Press. 1968. p.396. ISBN978-0-521-20093-6.
↑ Cyril E (1951). A medical history of Persia. Cambridge University Press. p.173.
1 2 Dols MW (1987). "The origins of the Islamic hospital: myth and reality". Bulletin of the History of Medicine. 61 (3): 367–390. JSTOR44442098. PMID3311248.
1 2 3 Hamarneh S (July 1962). "Development of hospitals in Islam". Journal of the History of Medicine and Allied Sciences. 17 (3): 366–384. doi:10.1093/jhmas/xvii.3.366. PMID13904051.
↑ Lapidus IM (October 1975). "The Separation of State and Religion in the Development of Early Islamic Society". International Journal of Middle East Studies. 6 (4): 363–385. doi:10.1017/s0020743800025344. S2CID162409061.
↑ Parker S (2013). Kill or cure: an illustrated history of medicine (First Americaned.). New York City. ISBN978-1-4654-0842-6.{{cite book}}: CS1 maint: location missing publisher (link)
↑ Becka J (January 1980). "[The father of medicine, Avicenna, in our science and culture. Abu Ali ibn Sina (980–1037)]". Casopis Lekaru Ceskych (in Czech). 119 (1): 17–23. PMID6989499.
↑ Musallam B (30 December 2012). "Avicenna: Medicine and Biology". Encyclopedia Iranica. pp.94–99. Archived from the original on 1 December 2019. Retrieved 20 December 2013.
↑ Pormann PE, Savage-Smith (2007). "On the dominance of the Greek humoral theory, which was the basis for the practice of bloodletting, in medieval Islamic medicine". Medieval Islamic medicine. Washington DC: Georgetown University. pp.10, 43–45. OL12911905W.
↑ Iskandar A (2006). "Al-Rāzī". Encyclopaedia of the history of science, technology, and medicine in non-western cultures (2nded.). Springer. pp.155–56.
↑ Ganchy S (2009). Islam and Science, Medicine, and Technology (1sted.). New York, NY: Rosen Pub. ISBN978-1-4358-5679-0.
↑ Tschanz DW (2003). "Arab(?) Roots of European Medicine". Heart Views. 4 (2).
↑ Elgood C (2010). A Medical History of Persia and The Eastern Caliphate (1sted.). London: Cambridge. pp.202–03. ISBN978-1-108-01588-2. By writing a monograph on 'Diseases in Children' he may also be looked upon as the father of paediatrics.
1 2 Speziale F, ed. (2012). "The Hospital and Other Muslim Institutions [Introduction]". Hospitals in Iran and India, 1500-1950s. Leiden, NV: Brill. pp.2–4. ISBN978-90-04-22829-0.
↑ Barker P (2020). History of Science in the Persianate World. Lecture (Report).
↑ Porter R (October 1999). The Greatest Benefit to Mankind. A medical history of humanity. The Norton History of Science. WW Norton & Company. pp.106–134. ISBN978-0-393-31980-4.
↑ Sharpe WD (January 1964). "Isidore of Seville: The Medical Writings, An English Translation with an Introduction and Commentary". Transactions of the American Philosophical Society. 54 (2): 1–75. doi:10.2307/1005938. JSTOR1005938.
↑ McKitterick R (2005). "The Carolingian Renaissance of Culture and Learning". In Story J (ed.). Charlemagne: Empire and Society. Manchester: Manchester University Press. ISBN978-0-7190-7089-1.
↑ Wallis F (2010). Medieval Medicine: A Reader. Toronto: University of Toronto Press. p.361. ISBN978-1-4426-0423-0.
↑ Vecchio I, Di Mauro S, Tornali C, Rampello L, Migliore M, Rampello L, Rigo GS, Castellino P (January 2012). "Jewish medicine and surgery in sicily before 1492"(PDF). Acta Medica Mediterranea. 28: 77–82. Archived(PDF) from the original on 2022-09-20. Retrieved 2022-09-20.
↑ Siraisi NG (May 2009). M Medieval and Early Renaissance Medicine: An Introduction to Knowledge and Practice. University of Chicago Press. p.21. ISBN978-0-226-76131-2.
↑ Bylebyl JJ (1979). "Chapter 10: The School of Padua: humanistic medicine in the 16th century". Health, Medicine and Mortality in the Sixteenth Century. Cambridge [England]: Cambridge University Press. ISBN978-0-521-22643-1.
1 2 Madigan M, Martinko J, eds. (2006). Brock Biology of Microorganisms (11thed.). Prentice Hall. ISBN978-0131443297.
↑ Lines DA (2012). "Reorganizing the Curriculum: Teaching and Learning in the University of Bologna, c. 1560–1590". History of Universities. 25 (2): 1–59.
↑ Gurunluoglu R, Shafighi M, Gurunluoglu A, Cavdar S (May 2011). "Giulio Cesare Aranzio (Arantius) (1530–89) in the pageant of anatomy and surgery". Journal of Medical Biography. 19 (2): 63–69. doi:10.1258/jmb.2010.010049. PMID21558532. S2CID10833758.
↑ Leonard AE (2006). "Female Religious Orders". In Hsia RP (ed.). A companion to the Reformation world. Oxford: Blackwell. pp.237–254. ISBN978-1-4051-7865-5.
↑ Harkness DE (2008). "A view from the streets: women and medical work in Elizabethan London". Bulletin of the History of Medicine. 82 (1): 52–85. doi:10.1353/bhm.2008.0001. PMID18344585. S2CID5695475.
↑ Dikotter F (2003). "China". In Porter R (ed.). The Cambridge History of Science. Vol.4: 18th-century Science. pp.695–697. ISBN978-0-521-57243-9.
↑ Rahman HS (1996). "Arab Medicine During the Ages". Studies in History of Medicine and Science. m 14 (1–2). New Delhi: IHMMR: 1–39.
↑ Meulenbeld, Gerrit Jan (1999). A history of Indian medical literature. Groningen oriental studies. Vol.IIA. Groningen: E. Forsten (published 1999–2002). pp.115–375. ISBN978-90-6980-124-7.
↑ Kumar D (2003). "India". In Porter R, Ross D (eds.). The Cambridge History of Science. Vol.4: 18th-century Science. Cambridge: Cambridge University Press. pp.680–683. ISBN978-0-521-57243-9.
↑ Broman TH (2003–2020). "The Medical Sciences". The Cambridge History of Science. Vol.4, Eighteenth-Century Science. Cambridge. pp.465–468. ISBN978-0-521-57243-9.{{cite book}}: CS1 maint: location missing publisher (link)
↑ Rosner L (1991). Medical Education in the Age of Improvement: Edinburgh Students and Apprentices 1760-1826. Edinburgh: Edinburgh University Press. ISBN978-0-7486-0245-2.
↑ Altman I (2003). The Early History of Greater Mexico. Upper Saddle River, N.J.: Prentice Hall. p.99. ISBN978-0-13-091543-6.
↑ Cook SF (1946). "The Incidence of Disease Among the Aztecs and Related Tribes". Hispanic American Historical Review. 36: 32–35.
↑ Cook ND (1998). Born to Die: Disease and New World Conquest, 1492–1650. Cambridge: Cambridge University Press. ISBN978-0-521-62730-6.
↑ Schendel G, Amézquita JA, Bustamante ME (2014). Medicine in Mexico: From Aztec Herbs to Betatrons. University of Texas Press. p.99. ISBN978-1-4773-0636-9.
↑ Lanning JT (1985). The Royal Protomedicato: The Regulation of the Medical Professions in the Spanish Empire. Durham: Duke University Press. ISBN978-0-8223-0651-1.
↑ Burke ME (1977). The Royal College of San Carlos: surgery and Spanish medical reform in the late eighteenth century. Durham, N.C.: Duke University Press. ISBN978-0-8223-0382-4.
↑ Cooper DB (1965). Epidemic Disease in Mexico City, 1761–1813: An Administrative, Social, and Medical Study (LLILAS Latin American Monograph Series). Austin: University of Texas Press. ISBN978-1-4773-0575-1.
↑ Voekel P (2002). "Chapter 7: The Rise of Medical Empiricism". Alone Before God: The Religious Origins of Modernity in Mexico. Durham: Duke University Press. ISBN978-0-8223-8429-8.
1 2 Frank AG (1998). ReOrient: global economy in the Asian Age. Berkeley: University of California Press. pp.96–100. ISBN978-0-520-92131-3. OCLC42922426.
↑ Donahue MP (2011). Nursing, The Finest Art: An Illustrated History (3rded.). Maryland Heights, Mo.: Mosby Elsevier. pp.112–125. ISBN978-0-323-05305-1.
↑ Magnello ME (2012). "Victorian statistical graphics and the iconography of Florence Nightingale's polar area graph". BSHM Bulletin. 27 (1): 13–37. doi:10.1080/17498430.2012.618102. S2CID121655727.
↑ Gunn SW, Masellis M (2008). Concepts and Practice of Humanitarian Medicine. New York: Springer Science & Business Media. pp.87–. ISBN978-0-387-72264-1.
↑ Cassedy JH (1992). "Numbering the North's medical events: humanitarianism and science in Civil War statistics". Bulletin of the History of Medicine. 66 (2): 210–233. PMID1290489.
↑ Porter R (1999). The Greatest Benefit to Mankind: A Medical History of Humanity from Antiquity to the Present. London: Fontana. p.493. ISBN978-0-393-31980-4.; Porter R (1992). "Madness and its Institutions". In Wear A (ed.). Medicine in Society: Historical Essays. Cambridge: Cambridge University Press. pp.277–302. ISBN978-0-521-33639-0.; Suzuki A (December 1991). "Lunacy in seventeenth- and eighteenth-century England: analysis of Quarter Sessions records. Part I". History of Psychiatry. 2 (8): 437–456. doi:10.1177/0957154X9100200807. PMID11612606. S2CID2250614.; Suzuki A (March 1992). "Lunacy in seventeenth- and eighteenth-century England: analysis of Quarter Sessions records. Part II". History of Psychiatry. 3 (9): 29–44. doi:10.1177/0957154X9200300903. PMID11612665. S2CID28734153.
↑ Porter R (2004). Madmen: a social history of madhouses, mad-doctors & lunatics. Tempus. pp.57–76, 239–44, 257–312. ISBN978-0752437309.; Hayward R (2011). "Medicine and the Mind". In Jackson M (ed.). The Oxford Handbook of the History of Medicine. Oxford University Press. pp.524–42. ISBN978-0-19-954649-7.
↑ Weiner DB (1994). " 'La geste du Pinel': The History of a Psychiatric Myth". In Micale MS, Porter R (eds.). Discovering the History of Psychiatry. New York & Oxford: Oxford University Press. pp.232–47. ISBN978-0-19-507739-1.
↑ Marx OM (1994). "The Beginning of Psychiatric Historiography in Nineteenth-Century Germany". In Micale MS, Porter R (eds.). Discovering the History of Psychiatry. New York & Oxford: Oxford University Press. pp.39–51. ISBN978-0195077391.
1 2 Hayward R (2011). "Medicine and the Mind". In Jackson M (ed.). The Oxford Handbook of the History of Medicine. Oxford University Press. pp.524–42. ISBN978-0-19-954649-7.
↑ Andrews J (2004). "The Rise of the Asylum in Britain". In Brunton D (ed.). Medicine Transformed: Health, Disease and Society in Europe 1800–1930. Manchester University Press. pp.298–330. ISBN978-0-7190-6735-8.; Porter R (2003). "Introduction". In Porter R, Wright D (eds.). The Confinement of the Insane: International Perspectives, 1800–1965. Cambridge University Press. pp.1–19. ISBN978-1-139-43962-6.
↑ Pick D (1993). Faces of Degeneration: A European Disorder, c. 1848–1918. Cambridge University Press. ISBN978-0-521-45753-8.[pageneeded]
↑ Ray LJ (1981). "Models of madness in Victorian asylum practice". European Journal of Sociology. 22 (2): 229–264. doi:10.1017/S0003975600003714. PMID11630885. S2CID33924282.; Cox C (2012). Negotiating Insanity in the Southeast of Ireland, 1820–1900. Manchester University Press. pp.54–55. ISBN978-0719075032.; Malcolm E (2003). "'Ireland's Crowded Madhouses': The Institutional Confinement of the Insane in Nineteenth- and Twentieth-Century Ireland". In Porter R, Wright D (eds.). The Confinement of the Insane: International Perspectives, 1800–1965. Cambridge University Press. pp.315–33. ISBN978-1-139-43962-6.
↑ Alexander C (2010). "The Shock of War". Smithsonian. 41 (5): 58–66.
↑ Berrios G, Porter R (1995). The History of Clinical Psychiatry:: The Origin and History of Psychiatric Disorders. London: Athlone Press. ISBN978-0-485-24211-9.
↑ Markell Morantz R (1982). "Feminism, Professionalism and Germs: The Thought of Mary Putnam Jacobi and Elizabeth Blackwell". American Quarterly. 34 (5): 461–78. doi:10.2307/2712640. JSTOR2712640.
↑ Eisler R (2007). The Real Wealth of Nations: Creating a Caring Economics. p.78.
↑ James ET, James GW, Boyer PS, eds. (1971). "Fulton". Notable American Women, 1607–1950: A Biographical Dictionary. Vol.2. Harvard University Press. pp.685–86. ISBN978-0674627345.
↑ van der Weiden RM, Uhlenbeck GC (May 2010). "European 18th-century obstetrical pioneers in Japan: a new light in the empire of the sun". Journal of Medical Biography. 18 (2): 99–101. doi:10.1258/jmb.2010.010006. PMID20519709. S2CID22701750.
↑ Ciriacono S (2010). "Scientific Transfer between Europe and Japan: The Influence of Dutch and German Medicine from the Edo Period to the Meiji Restoration". Comparativ: Leipziger Beiträge zur Universalgeschichte und Vergleichenden Gesellschaftsforschung. 20 (6): 134–53.
↑ Jannetta AB (2007). The Vaccinators: Smallpox, Medical Knowledge, and the 'Opening' of Japan. Stanford, California: Stanford University Press. ISBN978-0-8047-7949-4.
↑ Liu MS (2009). Prescribing colonization: the role of medical practices and policies in Japan-ruled Taiwan, 1895–1945. Ann Arbor, Michigan: Association for Asian Studies. p.286. ISBN978-0-924304-57-6.
↑ Fissell ME (1991). "The Disappearance of the Patient's Narrative and the Invention of Hospital Medicine". In French R, Wear A (eds.). British Medicine in an Age of Reform. Routledge. ISBN978-1-134-93531-4.
↑ Risse GB (1999). Mending bodies, saving souls: a history of hospitals. New York: Oxford University Press. ISBN978-0-19-974869-3.
↑ Reynolds MD (1994). How Pasteur Changed History: The Story of Louis Pasteur and the Pasteur Institute. Bradenton, Florida: McGuinn & McGuire. ISBN978-1-881117-05-6.
1 2 Weindling P (1992). "Scientific elites and laboratory organization in fin de siècle Paris and Berlin: The Pasteur Institute and Robert Koch's Institute for Infectious Diseases compared". In Cunningham A, Williams P (eds.). he Laboratory revolution in medicine. Cambridge: Cambridge University Press. pp.170–188. ISBN978-0-521-40484-6.
↑ Lesky E (1976). The Vienna Medical School of the 19th century. Baltimore: Johns Hopkins University Press. ISBN978-0-8018-1908-7.
↑ Adams GW, Wise CT (1999). "Doctors in Blue: The Medical History of the Union Army in the Civil War". Nursing History Review. 7 (1): 191–193. doi:10.1891/1062-8061.7.1.191. S2CID154115154.
↑ Schroeder-Lein GR (2008). The encyclopedia of Civil War medicine. Armonk, N.Y.: M.E. Sharpe, Inc. ISBN978-1-317-45710-7.
↑ Cunningham HH (November 2015). Doctors in Gray: The Confederate Medical Service. San Francisco: Golden Springs Publishing. ISBN978-1-78625-121-3.
↑ Gates A (February 1957). "Lincoln's Fifth Wheel: The Political History of the US Sanitary Commission". Civil War History. 3 (1): 97–98. doi:10.1353/cwh.1957.0048. S2CID143955518.
↑ Martin J (May 2011). "Heros Along with the Rest: Civil War Service, 1861–1863". Genius of place: the life of Frederick Law Olmsted. Da Capo Press. pp.178–230. ISBN978-0-306-82148-6.
↑ Levine P, Stetson RE (8 July 1939). "An unusual case of intra-group agglutination". Journal of the American Medical Association. 113 (2): 126. doi:10.1001/jama.1939.72800270002007a.
↑ Webb Jr LA (2009). Humanity's Burden: A Global History of Malaria. Cambridge: Cambridge University Press. ISBN978-0-521-67012-8.
↑ Packard RM (2021). The Making of a Tropical Disease: A Short History of Malaria. Johns Hopkins Biographies of Disease (Seconded.). Baltimore. ISBN978-1-4214-4179-5.{{cite book}}: CS1 maint: location missing publisher (link)
↑ Slater LB (2009). War and Disease: Biomedical Research on Malaria in the Twentieth Century. Critical Issues in Health and Medicine. New Brunswick, N.J.: Rutgers University Press. ISBN978-0-8135-4438-0.
↑ Webb JL (July 2011). "The first large-scale use of synthetic insecticide for malaria control in tropical Africa: lessons from Liberia, 1945–1962". Journal of the History of Medicine and Allied Sciences. 66 (3): 347–76. doi:10.1093/jhmas/jrq046. PMID20624820. ProjectMUSE445524.
↑ Van Hartesveldt FR (2010). "The Doctors and the 'Flu': The British Medical Profession's Response to the Influenza Pandemic of 1918–19". International Social Science Review. 85 (1): 28–39. JSTOR41887429.
↑ Irwin JF (2012). "Sauvons les Bébés: child health and U.S. humanitarian aid in the First World War era". Bulletin of the History of Medicine. 86 (1): 37–65. doi:10.1353/bhm.2012.0011. PMID22643983. S2CID10431895.
↑ Harrison M (2004). Medicine and Victory: British Military Medicine in the Second World War. Oxford: Oxford University Press. p.275. ISBN978-0-19-151496-8.
↑ Harrison M (2010). The medical war: British military medicine in the First World War. Oxford: Oxford University Press. ISBN978-0-19-957582-4.
↑ Nie JB, Guo N, Selden M, Kleinman A (2010). Japan's Wartime Medical Atrocities: Comparative Inquiries in Science, History, and Ethics. London: Routledge. ISBN978-1-136-95260-9.
↑ Soulsby L (August 2007). "Antimicrobials and animal health: a fascinating nexus". The Journal of Antimicrobial Chemotherapy. 60 (suppl_1): i77–i78. doi:10.1093/jac/dkm164. PMID17656389.
↑ Deutsch MB (October 2018). "Pre-Exposure Prophylaxis in Trans Populations: Providing Gender-Affirming Prevention for Trans People at High Risk of Acquiring HIV". LGBT Health. 5 (7): 387–390. doi:10.1089/lgbt.2018.0086. PMID30272493. S2CID52891606.
Bowers BS, ed. (2007). The Medieval Hospital and Medical Practice. Ashgate. p.258. ISBN978-0-7546-5110-9.
Breslaw EG (2014). Lotions, Potions, Pills, and Magic: Health Care in Early America. NYU Press. ISBN978-1479807048.
Brockliss LW, Jone C (1997). The Medical World of Early Modern France. Oxford: Clarendon Press. ISBN978-0-19-822750-2.
Burnham JC, ed. (2015). Health Care in America: A History. Baltimore: JHU Press. ISBN978-1-4214-1609-0.
Bynum WF, Porter R, eds. (1993). Companion Encyclopedia of the History of Medicine. London: Routledge. ISBN978-1-136-11036-8.
Bynum WF, Hardy A, Jacyna S, Lawrence C, Tansey EM (2006). The Western Medical Tradition. New York, NY: Cambridge University Press. ISBN978-0-521-47565-5.
Conrad LI, Neve M, Nutton V, Porter R, Wear A (1995). The Western Medical Tradition: 800 BC to AD 1800. Cambridge, Eng.: Cambridge University Press. ISBN978-0-521-47564-8.
Cooter R, Pickstone JV, eds. (2003). Companion to Medicine in the 20th Century. Taylor & Francis. ISBN978-0-415-28603-9.
Donahue, M. Patricia (2011). Nursing, the Finest Art: An Illustrated History. Mosby Elsevier. ISBN978-0-323-05305-1.
Jackson M, ed. (2011). The Oxford Handbook of the History of Medicine. Oxford University Press. ISBN978-0-19-954649-7.
Kessel G (2019). "Syriac Medicine". The Syriac World. London: Routledge. pp.438–59. ISBN978-1-138-89901-8.
Loudon I, ed. (1997). Western Medicine: An Illustrated History. Oxford: Oxford University Press. ISBN978-0-19-924813-1.
McGrew RE, McGrew MP (1985). Encyclopedia of Medical History. New York: McGraw-Hill. ISBN978-0-07-045087-5.
Porter R (1997). The Greatest Benefit to Mankind: A Medical History of Humanity from Antiquity to the Present. Harper Collins. ISBN978-0-393-31980-4.
Nutton V (2012). Ancient Medicine (2nded.). London: Routledge. ISBN978-0-415-52094-2.
Porter R (1996). The Cambridge Illustrated History of Medicine. Cambridge: Cambridge University Press. ISBN978-0-521-00252-3.
Porter R (2006). The Cambridge History of Medicine. Cambridge: Cambridge University Press. ISBN978-0-521-86426-8.
Porter R (2004). Blood and Guts: A Short History of Medicine. WW Norton & Company. ISBN978-0-393-32569-0.
Rosenberg CE, ed. (1992). Framing Disease: Studies in Cultural History. Rutgers University Press. ISBN978-0813517575.
Rousseau GS, Gill M, Haycock D, Herwig M, eds. (2003). Framing and Imagining Disease in Cultural History. Basingstoke: Palgrave Macmillan. ISBN978-1-4039-1292-3.
Singer CJ, Underwood AE (2006). A Short History of Medicine (Rev.ed.). Cambridge: Cambridge University Press. ISBN978-0-521-86426-8.
Siraisi NG (September 2012). "Medicine, 1450-1620, and the history of science". Isis; an International Review Devoted to the History of Science and Its Cultural Influences. 103 (3): 491–514. doi:10.1086/667970. PMID23286188. S2CID6954963.
Siraisi NG (1990). Medieval and Early Renaissance Medicine: An Introduction to Knowledge and Practice. Chicago: University of Chicago Press. ISBN978-0-226-76130-5.
Watts SJ (2003). Disease and Medicine in World History. Themes in World History. New York: Routledge. ISBN978-0-415-27817-1.
Wear A, ed. (1992). Medicine in Society: Historical Essays. Cambridge University Press. ISBN978-0-521-33639-0.
Weatherall M (1990). In Search of a Cure: A History of Pharmaceutical Discovery. Oxford: Oxford University Press. ISBN978-0-19-261747-7.
This page is based on this Wikipedia article Text is available under the CC BY-SA 4.0 license; additional terms may apply. Images, videos and audio are available under their respective licenses.
