Influenza A virus subtype H5N1

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Influenza A virus
Colorized transmission electron micrograph of Avian influenza A H5N1 viruses.jpg
Colorized transmission electron micrograph of Avian influenza A H5N1 viruses (seen in gold) grown in MDCK cells (seen in green)
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Insthoviricetes
Order: Articulavirales
Family: Orthomyxoviridae
Genus: Alphainfluenzavirus
Species:
Influenza A virus
Notable strains

Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic (maintained in the population) in many bird populations, and also panzootic (affecting animals of many species over a wide area). [1] A/H5N1 virus can also infect mammals (including humans) that have been exposed to infected birds; in these cases, symptoms are frequently severe or fatal. [2]

Contents

A/H5N1 virus is shed in the saliva, mucus, and feces of infected birds; other infected animals may shed bird flu viruses in respiratory secretions and other body fluids (such as milk). [3] The virus can spread rapidly through poultry flocks and among wild birds. [3] An estimated half a billion farmed birds have been slaughtered in efforts to contain the virus. [2]

Symptoms of A/H5N1 influenza vary according to both the strain of virus underlying the infection and on the species of bird or mammal affected. [4] [5] Classification as either Low Pathogenic Avian Influenza (LPAI) or High Pathogenic Avian Influenza (HPAI) is based on the severity of symptoms in domestic chickens and does not predict the severity of symptoms in other species. [6] Chickens infected with LPAI A/H5N1 virus display mild symptoms or are asymptomatic, whereas HPAI A/H5N1 causes serious breathing difficulties, a significant drop in egg production, and sudden death. [7]

In mammals, including humans, A/H5N1 influenza (whether LPAI or HPAI) is rare. Symptoms of infection vary from mild to severe, including fever, diarrhoea, and cough. [5] Human infections with A/H5N1 virus have been reported in 23 countries since 1997, resulting in severe pneumonia and death in about 50% of cases. [8] Between 2003 and August 2024, the World Health Organization has recorded 907 cases of confirmed H5N1 influenza, leading to 464 deaths. [9] The true fatality rate may be lower because some cases with mild symptoms may not have been identified as H5N1. [10]

A/H5N1 influenza virus was first identified in farmed birds in southern China in 1996. [11] Between 1996 and 2018, A/H5N1 coexisted in bird populations with other subtypes of the virus, but since then, the highly pathogenic subtype HPAI A(H5N1) has become the dominant strain in bird populations worldwide. [12] Some strains of A/H5N1 which are highly pathogenic to chickens have adapted to cause mild symptoms in ducks and geese, [13] [6] and are able to spread rapidly through bird migration. [14] Mammal species that have been recorded with H5N1 infection include cows, seals, goats, and skunks. [15]

Due to the high lethality and virulence of HPAI A(H5N1), its worldwide presence, its increasingly diverse host reservoir, and its significant ongoing mutations, the H5N1 virus is regarded as the world's largest pandemic threat. [16] Domestic poultry may potentially be protected from specific strains of the virus by vaccination. [17] In the event of a serious outbreak of H5N1 flu among humans, health agencies have prepared "candidate" vaccines that may be used to prevent infection and control the outbreak; however, it could take several months to ramp up mass production. [3] [18] [19]

Signs and symptoms

This section is an excerpt from Influenza A virus § Birds.[ edit ]
Some species of wild aquatic birds act as natural asymptomatic carriers of a large variety of influenza A viruses, which they can spread over large distances in their annual migration. [20] Symptoms of avian influenza vary according to both the strain of virus underlying the infection, and on the species of bird affected. Symptoms of influenza in birds may include swollen head, watery eyes, unresponsiveness, lack of coordination, respiratory distress such as sneezing or gurgling. [21]

Humans

Avian flu viruses, both HPAI and LPAI, can infect humans who are in close, unprotected contact with infected poultry. Incidents of cross-species transmission are rare, with symptoms ranging in severity from no symptoms or mild illness, to severe disease that resulted in death. [22] [23] As of February, 2024 there have been very few instances of human-to-human transmission, and each outbreak has been limited to a few people. [24] All subtypes of avian Influenza A have potential to cross the species barrier, with H5N1 and H7N9 considered the biggest threats. [25] [26]

In order to avoid infection, the general public are advised to avoid contact with sick birds or potentially contaminated material such as carcasses or feces. People working with birds, such as conservationists or poultry workers, are advised to wear appropriate personal protection equipment. [27]

The avian influenza hemagglutinin prefers to bind to alpha-2,3 sialic acid receptors, while the human influenza hemagglutinin prefers to bind to alpha-2,6 sialic acid receptors. [28] [29] This means that when the H5N1 strain infects humans, it will replicate in the lower respiratory tract (where alpha-2,3 sialic acid receptors are more plentiful in humans) and consequently cause viral pneumonia. [30] [31]

Between 2003 and August 2024, the World Health Organization has recorded 907 cases of confirmed H5N1 influenza, leading to 464 deaths. [32] The true fatality rate may be lower because some cases with mild symptoms may not have been identified as H5N1. [10]

Virology

Influenza virus nomenclature

Diagram of influenza nomenclature InfluenzaNomenclatureDiagram.svg
Diagram of influenza nomenclature

To unambiguously describe a specific isolate of virus, researchers use the internationally accepted Influenza virus nomenclature, [33] which describes, among other things, the species of animal from which the virus was isolated, and the place and year of collection. For example, A/chicken/Nakorn-Patom/Thailand/CU-K2/04(H5N1):

Other examples include: A/duck/Hong Kong/308/78(H5N3), and A/shoveler/Egypt/03(H5N2). [34]

Genetic structure

The N in H5N1 stands for "Neuraminidase", the protein depicted in this ribbon diagram. Neuraminidase Ribbon Diagram.jpg
The N in H5N1 stands for "Neuraminidase", the protein depicted in this ribbon diagram.

H5N1 is a subtype of Influenza A virus. Like all subtypes it is an enveloped negative-sense RNA virus, with a segmented genome. [35] Subtypes of IAV are defined by the combination of the antigenic hemagglutinin and neuraminidase proteins in the viral envelope. "H5N1" designates an IAV subtype that has a type 5 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. [36] Further variations exist within the subtypes and can lead to very significant differences in the virus's ability to infect and cause disease, as well as to the severity of symptoms. [37] [38]

Influenza viruses have a relatively high mutation rate that is characteristic of RNA viruses. [39] The segmentation of its genome facilitates genetic recombination by segment reassortment in hosts infected with two different strains of influenza viruses at the same time. [40] [41] Through a combination of mutation and genetic reassortment the virus can evolve to acquire new characteristics, enabling it to evade host immunity and occasionally to jump from one species of host to another. [42] [43]

Prevention and treatment

Vaccine

Humans - Several "candidate" (unproved) vaccines are available in case an avian virus acquires the ability to infect and transmit among humans; as of July 2024 these include Aflunov, Celldemic and Seqirus/Audenz. [44] [45] Some governments have prepared strategic stockpiles of vaccines against the H5N1 subtype which is considered the biggest risk. [46] [47] [45] However, because the influenza virus is highly variable any vaccine needs to be specifically targeted against the particular strain of virus which is causing concern. Existing influenza vaccine technologies can be adapted to a H5N1 strain causing the pandemic; in the event of an outbreak, the candidate vaccine would be rapidly tested for safety as well as efficacy against the zoonotic strain, and then authorised and distributed to vaccine manufacturers. [48] [44]

Poultry - it is possible to vaccinate poultry against specific strains of HPAI influenza. Vaccination should be combined with other control measures such as infection monitoring, early detection and biosecurity. [49] [50] In many countries, it is routine to vaccinate poultry against H5N1. [51] In China, the world's biggest poultry producer, there has been is a mandatory vaccination requirement since 2017; the vaccine is bivalent or trivalent, targeting the H5 and H7 subtypes of influenza A virus. It is manufactured using recombinant influenza virus. [52]

Treatment

In the event of an outbreak of human H5N1, the main antiviral drugs recommended are neuraminidase inhibitors, such as zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs can reduce the severity of symptoms if taken soon after infection and can also be taken as prophylaxis to decrease the risk of infection. [53] [54] [55] [56]

Epidemiology

History

Influenza A/H5N1 was first detected in 1959 after an outbreak of highly pathogenic avian influenza in Scotland, which infected two flocks of chickens. [57] [58] The next detection, and the earliest infection of humans by H5N1, was an epizootic (an epidemic in nonhumans) of H5N1 influenza in Hong Kong's poultry population in 1997. This outbreak was stopped by the killing of the entire domestic poultry population within the territory. Human infection was confirmed in 18 individuals who had been in close contact with poultry, 6 of whom died. [59] [60]

Since then, avian A/H5N1 bird flu has become widespread in wild birds worldwide, with numerous outbreaks among both domestic and wild birds. An estimated half a billion farmed birds have been slaughtered in efforts to contain the virus. [61] [62]

Pandemic potential

Influenza viruses have a relatively high mutation rate that is characteristic of RNA viruses. [63] The segmentation of the influenza A virus genome facilitates genetic recombination by segment reassortment in hosts who become infected with two different strains of influenza viruses at the same time. [64] [65] With reassortment between strains, an avian strain which does not affect humans may acquire characteristics from a different strain which enable it to infect and pass between humans - a zoonotic event. [66]

As of June 2024, there is concern about two subtypes of avian influenza which are circulating in wild bird populations worldwide, A/H5N1 and A/H7N9. Both of these have potential to devastate poultry stocks, and both have jumped to humans with relatively high case fatality rates. [67] A/H5N1 in particular has infected a wide range of mammals and may be adapting to mammalian hosts. [68]

Surveillance

The Global Influenza Surveillance and Response System (GISRS) is a global network of laboratories that monitor the spread of influenza with the aim to provide the World Health Organization with influenza control information and to inform vaccine development. [69] Several millions of specimens are tested by the GISRS network annually through a network of laboratories in 127 countries. GISRS monitors avian, swine, and other potentially zoonotic influenza viruses as well as human viruses. [70]

Transmission and prevention

The eight major flyways used by shorebirds (waders) on migration .mw-parser-output .legend{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .legend-color{display:inline-block;min-width:1.25em;height:1.25em;line-height:1.25;margin:1px 0;text-align:center;border:1px solid black;background-color:transparent;color:black}.mw-parser-output .legend-text{} Pacific Mississippi West Atlantic East Atlantic Mediterranean and Black Sea West Asia and Africa Central Asia and India East Asia and Australasia Main international flyways - bird migration-fr.svg
The eight major flyways used by shorebirds (waders) on migration
  Pacific
  Mississippi
  West Atlantic
  East Atlantic
  Mediterranean and Black Sea
  West Asia and Africa
  Central Asia and India
  East Asia and Australasia

Birds - Influenza A viruses of various subtypes have a large reservoir in wild waterfowl, which can infect the respiratory and gastrointestinal tract without affecting the health of the host. They can then be carried by the bird over large distances especially during annual migration. Infected birds can shed avian influenza A viruses in their saliva, nasal secretions, and feces; susceptible birds become infected when they have contact with the virus as it is shed by infected birds. [72] The virus can survive for long periods in water and at low temperatures, and can be spread from one farm to another on farm equipment. [73] Domesticated birds (chickens, turkeys, ducks, etc.) may become infected with avian influenza A viruses through direct contact with infected waterfowl or other infected poultry, or through contact with contaminated feces or surfaces.

Avian influenza outbreaks in domesticated birds are of concern for several reasons. There is potential for low pathogenic avian influenza viruses (LPAI) to evolve into strains which are high pathogenic to poultry (HPAI), and subsequent potential for significant illness and death among poultry during outbreaks. Because of this, international regulations state that any detection of H5 or H7 subtypes (regardless of their pathogenicity) must be notified to the appropriate authority. [74] [75] It is also possible that avian influenza viruses could be transmitted to humans and other animals which have been exposed to infected birds, causing infection with unpredictable but sometimes fatal consequences.

When an HPAI infection is detected in poultry, it is normal to cull infected animals and those nearby in an effort to rapidly contain, control and eradicate the disease. This is done together with movement restrictions, improved hygiene and biosecurity, and enhanced surveillance. [73]

Humans - Avian flu viruses, both HPAI and LPAI, can infect humans who are in close, unprotected contact with infected poultry. Incidents of cross-species transmission are rare, with symptoms ranging in severity from no symptoms or mild illness, to severe disease that resulted in death. [76] [75] As of February, 2024 there have been very few instances of human-to-human transmission, and each outbreak has been limited to a few people. [77] All subtypes of avian Influenza A have potential to cross the species barrier, with H5N1 and H7N9 considered the biggest threats. [78] [79]

In order to avoid infection, the general public are advised to avoid contact with sick birds or potentially contaminated material such as carcasses or feces. People working with birds, such as conservationists or poultry workers, are advised to wear appropriate personal protection equipment. [80]

Other animals - a wide range of other animals have been affected by avian flu, generally due to eating birds which had been infected. [81] There have been instances where transmission of the disease between mammals, including seals and cows, may have occurred. [82] [83]

Mortality

Confirmed human cases and mortality rate of avian influenza (H5N1) 2003–2024
Country
Flag of Australia (converted).svg  Australia
Flag of Azerbaijan.svg  Azerbaijan
Flag of Bangladesh.svg  Bangladesh
Flag of Cambodia.svg  Cambodia
Flag of Canada (Pantone).svg  Canada
Flag of Chile.svg  Chile
Flag of the People's Republic of China.svg  China
Flag of Djibouti.svg  Djibouti
Flag of Ecuador.svg  Ecuador
Flag of Egypt.svg  Egypt
Flag of India.svg  India
Flag of Indonesia.svg  Indonesia
Flag of Iraq.svg  Iraq
Flag of Laos.svg  Laos
Flag of Myanmar.svg  Myanmar
Flag of Nepal.svg  Nepal
Flag of Nigeria.svg  Nigeria
Flag of Pakistan.svg  Pakistan
Flag of Spain.svg  Spain
Flag of Thailand.svg  Thailand
Flag of Turkey.svg  Turkey
Flag of the United Kingdom.svg  United Kingdom
Flag of the United States.svg  United States
Flag of Vietnam.svg  Vietnam
Total
2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024Total
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
cases
deaths
CFR
100%100%
8562.5%8562.5%
100%200%300%11100%100%8112.5%
44100%22100%11100%100%100%11100%88100%33100%261453.8%9444.4%6466.7%10220.0%724359.7%
11100%11100%
100%100%
11100%8562.5%13861.5%5360.0%44100%7457.1%2150.0%11100%2150.0%22100%200%6116.7%11100%100%553258.2%
100%100%
100%100%
181055.6%25936.0%8450.0%39410.3%291344.8%391538.5%11545.5%4375.0%371437.8%1363928.7%10330.0%3133.3%35912033.4%
11100%11100%
201365.0%554581.8%423788.1%242083.3%211990.5%9777.8%121083.3%99100%33100%22100%22100%11100%20016884.0%
3266.6%3266.6%
22100%100%3266.7%
100%100%
11100%11100%
11100%11100%
3133.3%3133.3%
200%200%
171270.6%5240.0%33100%251768.0%
12433.3%12433.3%
100%400%500%
100%1300%1400%
33100%292069.0%611931.1%8562.5%6583.3%55100%7228.6%4250.0%2150.0%22100%100%11100%1296550.0%
44100%463269.6%984343.9%1157968.7%885967.0%443375.0%733243.8%482450.0%623454.8%322062.5%392564.1%522242.3%1454229.0%10330.0%4250.0%000%11100%100%2150.0%6116.7%12433.3%25312.0%90746451.1%
Updated 1 September 2024
Source: World Health Organization Global Influenza Program Cumulative Cases Report · edit this table

Outbreaks

1959–1997

2003

2004

2005

2006

2007

2008 to 2019

Many more outbreaks are recorded, in almost every country in the world, affecting both wild birds and poultry, with occasional spillover events infecting humans. [13] [58] [59]

2020–2024

This section is an excerpt from 2020–2024 H5N1 outbreak.[ edit ]

Since 2020, outbreaks of avian influenza subtype H5N1 have been occurring, with cases reported from every continent as of May 2024. [93] [94] [95] [96] Some species of wild aquatic birds act as natural asymptomatic carriers of a large variety of influenza A viruses, which can infect poultry, other bird species, mammals and humans if they come into close contact with infected feces or contaminated material, or by eating infected birds. [97] In late 2023, H5N1 was discovered in the Antarctic for the first time, raising fears of imminent spread throughout the region, potentially leading to a "catastrophic breeding failure" among animals that had not previously been exposed to avian influenza viruses. [98] The main virus involved in the global outbreak is classified as H5N1 clade 2.3.4.4b, however genetic diversification with other clades such as 2.3.2.1c has seen the virus evolve in ability to cause significant outbreaks in a broader range of species including mammals. [99] [100] [101]

H5N6 and H5N8 viruses with the H5-2.3.4.4b hemagglutinin (HA) gene became prominent globally in 2018–2020. [100] [102] In 2020, reassortment (genetic "swapping") between these H5-2.3.4.4b viruses and other strains of avian influenza led to the emergence of a H5N1 strain with a H5-2.3.4.4b gene. [100] The virus then spread across Europe, detected there in autumn, before spreading to Africa and Asia. [93] It continues to swap genes with local flu viruses as it travels the globe. [103] : (fig.1) 

Mammalian infections

In October 2022 an outbreak of H5N1 on a Spanish mink farm showed evidence of being the first recorded case of mammal-to-mammal transmission, with 4 percent of the farm's mink population dying from H5N1-related haemorrhagic pneumonia. This coincided with H5N1 detections in the area among gulls and other seabirds, which are the presumed source of the outbreak. [104] [105]

A mass Caspian seal die-off in December 2022, with 700 infected seals found dead along the Caspian Sea coastline of Russia's Dagestan republic, worried researchers regarding the possibility that wild mammal-to-mammal spread had begun. [106] A similar mass die-off of 95% of southern elephant seal pups in 2023 also raised concerns of mammal-to-mammal spread, as nursing pups would have had less exposure to birds. [107]

In April 2024, spread of H5N1 amongst dairy cow herds in nine states of the USA strongly indicated the presence of cow-to-cow transmission possibly occurring while the animals were being milked. [108] [109] Although mortality in bovines infected with H5N1 is rare, viable virus can be shed in the milk. [108] Around 50% of cats that lived on the affected dairy farms and were fed unpasteurised milk from symptomatic cows died within a few days from severe systemic influenza infection, raising significant concerns of cross-species mammal-to-mammal transmission. [110]

Research

H5N1 transmission studies in ferrets (2011)

Novel, contagious strains of H5N1 were created by Ron Fouchier of the Erasmus Medical Center in Rotterdam, the Netherlands, who first presented his work to the public at an influenza conference in Malta in September 2011. Three mutations were introduced into the H5N1 virus genome, and the virus was then passed from the noses of infected ferrets to the noses of uninfected ones, which was repeated 10 times. [111] After these 10 passages the H5N1 virus had acquired the ability of transmission between ferrets via aerosols or respiratory droplets.

After Fouchier offered an article describing this work to the leading academic journal Science , the US National Science Advisory Board for Biosecurity (NSABB) recommended against publication of the full details of the study, and the one submitted to Nature by Yoshihiro Kawaoka of the University of Wisconsin describing related work. However, after additional consultations at the World Health Organization and by the NSABB, the NSABB reversed its position and recommended publication of revised versions of the two papers. [112] However, then the Dutch government declared that this type of manuscripts required Fouchier to apply for an export permit in the light of EU directive 428/2009 on dual use goods. [note 1] After much controversy surrounding the publishing of his research, Fouchier complied (under formal protest) with Dutch government demands to obtain a special permit [113] for submitting his manuscript, and his research appeared in a special issue of the journal Science devoted to H5N1. [114] [115] [116] The papers by Fouchier and Kawaoka conclude that it is entirely possible that a natural chain of mutations could lead to an H5N1 virus acquiring the capability of airborne transmission between mammals, and that a H5N1 influenza pandemic would not be impossible. [117]

In May 2013, it was reported that scientists at the Harbin Veterinary Research Institute in Harbin, China, had created H5N1 strains which passed between guinea pigs. [118]

In response to Fouchier and Kawaoka's work, a number of scientists expressed concerns with the risks of creating novel potential pandemic pathogens, culminating in the formation of the Cambridge Working Group, a consensus statement calling for an assessment of the risks and benefits of such research. [119] [120]

See also

Notes

  1. ↑ The World Intellectual Property Organization (WIPO) lists strategic goods with prohibited goods or goods that require a special permit for import and export without which the carrier faces pecuniary punishment or up to 5 years' imprisonment.

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<span class="mw-page-title-main">Avian influenza</span> Influenza caused by viruses adapted to birds

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<span class="mw-page-title-main">Influenza pandemic</span> Pandemic involving influenza

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<span class="mw-page-title-main">Influenza A virus subtype H3N2</span> Virus subtype

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<span class="mw-page-title-main">Global spread of H5N1</span> Spread of bird flu

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<span class="mw-page-title-main">Transmission and infection of H5N1</span> Spread of an influenza virus

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<span class="mw-page-title-main">Influenza A virus subtype H5N2</span> Virus subtype

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<span class="mw-page-title-main">Influenza A virus subtype H7N2</span> Virus subtype

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<span class="mw-page-title-main">Global spread of H5N1 in 2006</span> 2006 worldwide disease outbreak

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<span class="mw-page-title-main">Global spread of H5N1 in 2005</span> Pandemic threat

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<span class="mw-page-title-main">Global spread of H5N1 in 2004</span>

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The Goose Guangdong virus refers to the strain A/Goose/Guangdong/1/96 (Gs/Gd)-like H5N1 HPAI viruses. It is a strain of the Influenzavirus A subtype H5N1 virus that was first detected in a goose in Guangdong in 1996. It is an HPAI virus, meaning that it can kill a very high percentage of chickens in a flock in mere days. It is believed to be the immediate precursor of the current dominant strain of HPAI A(H5N1) that evolved from 1999 to 2002 creating the Z genotype that is spreading globally and is epizootic and panzootic, killing tens of millions of birds and spurring the culling of hundreds of millions of others to stem its spread.

<span class="mw-page-title-main">Human mortality from H5N1</span>

H5N1 influenza virus is a type of influenza A virus which mostly infects birds. H5N1 flu is a concern due to the its global spread that may constitute a pandemic threat. The yardstick for human mortality from H5N1 is the case-fatality rate (CFR); the ratio of the number of confirmed human deaths resulting from infection of H5N1 to the number of those confirmed cases of infection with the virus. For example, if there are 100 confirmed cases of a disease and 50 die as a consequence, then the CFR is 50%. The case fatality rate does not take into account cases of a disease which are unconfirmed or undiagnosed, perhaps because symptoms were mild and unremarkable or because of a lack of diagnostic facilities. The Infection Fatality Rate (IFR) is adjusted to allow for undiagnosed cases.

<span class="mw-page-title-main">Influenza</span> Infectious disease

Influenza, commonly known as "the flu" or just "flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease.

<span class="mw-page-title-main">Influenza A virus subtype H7N9</span> Subtype of the influenza A virus

Influenza A virus subtype H7N9 (A/H7N9) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic in many bird populations. The virus can spread rapidly through poultry flocks and among wild birds; it can also infect humans that have been exposed to infected birds.

Since 2020, outbreaks of avian influenza subtype H5N1 have been occurring, with cases reported from every continent as of May 2024. Some species of wild aquatic birds act as natural asymptomatic carriers of a large variety of influenza A viruses, which can infect poultry, other bird species, mammals and humans if they come into close contact with infected feces or contaminated material, or by eating infected birds. In late 2023, H5N1 was discovered in the Antarctic for the first time, raising fears of imminent spread throughout the region, potentially leading to a "catastrophic breeding failure" among animals that had not previously been exposed to avian influenza viruses. The main virus involved in the global outbreak is classified as H5N1 clade 2.3.4.4b, however genetic diversification with other clades such as 2.3.2.1c has seen the virus evolve in ability to cause significant outbreaks in a broader range of species including mammals.

References

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Sources

  • Analysis of the efficacy of an adjuvant-based inactivated pandemic H5N1 influenza virus vaccine. https://link.springer.com/article/10.1007%2Fs00705-019-04147-7 Ainur NurpeisovaEmail authorMarkhabat KassenovNurkuisa RametovKaissar TabynovGourapura J. RenukaradhyaYevgeniy VolginAltynay SagymbayAmanzhol MakbuzAbylay SansyzbayBerik Khairullin

Research Institute for Biological Safety Problems (RIBSP), Zhambyl Region, Republic of Kazakhstan

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