| Influenza A virus subtype H5N3 | |
|---|---|
Virus classification  | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Insthoviricetes |
| Order: | Articulavirales |
| Family: | Orthomyxoviridae |
| Genus: | Alphainfluenzavirus |
| Species: | |
| Serotype: | Influenza A virus subtype H5N3 |
| Influenza (flu) |
|---|
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H5N3 is a subtype of the species Influenza A virus (sometimes called the bird flu virus).
H5N3 was identified in Quebec in August 2005 [1] and in Sweden in October 2005. [2]
H5N3 virus was identified at a farm in La Garnache, France in late January 2009. Ninety birds were found dead between 29 January 2009 and 31 January 2009. The remaining stock of 4,932 birds was culled on 1 February 2009. [3]
In Germany, in December 2013, 102 ostriches and 28 chickens in a farm in Blumberg were slaughtered due to suspicion of infection with avian influenza. Samples showed that the birds were infected with the H5N3 virus. [4]
Influenza A virus (IAV) is the only species of the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. It is a pathogen with strains that infect birds and some mammals, as well as causing seasonal flu in humans. Mammals in which different strains of IAV circulate with sustained transmission are bats, pigs, horses and dogs; other mammals can occasionally become infected.
Avian influenza, also known as avian flu or bird flu, is a disease caused by the influenza A virus, which primarily affects birds but can sometimes affect mammals including humans. Wild aquatic birds are the primary host of the influenza A virus, which is enzootic in many bird populations.
Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic in many bird populations, and also panzootic. A/H5N1 virus can also infect mammals that have been exposed to infected birds; in these cases, symptoms are frequently severe or fatal.
An influenza pandemic is an epidemic of an influenza virus that spreads across a large region and infects a large proportion of the population. There have been six major influenza epidemics in the last 140 years, with the 1918 flu pandemic being the most severe; this is estimated to have been responsible for the deaths of 50–100 million people. The 2009 swine flu pandemic resulted in under 300,000 deaths and is considered relatively mild. These pandemics occur irregularly.
Influenza A virus subtype H3N2 (A/H3N2) is a subtype of influenza A virus (IAV). Some human-adapted strains of A/H3N2 are endemic in humans and are one cause of seasonal influenza (flu). Other strains of H1N1 are endemic in pigs and in birds. Subtypes of IAV are defined by the combination of the antigenic H and N proteins in the viral envelope; for example, "H1N1" designates an IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein.
The global spread of H5N1 influenza in birds is considered a significant pandemic threat. While other H5N1 influenza strains are known, they are significantly different on a genetic level from a highly pathogenic, emergent strain of H5N1, which was able to achieve hitherto unprecedented global spread in 2008. The H5N1 strain is a fast-mutating, highly pathogenic avian influenza virus (HPAI) found in multiple bird species. It is both epizootic and panzootic. Unless otherwise indicated, "H5N1" in this timeline refers to the 2008 highly pathogenic strain of H5N1.
Transmission and infection of H5N1 from infected avian sources to humans has been a concern since the first documented case of human infection in 1997, due to the global spread of H5N1 that constitutes a pandemic threat.
H5 N2 is a subtype of the species Influenzavirus A. The subtype infects a wide variety of birds, including chickens, ducks, turkeys, falcons, and ostriches. Affected birds usually do not appear ill, and the disease is often mild as avian influenza viral subtypes go. Some variants of the subtype are much more pathogenic than others, and outbreaks of "high-path" H5N2 result in the culling of thousands of birds in poultry farms from time to time. It appears that people who work with birds can be infected by the virus, but suffer hardly any noticeable health effects. Even people exposed to the highly pathogenic H5N2 variety that killed ostrich chicks in South Africa only seem to have developed conjunctivitis, or a perhaps a mild respiratory illness. There is no evidence of human-to-human spread of H5N2. On November 12, 2005 it was reported that a falcon was found to have H5N2. On June 5, 2024, the first confirmed human case of H5N2 was reported in Mexico.
Influenza A virus subtype H7N7 (A/H7N7) is a subtype of Influenza A virus, a genus of Orthomyxovirus, the viruses responsible for influenza. Highly pathogenic strains (HPAI) and low pathogenic strains (LPAI) exist. H7N7 can infect humans, birds, pigs, seals, and horses in the wild; and has infected mice in laboratory studies. This unusual zoonotic potential represents a pandemic threat.
Influenza A virus subtype H7N2 (A/H7N2) is a subtype of the species Influenza A virus. This subtype is one of several sometimes called bird flu virus. H7N2 is considered a low pathogenicity avian influenza (LPAI) virus. With this in mind, H5 & H7 influenza viruses can re-assort into the Highly Pathogenic variant if conditions are favorable.
H5N8 is a subtype of the influenza A virus and is highly lethal to wild birds and poultry. H5N8 is typically not associated with humans. However, seven people in Russia were found to be infected in 2021, becoming the first documented human cases.
The genetic structure of H5N1, a highly pathogenic avian influenza virus, is characterized by a segmented RNA genome consisting of eight gene segments that encode for various viral proteins essential for replication, host adaptation, and immune evasion.
The global spread of H5N1 in birds is considered a significant pandemic threat.
The global spread of H5N1 in birds is considered a significant pandemic threat.
The global spread of H5N1 in birds is considered a significant pandemic threat.
Influenza, commonly known as "the flu" or just "flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease.
A H5N1 vaccine is an influenza vaccine intended to provide immunization to influenza A virus subtype H5N1.
Influenza A virus subtype H7N9 (A/H7N9) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic in many bird populations. The virus can spread rapidly through poultry flocks and among wild birds; it can also infect humans that have been exposed to infected birds.
H5N6 is a subtype of the species Influenza A virus. Infected birds shed the virus in their saliva, mucous, and feces. The virus was first detected in poultry in 2013, since then spreading among wild bird populations and poultry around the world. Humans can be infected through unprotected contact with infected birds or contaminated surfaces. The virus transmits by getting into a person's eyes, nose, mouth, and through inhalation. Human infections are rare. Since 2014, at least 87 cases have occurred in humans. 29 people have died. A spike in human cases was reported in 2021. There have been no confirmed cases of human-to-human transmission. Some infections have been identified where no direct contact with infected birds or contaminated surfaces has been known to had occurred. Only one infected woman has said that she never came into any contact with poultry.
In the early 2020s, an ongoing outbreak of avian influenza subtype H5N8 has been occurring at poultry farms and among wild bird populations in several countries and continents, leading to the subsequent cullings of millions of birds to prevent a pandemic similar to that of the H5N1 outbreak in 2008. The first case of human transmission of avian flu, also known as bird flu, was reported by Russian authorities in February 2021, as several poultry farm workers tested positive for the virus.
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