Influenza A virus subtype H5N8

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Influenza A virus subtype H5N8
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Insthoviricetes
Order: Articulavirales
Family: Orthomyxoviridae
Genus: Alphainfluenzavirus
Species:
Influenza A virus
Serotype:
Influenza A virus subtype H5N8

H5N8 is a subtype of the influenza A virus (sometimes called bird flu) and is highly lethal to wild birds and poultry. [1] H5N8 is typically not associated with humans. However, seven people in Russia were found to be infected in 2021, becoming the first documented human cases. [2] [3]

Contents

Virus and symptoms

The H5N8 virus manifests itself in various ways, from asymptomatic and sub-clinical to highly lethal in some populations. Many of the findings in wild birds are based on the discovery of dead animals. Its intravenous pathogenicity index (IVPI) is greater than 1.2, giving it a mortality rate of at least 75 percent. [4]

H5N8 has previously been used in place of the highly pathogenic H1N1 in studies. [5]

Outbreaks

1983

Perhaps the most known outbreak of H5N8 occurred in Ireland in 1983. Poultry on two farms showed the usual symptoms, plus diarrhea, nervousness, and depression. Poultry farms within close proximity soon began to show signs of infection, as well, but no contact between the farms could be established. In the end, 8,000 turkeys, 28,020 chickens, and 270,000 ducks were culled. When investigated in the lab, clinical findings demonstrated that turkeys were the most susceptible to infection. The virus could not be clinically reproduced in ducks. [6]

2014

An outbreak of H5N8 was reported in breeding ducks in North Jeolla Province, South Korea, on 18 January 2014. The virus spread in duck and chicken farms and at least 12 million poultry were culled. [7]

2016–17

In the second half of 2016, an H5N8 outbreak was first reported in Europe, spreading to Asia by the end of the year.[ citation needed ]

October 2016

On 27 October 2016, an H5N8 case was first reported in a wild swan in Hungary. Further reports were subsequently made from seven additional European countries. There were outbreaks in poultry and wild birds in Austria, Hungary, and Germany. There were reports of infection in wild birds only in Croatia, Denmark, Poland, and Switzerland.[ citation needed ]

November 2016

In the Netherlands, H5N8 was found in wild birds and birds in a zoo and on 26 November 190,000 ducks were destroyed at six farms. Outbreaks have also been reported in India, Israel, South Korea, Taiwan and Russia. [8]

December 2016

On 16 December 2016, it was confirmed that there was an outbreak of the H5N8 virus at a farm near Tetney, Louth — the first outbreak in the United Kingdom. This outbreak has caused the combined death and culling of 5,000 turkeys. At the time of writing (16 December 2016), a 3 km protection zone and a 10 km surveillance zone were enforced by the Department for Environment, Food and Rural Affairs. [9]

In the second week of December official delegations from Japan, South Korea and China gathered in Beijing for a symposium on preventing and controlling bird flu and other diseases in East Asia, according to the website of China's ministry of agriculture. [10]

By the end of December the outbreak had spread to South Korea, Japan, Germany, and the United Kingdom. Thousands of birds and animals were being culled in Germany to stop the spread. [11] In the United Kingdom the flu was found in a wild duck at a turkey farm in Lincolnshire. [12]

In South Korea, a record total of 18.4 million birds had been killed by December since the first outbreak of avian flu was reported at a farm on Nov. 18. [13]

Japan has reported five outbreaks since the end of November with 800,000 chickens having been culled in one month. [13]

January 2017

In early January 2017, France culled about 800,000 birds to prevent the spread of H5N8. [14] In Nigeria, it was reported that the virus affected 3.5 million birds. [15] The virus was also detected in Spain and Slovenia. [16]

Uganda detected aves flu in two locations, one affecting wild birds and another striking domestic birds. [17] [18]

February 2017

Two cases of the virus were detected in Northern Ireland amongst wild geese. As a response, the Department of Agriculture extended restrictions on poultry flocks until at least 16 March. [19]

June 2017

A case of the virus was detected in Harare, Zimbabwe at one of the major poultry producers, Irvine's Private Limited. The virus saw over 7,000 birds succumbing to the virus. As a result, the company, culled over 140,000 birds to prevent the spread of the virus. [20] Even though a ban on all avian products from Zimbabwe was issued, on 22 June an outbreak [21] [22] was reported at a commercial broiler poultry farm outside Villiers, South Africa after 5,000 chickens died. A few days later, just over 60 km away from the first outbreak, a separate outbreak was reported in Standerton, Mpumalanga, [23] where over 25,000 birds were culled to prevent the virus spreading. The South African Poultry Association reported that wild ducks migrating from Europe are spreading the virus. [24]

December 2017

On 20 December 2017, the Ministry of Environment, Water and Agriculture (MEWA) in Saudi Arabia announced the detection of the highly pathogenic H5N8 virus among birds at a poultry market in Riyadh. A few days later, the virus was detected in other farms in other cities including Al-Ahsa, Al-Kharj, Al-Quaiyat, Dharma, and Mazahmiya. This outbreak in the country led to a cull of more than 100,000 birds at 12 locations across the country to prevent the spread of the virus. [25]

2020

February

On 4 February, Saudi Arabia reported an outbreak of the highly pathogenic H5N8 bird flu virus on a poultry farm. The outbreak, which occurred in the central Sudair region, killed 22,700 birds. [26]

Summer

In the summer of 2020, H5N8 was detected in wild birds in western Russia and Kazakhstan. Because this included waterbirds that migrate into northern and western Europe, it was considered likely that the virus would be detected there later in the year (as would be confirmed in October–November). [1]

October–December

On 22 October, the agriculture minister Carola Schouten of the Netherlands confirmed that H5N8 had been found in samples from wild birds in the country. [27] As a countermeasure, it was required that birds in poultry farms were kept indoors and isolated. From late October to mid-November, it had spread to three chicken farms and a duck farm in the country, and the 320,000 birds in the farms had been eradicated to stop the spread. [28] Shortly after the first detection in the Netherlands, it was confirmed in the United Kingdom (October: poultry; November: wild birds and poultry), Germany (October: wild birds; November: wild birds and poultry), Ireland (October and November: wild birds), Belgium (November: wild birds), Denmark (November: wild birds and poultry), France (November: poultry) and Sweden (November: poultry). [1] These outbreaks resulted in countermeasures that were similar to those already taken in the Netherlands. [29] [30]

According to official confirmed reports from the Ministry of Agriculture Forestry and Fisheries of Japan, multiple dead chickens were found in 49 chicken poultry farms in Japan, from 5 November 2020 to 25 February 2021, 16 places in Shikoku Island, 15 places in Kyushu Island, ten places in Kantō region, five places in western Honshu and each one place in Awaji Island, Gifu Prefecture, and Toyama Prefecture. According to local official confirmed report, these cases were highly pathogenic H5N8 type flu.[ citation needed ]

On 10 November, South Korea's agriculture ministry said it had confirmed the highly pathogenic H5N8 strain of bird flu in samples from wild birds in the central west of the country and issued its bird flu warning. [31]

At the end of November 2020, about 10,500 turkeys were killed on a British farm in North Yorkshire in order to limit the spread of H5N8 bird flu after health officials discovered an outbreak. [32]

On 16 December several birds were found dead on the Isle of Wight, in the UK, and the cause of death was identified as H5N8.[ citation needed ]

2021

Urner Barry Egg Index Egg index.webp
Urner Barry Egg Index

January

India reported the virus first in the migratory birds following which in January 2021 culling of chickens and ducks began on Tuesday 6 Jan in parts of Kerala to contain the H5N8 strain of bird flu, while Jammu and Kashmir sounded an alert and started collecting samples from migratory species after Himachal Pradesh, Rajasthan and Madhya Pradesh reported cases of avian influenza. Kerala officials have said around 40,000 domestic birds, including 34,000 in the Kuttanad region alone, will be culled to check the spread of the H5N8 virus. Till now, 2,700 migratory birds, mostly bar-headed geese, have been found dead in the lake area and samples have been sent for testing, state animal husbandry officials said. [33]

According to Japan's Ministry of Agriculture, Forestry and Fisheries official report, several dead edible ducks were found in two poultry farms near Narita, Chiba Prefecture. Both cases were confirmed as H5N8 type bird flu via genetic test by a regional official on 21 January and 24. 5400 ducks were culled in response. [34] [35]

As a larger nationwide trend in avian flu, 7 million poultry were culled with aid from the Japan Ground Self-Defense Force as of February 17, 2021. [36]

February

On 20 February 2021, Russia reported the first known cases of H5N8 in humans. Seven people were confirmed to have been infected at a farm in southern Russia where outbreaks had been reported. There was no indication of human-to-human transmission and the seven cases were described as "mild." [2] Anna Popova, head of Rospotrebnadzor, has said the seven poultry workers have since recovered, and that "the situation did not develop further." [37] WHO later confirmed that all cases remained asymptomatic for the whole follow-up. [38]

March

In an interview published in The Moscow Times on 12 March 2021, Popova warned that there was a "high degree of probability" of human-to-human transmission of H5N8. [39]

Related Research Articles

<span class="mw-page-title-main">Avian influenza</span> Influenza caused by viruses adapted to birds

Avian influenza, also known as avian flu or bird flu, is a disease caused by the influenza A virus, which primarily affects birds but can sometimes affect mammals including humans. Wild aquatic birds are the primary host of the influenza A virus, which is enzootic in many bird populations.

<span class="mw-page-title-main">Influenza A virus subtype H5N1</span> Subtype of influenza A virus

Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic in many bird populations, and also panzootic. A/H5N1 virus can also infect mammals that have been exposed to infected birds; in these cases, symptoms are frequently severe or fatal.

<span class="mw-page-title-main">Global spread of H5N1</span> Spread of bird flu

The global spread of H5N1 influenza in birds is considered a significant pandemic threat. While other H5N1 influenza strains are known, they are significantly different on a genetic level from a highly pathogenic, emergent strain of H5N1, which was able to achieve hitherto unprecedented global spread in 2008. The H5N1 strain is a fast-mutating, highly pathogenic avian influenza virus (HPAI) found in multiple bird species. It is both epizootic and panzootic. Unless otherwise indicated, "H5N1" in this timeline refers to the 2008 highly pathogenic strain of H5N1.

<span class="mw-page-title-main">Transmission and infection of H5N1</span> Spread of an influenza virus

Transmission and infection of H5N1 from infected avian sources to humans has been a concern since the first documented case of human infection in 1997, due to the global spread of H5N1 that constitutes a pandemic threat.

<span class="mw-page-title-main">Influenza A virus subtype H5N2</span> Virus subtype

H5 N2 is a subtype of the species Influenzavirus A. The subtype infects a wide variety of birds, including chickens, ducks, turkeys, falcons, and ostriches. Affected birds usually do not appear ill, and the disease is often mild as avian influenza viral subtypes go. Some variants of the subtype are much more pathogenic than others, and outbreaks of "high-path" H5N2 result in the culling of thousands of birds in poultry farms from time to time. It appears that people who work with birds can be infected by the virus, but suffer hardly any noticeable health effects. Even people exposed to the highly pathogenic H5N2 variety that killed ostrich chicks in South Africa only seem to have developed conjunctivitis, or a perhaps a mild respiratory illness. There is no evidence of human-to-human spread of H5N2. On November 12, 2005 it was reported that a falcon was found to have H5N2. On June 5, 2024, the first confirmed human case of H5N2 was reported in Mexico.

<span class="mw-page-title-main">Influenza A virus subtype H7N7</span> Virus subtype

Influenza A virus subtype H7N7 (A/H7N7) is a subtype of Influenza A virus, a genus of Orthomyxovirus, the viruses responsible for influenza. Highly pathogenic strains (HPAI) and low pathogenic strains (LPAI) exist. H7N7 can infect humans, birds, pigs, seals, and horses in the wild; and has infected mice in laboratory studies. This unusual zoonotic potential represents a pandemic threat.

<span class="mw-page-title-main">Influenza A virus subtype H7N2</span> Virus subtype

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<span class="mw-page-title-main">Influenza A virus subtype H7N3</span> Virus subtype

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<span class="mw-page-title-main">Global spread of H5N1 in 2006</span> 2006 worldwide disease outbreak

The global spread of H5N1 in birds is considered a significant pandemic threat.

<span class="mw-page-title-main">Global spread of H5N1 in 2005</span> Pandemic threat

The global spread of H5N1 in birds is considered a significant pandemic threat.

<span class="mw-page-title-main">Global spread of H5N1 in 2004</span>

The global spread of H5N1 in birds is considered a significant pandemic threat.

<span class="mw-page-title-main">Fujian flu</span> Strains of influenza

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<span class="mw-page-title-main">Global spread of H5N1 in 2007</span>

The global spread of H5N1 in birds is considered a significant pandemic threat.

<span class="mw-page-title-main">Influenza A virus subtype H7N9</span> Subtype of the influenza A virus

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<span class="mw-page-title-main">Influenza A virus subtype H5N6</span> Virus subtype

H5N6 is a subtype of the species Influenza A virus. Infected birds shed the virus in their saliva, mucous, and feces. The virus was first detected in poultry in 2013, since then spreading among wild bird populations and poultry around the world. Humans can be infected through unprotected contact with infected birds or contaminated surfaces. The virus transmits by getting into a person's eyes, nose, mouth, and through inhalation. Human infections are rare. Since 2014, at least 87 cases have occurred in humans. 29 people have died. A spike in human cases was reported in 2021. There have been no confirmed cases of human-to-human transmission. Some infections have been identified where no direct contact with infected birds or contaminated surfaces has been known to had occurred. Only one infected woman has said that she never came into any contact with poultry.

<span class="mw-page-title-main">2015 United States H5N2 outbreak</span> 2015 outbreak of avian influenza subtype H5N2

In 2015, an outbreak of avian influenza subtype H5N2 was identified in a series of chicken and turkey farming operations in the Midwestern United States. By May 30, more than 43 million birds in 15 states had been destroyed as a result of the outbreak, including nearly 30 million in Iowa alone, the nation's largest egg producer. In the Midwestern U.S., the average price of eggs had increased 120% between April 22 and May 30. The effects however were seen nationwide, with prices in California up 71% in the same timeframe.

<span class="mw-page-title-main">2017 Central Luzon H5N6 outbreak</span> Bird flu outbreak in the Philippines

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<span class="mw-page-title-main">2020–2023 H5N8 outbreak</span> Outbreak of Avian influenza in poultry farms and wild birds

In the early 2020s, an ongoing outbreak of avian influenza subtype H5N8 has been occurring at poultry farms and among wild bird populations in several countries and continents, leading to the subsequent cullings of millions of birds to prevent a pandemic similar to that of the H5N1 outbreak in 2008. The first case of human transmission of avian flu, also known as bird flu, was reported by Russian authorities in February 2021, as several poultry farm workers tested positive for the virus.

<span class="mw-page-title-main">Influenza A virus subtype H10N3</span> Influenza virus subtype

Influenza A virus subtype H10N3 is a subtype of viruses that causes influenza (flu). It is mostly present in wild avian species. The first human case was reported in 2021.

Since 2020, outbreaks of avian influenza subtype H5N1 have been occurring, with cases reported from every continent as of May 2024. Some species of wild aquatic birds act as natural asymptomatic carriers of a large variety of influenza A viruses, which can infect poultry, other bird species, mammals and humans if they come into close contact with infected feces or contaminated material, or by eating infected birds. In late 2023, H5N1 was discovered in the Antarctic for the first time, raising fears of imminent spread throughout the region, potentially leading to a "catastrophic breeding failure" among animals that had not previously been exposed to avian influenza viruses. The main virus involved in the global outbreak is classified as H5N1 clade 2.3.4.4b, however genetic diversification with other clades such as 2.3.2.1c has seen the virus evolve in ability to cause significant outbreaks in a broader range of species including mammals.

References

  1. 1 2 3 "Avian influenza overview – update on 19 November 2020, EU/EEA and the UK" (PDF). European Centre for Disease Prevention and Control. 19 November 2020.
  2. 1 2 "Russia reports first human cases of H5N8 bird flu". BNO News. 20 February 2021. Retrieved 20 February 2021.
  3. ↑ "Human infection with avian influenza A (H5N8) – the Russian Federation". World Health Organization. 26 February 2021. Archived from the original on 26 February 2021. Retrieved 26 February 2021.
  4. ↑ Updates on the spread of H5N8 Avian Influenza from an African perspective
  5. ↑ "RCI Inactivation of Avian Influenza" (PDF). www.activtek.eu. Archived from the original (PDF) on 16 February 2012. Retrieved 12 April 2012.
  6. ↑ Swain, David (25 March 2008). Avian Influenza. Wiley. ISBN   9780813820477.
  7. ↑ Highly Pathogenic Avian Influenza A(H5N8) Virus from Waterfowl, South Korea, 2014
  8. ↑ "Outbreaks of highly pathogenic avian influenza A(H5N8) in Europe" (PDF). European Centre for Disease Prevention and Control . 18 November 2016. Archived from the original (PDF) on 22 November 2016. Retrieved 27 November 2016.
  9. ↑ "Bird flu outbreak confirmed at turkey farm in Lincolnshire". The Guardian. 16 December 2016. Retrieved 10 July 2020.
  10. ↑ "Chinese farmers bolster bird flu defenses as Asia outbreaks, and jitters, spread". Channel NewsAsia. Archived from the original on 1 January 2017. Retrieved 31 December 2016.
  11. ↑ "H5N8 bird flu strain discovered in farms in Cloppenburg in Germany's Lower Saxony". DW.COM. 26 December 2016. Retrieved 31 December 2016.
  12. ↑ "Bird flu alert as duck in Llanelli found to be infected". BBC News. 22 December 2016. Retrieved 31 December 2016.
  13. 1 2 "South Korea, Japan step up poultry cull to contain bird flu". Fox News. 19 December 2016. Retrieved 31 December 2016.
  14. ↑ "French authorities gas thousands of ducks after bird flu outbreaks". The Guardian. 6 January 2017. Retrieved 13 January 2017.
  15. ↑ Abuja, Joke (11 January 2017). "New bird flu strain hits poultry industry, 3.5m birds infected". The Guardian. Retrieved 13 January 2017.
  16. ↑ Schnirring, Lisa (12 January 2017). "H5N8 detected in Spain, Slovenia for first time". CIDRAP. University of Minnesota. Retrieved 13 January 2017.
  17. ↑ (Reuters)
  18. ↑ "RPT-Uganda detects bird flu in wild, domestic birds | News by Country". Reuters. 15 January 2017. Archived from the original on 16 January 2017. Retrieved 18 January 2017.
  19. ↑ "Second case of bird flu confirmed in Northern Ireland". BBC News. 10 February 2017. Retrieved 10 February 2017.
  20. ↑ "Irvines culls 140 000 birds after avian flu outbreak | The Financial Gazette". www.financialgazette.co.zw. 6 June 2017. Archived from the original on 16 September 2018. Retrieved 13 July 2017.
  21. ↑ "H5N8 bird flu outbreak reported on Free State farm". Eyewitness News. Reuters. 23 June 2017. Retrieved 13 July 2017.
  22. ↑ Motsoeneng, Tiisetso (23 June 2017). "SA reports outbreak of H5N8 bird flu, industry body says". Moneyweb. Retrieved 13 July 2017.
  23. ↑ Groenewald, Yolandi (27 June 2017). "Bird flu outbreak poses new threat to SA poultry industry". Fin24. Retrieved 13 July 2017.
  24. ↑ Jadoo, Yadhana (26 June 2017). "Migrating ducks spreading bird flu in SA". The Citizen. Retrieved 13 July 2017.
  25. ↑ "بيان حول ظهور إنفلونزا الطيور (H5N8) في مدينة الرياض" (in Arabic). Saudi Arabia: Ministry of Environment, Water & Agriculture. Retrieved 10 June 2018.
  26. ↑ "Saudi Arabia reports H5N8 bird flu on farm". Khaleej Times. 5 February 2020. Retrieved 5 February 2020.
  27. ↑ Ophokplicht pluimvee vanwege nieuwe vogelgriep, NOS (22 October 2020)
  28. ↑ Vogelgriep rukt op, ook mensen kunnen rol spelen bij verspreiding, NOS (14 November 2020)
  29. ↑ "Update1-Germany may cull up to 70,000 chickens as bird flu found on another farm". SF. 17 November 2020. Archived from the original on 22 November 2020. Retrieved 21 November 2020.
  30. ↑ "Sweden culls over 3,000 turkeys as bird flu moves through northern Europe". The Poultry Site. 19 November 2020.
  31. ↑ "South Korea confirms H5N8 bird flu in wild birds, issues warning". Reuters. 10 November 2020. Retrieved 10 November 2020.[ dead link ]
  32. ↑ "Over 10,000 Turkeys to Be Culled After Bird Flu Breakout in U.K." www.msn.com. Retrieved 3 December 2020.
  33. ↑ "Bird flu: Culling of chickens, ducks starts in Kerala; Karnataka, Tamil Nadu and J&K on alert". Firstpost. 5 January 2021. Retrieved 22 February 2021.
  34. ↑ "千葉 匝瑳 農場のアヒルから鳥インフル検出 県内4例目". NHK (in Japanese). 20 February 2021. Retrieved 20 February 2021.
  35. ↑ "New bird flu outbreaks confirmed in Chiba and Miyazaki prefectures". Japan Times. 20 February 2021. Retrieved 20 February 2021.
  36. ↑ "More than 7 Million Birds Culled in Japan After Severe Avian Flu Outbreaks". Nippon. 20 February 2021. Retrieved 20 February 2021.
  37. ↑ "Russia records first cases of human infection with bird flu strain H5N8". Sky News. 20 February 2021. Retrieved 21 February 2021.
  38. ↑ "WHO | Human infection with avian influenza A (H5N8) – the Russian Federation". Archived from the original on 26 February 2021.
  39. ↑ "Russia Warns of H5N8 Bird Flu Transmission". The Moscow Times. 12 March 2021. Retrieved 14 March 2021.

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