Neurosurgery

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Neurosurgery
Parkinson surgery.jpg
Stereotactic guided insertion of DBS electrodes in neurosurgery
Occupation
Activity sectors
 Surgery
Description
Education required

or

or

Fields of
employment
 Hospitals, clinics

Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty that focuses on the surgical treatment or rehabilitation of disorders which affect any portion of the nervous system including the brain, spinal cord, peripheral nervous system, and cerebrovascular system. [1] Neurosurgery as a medical specialty also includes non-surgical management of some neurological conditions. [2]

Contents

Education and context

In different countries, there are different requirements for an individual to legally practice neurosurgery, and there are varying methods through which they must be educated. In most countries, neurosurgeon training requires a minimum period of seven years after graduating from medical school. [3]

United Kingdom

In the United Kingdom, students must gain entry into medical school. The MBBS qualification (Bachelor of Medicine, Bachelor of Surgery) takes four to six years depending on the student's route. The newly qualified physician must then complete foundation training lasting two years; this is a paid training program in a hospital or clinical setting covering a range of medical specialties including surgery. Junior doctors then apply to enter the neurosurgical pathway. Unlike most other surgical specialties, it currently has its own independent training pathway which takes around eight years (ST1-8); before being able to sit for consultant exams with sufficient amounts of experience and practice behind them. Neurosurgery remains consistently amongst the most competitive medical specialties in which to obtain entry.

United States

In the United States, a neurosurgeon must generally complete four years of undergraduate education, four years of medical school, and seven years of residency (PGY-1-7). [4] Most, but not all, residency programs have some component of basic science or clinical research. Neurosurgeons may pursue additional training in the form of a fellowship after residency, or, in some cases, as a senior resident in the form of an enfolded fellowship. These fellowships include pediatric neurosurgery, trauma/neurocritical care, functional and stereotactic surgery, surgical neuro-oncology, radiosurgery, neurovascular surgery, skull-base surgery, peripheral nerve and complex spinal surgery. [5] Fellowships typically span one to two years. In the U.S., neurosurgery is a very small, highly competitive specialty, constituting only 0.5 percent of all physicians. [6]

History

Neurosurgery, or the premeditated incision into the head for pain relief, has been around for thousands of years, but notable advancements in neurosurgery have only come within the last hundred years. [7]

Trepanned skull from Edinburgh Edinburgh Skull, trepanning showing hole in back of skull Wellcome M0009393.jpg
Trepanned skull from Edinburgh

Ancient

The Incas appear to have practiced a procedure known as trepanation since before European colonization. [8] During the Middle Ages in Al-Andalus from 936 to 1013 AD, Al-Zahrawi performed surgical treatments of head injuries, skull fractures, spinal injuries, hydrocephalus, subdural effusions and headache. [9] During the Roman Empire, doctors and surgeons performed neurosurgery on depressed skull fractures. [10] [11] Simple forms of neurosurgery were performed on King Henri II in 1559, after a jousting accident with Gabriel Montgomery fatally wounded him. Ambroise Paré and Andreas Vesalius, both experts in their field at the time, attempted their own methods, to no avail, in curing Henri. [12] In China, Hua Tuo created the first general anaesthesia called mafeisan, which he used on surgical procedures on the brain. [13]

Modern

History of tumor removal: In 1879, after locating it via neurological signs alone, Scottish surgeon William Macewen (1848–1924) performed the first successful brain tumor removal. [4] On November 25, 1884, after English physician Alexander Hughes Bennett (1848–1901) used Macewen's technique to locate it, English surgeon Rickman Godlee (1849–1925) performed the first primary brain tumor removal, [5] [14] which differs from Macewen's operation in that Bennett operated on the exposed brain, whereas Macewen operated outside of the "brain proper" via trepanation. [15] On March 16, 1907, Austrian surgeon Hermann Schloffer became the first to successfully remove a pituitary tumor. [16]

Lobotomy : also known as leucotomy, was a form of psychosurgery, a neurosurgical treatment of mental disorders that involves severing connections in the brain's prefrontal cortex. [17] The originator of the procedure, Portuguese neurologist António Egas Moniz, shared the Nobel Prize for Physiology or Medicine of 1949. [18] [19] Some patients improved in some ways after the operation, but complications and impairments –sometimes severe –were frequent. The procedure was controversial from its initial use, in part due to the balance between benefits and risks. It is mostly rejected as a treatment now and non-compliant with patients' rights.

History of electrodes in the brain: In 1878, Richard Caton discovered that electrical signals transmitted through an animal's brain. In 1950 Jose Delgado invented the first electrode that was implanted in an animal's brain (bull), using it to make it run and change direction. [20] In 1972 the cochlear implant, a neurological prosthetic that allowed deaf people to hear was marketed for commercial use. In 1998 researcher Philip Kennedy implanted the first Brain Computer Interface (BCI) into a human subject. [21]

A survey done in 2010 on 100 most cited works in neurosurgery shows that the works mainly cover clinical trials evaluating surgical and medical therapies, descriptions of novel techniques in neurosurgery, and descriptions of systems classifying and grading diseases. [22]

Modern surgical instruments

The main advancements in neurosurgery came about as a result of highly crafted tools. Modern neurosurgical tools, or instruments, include chisels, curettes, dissectors, distractors, elevators, forceps, hooks, impactors, probes, suction tubes, power tools, and robots. [23] [24] Most of these modern tools have been in medical practice for a relatively long time. The main difference of these tools in neurosurgery, were the precision in which they were crafted. These tools are crafted with edges that are within a millimeter of desired accuracy. [25] Other tools, such as hand held power saws and robots have only recently been commonly used inside of a neurological operating room. As an example, the University of Utah developed a device for computer-aided design / computer-aided manufacturing (CAD-CAM) which uses an image-guided system to define a cutting tool path for a robotic cranial drill. [26]

Organised neurosurgery

World Academy of Neurological Surgery's conference Robert Spetzler in a Neurosurgeons Group.jpg
World Academy of Neurological Surgery's conference

The World Federation of Neurosurgical Societies (WFNS), founded in 1955, in Switzerland, as a professional, scientific, non governmental organization, is composed of 130 member societies: consisting of 5 Continental Associations (AANS, AASNS, CAANS, EANS and FLANC), 6 Affiliate Societies, and 119 National Neurosurgical Societies, representing some 50,000 neurosurgeons worldwide. [27] It has a consultative status in the United Nations. The official Journal of the Organization is World Neurosurgery. [28] [29] The other global organisations being the World Academy of Neurological Surgery (WANS) and the World Federation of Skull Base Societies (WFSBS).

Main divisions

General neurosurgery involves most neurosurgical conditions including neuro-trauma and other neuro-emergencies such as intracranial hemorrhage. Most level 1 hospitals have this kind of practice. [30]

Specialized branches have developed to cater to special and difficult conditions. These specialized branches co-exist with general neurosurgery in more sophisticated hospitals. To practice advanced specialization within neurosurgery, additional higher fellowship training of one to two years is expected from the neurosurgeon. Some of these divisions of neurosurgery are:

  1. Vascular neurosurgery includes clipping of aneurysms and performing carotid endarterectomy (CEA).
  2. Stereotactic neurosurgery, functional neurosurgery, and epilepsy surgery (the latter includes partial or total corpus callosotomy – severing part or all of the corpus callosum to stop or lessen seizure spread and activity, and the surgical removal of functional, physiological and/or anatomical pieces or divisions of the brain, called epileptic foci, that are operable and that are causing seizures, and also the more radical and rare partial or total lobectomy, or even hemispherectomy – the removal of part or all of one of the lobes, or one of the cerebral hemispheres of the brain; those two procedures, when possible, are also very, very rarely used in oncological neurosurgery or to treat very severe neurological trauma, such as stab or gunshot wounds to the brain)
  3. Oncological neurosurgery also called neurosurgical oncology; includes pediatric oncological neurosurgery; treatment of benign and malignant central and peripheral nervous system cancers and pre-cancerous lesions in adults and children (including, among others, glioblastoma multiforme and other gliomas, brain stem cancer, astrocytoma, pontine glioma, medulloblastoma, spinal cancer, tumors of the meninges and intracranial spaces, secondary metastases to the brain, spine, and nerves, and peripheral nervous system tumors)
  4. Skull base surgery
  5. Spinal neurosurgery
  6. Peripheral nerve surgery
  7. Pediatric neurosurgery (for cancer, seizures, bleeding, stroke, cognitive disorders or congenital neurological disorders)

Commonly performed surgeries

According to an analysis by the American College of Surgeons National Surgical Quality Improvement Program (NSQIP), the most common surgeries performed by neurosurgeons in between 2006 and 2014 were the following: [31]

Neuropathology

Histopathology specimen of Angiocentric glioma, higher magnification, HE stain Neuropathology case V 03.jpg
Histopathology specimen of Angiocentric glioma, higher magnification, HE stain

Neuropathology is a specialty within the study of pathology focused on the disease of the brain, spinal cord, and neural tissue. [32] This includes the central nervous system and the peripheral nervous system. Tissue analysis comes from either surgical biopsies or post mortem autopsies. Common tissue samples include muscle fibers and nervous tissue. [33] Common applications of neuropathology include studying samples of tissue in patients who have Parkinson's disease, Alzheimer's disease, dementia, Huntington's disease, amyotrophic lateral sclerosis, mitochondria disease, and any disorder that has neural deterioration in the brain or spinal cord. [34] [35]

History

While pathology has been studied for millennia only within the last few hundred years has medicine focused on a tissue- and organ-based approach to tissue disease. In 1810, Thomas Hodgkin started to look at the damaged tissue for the cause. This was conjoined with the emergence of microscopy and started the current understanding of how the tissue of the human body is studied. [36]

Neuroanesthesia

Neuroanesthesia is a field of anesthesiology which focuses on neurosurgery. Anesthesia is not used during the middle of an "awake" brain surgery. Awake brain surgery is where the patient is conscious for the middle of the procedure and sedated for the beginning and end. This procedure is used when the tumor does not have clear boundaries and the surgeon wants to know if they are invading on critical regions of the brain which involve functions like talking, cognition, vision, and hearing. It will also be conducted for procedures which the surgeon is trying to combat epileptic seizures. [37]

History

The physician Hippocrates (460–370 BCE) made accounts of using different wines to sedate patients while trepanning. In 60 CE, Dioscorides, a physician, pharmacologist, and botanist, detailed how mandrake, henbane, opium, and alcohol were used to put patients to sleep during trepanning. In 972 CE, two brother surgeons in Paramara, now India, used "samohine" to sedate a patient while removing a small tumor, and awoke the patient by pouring onion and vinegar in the patient's mouth. The combination of carbon dioxide, hydrogen, and nitrogen, was a form of neuroanesthesia adopted in the 18th century and introduced by Humphry Davy. [38]

Neurosurgery methods

Neurosurgery
ICD-10-PCS 00-01
ICD-9-CM 01–05
MeSH D019635
OPS-301 code 5-01...5-05

Various Imaging methods are used in modern neurosurgery diagnosis and treatment. They include computer assisted imaging computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), magnetoencephalography (MEG), and stereotactic radiosurgery. Some neurosurgery procedures involve the use of intra-operative MRI and functional MRI. [39]

In conventional neurosurgery the neurosurgeon opens the skull, creating a large opening to access the brain. Techniques involving smaller openings with the aid of microscopes and endoscopes are now being used as well. Methods that utilize small craniotomies in conjunction with high-clarity microscopic visualization of neural tissue offer excellent results. However, the open methods are still traditionally used in trauma or emergency situations. [16] [23]

Microsurgery is utilized in many aspects of neurological surgery. Microvascular techniques are used in EC-IC bypass surgery and in restoration carotid endarterectomy. The clipping of an aneurysm is performed under microscopic vision. Minimally-invasive spine surgery utilizes microscopes or endoscopes. Procedures such as microdiscectomy, laminectomy, and artificial disc replacement rely on microsurgery. [24]

Using stereotaxy neurosurgeons can approach a minute target in the brain through a minimal opening. This is used in functional neurosurgery where electrodes are implanted or gene therapy is instituted with high level of accuracy as in the case of Parkinson's disease or Alzheimer's disease. Using the combination method of open and stereotactic surgery, intraventricular hemorrhages can potentially be evacuated successfully. [25] Conventional surgery using image guidance technologies is also becoming common and is referred to as surgical navigation, computer-assisted surgery, navigated surgery, stereotactic navigation. Similar to a car or mobile Global Positioning System (GPS), image-guided surgery systems, like Curve Image Guided Surgery and StealthStation, use cameras or electromagnetic fields to capture and relay the patient's anatomy and the surgeon's precise movements in relation to the patient, to computer monitors in the operating room. These sophisticated computerized systems are used before and during surgery to help orient the surgeon with three-dimensional images of the patient's anatomy including the tumor. [40] Real-time functional brain mapping has been employed to identify specific functional regions using electrocorticography (ECoG) [41]

Minimally invasive endoscopic surgery is commonly utilized by neurosurgeons when appropriate. Techniques such as endoscopic endonasal surgery are used in pituitary tumors, craniopharyngiomas, chordomas, and the repair of cerebrospinal fluid leaks. Ventricular endoscopy is used in the treatment of intraventricular bleeds, hydrocephalus, colloid cyst and neurocysticercosis. Endonasal endoscopy is at times carried out with neurosurgeons and ENT surgeons working together as a team.[ citation needed ]

Repair of craniofacial disorders and disturbance of cerebrospinal fluid circulation is done by neurosurgeons who also occasionally team up with maxillofacial and plastic surgeons. Cranioplasty for craniosynostosis is performed by pediatric neurosurgeons with or without plastic surgeons. [42]

Neurosurgeons are involved in stereotactic radiosurgery along with radiation oncologists in tumor and AVM treatment. Radiosurgical methods such as Gamma knife, Cyberknife and Novalis Radiosurgery are used as well. [43]

Endovascular neurosurgery utilize endovascular image guided procedures for the treatment of aneurysms, AVMs, carotid stenosis, strokes, and spinal malformations, and vasospasms. Techniques such as angioplasty, stenting, clot retrieval, embolization, and diagnostic angiography are endovascular procedures. [44]

A common procedure performed in neurosurgery is the placement of ventriculo-peritoneal shunt (VP shunt). In pediatric practice this is often implemented in cases of congenital hydrocephalus. The most common indication for this procedure in adults is normal pressure hydrocephalus (NPH). [45]

Neurosurgery of the spine covers the cervical, thoracic and lumbar spine. Some indications for spine surgery include spinal cord compression resulting from trauma, arthritis of the spinal discs, or spondylosis. In cervical cord compression, patients may have difficulty with gait, balance issues, and/or numbness and tingling in the hands or feet. Spondylosis is the condition of spinal disc degeneration and arthritis that may compress the spinal canal. This condition can often result in bone-spurring and disc herniation. Power drills and special instruments are often used to correct any compression problems of the spinal canal. Disc herniations of spinal vertebral discs are removed with special rongeurs. This procedure is known as a discectomy. Generally once a disc is removed it is replaced by an implant which will create a bony fusion between vertebral bodies above and below. Instead, a mobile disc could be implanted into the disc space to maintain mobility. This is commonly used in cervical disc surgery. At times instead of disc removal a Laser discectomy could be used to decompress a nerve root. This method is mainly used for lumbar discs. Laminectomy is the removal of the lamina of the vertebrae of the spine in order to make room for the compressed nerve tissue. [46]

Surgery for chronic pain is a sub-branch of functional neurosurgery. Some of the techniques include implantation of deep brain stimulators, spinal cord stimulators, peripheral stimulators and pain pumps. [47]

Surgery of the peripheral nervous system is also possible, and includes the very common procedures of carpal tunnel decompression and peripheral nerve transposition. Numerous other types of nerve entrapment conditions and other problems with the peripheral nervous system are treated as well. [48]

Conditions

Conditions treated by neurosurgeons include, but are not limited to: [49]

Recovery

Postoperative pain

Pain following brain surgery can be significant and may lengthen recovery, increase the amount of time a person stays in the hospital following surgery, and increase the risk of complications following surgery. [50] Severe acute pain following brain surgery may also increase the risk of a person developing a chronic post-craniotomy headache. [50] Approaches to treating pain in adults include treatment with nonsteroidal anti‐inflammatory drugs (NSAIDs), which have been shown to reduce pain for up to 24 hours following surgery. [50] Low-quality evidence supports the use of the medications dexmedetomidine, pregabalin or gabapentin to reduce post-operative pain. [50] Low-quality evidence also supports scalp blocks and scalp infiltration to reduce postoperative pain. [50] Gabapentin or pregabalin may also decrease vomiting and nausea following surgery, based on very low-quality medical evidence. [50]

Notable neurosurgeons

Bioethics in neurosurgery

Neurosurgery is a part of practical medicine and the only specialty that involves invasive intervention in the activity of the living brain. The brain ensures the structural and functional integrity of the body and the implementation of all the main life processes of the body. Therefore, neurosurgery faces a wide range of bioethical issues and a significant selection of the latest treatment technologies. [54]

Neurosurgery has the following applied scientific and ethical problems:

See also

Related Research Articles

Lars Leksell was a Swedish physician and professor of Neurosurgery at the Karolinska Institute in Stockholm, Sweden. He was the inventor of radiosurgery.

<span class="mw-page-title-main">Radiosurgery</span> Surgical Specialty

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<span class="mw-page-title-main">Stereotactic surgery</span> Medical procedure

Stereotactic surgery is a minimally invasive form of surgical intervention that makes use of a three-dimensional coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery (SRS), etc.

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The study of neurology and neurosurgery dates back to prehistoric times, but the academic disciplines did not begin until the 16th century. The formal organization of the medical specialties of neurology and neurosurgery are relatively recent, taking place in Europe and the United States only in the 20th century with the establishment of professional societies distinct from internal medicine, psychiatry and general surgery. From an observational science they developed a systematic way of approaching the nervous system and possible interventions in neurological disease.

<span class="mw-page-title-main">Brain biopsy</span> Diagnostic procedure of brain tissue sample

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Hypophysectomy is the surgical removal of the hypophysis. It is most commonly performed to treat tumors, especially craniopharyngioma tumors. Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma or Simmond's disease It is also applied in neurosciences to understand the functioning of hypophysis. There are various ways a hypophysectomy can be carried out. These methods include transsphenoidal hypophysectomy, open craniotomy, and stereotactic radiosurgery.

The Neurologic & Orthopedic Hospital of Chicago was a medical center from 1987 to 2009.

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<span class="mw-page-title-main">Roger Härtl</span> American neurosurgeon

Roger Härtl is an American neurological surgeon at Weill-Cornell Medical College and NewYork-Presbyterian Hospital. He is the Director of Spinal Surgery at the Weill Cornell Brain & Spine Center. Härtl has been named by Becker's Spine Review as one of the Top 50 Spine Surgeons in the United States as well as one of the Top 10 Spine and Neurosurgeon Leaders at Non-Profit Hospitals. He was named one of New York's Top Doctors by New York Magazine after he saved the life of New York firefighter Eugene Stolowski.

<span class="mw-page-title-main">Barrow Neurological Institute</span> Hospital in Arizona, United States

Barrow Neurological Institute is the world's largest neurological disease treatment and research institution, and is consistently ranked as one of the best neurosurgical training centers in the United States. Founded in 1962, the main campus is located at 350 W. Thomas Road in Phoenix, Arizona.

The Mischer Neuroscience Institute is a combined research and education effort between the Vivian L. Smith Department of Neurosurgery and the Department of Neurology at McGovern Medical School at UTHealth Houston and Memorial Hermann Hospital. Located in Houston, the Institute draws patients from around the world for specialized treatment of diseases of the brain and spine. It was the first center in Texas and one of only a few institutions in the country to fully integrate neurology, neurosurgery, neuroradiology, neuro-oncology, spine surgery, pain medicine and neurorehabilitation.

<span class="mw-page-title-main">Michael L. J. Apuzzo</span> American academic neurological surgeon

Michael L. J. Apuzzo is an American academic neurological surgeon, the Edwin M. Todd/Trent H. Wells, Jr. Professor Emeritus of Neurological Surgery and Radiation Oncology, Biology, and Physics at the Keck School of Medicine, of the University of Southern California. He is also editor emeritus of the peer-reviewed journals World Neurosurgery and Neurosurgery. He is distinguished adjunct professor of neurosurgery at the Yale School of Medicine, distinguished professor of advanced neurosurgery and neuroscience and senior advisor, at the Neurological Institute, Wexner Medical School, The Ohio State University, and adjunct professor of neurosurgery, Weill Cornell Medicine, Department of Neurological Surgery & Weill Cornell Brain and Spine Center.

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Isabelle M. Germano is a neurosurgeon and professor of neurosurgery, neurology, and oncology at the Icahn School of Medicine at Mount Sinai Hospital. She is a Fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Germano works with image-guided brain and spine surgery.

<span class="mw-page-title-main">Jefferson Hospital for Neuroscience</span> Hospital in Pennsylvania, U.S.

Jefferson Hospital for Neuroscience is a hospital in Center City Philadelphia, affiliated with Thomas Jefferson University and Thomas Jefferson University Hospital in Philadelphia. The hospital focuses on treating brain-related diseases and disorders. It is the only hospital of its kind in the Philadelphia area.

Robert Wheeler Rand, was an American neurosurgeon, inventor, and Professor of Neurosurgery in the Department of Neurosurgery at the University of California Los Angeles (UCLA) from 1953 to 1989.

<span class="mw-page-title-main">B. K. Misra</span> Neurosurgeon

Dr. Basant Kumar Misra is a neurosurgeon specialising in treating brain, spine, cerebrovascular and peripheral nervous system disorders, injuries, pathologies and malformations. He is the Vice-President of the World Federation of Neurosurgical Societies, and the former President of the Asian Australasian Society of Neurological Surgeons, and the Neurological Society of India. He is a recipient of Dr. B. C. Roy Award, the highest medical honour in India.

<span class="mw-page-title-main">Konstantin Slavin</span>

Konstantin Slavin is a Professor and Head of the Department of Stereotactic and functional neurosurgery at the University of Illinois College of Medicine. He is a former president of the American Society for Stereotactic and functional neurosurgery and current vice-president of the World Society for Stereotactic and Functional Neurosurgery. His specialties include Aneurysm, Brain surgery, Brain Tumor, Cerebrovascular Disorders, Craniotomy, Dystonia, Essential Tremor, Facial Nerve Pain, Facial Pain, Glioblastoma, Headache disorders, Laminectomy, Lower back pain, Movement Disorders, Multiple Sclerosis, Neck Pain, Neurosurgery, Neurosurgical Procedures, Pain, Parkinson Disease, Spinal Cord Injuries, and Stroke.

<span class="mw-page-title-main">Deepak Agrawal</span> Indian neurosurgeon

Deepak Agrawal born 10 November 1970, is a professor neurosurgery at All India Institute of Medical Sciences, New Delhi is one of the top 10 surgeons in the neurosurgery. During his stint as chairman computerization, he reformed the ICT processes at AIIMS, New Delhi and also helped patients in All India Institute of Medical Sciences, New Delhi to get a Unique Health Identification (UHID), which documents their journey in the hospital. He also pioneered stem cell research in spinal cord injury in India and set up the Stem Cell translational research in Neuroscience LAB (SCRTN) at AIIMS, New Delhi.

References

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