Brain mapping

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Brain mapping
MeSH D001931

Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps.

Contents

According to the definition established in 2013 by Society for Brain Mapping and Therapeutics (SBMT), brain mapping is specifically defined, in summary, as the study of the anatomy and function of the brain and spinal cord through the use of imaging, immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering, neurophysiology and nanotechnology.

In 2024, a team of 287 researchers completed a full brain mapping of an adult animal (a Drosophila melanogaster , or fruit fly) and published their results in Nature. [1] [2]

Overview

All neuroimaging is considered part of brain mapping. Brain mapping can be conceived as a higher form of neuroimaging, producing brain images supplemented by the result of additional (imaging or non-imaging) data processing or analysis, such as maps projecting (measures of) behavior onto brain regions (see fMRI). One such map, called a connectogram, depicts cortical regions around a circle, organized by lobes. Concentric circles within the ring represent various common neurological measurements, such as cortical thickness or curvature. In the center of the circles, lines representing white matter fibers illustrate the connections between cortical regions, weighted by fractional anisotropy and strength of connection. [3] At higher resolutions brain maps are called connectomes. These maps incorporate individual neural connections in the brain and are often presented as wiring diagrams. [4]

Brain mapping techniques are constantly evolving, and rely on the development and refinement of image acquisition, representation, analysis, visualization and interpretation techniques. [5] Functional and structural neuroimaging are at the core of the mapping aspect of brain mapping.

Some scientists have criticized the brain image-based claims made in scientific journals and the popular press, like the discovery of "the part of the brain responsible" things like love or musical abilities or a specific memory. Many mapping techniques have a relatively low resolution, including hundreds of thousands of neurons in a single voxel. Many functions also involve multiple parts of the brain, meaning that this type of claim is probably both unverifiable with the equipment used, and generally based on an incorrect assumption about how brain functions are divided. It may be that most brain functions will only be described correctly after being measured with much more fine-grained measurements that look not at large regions but instead at a very large number of tiny individual brain circuits. Many of these studies also have technical problems like small sample size or poor equipment calibration which means they cannot be reproduced - considerations which are sometimes ignored to produce a sensational journal article or news headline. In some cases the brain mapping techniques are used for commercial purposes, lie detection, or medical diagnosis in ways which have not been scientifically validated. [6] [ page needed ]

History

In the late 1980s in the United States, the Institute of Medicine of the National Academy of Science was commissioned to establish a panel to investigate the value of integrating neuroscientific information across a variety of techniques. [7] [ page needed ]

Of specific interest is using structural and functional magnetic resonance imaging (fMRI), diffusion MRI (dMRI), magnetoencephalography (MEG), electroencephalography (EEG), positron emission tomography (PET), Near-infrared spectroscopy (NIRS) and other non-invasive scanning techniques to map anatomy, physiology, perfusion, function and phenotypes of the human brain. Both healthy and diseased brains may be mapped to study memory, learning, aging, and drug effects in various populations such as people with schizophrenia, autism, and clinical depression. This led to the establishment of the Human Brain Project. [8] [ page needed ] It may also be crucial to understanding traumatic brain injuries (as in the case of Phineas Gage) [9] and improving brain injury treatment. [10] [11]

Following a series of meetings, the International Consortium for Brain Mapping (ICBM) evolved. [12] [ page needed ] The ultimate goal is to develop flexible computational brain atlases.

Achievements

The Eyewire Museum is an interactive digital catalog visualizing data of mouse retinal cells. [13]

The interactive and citizen science website Eyewire maps mices' retinal cells and was launched in 2012. In 2021, the most comprehensive 3D map of the human brain was published by researchers at Google. It shows neurons and their connections along with blood vessels and other components of a millionth of a brain. For the map, the 1 mm³ sized fragment was sliced into about 5,300 pieces of about 30 nanometer thickness which were then each scanned with an electron microscope. The interactive map required 1.4 petabytes of storage-space. [14] [15] About two months later, scientists reported that they created the first complete neuron-level-resolution 3D map of a monkey brain which they scanned via a new method within 100 hours. They made only a fraction of the 3D map publicly available as the entire map takes more than 1 petabyte of storage space even when compressed. [16] [17]

In October 2021, the BRAIN Initiative Cell Census Network concluded the first phase of a long-term project to generate an atlas of the entire mouse (mammalian) brain with 17 studies, including an atlas and census of cell types in the primary motor cortex. [18] [19] [20]

In 2024, FlyWire, a team of 287 researchers spanning 76 institutions completed a brain mapping, or connectome, of an adult animal (a Drosophila melanogaster , or fruit fly) and published their results in Nature . [1] Prior to this, the only adult animal to have its brain entirely reconstructed was the nematode Caenorhabditis elegans , but the fruit fly brain map is the first "complete map of any complex brain", according to Murthy, one of the researchers involved. [2] Primary mapping data was collected through electron microscopy, assisted by artificial intelligence and citizen scientists, who corrected errors that artificial intelligence made. The resulting model had more than 140,000 neurons with over 50 million synapses. [21] From the model, research expect to identify how the brain creates new connections for functions such as vision, creating digital twin equivalents to track how segments of the neuron connection map interact to external signals, including the nervous system. [22]

Brain development

In 2021, the first connectome that shows how an animal's brain changes throughout its lifetime was reported. Scientists mapped and compared the whole brains of eight isogenic C. elegans worms, each at a different stage of development. [23] [24] Later that year, scientists combined electron microscopy and brainbow imaging to show for the first time the development of a mammalian neural circuit. They reported the complete wiring diagrams between the CNS and muscles of ten individual mice. [25]

Vision

In August 2021, scientists of the MICrONS program, launched in 2016, [26] published a functional connectomics dataset that "contains calcium imaging of an estimated 75,000 neurons from primary visual cortex (VISp) and three higher visual areas (VISrl, VISal and VISlm), that were recorded while a mouse viewed natural movies and parametric stimuli". [27] [28] Based on this data they also published "interactive visualizations of anatomical and functional data that span all 6 layers of mouse primary visual cortex and 3 higher visual areas (LM, AL, RL) within a cubic millimeter volume" – the MICrONS Explorer. [29]

Brain regeneration

In 2022, a first spatiotemporal cellular atlas of the axolotl brain development and regeneration, the interactive Axolotl Regenerative Telencephalon Interpretation via Spatiotemporal Transcriptomic Atlas , revealed key insights about axolotl brain regeneration. [30] [31]

Current atlas tools

See also

Related Research Articles

<span class="mw-page-title-main">Cerebral cortex</span> Outer layer of the cerebrum of the mammalian brain

The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. It is the largest site of neural integration in the central nervous system, and plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is the part of the brain responsible for cognition.

The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology to describe and provide insight into the cellular and molecular mechanisms by which complex nervous systems develop, from nematodes and fruit flies to mammals.

<span class="mw-page-title-main">Claustrum</span> Structure in the brain

The claustrum is a thin sheet of neurons and supporting glial cells, that connects to the cerebral cortex and subcortical regions including the amygdala, hippocampus and thalamus of the brain. It is located between the insular cortex laterally and the putamen medially, encased by the extreme and external capsules respectively. Blood to the claustrum is supplied by the middle cerebral artery. It is considered to be the most densely connected structure in the brain, and thus hypothesized to allow for the integration of various cortical inputs such as vision, sound and touch, into one experience. Other hypotheses suggest that the claustrum plays a role in salience processing, to direct attention towards the most behaviorally relevant stimuli amongst the background noise. The claustrum is difficult to study given the limited number of individuals with claustral lesions and the poor resolution of neuroimaging.

<span class="mw-page-title-main">Cortical minicolumn</span>

A cortical minicolumn (also called cortical microcolumn) is a vertical column through the cortical layers of the brain. Neurons within the microcolumn "receive common inputs, have common outputs, are interconnected, and may well constitute a fundamental computational unit of the cerebral cortex". Minicolumns comprise perhaps 80–120 neurons, except in the primate primary visual cortex (V1), where there are typically more than twice the number. There are about 2×108 minicolumns in humans. From calculations, the diameter of a minicolumn is about 28–40 μm. Minicolumns grow from progenitor cells within the embryo and contain neurons within multiple layers (2–6) of the cortex.

<span class="mw-page-title-main">FreeSurfer</span> Brain imaging software package

FreeSurfer is brain imaging software originally developed by Bruce Fischl, Anders Dale, Martin Sereno, and Doug Greve. Development and maintenance of FreeSurfer is now the primary responsibility of the Laboratory for Computational Neuroimaging at the Athinoula A. Martinos Center for Biomedical Imaging. FreeSurfer contains a set of programs with a common focus of analyzing magnetic resonance imaging (MRI) scans of brain tissue. It is an important tool in functional brain mapping and contains tools to conduct both volume based and surface based analysis. FreeSurfer includes tools for the reconstruction of topologically correct and geometrically accurate models of both the gray/white and pial surfaces, for measuring cortical thickness, surface area and folding, and for computing inter-subject registration based on the pattern of cortical folds.

In neuroanatomy, topographic map is the ordered projection of a sensory surface or an effector system to one or more structures of the central nervous system. Topographic maps can be found in all sensory systems and in many motor systems.

<span class="mw-page-title-main">Connectome</span> Comprehensive map of neural connections in the brain

A connectome is a comprehensive map of neural connections in the brain, and may be thought of as its "wiring diagram". An organism's nervous system is made up of neurons which communicate through synapses. A connectome is constructed by tracing the neuron in a nervous system and mapping where neurons are connected through synapses.

Connectomics is the production and study of connectomes: comprehensive maps of connections within an organism's nervous system. More generally, it can be thought of as the study of neuronal wiring diagrams with a focus on how structural connectivity, individual synapses, cellular morphology, and cellular ultrastructure contribute to the make up of a network. The nervous system is a network made of billions of connections and these connections are responsible for our thoughts, emotions, actions, memories, function and dysfunction. Therefore, the study of connectomics aims to advance our understanding of mental health and cognition by understanding how cells in the nervous system are connected and communicate. Because these structures are extremely complex, methods within this field use a high-throughput application of functional and structural neural imaging, most commonly magnetic resonance imaging (MRI), electron microscopy, and histological techniques in order to increase the speed, efficiency, and resolution of these nervous system maps. To date, tens of large scale datasets have been collected spanning the nervous system including the various areas of cortex, cerebellum, the retina, the peripheral nervous system and neuromuscular junctions.

Gyrification is the process of forming the characteristic folds of the cerebral cortex.

The Human Connectome Project (HCP) is a five-year project sponsored by sixteen components of the National Institutes of Health, split between two consortia of research institutions. The project was launched in July 2009 as the first of three Grand Challenges of the NIH's Blueprint for Neuroscience Research. On September 15, 2010, the NIH announced that it would award two grants: $30 million over five years to a consortium led by Washington University in St. Louis and the University of Minnesota, with strong contributions from University of Oxford (FMRIB) and $8.5 million over three years to a consortium led by Harvard University, Massachusetts General Hospital and the University of California Los Angeles.

<span class="mw-page-title-main">Resting state fMRI</span> Type of functional magnetic resonance imaging

Resting state fMRI is a method of functional magnetic resonance imaging (fMRI) that is used in brain mapping to evaluate regional interactions that occur in a resting or task-negative state, when an explicit task is not being performed. A number of resting-state brain networks have been identified, one of which is the default mode network. These brain networks are observed through changes in blood flow in the brain which creates what is referred to as a blood-oxygen-level dependent (BOLD) signal that can be measured using fMRI.

The following outline is provided as an overview of and topical guide to brain mapping:

Connectograms are graphical representations of connectomics, the field of study dedicated to mapping and interpreting all of the white matter fiber connections in the human brain. These circular graphs based on diffusion MRI data utilize graph theory to demonstrate the white matter connections and cortical characteristics for single structures, single subjects, or populations.

A Drosophila connectome is a list of neurons in the Drosophila melanogaster nervous system, and the chemical synapses between them. The fly's nervous system consists of the brain plus the ventral nerve cord, and both are known to differ considerably between male and female. Dense connectomes have been completed for the female adult brain, the male nerve cord, and the female larval stage. The available connectomes show only chemical synapses - other forms of inter-neuron communication such as gap junctions or neuromodulators are not represented. Drosophila is the most complex creature with a connectome, which had only been previously obtained for three other simpler organisms, first C. elegans. The connectomes have been obtained by the methods of neural circuit reconstruction, which over the course of many years worked up through various subsets of the fly brain to the almost full connectomes that exist today.

A brain atlas is composed of serial sections along different anatomical planes of the healthy or diseased developing or adult animal or human brain where each relevant brain structure is assigned a number of coordinates to define its outline or volume. Brain atlases are contiguous, comprehensive results of visual brain mapping and may include anatomical, genetic or functional features. A functional brain atlas is made up of regions of interest, where these regions are typically defined as spatially contiguous and functionally coherent patches of gray matter.

Neural circuit reconstruction is the reconstruction of the detailed circuitry of the nervous system of an animal. It is sometimes called EM reconstruction since the main method used is the electron microscope (EM). This field is a close relative of reverse engineering of human-made devices, and is part of the field of connectomics, which in turn is a sub-field of neuroanatomy.

The MICrONS program is a five-year project run by the United States government through the Intelligence Advanced Research Projects Activity (IARPA) with the goal of reverse engineering one cubic millimeter—spanning many petabytes of volumetric data—of a rodent's brain tissue and use insights from its study to improve machine learning and artificial intelligence by constructing a connectome. The program is part of the White House BRAIN Initiative.

Jeff W. Lichtman is an American neuroscientist. He is the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is best known for his pioneering work developing the neuroimaging connectomic technique known as Brainbow.

References

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