Anterior temporal lobectomy

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Anterior temporal lobectomy
ICD-9-CM 01.53
MeSH D038481

Anterior temporal lobectomy (ATL) is the complete or partial removal of the anterior portion of the temporal lobe of the brain. The exact boundaries for removal can vary slightly in practice and between neurosurgeons. [1] It is a treatment option for temporal lobe epilepsy for those in whom anticonvulsant medications do not control epileptic seizures, and who have frequent seizures, and who additionally qualify based on a WADA test to localize the dominant hemisphere for language module. [2]

Contents

Techniques

The techniques for removing temporal lobe tissue vary from resection of large amounts of tissue, including lateral temporal cortex along with medial structures, from using more restricted ATL to more restricted removal of only the medial structures (selective amygdalohippocampectomy). [3] [4]

Nearly all reports of seizure outcome following these procedures indicate that the best outcome group includes patients with MRI evidence of mesial temporal sclerosis (hippocampal atrophy with increased T-2 signal). The range of seizure-free outcomes for these patients is reported to be between 80% and 90%, which is typically reported as a sub-set of data within a larger surgical series. [5] [6]

Risks and complications

Open surgical procedures such as ATL have inherent risks including damage to the brain (either directly or indirectly by injury to important blood vessels), bleeding (which can require re-operation), blood loss (which can require transfusion), and infection. Furthermore, open procedures require several days of care in the hospital including at least one night in an intensive care unit. Although such treatment can be costly, multiple studies have demonstrated that ATL in patients who have failed at least two anticonvulsant drug trials (thereby meeting the criteria for medically intractable temporal lobe epilepsy) has lower mortality, lower morbidity and lower long-term cost in comparison with continued medical therapy without surgical intervention. [7]

The strongest evidence supporting ATL over continued medical therapy for medically refractory temporal lobe epilepsy is a prospective, randomized trial of ATL compared to best medical therapy (anticonvulsants), which convincingly demonstrated that the seizure-free rate after surgery was about 60% as compared to only 8% for the medicine only group. [8] Furthermore, there was no mortality in the surgery group, while there was seizure-related mortality in the medical therapy group. Therefore, ATL is considered the standard of care for patients with medically intractable mesial temporal lobe epilepsy. [9]

Recovery

Recovery after ATL can take several weeks to months. Anti-seizure medications will be continued for several months after ATL. As it is an open surgery it takes time for the brain to heal. [10] Speech therapy, occupational therapy, etc. can help recovery. About 90% of people experience an improvement in seizures after temporal lobectomy. In mesial temporal lobe epilepsy, NAA (N-acetyl aspartate) has reduced concentration in epileptogenic hippocampus and contralateral hippocampus. In post-operative seizure free patients, NAA levels were significantly higher than post-operative non-seizure free patients and then returned to the normal level. [11]

History

ATL was popularised in the early 1980s and was found effective. [12]

Related Research Articles

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Henry Gustav Molaison, known widely as H.M., was an American who had a bilateral medial temporal lobectomy to surgically resect the anterior two thirds of his hippocampi, parahippocampal cortices, entorhinal cortices, piriform cortices, and amygdalae in an attempt to cure his epilepsy. Although the surgery was partially successful in controlling his epilepsy, a severe side effect was that he became unable to form new memories.

<span class="mw-page-title-main">Temporal lobe</span> One of the four lobes of the mammalian brain

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<span class="mw-page-title-main">Hippocampal sclerosis</span> Medical condition

Hippocampal sclerosis (HS) or mesial temporal sclerosis (MTS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus. Neuroimaging tests such as magnetic resonance imaging (MRI) and positron emission tomography (PET) may identify individuals with hippocampal sclerosis. Hippocampal sclerosis occurs in 3 distinct settings: mesial temporal lobe epilepsy, adult neurodegenerative disease and acute brain injury.

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<span class="mw-page-title-main">Electrocorticography</span>

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<span class="mw-page-title-main">Dysembryoplastic neuroepithelial tumour</span> Medical condition

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Epilepsy is a neurological condition of recurrent episodes of unprovoked epileptic seizures. A seizure is an abnormal neuronal brain activity that can cause intellectual, emotional, and social consequences. Epilepsy affects children and adults of all ages and races, it is one of the most common neurological disorders of the nervous system. As well as, this condition is more common among children than adults affecting about 6 out of 1000 US children that are between the age of 0 to 5 years old. The epileptic seizures can be of different types depending on the part of the brain that was affected, seizures are classified in 2 main types partial seizure or genralized seizure.

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References

  1. ↑ "Epilepsy surgery, Temporal lobectomy, Vagus Nerve Stimulation". Cincinnati Ohio Mayfield Brain & Spine. Retrieved 20 January 2022.
  2. ↑ "Wada Test". Epilepsy Foundation. Retrieved 20 January 2022.
  3. ↑ Bonilha, Leonardo; Yasuda, Clarissa Lin; Rorden, Chris; Li, Li M.; Tedeschi, Helder; de Oliveira, Evandro; Cendes, Fernando (March 2007). "Does resection of the medial temporal lobe improve the outcome of temporal lobe epilepsy surgery?". Epilepsia. 48 (3): 571–578. doi: 10.1111/j.1528-1167.2006.00958.x . ISSN   0013-9580. PMID   17326795. S2CID   25692616.
  4. ↑ "Anteromedial Temporal Lobectomy". Neurosurgical Atlas. Retrieved 20 January 2022.
  5. ↑ Engel J (March 1996). "Surgery for seizures". The New England Journal of Medicine. 334 (10): 647–652. doi:10.1056/nejm199603073341008. PMID   8592530.
  6. ↑ Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Shinnar S, Langfitt JT, Walczak TS, Pacia SV (September 2005). "Predicting long-term seizure outcome after resective epilepsy surgery: the multicenter study". Neurology. 65 (6): 912–918. doi:10.1212/01.wnl.0000176055.45774.71. PMID   16186534. S2CID   24280239.
  7. ↑ "anterior_temporal_lobectomy". Operative Neurosurgery. Retrieved 7 January 2022.
  8. ↑ Wiebe S, Blume WT, Girvin JP, Eliasziw M (August 2001). "A randomized, controlled trial of surgery for temporal-lobe epilepsy". The New England Journal of Medicine. 345 (5): 311–318. doi: 10.1056/NEJM200108023450501 . PMID   11484687. S2CID   31539171.
  9. ↑ Muzumdar, Dattatraya; Patil, Manoj; Goel, Atul; Ravat, Sangeeta; Sawant, Nina; Shah, Urvashi (1 December 2016). "Mesial temporal lobe epilepsy – An overview of surgical techniques". International Journal of Surgery. Epilepsy surgery for pharmacoresistant epilepsy. 36 (Pt B): 411–419. doi: 10.1016/j.ijsu.2016.10.027 . ISSN   1743-9191. PMID   27773861.
  10. ↑ "Recovery and Life After Surgery". Epilepsy Foundation. Retrieved 7 January 2022.
  11. ↑ Vermathen, P.; Ende, G.; Laxer, K. D.; Walker, J. A.; Knowlton, R. C.; Barbaro, N. M.; Matson, G. B.; Weiner, M. W. (27 August 2002). "Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS". Neurology. 59 (4): 633–636. doi:10.1212/wnl.59.4.633. ISSN   0028-3878. PMC   2753242 . PMID   12196667.
  12. ↑ Van Gompel, Jamie J.; Ottman, Ruth; Worrell, Gregory A.; Marsh, W. Richard; Wetjen, Nicholas M.; Cascino, Gregory D.; Meyer, Fredric B. (November 2012). "Use of Anterior Temporal Lobectomy for Epilepsy in a Community-Based Population". Archives of Neurology. 69 (11): 1476–1481. doi:10.1001/archneurol.2012.1200. ISSN   0003-9942. PMC   3526693 . PMID   22911042.
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