|Other names||VLA2001, VLA2101|
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Valneva COVID-19 vaccine, also known as the VLA2001and VLA2101, is a COVID-19 vaccine candidate developed by French biotechnology company Valneva SE in collaboration with American company Dynavax Technologies.
It is a whole-virus inactivated vaccine, grown in culture using the Vero cell line and inactivated with BPL. It also contains two adjuvants, alum and CpG 1018. It uses the same manufacturing technology as Valneva’s Ixiaro vaccine for Japanese encephalitis.
VLA2001 is currently undergoing a Phase I/II trial with 150 participants in the United Kingdom.[ needs update ] The trial was expected to be complete by 15 February 2021, with full reporting completed by August 2021. The trials are being supported by the UK National Institute for Health Research and four British universities.
On 21 April 2021, VLA2001 commenced Phase III trials with approximately 4,000 volunteers.In August 2021, New Zealand has been chosen for trialing on 300 adult volunteers due to low case numbers and slow vaccine rollout.
In September 2020, Valneva reached an agreement with Dynavax to help manufacture up to 100 million doses of vaccine in 2021 at its facility in Livingston, Scotland, and to provide up to 190 million doses over a 5-year period to the UK government.Due to government support, Valneva will progress immediately into Phase III trials and develop production capacity before the full evaluation of the Phase I/II trial, rather than the traditional slower sequential approach which has lower financial risk.
In September 2021, Valneva announced that the UK government had cancelled the vaccine order.
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Valneva SE is a French biotech company headquartered in Saint-Herblain, France, developing and commercializing vaccines for infectious diseases. It has manufacturing sites in Livingston, Scotland; Solna, Sweden and Vienna, Austria, with other offices in France, Canada and the United States.
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|Scholia has a profile for VLA2001 (Q104902499).|