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Butanvac embalagem.jpg
Packaging for the Brazilian version of NDV-HXP-S, ButanVac
Vaccine description
Target SARS-CoV-2
Vaccine type viral vector or inactivated
Clinical data
Trade names ButanVac (Brazil)
COVIVAC (Vietnam)
HXP-GPOVac (Thailand)
Patria (Mexico)
Other namesADAPTCOV
Routes of
Intramuscular, [1] Intranasal

NDV-HXP-S (known as ButanVac [2] [3] or ADAPTCOV [4] in Brazil, COVIVAC [5] in Vietnam, HXP-GPOVac [6] in Thailand, Patria [7] in Mexico) is a COVID-19 vaccine candidate developed by a team led by Jason McLellan at the University of Texas at Austin, [8] together with groups from the Icahn School of Medicine at Mount Sinai and the National Institute of Allergy and Infectious Diseases Vaccine Research Center, based on an improved spike protein central to its resilience and efficacy. [9]


The name NDV-HXP-S comes from the terms Newcastle disease virus, HexaPro, and spike protein. [10] [ failed verification ]


NDV-HXP-S uses the Newcastle disease virus as its viral vector or inactivated. [11]


Unlike vaccines such as Moderna's mRNA-1273, the Janssen vaccine, and Pfizer–BioNTech's tozinameran, which all require both specialized manufacturing facilities and also rare or expensive ingredients, NDV-HXP-S can be produced using chicken eggs in a fashion similar to flu vaccine production, making it especially important to and for middle- and low-income countries. [9] Those existing vaccines are based on the 2P spike, while NDV-HXP-S is further refined via the same process, resulting in a new spike called HexaPro; [12] the 2P spike contained two prolines compared with HexaPro's six. It is also more resistant to heat and chemicals than the original 2P spike; the vaccine can be stored at 2–8 °C. [10]



Its development was coordinated by the PATH Center for Vaccine Innovation and Access, and UT Austin and ISMMS have arranged royalty-free licensing agreements with labs and corporations in 80 countries. McLellan has noted that "the share of vaccines ['low- and middle-income countries' have] received so far is terrible". [9]

Clinical trials

Sao Paulo governor Joao Doria displaying Butanvac at a press conference on March 26, 2021. Joao Doria anuncia a Butanvac.jpg
São Paulo governor João Doria displaying Butanvac at a press conference on March 26, 2021.

As of April 2021 NDV-HXP-S is undergoing initial clinical trials in humans in at least four countries. In Brazil, on March 26, 2021, the Butantan Institute announced it would seek to begin clinical trials. Mexico-based Avimex plans to create an intranasal spray version of the vaccine. In Thailand the Government Pharmaceutical Organization is conducting a trial in coordination with Mahidol University. [13] [14] Reflecting the freedom offered by the ease of the manufacturing process, Thai health minister Anutin Charnvirakul referred to the vaccine as "produced by Thai people for Thai people". [9]

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