SARS-CoV-2 Eta variant

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Countries with confirmed cases of Eta variant as of 1 July 2021 (GISAID)
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1000+ confirmed sequences
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None or no data available Eta variant countries.svg
Countries with confirmed cases of Eta variant as of 1 July 2021 (GISAID)
Legend:
  1000+ confirmed sequences
  500–999 confirmed sequences
  100–499 confirmed sequences
  10–99 confirmed sequences
  2–9 confirmed sequences
  1 confirmed sequence
  None or no data available

The Eta variant is a variant of SARS-CoV-2, the virus that causes COVID-19. The Eta variant or lineage B.1.525, also called VUI-21FEB-03 (previously VUI-202102/03) by Public Health England (PHE) and formerly known as UK1188, 21D or 20A/S:484K, does not carry the same N501Y mutation found in Alpha, Beta and Gamma, but carries the same E484K-mutation as found in the Gamma, Zeta, and Beta variants, and also carries the same ΔH69/ΔV70 deletion (a deletion of the amino acids histidine and valine in positions 69 and 70) as found in Alpha, N439K variant (B.1.141 and B.1.258) and Y453F variant (Cluster 5). [1]

Contents

Eta differs from all other variants by having both the E484K-mutation and a new F888L mutation (a substitution of phenylalanine (F) with leucine (L) in the S2 domain of the spike protein). As of 5 March 2021, it had been detected in 23 countries. [2] [3] [4] It has also been reported in Mayotte, the overseas department/region of France. [2] The first cases were detected in December 2020 in the UK and Nigeria, and as of 15 February, it had occurred in the highest frequency among samples in the latter country. [4] As of 24 February, 56 cases were found in the UK. Denmark, which sequences all its COVID-19 cases, found 113 cases of this variant from January 14 to February 21, of which seven were directly related to foreign travels to Nigeria. [3]

UK experts are studying it to understand how much of a risk it could be. It is currently regarded as a "variant under investigation", but pending further study, it may become a "variant of concern". Prof Ravi Gupta, from the University of Cambridge spoke to the BBC and said lineage B.1.525 appeared to have "significant mutations" already seen in some of the other newer variants, which is partly reassuring as their likely effect is to some extent more predictable.

Under the simplified naming scheme proposed by the World Health Organization, lineage B.1.525 has been labelled variant Eta.

Statistics

Cases by country (Updated as of 27 August 2021) GISAID [6]
CountryConfirmed casesLast Reported Case
Flag of Canada (Pantone).svg Canada1,403
Flag of the United States.svg USA1,18411 June 2021
Flag of Germany.svg Germany73823 June 2021
Flag of France.svg France68608 June 2021
Flag of Denmark.svg Denmark61324 May 2021
Flag of the United Kingdom.svg United Kingdom51731 May 2021
Flag of Italy.svg Italy39722 June 2021
Flag of Nigeria.svg Nigeria25521 May 2021
Flag of India.svg India22131 May 2021
Flag of Spain.svg Spain17418 June 2021
Flag of Norway.svg Norway8109 May 2021
Flag of Belgium (civil).svg Belgium7422 June 2021
Flag of Ireland.svg Ireland7129 May 2021
Flag of Switzerland.svg  Switzerland5513 June 2021
Flag of the Netherlands.svg Netherlands5431 May 2021
Flag of Luxembourg.svg Luxembourg5220 May 2021
Flag of Slovenia.svg Slovenia5208 April 2021
Flag of Turkey.svg Turkey4731 March 2021
Flag of Ghana.svg Ghana3804 April 2021
Flag of Uganda.svg Uganda3712 May 2021
Flag of South Sudan.svg South Sudan3603 April 2021
Flag of Finland.svg Finland2509 April 2021
Flag of Togo.svg Togo2525 February 2021
Flag of Portugal.svg Portugal2411 June 2021
Flag of Bangladesh.svg Bangladesh1815 June 2021
Flag of Austria.svg Austria1730 April 2021
Flag of Israel.svg Israel1718 May 2021
Flag of Japan.svg Japan1702 June 2021
Flag of Australia (converted).svg Australia1531 May 2021
Flag of Kenya.svg Kenya1330 April 2021
Flag of Malta.svg Malta1321 June 2021
Flag of South Africa.svg South Africa1326 May 2021
Flag of Cote d'Ivoire.svg Cote d'Ivoire1025 February 2021
Flag of Poland.svg Poland1014 March 2021
Flag of Singapore.svg Singapore1027 April 2021
Flag of Sweden.svg Sweden814 April 2021
Flag of Angola.svg Angola716 April 2021
Flag of Cameroon.svg Cameroon702 March 2021
Flag of Niger.svg Niger601 April 2021
Flag of the Philippines.svg Philippines624 March 2021
Flag of Guinea.svg Guinea5
Flag of Indonesia.svg Indonesia505 May 2021
Flag of Kuwait.svg Kuwait505 June 2021
Flag of Rwanda.svg Rwanda528 January 2021
Flag of Costa Rica.svg Costa Rica428 March 2021
Flag of France.svg Reunion425 May 2021
Flag of Malaysia.svg Malaysia327 March 2021
Flag of Mali.svg Mali304 April 2021
Flag of Greece.svg Greece209 April 2021
Flag of France.svg Guadeloupe211 March 2021
Flag of Jordan.svg Jordan207 January 2021
Flag of France.svg Mayotte229 March 2021
Flag of Qatar.svg Qatar215 April 2021
Flag of Russia.svg Russia211 May 2021
Flag of South Korea.svg South Korea226 February 2021
Flag of Thailand.svg Thailand201 March 2021
Flag of Argentina.svg Argentina104 May 2021
Flag of Belarus.svg Belarus122 March 2021
Flag of Brazil.svg Brazil115 February 2021
Flag of Estonia.svg Estonia129 March 2021
Flag of Gabon.svg Gabon130 March 2021
Flag of The Gambia.svg Gambia1
Flag of Latvia.svg Latvia126 April 2021
Flag of Morocco.svg Morocco102 March 2021
Flag of Senegal.svg Senegal111 May 2021
Flag of Sri Lanka.svg Sri Lanka128 April 2021
Flag of Tunisia.svg Tunisia105 March 2021
Flag of Armenia.svg Armenia35 August 2021
Flag of Bhutan.svg Bhutan1
Flag of Gibraltar.svg Gibraltar2
Flag of Kyrgyzstan.svg Kyrgyzstan1617 June 2021
World (71 countries)Total: 7,129Total as of 27 August 2021

See also

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References

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  4. 1 2 "B.1.525". cov-lineages.org. Pango team. Retrieved March 22, 2021.
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