The Strategic Advisory Group of Experts (SAGE) is the principal advisory group to World Health Organization (WHO) for vaccines and immunization. Established in 1999 through the merging of two previous committees, notably the Scientific Advisory Group of Experts (which served the Program for Vaccine Development) and the Global Advisory Group (which served the EPI program) by Director-General of the WHO Gro Harlem Brundtland. It is charged with advising WHO on overall global policies and strategies, ranging from vaccines and biotechnology, research and development, to delivery of immunization and its linkages with other health interventions. [1] SAGE is concerned not just with childhood vaccines and immunization, but all vaccine-preventable diseases. [2] SAGE provide global recommendations on immunization policy and such recommendations will be further translated by advisory committee at the country level. [3]
The SAGE has 15 members, who are recruited and selected as acknowledged experts from around the world in the fields of epidemiology, public health, vaccinology, paediatrics, internal medicine, infectious diseases, immunology, drug regulation, programme management, immunization delivery, health-care administration, health economics, and vaccine safety. [4] Members are appointed by Director-General of the WHO to serve an initial term of 3 years, and can only be renewed once. [1]
SAGE meets at least twice annually in April and November, with working groups established for detailed review of specific topics prior to discussion by the full group. Priorities of work and meeting agendas are developed by the Group in consultation with WHO. [5]
UNICEF, the Secretariat of the GAVI Alliance, and WHO Regional Offices participate as observers in SAGE meetings and deliberations. WHO also invites other observers to SAGE meetings, including representatives from WHO regional technical advisory groups, non-governmental organizations, international professional organizations, technical agencies, donor organizations and associations of manufacturers of vaccines and immunization technologies. Additional experts may be invited, as appropriate, to further contribute to specific agenda items. [1] [5]
As of December 2022, working groups were established for the following vaccines: [5]
The Advisory Committee on Immunization Practices (ACIP) is a committee within the United States Centers for Disease Control and Prevention (CDC) that provides advice and guidance on effective control of vaccine-preventable diseases in the U.S. civilian population. The ACIP develops written recommendations for routine administration of vaccines to the pediatric and adult populations, along with vaccination schedules regarding appropriate timing, dosage, and contraindications of vaccines. ACIP statements are official federal recommendations for the use of vaccines and immune globulins in the U.S., and are published by the CDC.
The Joint Committee on Vaccination and Immunisation (JCVI) is an independent expert advisory committee that advises United Kingdom health departments on immunisation, making recommendations concerning vaccination schedules and vaccine safety. It has a statutory role in England and Wales, and health departments in Scotland and Northern Ireland may choose to accept its advice.
Serum Institute of India (SII) is an Indian biotechnology and biopharmaceuticals company, based in Pune. It is the world's largest manufacturer of vaccines. It was founded by Cyrus Poonawalla in 1966 and is a part of Cyrus Poonawalla Group.
A vaccination policy is a health policy adopted in order to prevent the spread of infectious disease. These policies are generally put into place by State or local governments, but may also be set by private facilities, such as workplaces or schools. Many policies have been developed and implemented since vaccines were first made widely available.
Jean Marie Okwo-Bele is a Congolese physician, public health expert and former Director of the Department of Immunization, Vaccines and Biologicals of the World Health Organization (WHO).
Yellow fever vaccine is a vaccine that protects against yellow fever. Yellow fever is a viral infection that occurs in Africa and South America. Most people begin to develop immunity within ten days of vaccination and 99% are protected within one month, and this appears to be lifelong. The vaccine can be used to control outbreaks of disease. It is given either by injection into a muscle or just under the skin.
In 2012, life expectancy at birth in Spain reached 82.5 years, one of the highest among OECD countries and more than two years higher than the OECD average. Only Japan, Iceland and Switzerland had a higher life expectancy than Spain in 2012. The top three causes of death since 1970 have been cardiovascular diseases, cancer and respiratory diseases.
Universal Immunisation Programme (UIP) is a vaccination programme launched by the Government of India in 1985. It became a part of Child Survival and Safe Motherhood Programme in 1992 and is currently one of the key areas under the National Health Mission since 2005. The programme now consists of vaccination for 12 diseases- tuberculosis, diphtheria, pertussis, tetanus, poliomyelitis, measles, hepatitis B, rotaviral gastroenteritis, Japanese encephalitis, rubella, pneumonia and Pneumococcal diseases. Hepatitis B and Pneumococcal diseases were added to the UIP in 2007 and 2017 respectively. The cost of all the vaccines are borne entirely by the Government of India and is funded through taxes with a budget of ₹7,234 crore (US$910 million) in 2022 and the program covers all residents of India, including foreign residents.
GAVI, officially Gavi, the Vaccine Alliance is a public–private global health partnership with the goal of increasing access to immunization in poor countries. In 2016, Gavi channeled more than half of total donor assistance for health, and most donor assistance for immunization, by monetary measure.
Professor Helen Rees OBE GCOB D.Sc. Medicine LLD is a medical doctor, and the founder and executive director of Wits RHI, the largest research Institute at the University of the Witwatersrand in Johannesburg, South Africa. She is a Personal Professor in the University of Witwatersrand's Department of Obstetrics and Gynaecology, co-director and co-founder of the Wits African Leadership in Vaccinology Expertise (ALIVE), Honorary Professor in the Department of Clinical Research at the London School of Hygiene and Tropical Medicine and an Honorary Fellow at Cambridge University's Murray Edwards College, UK.
National Immunization Technical Advisory Group (NITAG) is an advisory committee consisting of multidisciplinary groups of experts responsible for providing information to national governments that is used to make evidence-based decisions regarding vaccine and immunization policy. The majority of industrialized and some developing countries have formally established advisory committees to guide immunization policies; other countries are working towards establishment of such committees.
The Standing Committee on Vaccination at the Robert Koch Institute, or STIKO, is a scientific committee comprising 18 members at the Robert Koch Institute in Berlin, Germany that provides official recommendations for the vaccination schedules used by the individual German states. The committee meets twice yearly to review the latest research regarding vaccination against infectious diseases. Although the STIKO makes recommendations, immunization in Germany is voluntary and there are no official government recommendations. German Federal States typically follow the STIKO's recommendations minimally, although each state can make recommendations for their geographic jurisdiction that extends beyond the recommended list. In addition to the proposed immunization schedule for children and adults, the STIKO recommends vaccinations for occupational groups, police, travelers, and other at risk groups.
Vaccine Safety Net (VSN) is a global network of websites aimed at helping people judge the quality of online information on vaccine safety. It was established in 2003 by the World Health Organization (WHO), which had previously set up the independent Global Advisory Committee on Vaccine Safety (GACVS), prompted by concern from public health officials regarding the dissemination of potentially harmful health information via the web. By appraising websites, using credibility and content criteria defined by GACVS, the VSN has been developed to deliver information that is easy to access and up-to-date. As of 2020, the initiative has 89 member sites in 40 countries and 35 languages.
The Global Advisory Committee on Vaccine Safety (GACVS) is a group of experts that provides independent and authoritative guidance to the World Health Organization (WHO) on the topic of safe vaccine use.
Folake Olayinka, physician and global health leader. Since October 2020, she has served as the United States Agency for International Development's (USAID) Global Immunization lead/STAR Fellow. She also served as Technical and Strategy lead for the COVID19 Vaccine Access and Delivery Initiative Washington DC, United States.
Adam Hugh Roderick Finn is professor of paediatrics at the University of Bristol and head of the Bristol Children's Vaccine Centre. He has been chairman of the World Health Organization (WHO) European Technical Advisory Group of Experts (ETAGE) on Immunization since 2011 and is an ex-officio member of the WHO Strategic Advisory Group of Experts.
The National Advisory Committee on Immunization is an advisory body that provides the Government of Canada with medical and scientific advice relating to human immunization.
Dr. Shelley Deeks, MD, MHSc, FRCPC, FFAFPM, is a Canadian public health expert who is the chair of the National Advisory Committee on Immunization. Her advertised "specialities include communicable disease control, outbreak investigations, vaccine safety, epidemiology and program evaluation." She is a fellow of the Royal College of Physicians of Canada and the Australian Faculty of Public Health Medicine. Deeks was the executive lead in Ontario's COVID-19 pandemic response in 2020 in her role at Public Health Ontario.
The Australian Technical Advisory Group on Immunisation (ATAGI) is a technical advisory group of the Australian Government. As part of the Department of Health, ATAGI provides advice to the Minister of Health on the immunisation program of Australia and related matters, including the strength of evidence pertaining to existing, new, and emerging vaccines.
Julie Leask or Julie-Anne Leask is an Australian social scientist and professor in the Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, University of Sydney. Leask is a leading researcher on social and behavioural aspects of vaccination and infectious disease prevention. Leask’s research focuses on vaccine uptake, communication, strengthening vaccination programs and policy. Leask’s flagship project is Sharing Knowledge About Immunisation (SKAI) - a vaccination communication package designed to improve vaccination conversations between parents and health care workers. Additionally, Leask is an advisor to the World Health Organization (WHO) on vaccine acceptance and demand issues and was the chair of the WHO Measuring Behavioural and Social Drivers of Vaccination working group (2018-2022).