Enteric glia

Last updated
Enteric glia
Enteric Glial Cells in Immunological Disorders of the Gut - Fig 1.jpg
Anatomical terminology

The enteric glia,enteric glial cells or EGCs are a population of neuroglial cells that populate the enteric nervous system. [1]

These cells are one of the major neural-crest-derived cell lineages, found throughout the gastrointestinal tract. The enteric glial cells play a variety of roles, such as modulating nociception (pain sensation), exerting immune functions, and coordinating gastrointestinal motility. [1] [2] [3] They are the largest glial population outside the brain, and considered "a key node of the gut-brain axis". [4]

References

  1. 1 2 Liu, Chang; Yang, Jing (2022-04-28). "Enteric Glial Cells in Immunological Disorders of the Gut". Frontiers in Cellular Neuroscience. 16. doi: 10.3389/fncel.2022.895871 . ISSN   1662-5102. PMC   9095930 . PMID   35573829.
  2. Morales-Soto, Wilmarie; Gonzales, Jacques; Jackson, William F.; Gulbransen, Brian D. (2023-11-21). "Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors". Science Signaling. 16 (812): eadg1668. doi:10.1126/scisignal.adg1668. ISSN   1945-0877. PMC   10733972 . PMID   37988454.
  3. Scavuzzo, Marissa A.; Letai, Katherine C.; Maeno-Hikichi, Yuka; Wulftange, William J.; Shah, Isha K.; Rameshbabu, Jeyashri S.; Tomar, Alka; Shick, H. Elizabeth; Shah, Aakash K.; Xiong, Ying; Cohn, Erin F.; Allan, Kevin C.; Tesar, Paul J. (2023-06-09). "Enteric glial hub cells coordinate intestinal motility". bioRxiv: 2023.06.07.544052. doi:10.1101/2023.06.07.544052. PMC   10274798 . PMID   37333182.
  4. Rosenberg, Harry J.; Rao, Meenakshi (August 2021). "Enteric glia in homeostasis and disease: From fundamental biology to human pathology". iScience. 24 (8): 102863. Bibcode:2021iSci...24j2863R. doi:10.1016/j.isci.2021.102863. ISSN   2589-0042. PMC   8348155 . PMID   34401661.