Erika Crouch

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Erika Crouch is a professor of pathology and the Carol B. and Jerome T. Loeb Professor of Medical Education at Washington University in St. Louis.

Contents

Early life and education

Crouch received her B.S. from Washington State University in 1972. [1] Crouch earned her Ph.D. in 1978 and then her M.D. in 1979, both from the University of Washington. She was a postdoctoral fellow and then a resident in anatomic pathology at the University of Washington. She completed a fellowship in pulmonary pathology at the University of British Columbia as a Parker B. Francis Fellow. [2] In 1983 Crouch joined the Washington University School of Medicine faculty, and as of 2024 she is the Carol B. and Jerome T. Loeb Professor of Medical Education. [3]

Career and research

Crouch is known for her research in collectins, a carbohydrate binding protein that is involved in the immune system. [4] She identified CP4, a novel secreted collagenous protein, [5] and went on to determine its molecular structure. [6] Working with John Heuser, she examined a surfactant protein, SP-D, [7] [8] and researched the interactions between SP-D and influenza A virus. [9] She has also used structure-function analysis via crystallographic analysis and site-directed mutagenesis. [10]

Publications

References

  1. "Erika Crouch | Medical Scientist Training Program" . Retrieved 2024-05-22.
  2. "Erika Crouch and SP-D | Erika Crouch Lab". wupathlabs.wustl.edu. Retrieved 2023-02-28.
  3. "Erika Crouch, MD, PhD | Pathology & Immunology | Washington University in St. Louis". pathology.wustl.edu. Retrieved 2023-02-28.
  4. Crouch, Erika C. (1998-08-01). "Collectins and Pulmonary Host Defense" . American Journal of Respiratory Cell and Molecular Biology. 19 (2): 177–201. doi:10.1165/ajrcmb.19.2.140. ISSN   1044-1549. PMID   9698590.
  5. Persson, Anders; Rust, Kevin; Chang, Donald; Moxley, Michael; Longmore, William; Crouch, Edmound (1988-11-15). "CP4: a pneumocyte-derived collagenous surfactant-associated protein. Evidence for heterogeneity of collagenous surfactant proteins" . Biochemistry. 27 (23): 8576–8584. doi:10.1021/bi00423a011. ISSN   0006-2960. PMID   3219363.
  6. Crouch, E.; Persson, A.; Chang, D.; Heuser, J. (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". Journal of Biological Chemistry. 269 (25): 17311–17319. doi: 10.1016/s0021-9258(17)32556-5 . ISSN   0021-9258. PMID   8006040.
  7. Crouch, Erika C. (1998-11-19). "Structure, biologic properties, and expression of surfactant protein D (SP-D)". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1408 (2): 278–289. doi:10.1016/S0925-4439(98)00073-8. ISSN   0925-4439.
  8. Hanson, Phyllis I.; Stahl, Philip D. (2004). "From the neuromuscular junction to cellular architecture and beyond – commentary on 30 years of imaging by John E. Heuser" . European Journal of Cell Biology. 83 (6): 229–242. doi:10.1078/0171-9335-00398. ISSN   0171-9335. PMID   15511079.
  9. Hartshorn, K L; Crouch, E C; White, M R; Eggleton, P; Tauber, A I; Chang, D; Sastry, K (1994-07-01). "Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses". Journal of Clinical Investigation. 94 (1): 311–319. doi:10.1172/JCI117323. ISSN   0021-9738. PMC   296311 . PMID   8040272.
  10. Seaton, Barbara A.; Crouch, Erika C.; McCormack, Francis X.; Head, James F.; Hartshorn, Kevan L.; Mendelsohn, Richard (2010). "Review: Structural determinants of pattern recognition by lung collectins". Innate Immunity. 16 (3): 143–150. doi:10.1177/1753425910368716. ISSN   1753-4259. PMID   20423923.