Eriko Takano

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Eriko Takano
Eriko Takano for Institut des Hautes Etudes Scientifiques.jpg
Eriko Takano lectures for the Institut des Hautes Études Scientifiques in 2015
Alma mater Kitasato University (BSc)
University of East Anglia (PhD)
Known for Synthetic Biology
Scientific career
Institutions University of East Anglia
University of Manchester
University of Tübingen
University of Groningen
Thesis ppGpp and antibiotic production in Streptomyces coelicolor A3(2)  (1993)
Website www.research.manchester.ac.uk/portal/eriko.takano.html

Eriko Takano is a professor of synthetic biology and a director of the Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM) at the University of Manchester. [1] [2] She develops antibiotics and other high-value chemicals using microbial synthetic biology tools.

Contents

Early life and education

Takano was born in Japan. [3] She studied pharmacy at Kitasato University and graduated in 1985. [3] After graduating she worked as a researcher in the Meiji Seika Kaisha Department of Genetics. She moved to the United Kingdom for her graduate studies, where she joined the John Innes Centre. [3] In 1994 she earned her PhD at the University of East Anglia, [4] and she was appointed a postdoctoral researcher in the molecular biology department. [3]

Research and career

In 2002 Takano was appointed an assistant professor in the Department of Microbiology at University of Tübingen. Here she worked on the γ-butyrolactone molecules that act to regulate antibiotic production and morphological differentiation in Streptomyces . [5] She was made a Rosalind Franklin Fellow at the University of Groningen in 2006 and promoted to associate professor in 2010. [3]

In 2012 Takano was made Professor of Synthetic Biology at the University of Manchester. She leads the biotechnology theme in the Faculty of Life Sciences. Her research considers synthetic biology for the production of antibiotics, as well as the development of software for bioinformatics that can design natural products. [3] [6] [7] Her software contributions includes antiSMASH [8] and MultiGeneBlast. [9] These can include the secondary biosynthetic pathways that have been identified from any genome sequence. [10] Genome sequencing offers new opportunities to find production pathways for antibiotics. [11] Takano is developing robotic systems to explore the potential biosynthetic pathways, testing thousands of new compounds every year. [11] [12]

Takano is a director of the European Centre of Excellence Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM). [13] In 2015 Vince Cable announced a £10 million investment into Synthetic Biology to the Manchester Institute of Biotechnology, University of Manchester. [14]

Awards and honours

Her awards and honours include;

Selected publications

Her publications [1] include;

References

  1. 1 2 Eriko Takano publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  2. ↑ Eriko Takano publications from Europe PubMed Central
  3. 1 2 3 4 5 6 7 8 9 "Prof Eriko Takano PhD | The University of Manchester". www.research.manchester.ac.uk. Retrieved 2019-09-04.
  4. ↑ Takano, Eriko (1993). ppGpp and antibiotic production in Streptomyces coelicolor A3(2) (PhD thesis). University of East Anglia. OCLC   557313992. EThOS   uk.bl.ethos.359366.
  5. ↑ Takano, Eriko (2006). "γ-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation". Current Opinion in Microbiology. 9 (3): 287–294. doi:10.1016/j.mib.2006.04.003. hdl: 11370/1a6bd16d-2b68-4255-bb68-517489183d4c . ISSN   1369-5274. PMID   16675291.
  6. ↑ "Synthetic Biology for the Development of New Antibiotics". iBiology. Retrieved 2019-09-04.
  7. ↑ Breitling, Rainer; Takano, Eriko; Yan, Cunyu; Swainston, Neil; W. Rattray, Nicholas J.; J. Jervis, Adrian; Currin, Andrew; Carbonell, Pablo (2016). "Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle". Natural Product Reports. 33 (8): 925–932. doi:10.1039/C6NP00018E. PMC   5063057 . PMID   27185383.
  8. 1 2 Tanako, Eriko (2015). "antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters". Nucleic Acids Research. 43 (W1): W237 –W243. doi:10.1093/nar/gkv437. PMC   4489286 . PMID   25948579.
  9. ↑ Medema, Marnix H.; Takano, Eriko; Breitling, Rainer (2013-02-14). "Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast". Molecular Biology and Evolution. 30 (5): 1218–1223. doi:10.1093/molbev/mst025. ISSN   1537-1719. PMC   3670737 . PMID   23412913.
  10. ↑ Takano, Eriko; Roel Bovenberg; Breitling, Rainer; Medema, Marnix H. (2011). "Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms". Nature Reviews Microbiology. 9 (2): 131–137. doi:10.1038/nrmicro2478. ISSN   1740-1534. PMID   21189477. S2CID   28455490.
  11. 1 2 "How robots could solve the antibiotics production crisis". How robots could solve the antibiotics production crisis. Retrieved 2019-09-04.
  12. ↑ "MANCHESTER EVENING NEWS: Could Mancunian robots save humanity from superbugs? | Research Explorer | The University of Manchester". www.research.manchester.ac.uk. Retrieved 2019-09-04.
  13. ↑ "SYNBIOCHEM - About - Leadership" . Retrieved 2019-09-04.
  14. ↑ Vince Cable Announces £10m Investment At Manchester Uni, 29 January 2015, retrieved 2019-09-04
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