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Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or "knock out", genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome.
Safety engineering is an engineering discipline which assures that engineered systems provide acceptable levels of safety. It is strongly related to industrial engineering/systems engineering, and the subset system safety engineering. Safety engineering assures that a life-critical system behaves as needed, even when components fail.
Fault tree analysis (FTA) is a type of failure analysis in which an undesired state of a system is examined. This analysis method is mainly used in safety engineering and reliability engineering to understand how systems can fail, to identify the best ways to reduce risk and to determine event rates of a safety accident or a particular system level (functional) failure. FTA is used in the aerospace, nuclear power, chemical and process, pharmaceutical, petrochemical and other high-hazard industries; but is also used in fields as diverse as risk factor identification relating to social service system failure. FTA is also used in software engineering for debugging purposes and is closely related to cause-elimination technique used to detect bugs.
Risk assessment determines possible mishaps, their likelihood and consequences, and the tolerances for such events. The results of this process may be expressed in a quantitative or qualitative fashion. Risk assessment is an inherent part of a broader risk management strategy to help reduce any potential risk-related consequences.
A seismic hazard is the probability that an earthquake will occur in a given geographic area, within a given window of time, and with ground motion intensity exceeding a given threshold. With a hazard thus estimated, risk can be assessed and included in such areas as building codes for standard buildings, designing larger buildings and infrastructure projects, land use planning and determining insurance rates. The seismic hazard studies also may generate two standard measures of anticipated ground motion, both confusingly abbreviated MCE; the simpler probabilistic Maximum Considered Earthquake, used in standard building codes, and the more detailed and deterministic Maximum Credible Earthquake incorporated in the design of larger buildings and civil infrastructure like dams or bridges. It is important to clarify which MCE is being discussed.
A safety-critical system (SCS) or life-critical system is a system whose failure or malfunction may result in one of the following outcomes:
In science and engineering, root cause analysis (RCA) is a method of problem solving used for identifying the root causes of faults or problems. It is widely used in IT operations, manufacturing, telecommunications, industrial process control, accident analysis, medicine, healthcare industry, etc. Root cause analysis is a form of deductive inference since it requires an understanding of the underlying causal mechanisms of the potential root causes and the problem.
Failure mode and effects analysis is the process of reviewing as many components, assemblies, and subsystems as possible to identify potential failure modes in a system and their causes and effects. For each component, the failure modes and their resulting effects on the rest of the system are recorded in a specific FMEA worksheet. There are numerous variations of such worksheets. An FMEA can be a qualitative analysis, but may be put on a quantitative basis when mathematical failure rate models are combined with a statistical failure mode ratio database. It was one of the first highly structured, systematic techniques for failure analysis. It was developed by reliability engineers in the late 1950s to study problems that might arise from malfunctions of military systems. An FMEA is often the first step of a system reliability study.
Induced seismicity is typically earthquakes and tremors that are caused by human activity that alters the stresses and strains on Earth's crust. Most induced seismicity is of a low magnitude. A few sites regularly have larger quakes, such as The Geysers geothermal plant in California which averaged two M4 events and 15 M3 events every year from 2004 to 2009. The Human-Induced Earthquake Database (HiQuake) documents all reported cases of induced seismicity proposed on scientific grounds and is the most complete compilation of its kind.
Reliability engineering is a sub-discipline of systems engineering that emphasizes the ability of equipment to function without failure. Reliability describes the ability of a system or component to function under stated conditions for a specified period of time. Reliability is closely related to availability, which is typically described as the ability of a component or system to function at a specified moment or interval of time.
Probabilistic risk assessment (PRA) is a systematic and comprehensive methodology to evaluate risks associated with a complex engineered technological entity or the effects of stressors on the environment.
A hazard analysis is used as the first step in a process used to assess risk. The result of a hazard analysis is the identification of different types of hazards. A hazard is a potential condition and exists or not. It may, in single existence or in combination with other hazards and conditions, become an actual Functional Failure or Accident (Mishap). The way this exactly happens in one particular sequence is called a scenario. This scenario has a probability of occurrence. Often a system has many potential failure scenarios. It also is assigned a classification, based on the worst case severity of the end condition. Risk is the combination of probability and severity. Preliminary risk levels can be provided in the hazard analysis. The validation, more precise prediction (verification) and acceptance of risk is determined in the risk assessment (analysis). The main goal of both is to provide the best selection of means of controlling or eliminating the risk. The term is used in several engineering specialties, including avionics, chemical process safety, safety engineering, reliability engineering and food safety.
ARP4761, Guidelines and Methods for Conducting the Safety Assessment Process on Civil Airborne Systems and Equipment is an Aerospace Recommended Practice from SAE International. In conjunction with ARP4754, ARP4761 is used to demonstrate compliance with 14 CFR 25.1309 in the U.S. Federal Aviation Administration (FAA) airworthiness regulations for transport category aircraft, and also harmonized international airworthiness regulations such as European Aviation Safety Agency (EASA) CS–25.1309.
Failure mode effects and criticality analysis (FMECA) is an extension of failure mode and effects analysis (FMEA).
The system safety concept calls for a risk management strategy based on identification, analysis of hazards and application of remedial controls using a systems-based approach. This is different from traditional safety strategies which rely on control of conditions and causes of an accident based either on the epidemiological analysis or as a result of investigation of individual past accidents. The concept of system safety is useful in demonstrating adequacy of technologies when difficulties are faced with probabilistic risk analysis. The underlying principle is one of synergy: a whole is more than sum of its parts. Systems-based approach to safety requires the application of scientific, technical and managerial skills to hazard identification, hazard analysis, and elimination, control, or management of hazards throughout the life-cycle of a system, program, project or an activity or a product. "Hazop" is one of several techniques available for identification of hazards.
A process hazard analysis (PHA) (or process hazard evaluation) is a set of organized and systematic assessments of the potential hazards associated with an industrial process. A PHA provides information intended to assist managers and employees in making decisions for improving safety and reducing the consequences of unwanted or unplanned releases of hazardous chemicals. A PHA is directed toward analyzing potential causes and consequences of fires, explosions, releases of toxic or flammable chemicals and major spills of hazardous chemicals, and it focuses on equipment, instrumentation, utilities, human actions, and external factors that might impact the process.
Event tree analysis (ETA) is a forward, top-down, logical modeling technique for both success and failure that explores responses through a single initiating event and lays a path for assessing probabilities of the outcomes and overall system analysis. This analysis technique is used to analyze the effects of functioning or failed systems given that an event has occurred.
A genetically modified tree is a tree whose DNA has been modified using genetic engineering techniques. In most cases the aim is to introduce a novel trait to the plant which does not occur naturally within the species. Examples include resistance to certain pests, diseases, environmental conditions, and herbicide tolerance, or the alteration of lignin levels in order to reduce pulping costs.
Vicki Marion Bier is an American systems engineer and decision analyst whose work concerns risk management, disaster preparedness, and critical infrastructure protection, including analysis of the safety of nuclear power, anti-terrorism, and preparedness for sea level rise caused by global warming. She is professor emerita of industrial and systems engineering at the University of Wisconsin–Madison, an external fellow in the Center for Risk and Economic Analysis of Terrorism Events at the University of Southern California, and editor-in-chief of the journal Decision Analysis.
A bow-tie diagram, when used in the field of pure risk, is a partial and simplified model of the process leading to adverse Consequences. A process model of this nature is of use in risk/safety science education and practice as the constituent terms can be defined objectively and comprehensively.
References
- National Research Council (US), Committee on Environmental Impacts Associated with Commercialization of Transgenic Plants, Board on Agriculture and Natural Resources, Division on Earth and Life Studies. (2002). Environmental Effects of Transgenic Plants: the Scope and Adequacy of Regulation. Washington, D.C.: National Academy Press. ISBN 9780309082631; OCLC 231950695
- Wang, John X. and Marvin L. Roush. (2000). What Every Engineer Should Know About Risk Engineering and Management. London: CRC Press. ISBN 9781420026962; OCLC 5030452
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