FOLFOXIRI is a chemotherapy regimen for the treatment of advanced colorectal cancer. [1] [2] [3] [4] [5] The role of FOLFOXIRI in colorectal cancer has been reviewed. [1] [6]
The chemotherapy regimen is made up of the following four drugs:
It is usually given with bevacizumab, [7] unlike FOLFIRINOX for treatment of advanced pancreatic cancer. Also, the doses (Day 1: irinotecan 165 mg/m2 IV, plus oxaliplatin 85 mg/m2 IV; Day 1: leucovorin 400 mg/m2; Days 1–3: fluorouracil 1,600 mg/m2/day × 2 days (total 3,200 mg/m2 over 48 hours) continuous infusion starting on day 1; Day 1: bevacizumab 5 mg/kg IV; repeat cycle every 2 weeks) [1] [8] [9] are slightly dissimilar to FOLFIRINOX.
Upfront FOLFOXIRI with bevacizumab can be followed by fluoropyrimidine with bevacizumab maintenance. [10]