Filter dryer

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Filter dryer

A filter drier is a piece of process equipment used during the filtration and drying phase of a pharmaceutical, bio pharmaceutical or chemical process for an active pharmaceutical ingredient (API) or other compounds production. Filter dryers are designed for washing and isolating solids with or without integrated containment systems. [1]

Several actions have to be undertaken as part of the filtration and drying process including:

An agitated nutsche filter dryer (ANFD) is one class of such filter dryers that has been specifically designed so all these operations can take place within one vessel.

A Turbo Filter-Dryer is another class of filter dryer which also incorporates the listed operations, but works on a different set of filtration principle. [3]

The ANFD class of filter dryer consists of a main insulated jacketed vessel and filtration base which can be lowered for inspection and replacement of the filter media. The vessel base is secured to the main vessel body via manually operated c-clamps or an automated bayonet locking system. The vessel is sealed with an O-ring sealing system utilizing FDA approved materials such as perfluoroelastomer. [4]

The charging of slurry, solvent or water is carried out via nozzles mounted in the head of the vessel and the filtration process is performed under pressure using nitrogen purge and vacuum from beneath the filter base.

Different manufacturers use different heating technology, ANFDs should have a heating jacket on the walls as standard, on the top dome if necessary and heated agitator shaft and blade options for direct contact with the cake if required. One method of drying is through direct under-plate heating systems that are located in the filter plate at the bottom of the vessel. [5]

Related Research Articles

<span class="mw-page-title-main">Filtration</span> Process that separates solids from fluids

Filtration is a physical separation process that separates solid matter and fluid from a mixture using a filter medium that has a complex structure through which only the fluid can pass. Solid particles that cannot pass through the filter medium are described as oversize and the fluid that passes through is called the filtrate. Oversize particles may form a filter cake on top of the filter and may also block the filter lattice, preventing the fluid phase from crossing the filter, known as blinding. The size of the largest particles that can successfully pass through a filter is called the effective pore size of that filter. The separation of solid and fluid is imperfect; solids will be contaminated with some fluid and filtrate will contain fine particles. Filtration occurs both in nature and in engineered systems; there are biological, geological, and industrial forms.

<span class="mw-page-title-main">Spray drying</span> Method of converting liquid or slurry to powder

Spray drying is a method of forming a dry powder from a liquid or slurry by rapidly drying with a hot gas. This is the preferred method of drying of many thermally-sensitive materials such as foods and pharmaceuticals, or materials which may require extremely consistent, fine particle size. Air is the heated drying medium; however, if the liquid is a flammable solvent such as ethanol or the product is oxygen-sensitive then nitrogen is used.

Microfiltration is a type of physical filtration process where a contaminated fluid is passed through a special pore-sized membrane filter to separate microorganisms and suspended particles from process liquid. It is commonly used in conjunction with various other separation processes such as ultrafiltration and reverse osmosis to provide a product stream which is free of undesired contaminants.

<span class="mw-page-title-main">Freeze drying</span> Low temperature dehydration process

Freeze drying, also known as lyophilization or cryodesiccation, is a low temperature dehydration process that involves freezing the product and lowering pressure, thereby removing the ice by sublimation. This is in contrast to dehydration by most conventional methods that evaporate water using heat.

<span class="mw-page-title-main">Air filter</span> Device composed of fibrous or porous materials which removes solid particulates from the air

A particulate air filter is a device composed of fibrous, or porous materials which removes particulates such as smoke, dust, pollen, mold, viruses and bacteria from the air. Filters containing an adsorbent or catalyst such as charcoal (carbon) may also remove odors and gaseous pollutants such as volatile organic compounds or ozone. Air filters are used in applications where air quality is important, notably in building ventilation systems and in engines.

<span class="mw-page-title-main">Rotary vacuum-drum filter</span> Drum used to filter a slurry

A Rotary Vacuum Filter Drum consists of a cylindrical filter membrane that is partly sub-merged in a slurry to be filtered. The inside of the drum is held lower than the ambient pressure. As the drum rotates through the slurry, the liquid is sucked through the membrane, leaving solids to cake on the membrane surface while the drum is submerged. A knife or blade is positioned to scrape the product from the surface.

<span class="mw-page-title-main">Agitated Nutsche Filter</span> Type of filter for liquid

Agitated Nutsche filter (ANF) is a filtration technique used in applications such as dye, paint, and pharmaceutical production and waste water treatment. Safety requirements and environmental concerns due to solvent evaporation led to the development of this type of filter wherein filtration under vacuum or pressure can be carried out in closed vessels and solids can be discharged straightaway into a dryer.

<span class="mw-page-title-main">Cross-flow filtration</span>

In chemical engineering, biochemical engineering and protein purification, cross-flow filtration is a type of filtration. Cross-flow filtration is different from dead-end filtration in which the feed is passed through a membrane or bed, the solids being trapped in the filter and the filtrate being released at the other end. Cross-flow filtration gets its name because the majority of the feed flow travels tangentially across the surface of the filter, rather than into the filter. The principal advantage of this is that the filter cake is substantially washed away during the filtration process, increasing the length of time that a filter unit can be operational. It can be a continuous process, unlike batch-wise dead-end filtration.

<span class="mw-page-title-main">Filter press</span>

An industrial filter press is a tool used in separation processes, specifically to separate solids and liquids. The machine stacks many filter elements and allows the filter to be easily opened to remove the filtered solids, and allows easy cleaning or replacement of the filter media.

A vacuum ceramic filter is designed to separate liquids from solids for dewatering of ore concentrates purposes. The device consists of a rotator, slurry tank, ceramic filter plate, distributor, discharge scraper, cleaning device, frame, agitating device, pipe system, vacuum system, automatic acid dosing system, automatic lubricating system, valve and discharge chute. The operation and construction principle of vacuum ceramic filter resemble those of a conventional disc filter, but the filter medium is replaced by a finely porous ceramic disc. The disc material is inert, has a long operational life and is resistant to almost all chemicals. Performance can be optimized by taking into account all those factors which affect the overall efficiency of the separation process. Some of the variables affecting the performance of a vacuum ceramic filter include the solid concentration, speed rotation of the disc, slurry level in the feed basin, temperature of the feed slurry, and the pressure during dewatering stages and filter cake formation.

<span class="mw-page-title-main">Recrystallization (chemistry)</span> Separation and purification process of crystalline solids

In chemistry, recrystallization is a technique used to purify chemicals. By dissolving a mixture of a compound and impurities in an appropriate solvent, either the desired compound or impurities can be removed from the solution, leaving the other behind. It is named for the crystals often formed when the compound precipitates out. Alternatively, recrystallization can refer to the natural growth of larger ice crystals at the expense of smaller ones.

<span class="mw-page-title-main">Belt filter</span>

The belt filter is an industrial machine, used for solid/liquid separation processes, particularly the dewatering of sludges in the chemical industry, mining and water treatment. Belt filter presses are also used in the production of apple juice, cider and winemaking. The process of filtration is primarily obtained by passing a pair of filtering cloths and belts through a system of rollers. The system takes a sludge or slurry as a feed, and separates it into a filtrate and a solid cake.

<span class="mw-page-title-main">Nano spray dryer</span>

Nano spray dryers refer to using spray drying to create particles in the nanometer range. Spray drying is a gentle method for producing powders with a defined particle size out of solutions, dispersions, and emulsions which is widely used for pharmaceuticals, food, biotechnology, and other industrial materials synthesis.

<span class="mw-page-title-main">Belt dryer</span>

A belt dryer a kind of industrial dryer, is an apparatus which is used for continuous drying and cooling of woodchip, pellets, pastes, moulded compounds and panels using air, inert gas, or flue gas.

<span class="mw-page-title-main">Pusher centrifuge</span>

A pusher centrifuge is a type of filtration technique that offers continuous operation to de-water and wash materials such as relatively in-compressible feed solids, free-draining crystalline, polymers and fibrous substances. It consists of a constant speed rotor and is fixed to one of several baskets. This assembly is applied with centrifugal force that is generated mechanically for smaller units and hydraulically for larger units to enable separation.

The peeler centrifuge is a device that performs by rotating filtration basket in an axis. A centrifuge follows on the principle of centrifugal force to separate solids from liquids by density difference. High rotation speed provides high centrifugal force that allows the suspended solid in feed to settle on the inner surface of basket. There are three kinds of centrifuge, horizontal, vertical peeler centrifuge and siphon peeler centrifuge. These classes of instrument apply to various areas such as fertilisers, pharmaceutical, plastics and food including artificial sweetener and modified starch.

<span class="mw-page-title-main">Solid bowl centrifuge</span>

A solid bowl centrifuge is a type of centrifuge that uses the principle of sedimentation. A centrifuge is used to separate a mixture that consists of two substances with different densities by using the centrifugal force resulting from continuous rotation. It is normally used to separate solid-liquid, liquid-liquid, and solid-solid mixtures. Solid bowl centrifuges are widely used in various industrial applications, such as wastewater treatment, coal manufacturing, and polymer manufacturing. One advantage of solid bowl centrifuges for industrial uses is the simplicity of installation compared to other types of centrifuge. There are three design types of solid bowl centrifuge, which are conical, cylindrical, and conical-cylindrical.

Gyratory equipment, used in mechanical screening and sieving is based on a circular motion of the machine. Unlike other methods, gyratory screen operates in a gentler manner and is more suited to handle fragile things, enabling it to produce finer products. This method is applicable for both wet and dry screening.

Screen/Scroll centrifuge is a filtering or screen centrifuge which is also known as worm screen or conveyor discharge centrifuge. This centrifuge was first introduced in the midst of 19th century. After developing new technologies over the decades, it is now one of the widely used processes in many industries for the separation of crystalline, granular or fibrous materials from a solid-liquid mixture. Also, this process is considered to dry the solid material. This process has been some of the most frequently seen within, especially, coal preparation industry. Moreover, it can be found in other industries such as chemical, environmental, food and other mining fields.

Compressed air dryers are special types of filter systems that are specifically designed to remove the water that is inherent in compressed air. The compression of air raises its temperature and concentrates atmospheric contaminants, primarily water vapor, as resulting in air with elevated temperature and 100% relative humidity. As the compressed air cools down, water vapor condenses into the tank(s), pipes, hoses and tools connected downstream from the compressor which may be damaging. Therefore water vapor is removed from compressed air to prevent condensation from occurring and to prevent moisture from interfering in sensitive industrial processes.

References

  1. Maurice Pitcher, PSL, http://www.powdersystems.com/Filter Dryers-FilterDriers.html, 2011.
  2. Christian Parker (May 2012), Pharmaceutical Manufacturing and Packing Sourcer Magazine (PMPS).
  3. N Muralidhar, Alpha Process Engineers, Chennai, India. Refer website http://alphaprocessengineers.com
  4. Michelle Fri-sch, Powder Systems Ltd, http://www.powdersystems.com/pilot-and-plant-production.html, 2012.
  5. Sahni, Ekneet; Hallisey, Jim; Morgan, Brian; Strong, John; Chaudhuri, Bodhisattwa (March 2012). "Quantifying drying performance of a filter dryer: Experiments and simulations". Advanced Powder Technology. 23 (2): 239–249. doi:10.1016/j.apt.2011.03.002.