Fondation Jean Dausset-CEPH

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CEPH Centre Etude Polymorphisme Humain Institut Genetique Moleculaire Paris France.jpg
CEPH

The Fondation Jean Dausset-CEPH or CEPH, formerly the Centre d'Etude du Polymorphisme Humain (the Center for the Study of Human Polymorphisms ), [1] is an international genetic research center located in Paris, France. It produced a map that includes genetic markers of human chromosomes using a resource of immortalised cell cultures.

Polymorphism (biology) Occurrence of two or more clearly different morphs or forms in the population of a species

Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. To be classified as such, morphs must occupy the same habitat at the same time and belong to a panmictic population.

Paris Capital of France

Paris is the capital and most populous city of France, with an area of 105 square kilometres and an official estimated population of 2,140,526 residents as of 1 January 2019. Since the 17th century, Paris is one of Europe's major centres of finance, diplomacy, commerce, fashion, science, and the arts.

France Republic with mainland in Europe and numerous oversea territories

France, officially the French Republic, is a country whose territory consists of metropolitan France in Western Europe and several overseas regions and territories. The metropolitan area of France extends from the Mediterranean Sea to the English Channel and the North Sea, and from the Rhine to the Atlantic Ocean. It is bordered by Belgium, Luxembourg and Germany to the northeast, Switzerland and Italy to the east, and Andorra and Spain to the south. The overseas territories include French Guiana in South America and several islands in the Atlantic, Pacific and Indian oceans. The country's 18 integral regions span a combined area of 643,801 square kilometres (248,573 sq mi) and a total population of 67.3 million. France, a sovereign state, is a unitary semi-presidential republic with its capital in Paris, the country's largest city and main cultural and commercial centre. Other major urban areas include Lyon, Marseille, Toulouse, Bordeaux, Lille and Nice.

Contents

Background

In his 2005 addendum to his biography for the 1980 Nobel Prize, [2] Jean Dausset noted that, thanks to his Nobel Prize and a grant from the French Téléthon, he had been able in 1984 to create the Human Polymorphism Study Centre (CEPH), which soon after became Foundation Jean Dausset-CEPH. Dausset founded CEPH with the collaboration of Professors Howard Cann and Daniel Cohen.

Nobel Prize set of annual international awards, primarily 5 established in 1895 by Alfred Nobel

The Nobel Prize is a set of annual international awards bestowed in several categories by Swedish and Norwegian institutions in recognition of academic, cultural, or scientific advances.

Jean Dausset French immunologist

Jean-Baptiste-Gabriel-Joachim Dausset was a French immunologist born in Toulouse, France. Dausset received the Nobel Prize in Physiology or Medicine in 1980 along with Baruj Benacerraf and George Davis Snell for their discovery and characterisation of the genes making the major histocompatibility complex. Using the money from his Nobel Prize and a grant from the French Television, Dausset founded the Human Polymorphism Study Center (CEPH) in 1984, which was later renamed the Foundation Jean Dausset-CEPH in his honour. He married Rose Mayoral in 1963, with whom he had two children, Henri and Irène. Jean Dausset died on June 6, 2009 in Majorca, Spain, at the age of 92.

The scientific director of CEPH is currently Jean-François Deleuze and its president is François d'Aubert, a French politician, an auditor at the Cour des Comptes and a former minister delegate to research.

François dAubert French politician

François d’Aubert is a French politician.

Human genome

Numerous collaborators working on the same large families as Dausset had collected for his Nobel Prize-winning studies on the human leukocyte antigen system, led to the addition of numerous gene markers and made it feasible to publish the first genetic map and, later on, the first physical map of the human genome.

Human leukocyte antigen

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. Different classes have different functions:

Human genome complete set of nucleic acid sequence for humans

The human genome is the complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome, and the mitochondrial genome. Human genomes include both protein-coding DNA genes and noncoding DNA. Haploid human genomes, which are contained in germ cells consist of three billion DNA base pairs, while diploid genomes have twice the DNA content. While there are significant differences among the genomes of human individuals, these are considerably smaller than the differences between humans and their closest living relatives, the chimpanzees and bonobos.

New resources

An exhaustive study of human populations around the world has also produced important publications from CEPH. Besides this, DNA samples from sibships of people over 95 years old and a bank of centenarians now provide a valuable research resource at the Foundation Jean Dausset-CEPH.

Centenarian person who lives to or beyond the age of 100 years

A centenarian is a person who lives to the age of 100 years. Because life expectancies worldwide are below 100 years, the term is invariably associated with longevity. In 2012, the United Nations estimated that there were 316,600 living centenarians worldwide.

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Salvador Luria Italian American microbiologist

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The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease and responses to drugs and environmental factors. The information produced by the project is made freely available for research.

Pasteur Institute organization

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The Government College University is a public university located in Lahore, Punjab, Pakistan.

George Davis Snell was an American mouse geneticist and basic transplant immunologist.

The Human Genome Diversity Project (HGDP) was started by Stanford University's Morrison Institute and a collaboration of scientists around the world. It is the result of many years of work by Luigi Cavalli-Sforza, one of the most cited scientists in the world, who has published extensively in the use of genetics to understand human migration and evolution. The HGDP data sets have often been cited in papers on such topics as population genetics, anthropology, and heritable disease research.

Baruj Benacerraf American immunologist

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Genetic marker Gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species

A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change, or a long one, like minisatellites.

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The School for Advanced Studies in the Social Sciences is a French grande école specialised in the social sciences and an associated college of Université PSL.

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Gene mapping describes the methods used to identify the locus of a gene and the distances between genes.

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Jeffrey M. Friedman Physician scientist studying the genetic mechanisms that regulate body weight.

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Jules A. Hoffmann French biologist

Jules A. Hoffmann is a Luxembourg-born French biologist. During his youth, growing up in Luxembourg, he developed a strong interest in insects under the influence of his father, Jos Hoffmann. This eventually resulted in the younger Hoffmann's dedication to the field of biology using insects as model organisms. He currently holds a faculty position at the University of Strasbourg. He is a research director and member of the board of administrators of the National Center of Scientific Research (CNRS) in Strasbourg, France. He was elected to the positions of Vice-President (2005-2006) and President (2007-2008) of the French Academy of Sciences. Hoffmann and Bruce Beutler were jointly awarded a half share of the 2011 Nobel Prize in Physiology or Medicine for "their discoveries concerning the activation of innate immunity,". [More specifically, the work showing increased Drosomycin expression following activation of Toll pathway in microbial infection.]

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Ceph or CEPH may refer to:

References

  1. Jack J. Pasternak (2005). An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases. Wiley. ISBN   9780471719175.

Coordinates: 48°52′32″N2°22′07″E / 48.875592°N 2.368539°E / 48.875592; 2.368539

Geographic coordinate system Coordinate system

A geographic coordinate system is a coordinate system that enables every location on Earth to be specified by a set of numbers, letters or symbols. The coordinates are often chosen such that one of the numbers represents a vertical position and two or three of the numbers represent a horizontal position; alternatively, a geographic position may be expressed in a combined three-dimensional Cartesian vector. A common choice of coordinates is latitude, longitude and elevation. To specify a location on a plane requires a map projection.