GTP cyclohydrolase

Guanosine triphosphate (GTP), the substrate of GTP cyclohydrolases

GTP cyclohydrolases are enzymes that catalyze imidazole ring opening of guanosine triphosphate (GTP). ^[1] This reaction is the committed step in the biosynthesis of multiple coenzymes (such as riboflavin and folate), tRNA bases, and the phytotoxin toxoflavin. ^[1] Several GTP cyclohydrolases exist, which sometimes synthesize different products for different purposes:

• GTP cyclohydrolase I, part of the tetrahydrobiopterin, tetrahydrofolate, queuosine and other biosynthetic pathways ^[1]
• GTP cyclohydrolase Ia,
• GTP cyclohydrolase Ib, part of the tetrahydrobiopterin, tetrahydrofolate, queueosine and other biosynthetic pathways ^[1]
• GTP cyclohydrolase II, part of the riboflavin and toxoflavin biosynthetic pathways ^[1]
• GTP cyclohydrolase IIa ^[2] (or GTP cyclohydrolase III ^[3] ), part of the riboflavin and deazaflavin cofactor biosynthetic pathways ^[1]
• GTP cyclohydrolase IV
• GTP cyclohydrolase MptA, GTP cyclohydrolase Ib paralog ^[1]

These enzymes require divalent cations for catalysis. ^[1]

References

1. Gräwert, Tobias; Fischer, Markus; Bacher, Adelbert (Mar 4, 2013). "Structures and reaction mechanisms of GTP cyclohydrolases". IUBMB Life. 65 (4): 310–322. doi: 10.1002/iub.1153 . PMID   23457054. S2CID   5470658.
2. Graham, David E.; Xu, Huimin; White, Robert H. (2002-12-01). "A Member of a New Class of GTP Cyclohydrolases Produces Formylaminopyrimidine Nucleotide Monophosphates" . Biochemistry. 41 (50): 15074–15084. doi:10.1021/bi0268798. ISSN   0006-2960. PMID   12475257.
3. "ENZYME - 3.5.4.29 GTP cyclohydrolase IIa". enzyme.expasy.org. Retrieved 2023-01-23.