Genedata

Last updated
Genedata
Industry
Founded1997;27 years ago (1997)
Headquarters Basel, Switzerland
Area served
Worldwide
Key people
Othmar Pfannes (Founder & CEO)
Products https://www.genedata.com/products-services
Number of employees
~400
Website https://www.genedata.com/

Genedata is a bioinformatics company that develops enterprise software solutions to accelerate biopharmaceutical research and development. Founded in 1997 by Othmar Pfannes, Genedata has since grown to approximately 400 employees. Genedata is headquartered in Basel, Switzerland with additional offices in Boston, London, Munich, San Francisco, Singapore, and Tokyo positioning the company in the heart of biopharma clusters around the globe.

Today, top 25 biopharmaceutical enterprises, innovative biotechnology companies, and scientific research institutions use the Genedata Biopharma Platform to increase the efficiency of their R&D operations. With its knowledgeable scientific experts, modular software portfolio, and collaborative approach, Genedata helps companies to more efficiently discover, develop, characterize, and manufacture innovative biotherapeutics of all modalities including antibodies, cell and gene therapies (CGTs), RNA, and vaccines.

Genedata's solutions drive digitalization, automation, standardization, and data FAIRness while complying with regulatory standards. [1]

In July 2024, Genedata joined the Danaher Group.

Genedata Products

Genedata developed its first product for drug target discovery in 1998.The Genedata Biopharma Platform encompasses purpose-built workflow and analysis systems that support discovery, development, and translational research, as well as technology-focused analytical workflows. These systems can be used either individually or together to connect distinct data streams within organizations. [2]

Screener – For assay data analytics and management in discovery and development [3]

Expressionist – For MS-based characterization and QC of biotherapeutics [4]

Selector – For NGS-based target discovery, bioprocess development, and QC of biotherapeutics [5]

Biologics – For covering the end-to-end biotherapeutics discovery workflow for all modalities [6]

Profiler – For translational research and precision medicine development [7]

Bioprocess – For bioprocess development workflows [8]

Chromatics – For integrated chromatography data management and analysis (To be released in 2025)

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References

  1. Fischer, Sascha (2023-04-18). "Accelerating time to market through digitalisation". Drug Discovery World (DDW).
  2. "The Genedata Biopharma Platform". www.genedata.com.
  3. Fang, Jie; Singh, Shivendra; Cheng, Changde; Natarajan, Sivaraman; Sheppard, Heather; Abu-Zaid, Ahmed; Durbin, Adam D.; Lee, Ha Won; Wu, Qiong; Steele, Jacob; Connelly, Jon P.; Jin, Hongjian; Chen, Wenan; Fan, Yiping; Pruett-Miller, Shondra M. (2023-07-06). "Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma". Nature Communications. 14 (1): 4003. Bibcode:2023NatCo..14.4003F. doi:10.1038/s41467-023-39717-6. ISSN   2041-1723. PMC   10326052 . PMID   37414763.
  4. Dhenin, Jonathan; Lafont, Valérie; Dupré, Mathieu; Krick, Alain; Mauriac, Christine; Chamot-Rooke, Julia (2023-07-21). "Monitoring mAb proteoforms in mouse plasma using an automated immunocapture combined with top-down and middle-down mass spectrometry". Proteomics. 24 (3–4): e2300069. doi: 10.1002/pmic.202300069 . ISSN   1615-9853. PMID   37480175.
  5. Schmieder, Valerie; Fieder, Juergen; Drerup, Raphael; Gutierrez, Erik Arango; Guelch, Carina; Stolzenberger, Jessica; Stumbaum, Mihaela; Mueller, Volker Steffen; Higel, Fabian; Bergbauer, Martin; Bornhoefft, Kim; Wittner, Manuel; Gronemeyer, Petra; Braig, Christian; Huber, Michaela (2022-04-10). "Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable pool". Journal of Biotechnology. 349: 53–64. doi: 10.1016/j.jbiotec.2022.03.010 . ISSN   0168-1656.
  6. Furtmann, Norbert; Schneider, Marion; Spindler, Nadja; Steinmann, Bjoern; Li, Ziyu; Focken, Ingo; Meyer, Joachim; Dimova, Dilyana; Kroll, Katja; Leuschner, Wulf Dirk; Debeaumont, Audrey; Mathieu, Magali; Lange, Christian; Dittrich, Werner; Kruip, Jochen (2021). "An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics". mAbs. 13 (1): 1955433. doi:10.1080/19420862.2021.1955433. ISSN   1942-0870. PMC   8366542 . PMID   34382900.
  7. Hartwig, Christina; Müller, Jan; Klett, Hagen; Kouhestani, Dina; Mittelstädt, Anke; Anthuber, Anna; David, Paul; Brunner, Maximilian; Jacobsen, Anne; Glanz, Karolina; Swierzy, Izabela; Roßdeutsch, Lotta; Klösch, Bettina; Grützmann, Robert; Wittenberger, Timo (2024-02-02). "Discrimination of pancreato-biliary cancer and pancreatitis patients by non-invasive liquid biopsy". Molecular Cancer. 23 (1): 28. doi: 10.1186/s12943-024-01943-x . ISSN   1476-4598. PMC   10836044 . PMID   38308296.
  8. PhD, Vivienne Raper (2024-03-06). "Pharma Companies Embrace Unified Record Keeping". GEN - Genetic Engineering and Biotechnology News.