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Biostatistics is a branch of statistics that applies statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results.
Triticale is a hybrid of wheat (Triticum) and rye (Secale) first bred in laboratories during the late 19th century in Scotland and Germany. Commercially available triticale is almost always a second-generation hybrid, i.e., a cross between two kinds of primary (first-cross) triticales. As a rule, triticale combines the yield potential and grain quality of wheat with the disease and environmental tolerance of rye. Only recently has it been developed into a commercially viable crop. Depending on the cultivar, triticale can more or less resemble either of its parents. It is grown mostly for forage or fodder, although some triticale-based foods can be purchased at health food stores and can be found in some breakfast cereals.
A quantitative trait locus (QTL) is a locus that correlates with variation of a quantitative trait in the phenotype of a population of organisms. QTLs are mapped by identifying which molecular markers correlate with an observed trait. This is often an early step in identifying the actual genes that cause the trait variation.
A polygene is a member of a group of non-epistatic genes that interact additively to influence a phenotypic trait, thus contributing to multiple-gene inheritance, a type of non-Mendelian inheritance, as opposed to single-gene inheritance, which is the core notion of Mendelian inheritance. The term "monozygous" is usually used to refer to a hypothetical gene as it is often difficult to distinguish the effect of an individual gene from the effects of other genes and the environment on a particular phenotype. Advances in statistical methodology and high throughput sequencing are, however, allowing researchers to locate candidate genes for the trait. In the case that such a gene is identified, it is referred to as a quantitative trait locus (QTL). These genes are generally pleiotropic as well. The genes that contribute to type 2 diabetes are thought to be mostly polygenes. In July 2016, scientists reported identifying a set of 355 genes from the last universal common ancestor (LUCA) of all organisms living on Earth.
A molecular marker is a molecule, sampled from some source, that gives information about its source. For example, DNA is a molecular marker that gives information about the organism from which it was taken. For another example, some proteins can be molecular markers of Alzheimer's disease in a person from which they are taken. Molecular markers may be non-biological. Non-biological markers are often used in environmental studies.
Marker assisted selection or marker aided selection (MAS) is an indirect selection process where a trait of interest is selected based on a marker linked to a trait of interest, rather than on the trait itself. This process has been extensively researched and proposed for plant- and animal- breeding.
A doubled haploid (DH) is a genotype formed when haploid cells undergo chromosome doubling. Artificial production of doubled haploids is important in plant breeding.
In genetics, association mapping, also known as "linkage disequilibrium mapping", is a method of mapping quantitative trait loci (QTLs) that takes advantage of historic linkage disequilibrium to link phenotypes to genotypes, uncovering genetic associations.
Nested association mapping (NAM) is a technique designed by the labs of Edward Buckler, James Holland, and Michael McMullen for identifying and dissecting the genetic architecture of complex traits in corn. It is important to note that nested association mapping is a specific technique that cannot be performed outside of a specifically designed population such as the Maize NAM population, the details of which are described below.
In statistical genetics, inclusive composite interval mapping (ICIM) has been proposed as an approach to QTL mapping for populations derived from bi-parental crosses. QTL mapping is based on genetic linkage map and phenotypic data and attempts to locate individual genetic factors on chromosomes and to estimate their genetic effects.
A recombinant inbred strain or recombinant inbred line (RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. F1 and F2 generations are produced by intercrossing the inbred strains; pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding.
Plant breeding is the science of changing the traits of plants in order to produce desired characteristics. It has been used to improve the quality of nutrition in products for humans and animals. The goals of plant breeding are to produce crop varieties that boast unique and superior traits for a variety of applications. The most frequently addressed agricultural traits are those related to biotic and abiotic stress tolerance, grain or biomass yield, end-use quality characteristics such as taste or the concentrations of specific biological molecules and ease of processing.
Quantitative trait loci mapping or QTL mapping is the process of identifying genomic regions that potentially contain genes responsible for important economic, health or environmental characters. Mapping QTLs is an important activity that plant breeders and geneticists routinely use to associate potential causal genes with phenotypes of interest. Family-based QTL mapping is a variant of QTL mapping where multiple-families are used.
Molecular breeding is the application of molecular biology tools, often in plant breeding and animal breeding. In the broad sense, molecular breeding can be defined as the use of genetic manipulation performed at the level of DNA to improve traits of interest in plants and animals, and it may also include genetic engineering or gene manipulation, molecular marker-assisted selection, and genomic selection. More often, however, molecular breeding implies molecular marker-assisted breeding (MAB) and is defined as the application of molecular biotechnologies, specifically molecular markers, in combination with linkage maps and genomics, to alter and improve plant or animal traits on the basis of genotypic assays.
A sequence related amplified polymorphism (SRAP) is a molecular technique, developed by G. Li and C. F. Quiros in 2001, for detecting genetic variation in the open reading frames (ORFs) of genomes of plants and related organisms.
Michael Edward "Mike" Goddard is a professorial fellow in animal genetics at the University of Melbourne, Australia.
In genetics, a polygenic score (PGS), also called a polygenic index (PGI), polygenic risk score (PRS), genetic risk score, or genome-wide score, is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype, typically calculated as a weighted sum of trait-associated alleles. It reflects an individual's estimated genetic predisposition for a given trait and can be used as a predictor for that trait. In other words, it gives an estimate of how likely an individual is to have a given trait only based on genetics, without taking environmental factors into account. Polygenic scores are widely used in animal breeding and plant breeding due to their efficacy in improving livestock breeding and crops. In humans, polygenic scores are typically generated from genome-wide association study (GWAS) data.
Polygenic adaptation describes a process in which a population adapts through small changes in allele frequencies at hundreds or thousands of loci.
The infinitesimal model, also known as the polygenic model, is a widely used statistical model in quantitative genetics and in genome-wide association studies. Originally developed in 1918 by Ronald Fisher, it is based on the idea that variation in a quantitative trait is influenced by an infinitely large number of genes, each of which makes an infinitely small (infinitesimal) contribution to the phenotype, as well as by environmental factors. In "The Correlation between Relatives on the Supposition of Mendelian Inheritance", the original 1918 paper introducing the model, Fisher showed that if a trait is polygenic, "then the random sampling of alleles at each gene produces a continuous, normally distributed phenotype in the population". However, the model does not necessarily imply that the trait must be normally distributed, only that its genetic component will be so around the average of that of the individual's parents. The model served to reconcile Mendelian genetics with the continuous distribution of quantitative traits documented by Francis Galton.
Rohan L. Fernando is a Sri Lankan American geneticist who is a professor of quantitative genetics in the Department of Animal Science at Iowa State University (ISU), US. Fernando's efforts have focused primarily on theory and methods for use of genetic markers in breeding, theory and methods for genetic evaluations of crossbred animals, methodology related to the estimation of genetic parameters and the prediction of genetic merit in populations undergoing selection and non-random mating, Bayesian methodology for analysis of unbalanced mixed model data, optimization of breeding programs, and use of computer simulation to study dynamics of genetic system.
References
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- 1 2 3 Heffner EL, Sorrells ME, Jannink JL (January 2009). "Genomic Selection for Crop Improvement". Crop Science. 49 (1): 1–12. doi:10.2135/cropsci2008.08.0512.
{{cite journal}}: CS1 maint: date and year (link) - ↑ Dekkers JC, Hospital F (January 2002). "The use of molecular genetics in the improvement of agricultural populations". Nature Reviews. Genetics. 3 (1): 22–32. doi:10.1038/nrg701. PMID 11823788. S2CID 32216266.
- ↑
- •Schön CC, Utz HF, Groh S, Truberg B, Openshaw S, Melchinger AE (May 2004). "Quantitative trait locus mapping based on resampling in a vast maize testcross experiment and its relevance to quantitative genetics for complex traits". Genetics. 167 (1): 485–498. doi:10.1534/genetics.167.1.485. PMC 1470842 . PMID 15166171.
- •Maloof, Julin (2004). "Faculty Opinions recommendation of Quantitative trait locus mapping based on resampling in a vast maize testcross experiment and its relevance to quantitative genetics for complex traits". Faculty Opinions Ltd. doi: 10.3410/f.1020376.234444 . S2CID 224103363.
{{cite journal}}: Cite journal requires|journal=(help) - •Jannink, Jean-Luc; Lorenz, A. J.; Iwata, H. (2010). "Genomic selection in plant breeding: from theory to practice". Briefings in Functional Genomics . Oxford University Press (OUP). 9 (2): 166–177. doi:10.1093/bfgp/elq001. ISSN 2041-2649. PMID 20156985. S2CID 3379276.
- •Varshney, R. K.; Roorkiwal, Manish; Sorrells, Mark E. (2017). Genomic Selection for Crop Improvement : New Molecular Breeding Strategies for Crop Improvement (1 ed.). Cham, Switzerland: Springer International Publishing AG. pp. xii+258. doi:10.1007/978-3-319-63170-7. ISBN 978-3-319-63170-7. OCLC 1015215250. S2CID 6537864. ISBN 978-3-319-63168-4. ISBN 978-3-319-87489-0.: 16