Gholam A. Peyman

Last updated
Gholam A. Peyman
Gholam Peyman.jpg
Born
Gholam Ali Peyman

(1937-01-01) 1 January 1937 (age 86) [1]
Nationality Iranian American
Alma mater University of Freiburg
University of Essen
Known forInventor of LASIK [2]
Awards National Medal of Technology and Innovation (2012)
Scientific career
Fields Ophthalmology, Engineering
InstitutionsProfessor of Basic Medical Sciences at the University of Arizona, Phoenix & Optical Sciences at University of Arizona Tucson, Arizona
Emeritus Professor of Ophthalmology, Tulane University

Gholam A. Peyman (born 1 January 1937) is an Iranian American ophthalmologist, retina surgeon, and inventor. He is best known for his invention of LASIK eye surgery, [2] a vision correction procedure designed to allow people to see clearly without glasses. He was awarded the first US patent for the procedure in 1989.

Contents

Life and career

Peyman was born in Shiraz, Iran. At the age of 19, he moved to Germany to begin his medical studies. He received his MD at the University of Freiburg in 1962.[ citation needed ] He completed his internship at St. Johannes Hospital in Duisburg, Germany in 1964 and at Passaic General Hospital in Passaic, New Jersey in 1965.[ citation needed ] Peyman completed his residency in ophthalmology and a retina fellowship at the University of Essen, Essen Germany, in 1969 and an additional postdoctoral fellowship in retina at the Jules Stein Eye Institute, UCLA School of Medicine in Los Angeles in 1971. Peyman held the position of assistant professor of ophthalmology at the UCLA School of Medicine from 1971 and served as associate professor and then professor of ophthalmology and ocular oncology at the Illinois Eye and Ear Infirmary, University of Illinois at Chicago during 1971–1987.[ citation needed ]

Peyman held a joint appointment at the School of Medicine and also at the Neuroscience Center of Excellence at the Louisiana State University Medical University Medical Center in New Orleans during 1987–2000. During 1998-2000 Peyman held the Prince Abdul Aziz Bin Ahmed Bin Abdul Aziz Al Saud Chair in Retinal Diseases. During 2000–2006, Peyman served as professor of ophthalmology, ocular oncology and co-director, Vitreo-Retinal Service, Tulane University School of Medicine in New Orleans.[ citation needed ]

During 2006–2007, he was professor of ophthalmology at the University of Arizona, Tucson, with a cross appointment at University of Arizona College of Optical Sciences. He has been emeritus professor of ophthalmology at Tulane University since 2009.[ citation needed ]

Peyman is currently professor of basic medical sciences at the University of Arizona College of Medicine – Phoenix & Optical engineering at the University of Arizona in Tucson. Peyman was awarded in 2013 an honoree doctorate degree from the National University of Cordoba in Argentina. [3]

The Invention of LASIK surgery and its improvements

At the Illinois Eye and Ear Infirmary, Peyman, because of his interest in the effects of lasers on tissues in the eye, began evaluating the potential use of a CO2 laser to modify corneal refraction in rabbits. No prior study had existed on this concept. The laser was applied to the surface of the cornea using different patterns. This laser created significant scarring. His conclusions at that time were: 1) one has to wait for the development of an ablative laser and 2) one should not ablate the surface of the cornea but, instead, the ablation should take place under a flap in order to prevent scarring, pain and other undesirable sequelae. Peyman published the first article on this subject in 1980. [4]

In late 1982, he read an article from IBM Laboratories, published in Laser Focus, describing the photo-ablative properties of an excimer laser on organic material. This was very exciting information, but, unfortunately, Peyman did not have access to this laser, which at the time was new and very expensive. By 1985 and beyond, many investigators were interested in ablating the corneal surface. However, because of his previous experience with the CO2 laser, Peyman wanted to avoid surface ablation in order to prevent potential corneal scarring and the pain associated with the removal of the corneal epithelium, necessary to expose the surface of the cornea. Therefore, in July 1985, he applied for a patent that described a method of modifying corneal refractive errors using laser ablation under a corneal flap. This US patent was accepted after two revisions and issued in June, 1989. Peyman performed a number of experimental studies evaluating the effect of various excimer lasers in collaboration with Physics Department of the University of Helsinki, Finland. Since he had purchased an Erb-Yag laser in the U.S., he evaluated the concept using this laser in vivo in rabbit and primate eyes and described the creation of a hinged corneal flap to enable the ablation to be performed on the exposed corneal bed, thus reducing the potential for postoperative scarring and pain. [5]

Always aware of the potential limitations of his invention, Peyman devoted considerable time and effort in subsequent years to ameliorating them. In order to improve the risk/benefit considerations of the LASIK procedure, he invented in 2004 and patented a broad range of ablative and non-ablative inlays to be placed under the surgically created corneal flap (US Patent 6,702,807). These inlays offered many potential advantages over the standard LASIK technique, the most significant of which is that the inlay procedure is reversible. [6]

However, their ablation was not predictable. In October 2009, Peyman invented and applied for a patent on a method of preventing corneal implant rejection, which was approved in 2017 (US Patent 9,681,942). It consisted of forming a Lasik flap in the cornea, raising the flap, inserting a lamellar cornea under the flap so as to overlie the exposed stromal tissue. The inlay is ablated with wavefront guided excimer laser, to correct the refractive errors of the eye, applying a cross linking solution to the inlay and stromal tissue of the cornea, replacing the corneal flap and cross linking the inlay with UV radiation, killing the cellular elements in the inlay and its surrounding cornea, preventing cellular migration in the inlay and its rejection or encapsulation by the host corneal cells. This new procedure is now called “Mesoick” (Meso means Inside, Implant, Crosslinking Keratomileusis (US Patent 9,037,033). This creates an immune privileged cell free space that does not initiate an immune response to an implant. A synthetic, crosslinked organic or polymeric lens can be implanted in the corneal pocket to compensate for the patient's refractive error. The implant can be exchanged as the eye grows or refractive need dictates. [7]

Laser in ophthalmology

Peyman has been granted 200 US Patents [8] covering a broad range of novel medical devices, intra-ocular drug delivery, surgical techniques, as well as new methods of diagnosis and treatment.

Development of direct intraocular drug delivery and Vitrectomy

Surgical removal of intraocular tumors

Remote controlled system for Laser Surgery

This technology enables an ophthalmologist to treat a patient located in another location e.g. another city by a laser system controlled remotely, via the internet, using a sophisticated secure system in a non-contact fashion.

US Patent 9,931,171Laser treatment of an eye structure or a body surface from a remote location
US Patent 9,510,974Laser coagulation of an eye structure or a body surface from a remote location
US Patent 9,037,217Laser coagulation of an eye structure or a body surface from a remote location
US Patent 8,903,468Laser coagulation of an eye structure from a remote location
US Patent 8,452,372System for laser coagulation of the retina from a remote location

Development of precision thermotherapy in oncology Therapy of malignant tumors in early-stage along with imaging and immune therapy and precision localized drug delivery:

US Patent 10,376,600Early disease detection and therapy
US Patent 10,300,121Early cancer detection and enhance immunotherpay
US Patent 9,849,092Early cancer detection and enhance immunotherapy
US Patent 9,393,396Method and composition for hyperthermally treating cells

Tele-laser system and tele- medicine with a novel Dynamic Identity recognition

US Patent 10,456,209Remote laser treatment system with dynamic imaging

Macular degeneration

Intravitreal slow-release Rock inhibitors alone or in combination with Anti-VEGF

US Patent 10,272,035Ophthalmic drug delivery method
US Patent 9,486,357Ophthalmic drug delivery system and method
US Patent 10,278,920Drug delivery implant and a method using the same

Artificial Retina Stimulation

Quantum dots and Optogenetic for artificial retinal and brain stimulation and gene therapy

Gene therapy with non-viral nanoparticles and CRISPR

Adaptic optic phoropter for automated vision correction and Tunable light field camera in use for VR and AR technology

Honors and awards

Among other awards and honors, Peyman has received the National Medal of Technology and Innovation (2012), [18] the Waring Medal of the Journal of Refractive Surgery (2008), [19] and the American Academy of Ophthalmology's Lifetime Achievement Award (2008) [20] He was named a fellow of the National Academy of Inventors in 2013. [21]

Related Research Articles

<span class="mw-page-title-main">Ophthalmology</span> Field of medicine treating eye disorders

Ophthalmology is a surgical subspecialty within medicine that deals with the diagnosis and treatment of eye disorders. A former term is oculism.

<span class="mw-page-title-main">Near-sightedness</span> Problem with distance vision

Near-sightedness, also known as myopia and short-sightedness, is an eye disease where light from distant objects focuses in front of, instead of on, the retina. As a result, distant objects appear blurry while close objects appear normal. Other symptoms may include headaches and eye strain. Severe near-sightedness is associated with an increased risk of macular degeneration, retinal detachment, cataracts, and glaucoma.

<span class="mw-page-title-main">Cornea</span> Transparent front layer of the eye

The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Along with the anterior chamber and lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is approximately 43 dioptres. The cornea can be reshaped by surgical procedures such as LASIK.

<span class="mw-page-title-main">Far-sightedness</span> Eye condition in which light is focused behind instead of on the retina

Far-sightedness, also known as long-sightedness, hypermetropia, and hyperopia, is a condition of the eye where distant objects are seen clearly but near objects appear blurred. This blur is due to incoming light being focused behind, instead of on, the retina due to insufficient accommodation by the lens. Minor hypermetropia in young patients is usually corrected by their accommodation, without any defects in vision. But, due to this accommodative effort for distant vision, people may complain of eye strain during prolonged reading. If the hypermetropia is high, there will be defective vision for both distance and near. People may also experience accommodative dysfunction, binocular dysfunction, amblyopia, and strabismus. Newborns are almost invariably hypermetropic, but it gradually decreases as the newborn gets older.

<span class="mw-page-title-main">LASIK</span> Corrective ophthalmological surgery

LASIK or Lasik, commonly referred to as laser eye surgery or laser vision correction, is a type of refractive surgery for the correction of myopia, hyperopia, and an actual cure for astigmatism, since it is in the cornea. LASIK surgery is performed by an ophthalmologist who uses a laser or microkeratome to reshape the eye's cornea in order to improve visual acuity.

<span class="mw-page-title-main">Eye surgery</span> Surgery performed on the eye or its adnexa

Eye surgery, also known as ophthalmic surgery or ocular surgery, is surgery performed on the eye or its adnexa. Eye surgery is part of ophthalmology and is performed by an ophthalmologist or eye surgeon. The eye is a fragile organ, and requires due care before, during, and after a surgical procedure to minimize or prevent further damage. An eye surgeon is responsible for selecting the appropriate surgical procedure for the patient, and for taking the necessary safety precautions. Mentions of eye surgery can be found in several ancient texts dating back as early as 1800 BC, with cataract treatment starting in the fifth century BC. It continues to be a widely practiced class of surgery, with various techniques having been developed for treating eye problems.

<span class="mw-page-title-main">Refractive surgery</span> Surgery to treat common vision disorders

Refractive surgery is optional eye surgery used to improve the refractive state of the eye and decrease or eliminate dependency on glasses or contact lenses. This can include various methods of surgical remodeling of the cornea (keratomileusis), lens implantation or lens replacement. The most common methods today use excimer lasers to reshape the curvature of the cornea. Refractive eye surgeries are used to treat common vision disorders such as myopia, hyperopia, presbyopia and astigmatism.

<span class="mw-page-title-main">Phakic intraocular lens</span> Lens implanted in eye in addition to the natural lens

A phakic intraocular lens (PIOL) is a special kind of intraocular lens that is implanted surgically into the eye to correct myopia (nearsightedness). It is called "phakic" because the eye's natural lens is left untouched. Intraocular lenses that are implanted into eyes after the eye's natural lens has been removed during cataract surgery are known as pseudophakic.

Ronald H. Silverman is an American ophthalmologist. He is currently Professor of Ophthalmic Science at Columbia University Medical Center. He is currently the director of the CUMC Basic Science Course in Ophthalmology, which takes place every January at the Harkness Eye Institute. He departed Weill Cornell Medical College in 2010, where he was Professor of Ophthalmology as well as a Dyson Scholar and the Research Director of the Bioacoustic Research Facility, Margaret M. Dyson Vision Research Institute at Weill Cornell.

Stephen Updegraff, M.D., FACS is an American refractive surgeon best known for his early involvement in, and contributions to, LASIK. He is a Fellow of the American College of Surgeons, a board-certified member of the American Board of Ophthalmology, a founding member of the American College of Ophthalmic Surgeons, and a member of the International Society of Refractive Surgery, the American Academy of Ophthalmology, the American Society of Cataract and Refractive Surgery, and the Pine Ridge Eye Study Society. Updegraff currently serves as the medical director of Updegraff Vision in St. Petersburg, Florida.

Jeff Machat MD, FRCSC, DABO is an ophthalmologist in the United States and Canada specializing in surgical vision correction better known as refractive eye surgery.

Peter S. Hersh is an American ophthalmologist and specialist in LASIK eye surgery, keratoconus, and diseases of the cornea. He co-authored the article in the journal Ophthalmology that presented the results of the study that led to the first approval by the U.S. Food and Drug Administration (FDA) of the excimer laser for the correction of nearsightedness in the United States. Hersh was also medical monitor of the study that led to approval of corneal collagen crosslinking for the treatment of keratoconus.

The aim of an accurate intraocular lens power calculation is to provide an intraocular lens (IOL) that fits the specific needs and desires of the individual patient. The development of better instrumentation for measuring the eye's axial length (AL) and the use of more precise mathematical formulas to perform the appropriate calculations have significantly improved the accuracy with which the surgeon determines the IOL power.

A corneal inlay is a device which is surgically implanted in the cornea of the eye as a treatment for presbyopia. Successful installation results in reducing dependence on reading glasses, so that the user can more easily engage in everyday tasks such as using a mobile phone, reading store shelf prices and working on a computer.

Sheraz Daya is a British ophthalmologist. Daya founded the Centre for Sight in 1996, and works in stem-cell research and sight recovery surgery.

Post-LASIK ectasia is a condition similar to keratoconus where the cornea starts to bulge forwards at a variable time after LASIK, PRK, or SMILE corneal laser eye surgery. However, the physiological processes of post-LASIK ectasia seem to be different from keratoconus. The visible changes in the basal epithelial cell and anterior and posterior keratocytes linked with keratoconus were not observed in post-LASIK ectasia.

<span class="mw-page-title-main">Farhad Hafezi</span> Swiss eye surgeon and researcher (born 1967)

Farhad Hafezi is a prominent Swiss eye surgeon and researcher. Hafezi first gained recognition as a leading retina researcher in 1994, having been the first to discover a gene responsible for light-induced retinal degeneration. However, he changed his research focus to the cornea in 2003, and it is this work, particularly on corneal collagen cross-linking (CXL), which he helped pioneer, and advanced laser refractive surgery that he is internationally known for today. Hafezi's current clinical and laboratory research is focused on gaining a better understanding of the cornea. His research group at the University of Zurich has three main research foci:

<span class="mw-page-title-main">John Marshall (eye laser scientist)</span> British medical scientist and inventor

John Marshall MBE, FMedSci, PhD, DSc, FRCPath, FRSB, FRCOphth(Hon), FRCOptom (Hon), FARVO is a British medical scientist and inventor. Currently he is the Frost Professor of Ophthalmology at the Institute of Ophthalmology UCL and Emeritus Professor King's College London. He is a pioneer of laser eye surgery.

<span class="mw-page-title-main">Peter Szurman</span> German ophthalmologist

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References

  1. "Gholam Peyman". National Science and Technology Medals Foundation.
  2. 1 2 US Patent 4,840,175, "METHOD FOR MODIFYING CORNEAL CURVATURE", granted June 20, 1989
  3. Archived at Ghostarchive and the Wayback Machine : Gholam Peyman fue distinguido con el Doctorado Honoris Causa de la UNC. YouTube .
  4. Ophthalmic Surgery 11:325-329, 1980
  5. Ophthalmology 96:1160-1170, 1989
  6. Examples of these inlays can be found in US Patents: #6,203,538, granted March 2001, #6,217,571, granted April 2001, AND #6,280,470, all entitled, "INTRASTROMAL CORNEAL MODIFICATION";
    1. 6,221,067, granted April 2001, entitled "CORNEAL MODIFICATION VIA IMPLANTATION"; and others
  7. US patent 9,370,446 "Method of altering the refractive properties of an eye" and US Patent 9,427,355 "Corneal transplantation with a cross-linked cornea"
  8. United States Patent and Trademark Office
  9. Ophthalmic Surg 11:325-329, 1980
  10. Ophthalmic Surg 15:496-501, 1984
  11. Int Ophthalmol 8:199-209, 1985
  12. Int Ophthalmol 10:213-220, 1987
  13. Int Ophthalmol 10:245-253, 1987
  14. Ophthalmic Surg 18:726-727, 1987
  15. Int Ophthalmol 11:159-62, 1988
  16. Int Ophthalmol 11:175-80, 1988
  17. Peyman GA, Tsipursky M, Nassiri N, Conway M. J Ophthalmic Vis Res. 2011 Jul;6(3):166-76
  18. President Obama Honors Nation’s Top Scientists and Innovators, White House Office of the Press Secretary (December 21, 2012).
  19. Contributor Awards, Journal of Refractive Surgery.
  20. Masoud Soheilian, A Tribute to Dr Gholam A Peyman, J Ophthalmic Vis Res. 2011 Jan; 6(1): 1–2.
  21. Two University of Arizona College of Medicine – Phoenix Faculty Named Fellows of the National Academy of Inventors (press release), University of Arizona Health Sciences (December 10, 2013).