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Amphetamine is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Amphetamine was discovered as a chemical in 1887 by Lazăr Edeleanu, and then as a drug in the late 1920s. It exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to the significant health risks associated with recreational use.
Modafinil, sold under the brand name Provigil among others, is a wakefulness-promoting medication used primarily to treat narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. Modafinil is also approved for stimulating wakefulness in people with sleep apnea and shift work sleep disorder. It is taken by mouth. Modafinil is not approved by the US Food and Drug Administration (FDA) for use in people under 17 years old.
Dextroamphetamine (INN:dexamfetamine) is a potent central nervous system (CNS) stimulant and enantiomer of amphetamine that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. Dextroamphetamine is generally regarded as the prototypical stimulant.
Adderall and Mydayis are trade names for a combination drug called mixed amphetamine salts containing four salts of amphetamine. The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. In terms of base, rather than salts, the ratio is 3.15:1 for dextro- to levoamphetamine. Both enantiomers are stimulants, but differ enough to give Adderall an effects profile distinct from those of racemic amphetamine or dextroamphetamine, which are marketed as Evekeo and Dexedrine/Zenzedi, respectively. MAS is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used illicitly as an athletic performance enhancer, cognitive enhancer, appetite suppressant, and recreationally as a euphoriant. It is a central nervous system (CNS) stimulant of the phenethylamine class.
Somnolence is a state of strong desire for sleep, or sleeping for unusually long periods. It has distinct meanings and causes. It can refer to the usual state preceding falling asleep, the condition of being in a drowsy state due to circadian rhythm disorders, or a symptom of other health problems. It can be accompanied by lethargy, weakness and lack of mental agility.
Shift work is an employment practice designed to keep a service or production line operational at all times. The practice typically sees the day divided into shifts, set periods of time during which different groups of workers perform their duties. The term "shift work" includes both long-term night shifts and work schedules in which employees change or rotate shifts.
Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999.
The Tarnak Farm incident is the killing, by an American Air National Guard pilot, of four Canadian soldiers and the injury of eight others from the 3rd Battalion, Princess Patricia's Canadian Light Infantry Battle Group (3PPCLIBG) on the night of April 17, 2002, near Kandahar, Afghanistan.
Armodafinil (trade name Nuvigil) is the enantiopure compound of the eugeroic modafinil (Provigil). It consists of only the (R)-(−)-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. and was approved by the U.S. Food and Drug Administration (FDA) in June 2007. In 2016, the FDA granted Mylan rights for the first generic version of Cephalon's Nuvigil to be marketed in the U.S.
Alertness is a state of active attention characterized by high sensory awareness. Someone who is alert is vigilant and promptly meets danger or emergency, or is quick to perceive and act. Alertness is a psychological and physiological state.
Lisdexamfetamine, sold under the brand names Vyvanse and Elvanse among others, is a stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults and for moderate-to-severe binge eating disorder in adults. Lisdexamfetamine is taken by mouth. Its effects generally begin within two hours and last for up to 14 hours.
The 192nd Wing, also referred to as the 192D Wing, is a unit of the Virginia Air National Guard and the United States Air Force, stationed at Joint Base Langley-Eustis, Virginia. If activated to federal service, the 192 WG is gained by Air Combat Command (ACC).
Sleep deprivation, also known as sleep insufficiency or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support decent alertness, performance, and health. It can be either chronic or acute and may vary widely in severity. All known animals sleep or exhibit some form of sleep behavior, and the importance of sleep is self-evident for humans, as nearly a third of a person's life is spent sleeping.
Combat Rescue Officer (CRO) is a Special Warfare Officer career field in the United States Air Force. Its Air Force Specialty Code (AFSC) is 19ZXC and it was created to strengthen USAF Special Warfare personnel recovery capabilities by providing commissioned officer leadership that possessed an operational skillset paralleling that of the enlisted pararescuemen (PJ). The CRO specialty includes direct combatant command and control of Combat Search and Rescue (CSAR) operations. They plan, manage and execute the six tasks of CSAR: prepare, report, locate, support, recover, and reintegrate isolated personnel and materiel. CROs conduct strategic, operational and tactical level planning, provide battle staff expertise, manage theater personnel recovery operations and conduct combat special operations.
Fatigue is a major human factors issue in aviation safety. The Fatigue Avoidance Scheduling Tool (FAST) was developed by the United States Air Force in 2000–2001 to address the problem of aircrew fatigue in aircrew flight scheduling. FAST is a Windows program that allows scientists, planners and schedulers to quantify the effects of various work-rest schedules on human performance. It allows work and sleep data entry in graphic, symbolic (grid) and text formats. The graphic input-output display shows cognitive performance effectiveness as a function of time. An upper green area on the graph ends at the time for normal sleep, 90% effectiveness. The goal of the planner or scheduler is to keep performance effectiveness at or above 90% by manipulating the timing and lengths of work and rest periods. A work schedule is entered as red bands on the time line. Sleep periods are entered as blue bands across the time line, below the red bands.
Second wind, a colloquial name for the scientific term wake maintenance zone, is a sleep phenomenon in which a person, after a prolonged period of staying awake, temporarily ceases to feel drowsy, often making it difficult to fall asleep when exhausted. They are the result of circadian rhythms cycling into a phase of wakefulness. For example, many people experience the effects of a second wind in the early morning even after an entire night without sleep because it is the time when they would normally wake up.
Amphetamine and methamphetamine are central nervous system stimulants used to treat a variety of conditions. When used recreationally, they are colloquially known as "speed" or sometimes "crank". Amphetamine was first synthesized in 1887 in Germany by Romanian chemist Lazăr Edeleanu, who named it phenylisopropylamine. Around the same time, Japanese organic chemist Nagai Nagayoshi isolated ephedrine from the Chinese ephedra plant and later developed a method for ephedrine synthesis. Methamphetamine was synthesized from ephedrine in 1893 by Nagayoshi. Neither drug had a pharmacological use until 1934, when Smith, Kline & French began selling amphetamine as an inhaler under the trade name Benzedrine for congestion.
Sleeping in space is part of space medicine and mission planning, with impacts on the health, capabilities and morale of astronauts.
The International Civil Aviation Organization (ICAO) defines fatigue as "A physiological state of reduced mental or physical performance capability resulting from sleep loss or extended wakefulness, circadian phase, or workload." The phenomenon places great risk on the crew and passengers of an airplane because it significantly increases the chance of pilot error. Fatigue is particularly prevalent among pilots because of "unpredictable work hours, long duty periods, circadian disruption, and insufficient sleep". These factors can occur together to produce a combination of sleep deprivation, circadian rhythm effects, and 'time-on task' fatigue. Regulators attempt to mitigate fatigue by limiting the number of hours pilots are allowed to fly over varying periods of time.
References
- ↑ Air Force Special Operations Command Instruction 48-101 Archived June 11, 2014, at the Wayback Machine , U.S. Air Force Special Operations Command, November 30, 2012.
- ↑ Air Force Special Operations Command Instruction 48–101 Archived June 11, 2014, at the Wayback Machine (sects. 1.7.4), U.S. Air Force Special Operations Command, November 30, 2012.
- ↑ Bonne, Jon (Jan 13, 2006). "'Go pills': A war on drugs?". NBC News. Archived from the original on November 11, 2020. Retrieved 18 May 2024.
- ↑ Tech. Sgt. J.C. Woodring (30 April 2004). "Air Force scientists battle aviator fatigue". www.af.mil. Archived from the original on 14 October 2012. Retrieved 5 January 2017.
- ↑ Emonson DL, Vanderbeek RD (1995). "The use of amphetamines in U.S. Air Force tactical operations during Desert Shield and Storm". Aviation, Space, and Environmental Medicine. 66 (3): 260–3. PMID 7661838.