Godfrey's Cordial

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A woman and physician funnelling Godfrey's Cordial into a resisting man A doctor restraining a young man while a lady funnel-feeds h Wellcome V0011079.jpg
A woman and physician funnelling Godfrey's Cordial into a resisting man

Godfrey's Cordial was a patent medicine, containing laudanum (tincture of opium) in a sweet syrup, which was commonly used as a sedative to quieten infants and children in Victorian England. [1] Used mostly by mothers working in agricultural groups or industry, [2] it ensured that she could work the maximum hours of her employment, without being disturbed by her infant, and thus increased the family income. [3] It was also used by nurses and baby-minders to enable them to neglect their duties if they wished. [3] [4]

Contents

Origin and composition

The original formula was named after apothecary Thomas Godfrey of Hunsdon in Hertfordshire. After his death in 1721, without leaving a clear heir to his work, [5] others claimed to have the formula and it was mass-produced across England. [5] Some also ascribed the medicine to Ambroise Hackwitz, also an apothecary, at around the same time, who changed his name to Godfrey and did business in Southampton Row. [1]

Thomas Wakley analysed the formula in 1823, and the ingredients, as he discovered them, were published in The Lancet . They included ginger, rectified spirits of wine, oil of sassafras, tincture of opium and Venice treacle. [5] [6] Other preparations have also been suggested, especially in light of the fact that opium was one of the most adulterated drugs in Victorian England. [3] Godfrey's cordial contained about 114 grain of opium per ounce apothecaries' system (~0.26% by mass) and was readily available without prescription in England and North America. [7] [8]

Infant deaths and usage

Various quack-cures suggest how they can help an ailing goose - Godfrey's Cordial is at the front of the queue. A large group of doctors deliberating around a patient; pres Wellcome V0011028.jpg
Various quack-cures suggest how they can help an ailing goose – Godfrey's Cordial is at the front of the queue.

Godfrey's cordial had long been recognised as leading to fatal cases of opium poisoning. [9]

However, it continued to be made and used until the early twentieth century, [3] at least in part due to the ease with which it could be manufactured. It was reportedly sold in enormous quantities in eighteenth century England, [1] [8] a time-span that has been popularly referred to as the golden age of physic, due to the widespread availability and consumption of enormous amounts of proprietary medicines. [10] Its low cost [11] and a lack of public knowledge about infant management [3] further increased its popularity.

Though many cases of infant death had been conclusively linked to an indiscriminate use of the medicine by mothers and nurses, [1] [5] [7] [12] exact numbers are hard to ascertain. [3] [11] Those who survived often, reportedly, had a severely damaged physical constitution. [3]

Decline

In 1857, with ill-advised opioid usage reaching alarming levels, a parliamentary bill was put forward which classified opium and its derivatives as poisons. This was intended to severely restrict the sale of such compounds, but it failed to pass through parliament, after being subject to intensive lobbying by trading chemists. It was also widely criticised as an impractical solution from an overall perspective. [3] A much-diluted version of the original proposed bill was finally implemented as the Pharmacy Act 1868 which limited the sale of opium derivatives to registered chemists and legally qualified apothecaries. [8] It explicitly excused patent medicines (and thus Godfrey's Cordial) from its purview. [3]

Usage of Godfrey's Cordial gradually declined post-1890 as several court rulings held that the act applied equally to patent medicines [3] and the British Medical Association subsequently published lists of safe home remedies, in a bid to increase public health awareness, which mentioned calomel and sugar-based derivatives as substitute sedative agents. Finally, the Pharmacy Act 1908, which classified it as a Schedule-I poison, [3] followed by the Dangerous Drugs Act 1920 which mandated a medical prescription, [8] heavily restricted the availability and usage of any such opioid-based drug.

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Morphine Pain medication of the opiate family

Morphine is a pain medication of the opiate family that is found naturally in a dark brown, resinous form, from the poppy plant. It can be taken orally or injected. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Morphine can be administered by mouth, by injection into a muscle, by injection under the skin, intravenously, injection into the space around the spinal cord, or rectally. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours. Long-acting formulations of morphine are available as MS-Contin, Kadian, and other brand names as well as generically.

Opium Dried latex obtained from the opium poppy

Opium is dried latex obtained from the seed capsules of the opium poppy Papaver somniferum. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade. The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to scratch ("score") the immature seed pods (fruits) by hand; the latex leaks out and dries to a sticky yellowish residue that is later scraped off and dehydrated. The word "meconium" historically referred to related, weaker preparations made from other parts of the opium poppy or different species of poppies.

Narcotic Chemical substance with psycho-active properties

The term narcotic originally referred medically to any psychoactive compound with numbing or paralyzing properties. In the United States, it has since become associated with opiates and opioids, commonly morphine and heroin, as well as derivatives of many of the compounds found within raw opium latex. The primary three are morphine, codeine, and thebaine.

Laudanum Tincture of opium

Laudanum is a tincture of opium containing approximately 10% powdered opium by weight. In short, laudanum is prepared by dissolving extracts from the opium poppy in alcohol (ethanol).

Paregoric Traditional patent medicine

Paregoric, or camphorated tincture of opium, also known as tinctura opii camphorata, is a traditional patent medicine known for its antidiarrheal, antitussive, and analgesic properties.

Naloxone Opioid receptor antagonist

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Patent medicine

A patent medicine, also known as a nostrum, is a commercial product advertised as an over-the-counter medicine, without regard to its actual effectiveness. Patent medicines are typically characterized as pseudoscientific.

Opioid Psychoactive chemical

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Chlorodyne

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Dalbys Carminative Drug

Dalby's Carminative was one of the two most widely used patent medicines given to babies and children at the end of the 18th and beginning of the 19th centuries. Together with its rival, Godfrey's Cordial, they were known as "mother's friends" and were used for everything from colic and coughs to typhoid.

Codeine Opiate and prodrug of morphine used to treat pain

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Opiate Substance derived from opium

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Warburg's tincture was a pharmaceutical drug, now obsolete. It was invented in 1834 by Dr. Carl Warburg.

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Dr. Batemans Pectoral Drops

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References

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  2. Parssinen, Terry M. (1983). Secret Passions, Secret Remedies: Narcotic Drugs in British Society, 1820-1930. Manchester University Press. ISBN   9780719009525.
  3. 1 2 3 4 5 6 7 8 9 10 11 Lomax, Elizabeth (1973). "The Uses and Abuses of Opiates in Nineteenth-Century England". Bulletin of the History of Medicine. 47 (2): 167–176. JSTOR   44447528. PMID   4584236.
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  8. 1 2 3 4 Milner, Larry Stephen (2000). Hardness of Heart/hardness of Life: The Stain of Human Infanticide. University Press of America. ISBN   9780761815785.
  9. C., T. E. (1 June 1970). "What were Godfrey's Cordial and Dalby's Carminative?". Pediatrics. 45 (6). ISSN   0031-4005.
  10. Kelly, James (2008). "Health for sale: mountebanks, doctors, printers and the supply of medication in eighteenth-century Ireland". Proceedings of the Royal Irish Academy, Section C: Archaeology, Celtic Studies, History, Linguistics, Literature. 108C: 75–113. doi:10.3318/PRIAC.2008.108.75. JSTOR   40657923.
  11. 1 2 Jordan, Thomas Edward (1987). Victorian Childhood: Themes and Variations. SUNY Press. ISBN   9780887065446.
  12. "Death from Godfrey's Cordial". The Lancet. 140 (3610): 1061. 5 November 1892. doi:10.1016/S0140-6736(01)92752-7. ISSN   0140-6736.