Grey's Anatomy season 22

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Grey's Anatomy
Season 22
Greys Anatomy season 22 promotional poster.jpg
Promotional poster
ShowrunnerMeg Marinis
Starring
No. of episodes3
Release
Original network ABC
Original releaseOctober 9, 2025 (2025-10-09) –
present
Season chronology
← Previous
Season 21
List of episodes

The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premiered in the United States on the American Broadcasting Company (ABC) on October 9, 2025. [1] [2]

This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively. [3]

Episodes

No.
overall		No. in
season		Title  [4] Directed byWritten by  [5] Original release date  [4] U.S. viewers
(millions)
4491"Only the Strong Survive" Debbie Allen Meg MarinisOctober 9, 2025 (2025-10-09)2.61 [6]
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
4502"We Built This City" Kevin McKidd Zoanne Clack October 16, 2025 (2025-10-16)2.20 [7]
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Meanwhile, Meredith and Maggie spend time with Amelia.
4513"Between Two Lungs"Debbie AllenSandra HamadaOctober 23, 2025 (2025-10-23)2.16 [8]
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
4524"Goodbye Horses" Sammi Cannold Jase Miles-PerezOctober 30, 2025 (2025-10-30)TBD
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
4535"Sometimes I Feel Like a Motherless Child" Bille Woodruff TBANovember 6, 2025 (2025-11-06)TBD
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
4546"When I Crash" Phylicia Rashad TBANovember 13, 2025 (2025-11-13)TBD
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience.
4557TBATBATBAJanuary 8, 2026 (2026-01-08)TBD
4568TBATBATBAJanuary 15, 2026 (2026-01-15)TBD

Cast and characters

Main

Recurring

Notable guests

Production

Development

On April 3, 2025, ABC renewed the series for a twenty-second season with Meg Marinis third year as showrunner. [1] The season consists of 18 episodes, consistent with the episode order of Season 21. [12] It will also surpass the 450 episode mark during episode 2, extending its record as the longest-running American primetime medical drama. [13] Filming began on August 1. [14] Season 22 premiered in the United States on October 9, 2025. [15]

Casting

Ellen Pompeo will continue to narrate the series and receive star billing, appearing in seven episodes, as she did in Season 21. [16] Chandra Wilson and James Pickens Jr. remain the only original cast members confirmed to appear in all 18 episodes. [17]

On October 9, 2025, Trevor Jackson, who guest starred as Dr. Wes Bryant in the last two episodes of Season 21, was promoted to a series regular. [9]

Continuing from last season, the minimum episode guarantee for most series regulars was reduced to 14 out of 18 episodes. However, longtime cast member Caterina Scorsone's role was further scaled back, resulting in a total of 10 appearances for the season as part of a cost-cutting measure. Following her character's sabbatical in episode two, Scorsone was absent for eight episodes, returning for episode 11 in February 2026. [18]

Reception

Ratings

Viewership and ratings per episode of Grey's Anatomy season 22
No.TitleAir dateTimeslot (ET) Rating/share
(18–49)		Viewers
(millions)		DVR
(18–49)		DVR viewers
(millions)		Total
(18–49)		Total viewers
(millions)		Ref.
1"Only the Strong Survive"October 9, 2025Thursday 10:00 p.m.0.3/32.61———— [6]
2"We Built This City"October 16, 20250.2/22.20———— [7]
3"Between Two Lungs"October 23, 20250.2/32.16———— [8]

References

  1. 1 2 Otterson, Joe (April 3, 2025). "'9-1-1,' 'Grey's Anatomy,' 'The Rookie,' 'Shifting Gears,' 'Will Trent' Renewed at ABC". Variety . Retrieved July 15, 2025.
  2. ↑ White, Peter (July 29, 2025). "ABC Moves Up 'Grey's Anatomy', '9-1-1' & '9-1-1: Nashville' Premiere Dates". Deadline Hollywood . Retrieved July 29, 2025.
  3. ↑ Venable, Malcom (December 4, 2024). "'Grey's Anatomy' Showrunner Meg Marinis on That Shocking Mid-Season Finale, Two Big Departures, and What's Coming Next". Shondaland . Retrieved July 22, 2025.
  4. 1 2 "Shows A-Z – Grey's Anatomy on ABC". The Futon Critic . Retrieved October 23, 2025.
  5. ↑ "Grey's Anatomy". Writers Guild of America West . Retrieved October 6, 2025.
  6. 1 2 Pucci, Douglas (October 10, 2025). "Thursday Ratings: 9-1-1: Nashville on ABC Has Okay Debut". Programming Insider. Retrieved October 14, 2025.
  7. 1 2 Pucci, Douglas (October 17, 2025). "Thursday Ratings: CBS Leads Broadcast Networks Among Total Viewers, Year-Over-Year Erosion in Key Demos for Linear Overall". Programming Insider. Retrieved October 20, 2025.
  8. 1 2 Pucci, Douglas (October 27, 2025). "Thursday Ratings: Ghosts on CBS Earns Top 18-49 and 25-54 Demos Among Prime Time Broadcast Network Telecasts". Programming Insider. Retrieved October 27, 2025.
  9. 1 2 3 4 Andreeva, Nellie (October 9, 2025). "'Grey's Anatomy' Ups Trevor Jackson To Series Regular, Adds Jade Pettyjohn & Anita Kalathara As Recurring For Season 22'". Deadline Hollywood . Retrieved October 9, 2025.
  10. ↑ Roots, Kimberly; Swift, Andy; Matt, Mitovich; Nemetz, Dave; Franken, Claire; Schwartz, Ryan; Caruso, Nick; Mason, Charlie (September 10, 2025). "Fall TV Preview 2025: Exclusive Scoop and Photos on 30+ Returning Favorites!". TVLine . Retrieved September 11, 2025.
  11. ↑ Swift, Andy (October 23, 2025). "Sophia Bush Returns To Grey's Anatomy — Watch Cass' Awkward Reunion With Teddy (Exclusive)". TVLine . Retrieved October 23, 2025.
  12. ↑ Andreeva, Nellie (April 3, 2025). "'Grey's Anatomy' Renewed For Season 22 By ABC With Veteran Cast Poised To Return". Deadline Hollywood . Retrieved July 21, 2025.
  13. ↑ Levine, Daniel; Hyman, Lizzie (May 14, 2025). "Chandra Wilson Says After 20 Years, 'It Is Time' to Watch Grey's Anatomy for Herself: 'Got as Far as Season 3' (Exclusive)". People Magazine . Retrieved July 21, 2025.
  14. ↑ Camilla Luddington [@camillaluddington]; (July 31, 2025). "Backstory… Tonight I'm re-watching the season finale again to prepare for filming tmw. And suddenly.. Matt decides he needs to blend a smoothie. At 8pm.. during this scene.. I had to start recording 😂" . Retrieved August 10, 2025– via Instagram.
  15. ↑ Shanfeld, Ethan (July 29, 2025). "'Grey's Anatomy,' '9-1-1' and '9-1-1: Nashville' Move Up Premiere Dates on ABC". Variety . Retrieved July 29, 2025.
  16. ↑ Gao, Max (April 29, 2025). "Ellen Pompeo on Her Lasting Legacy, the 'Really S—ty' Streaming Residual Model and Meredith's Choice This Season She Was 'Deeply Against'". Variety. Retrieved July 21, 2025.
  17. ↑ Bell, Amanda (July 17, 2025). "'Grey's Anatomy' Season 22 Premiere Date Revealed". TV Insider. Retrieved July 21, 2025.
  18. ↑ Andreeva, Nellie (October 16, 2025). "'Grey's Anatomy' Sets Extended Break For Main Cast Member: Find Out When They Will Return". Deadline Hollywood . Retrieved October 16, 2025.
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