Canning made 15 appearances with 11 starts as a freshman at UCLA in 2015. He was 7–1 with a 2.97 ERA and 66 strikeouts. As a sophomore,he became UCLA's number one starter.[5] He made 15 starts,going 5–8 with a 3.70 ERA and 95 strikeouts.[6][7] Canning returned as UCLA's ace in 2017.[8] In 17 starts,he went 7–4 with a 2.34 ERA and 140 strikeouts.
On April 30, 2019, the Angels promoted Canning to the major leagues and he made his debut that night, against the Toronto Blue Jays, recording six strikeouts over 4+1⁄3 innings pitched.[14] After multiple trips to the injured list with elbow inflammation, the Angels announced on August 22, that they would shut down Canning for the rest of the season, cutting his rookie season short. He went 5–6 with a 4.58 ERA and 96 strikeouts.[15]
In 2020, Canning went 2–3 with a 3.99 ERA and 56 strikeouts in 11 starts. He was tied for the AL lead among pitchers with three defensive runs saved and made just one error out of 16 chances. Canning went on to win his first Gold Glove Award that season.[16]
In 2021, Canning went 5–4 with a 5.60 ERA and 62 strikeouts in 13 starts.[17] On July 3, 2021, Canning was optioned to Triple-A Salt Lake.[18] On August 10, 2021, the Angels announced that Canning would miss the rest of the season with a low back stress fracture.[19]
Canning was placed on the 60-day injured list to begin the 2022 season. In August, he was shut down after experiencing multiple setbacks in his recovery, and did not make a professional appearance on the year.[20] On January 13, 2023, Canning signed a one-year, $850,000 contract with the Angels, avoiding salary arbitration.[21]
Canning made 32 appearances (31 starts) for the Angels in 2024, compiling a 6–13 record and 5.19 ERA with 130 strikeouts across 171+2⁄3 innings pitched.
On October 31, 2024, Canning was traded to the Atlanta Braves in exchange for Jorge Soler.[22][23] However, on November 22, the Braves non–tendered Canning, making him a free agent.[24]
New York Mets
On December 19, 2024, Canning signed a one-year, $4.25 million contract with the New York Mets.[25]
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