Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia. Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
France Télévisions is the French national public television broadcaster. It is a state-owned company formed from the integration of the public television channels France 2 and France 3, later joined by the legally independent channels France 4, and France 5.
France 24 is a French state-owned international news television network based in Paris. Its channels broadcast in French, English, Arabic, and Spanish and are aimed at the overseas market.
WISC-TV is a television station in Madison, Wisconsin, United States, affiliated with CBS and MyNetworkTV. It is the flagship television property of locally based Morgan Murphy Media, which has owned the station since its inception. WISC-TV's studios are located on Raymond Road in Madison, and its transmitter is located on Mineral Point Road in the Middleton Junction section of the town of Middleton.
Freesat is a British free-to-air satellite television service, first formed as a joint venture between the BBC and ITV plc. The service was formed as a memorandum in 2007 and has been marketed since 6 May 2008. Freesat offers a satellite alternative to the Freeview service on digital terrestrial television, with a broadly similar selection of channels available without subscription for users purchasing a receiver.
DR1 is the flagship television channel of the Danish Broadcasting Corporation (DR). It became Denmark's first television station when it began broadcasting in 1951 – at first only for an hour a day three times a week.
Beta thalassemias are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. Global annual incidence is estimated at one in 100,000. Beta thalassemias occur due to malfunctions in the hemoglobin subunit beta or HBB. The severity of the disease depends on the nature of the mutation.
A locus control region (LCR) is a long-range cis-regulatory element that enhances expression of linked genes at distal chromatin sites. It functions in a copy number-dependent manner and is tissue-specific, as seen in the selective expression of β-globin genes in erythroid cells. Expression levels of genes can be modified by the LCR and gene-proximal elements, such as promoters, enhancers, and silencers. The LCR functions by recruiting chromatin-modifying, coactivator, and transcription complexes. Its sequence is conserved in many vertebrates, and conservation of specific sites may suggest importance in function. It has been compared to a super-enhancer as both perform long-range cis regulation via recruitment of the transcription complex.
The human β-globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of the beta parts of the oxygen transport protein Haemoglobin. This locus contains not only the beta globin gene but also delta, gamma-A, gamma-G, and epsilon globin. Expression of all of these genes is controlled by single locus control region (LCR), and the genes are differentially expressed throughout development.
Hemoglobin subunit beta is a globin protein, coded for by the HBB gene, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). It is 147 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains.
RTV21 is a media company based in Pristina, Kosovo, which includes a radio, a television, and a website.
GMA Network, Inc., commonly known as GMA, is a Filipino media company based in Diliman, Quezon City, Philippines. It is primarily involved in radio and television broadcasting, with subsidiaries dealing in various media related businesses. The majority of its profits are derived from publicity and marketing incomes associated to television distribution. GMA is the largest media company in the Philippines in terms of market capitalization, net income, revenue, reach, audience share and number of stations.
Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid cells.
Hemoglobin subunit delta is a protein that in humans is encoded by the HBD gene.
Freeview is the brand name of the digital terrestrial television platform in Australia intended to bring all of free-to-air (FTA) broadcasters onto a consistent marketing platform, to compete against subscription television, in particular Foxtel. The strategy coincided with the expansion to 3 digital channels for each FTA network and the planned phasing out of analog television in Australia. Important services from Freeview include its free-to-air channels with an enhanced EPG across all channels. Freeview also certifies televisions, set-top boxes and personal video recorders (PVR) which meet its standards.
Hybrid Broadcast Broadband TV (HbbTV) is both an industry standard and promotional initiative for hybrid digital TV to harmonise the broadcast, IPTV, and broadband delivery of entertainment to the end consumer through connected TVs and set-top boxes. The HbbTV Association, comprising digital broadcasting and Internet industry companies, has established a standard for the delivery of broadcast TV and broadband TV to the home, through a single user interface, creating an open platform as an alternative to proprietary technologies. Products and services using the HbbTV standard can operate over different broadcasting technologies, such as satellite, cable, or terrestrial networks.
HD+ is a premium high-definition (HD) satellite television service for German users, owned by HD PLUS GmbH, a subsidiary of SES based in Unterföhring near Munich, Germany.
TouchVision was an American digital broadcast and internet Video on demand television network that was owned by Think Televisual. The service provided rolling news coverage that was distributed to television, mobile and tablet platforms. TouchVision's operations were based out of the headquarters of Weigel Broadcasting in Chicago, Illinois.
Betibeglogene autotemcel, sold under the brand name Zynteglo, is a medication for the treatment for beta thalassemia. It was developed by Bluebird Bio and was given breakthrough therapy designation by the U.S. Food and Drug Administration in February 2015. It was approved for medical use in the European Union in May 2019.
