Haemolysin E

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Haemolysin E (HlyE)
PDB 1qoy EBI.jpg
Structure of E. coli hemolysin E toxin. [1]
Identifiers
SymbolHlyE
Pfam PF06109
InterPro IPR010356
SCOP2 1qoy / SCOPe / SUPFAM
TCDB 1.C.10
OPM superfamily 198
OPM protein 2wcd

Haemolysin E (HlyE) is a protein family that consists of several enterobacterial haemolysin (HlyE) proteins. Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli , Salmonella typhi , and Shigella flexneri .

HlyE is unrelated to the well characterised pore-forming E. coli hemolysins of the RTX family, haemolysin A.

HlyE is a protein of 34 kDa that is expressed during anaerobic growth of E. coli. Anaerobic expression is controlled by the transcription factor, FNR, such that, upon ingestion and entry into the anaerobic mammalian intestine, HlyE is produced and may then contribute to the colonisation of the host. [1]

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References

  1. 1 2 Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, Artymiuk PJ (January 2000). "E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy". Cell. 100 (2): 265–76. doi: 10.1016/S0092-8674(00)81564-0 . PMID   10660049. S2CID   1793308.
This article incorporates text from the public domain Pfam and InterPro: IPR013057