Hal Blumenfeld

Hal Blumenfeld
Born	(1962-03-28) March 28, 1962 (age 63) California
Education	Harvard University Columbia University
Occupation(s)	Professor of Neurology, Neuroscience, and Neurosurgery
Years active	25
Known for	Consciousness Research in Epilepsy
Medical career
Field	Neuroscience, Neurology
Institutions	Yale University School of Medicine Massachusetts General Hospital/Harvard Medical School Columbia Presbyterian Medical Center
Awards	Research Recognition Award, Clinical Science, American Epilepsy Society (2017) Javits Neuroscience Investigator Award, National Institute of Neurological Disorders and Stroke (2017) Mark Loughridge and Michele Williams Professorship, Yale University School of Medicine (2015 - ) Yale Graduate Mentor Award (2015). Visiting Professor, Xiangya School of Medicine, Changsha, Hunan, China (2015-2020).

Hal Blumenfeld (born March 28, 1962) is a professor of neurology, neuroscience, and neurosurgery ^[1] at Yale University. His focus is on brain mechanisms of consciousness and on altered consciousness in epilepsy. ^[2] As director of the Yale Clinical Neuroscience Imaging Center, ^[3] he leads multi-disciplinary research ^[4] and is also well known for his teaching contributions in neuroanatomy and clinical neuroscience. ^[5]

Biography

Blumenfeld was born in California, grew up in New York, and began his career in Bio-electrical Engineering at Harvard University (1984). ^[6] His passion for science would lead him to Columbia University, where, working with Eric Kandel and Steven Siegelbaum, he obtained his PhD (1990) in Physiology and Cellular Biophysics and his MD (1992). ^{[6] [7] [8]} He completed his internal medicine internship at Columbia Presbyterian Medical Center(1993) and entered the field of neurology, completing a three-year residency program at Massachusetts General Hospital in Boston (1996). He then completed his fellowship at Yale University's School of Medicine. ^[9]

Career

Blumenfeld dedicated his professional career to studying brain networks in various types of seizures as well as normal brain function. Using multiple modalities of brain imaging in humans and animal models, his research has made significant contributions towards determining why children with absence seizures become unconscious. ^{[10] [11] [12] [13] [14]}

Through active collaborations with Fahmeed Hyder ^[15] (also at Yale), Blumenfeld's direct recordings of the electrical activity of brain cells improved the analysis of indirect neuroimaging measurements of brain functions, utilizing fMRI.

Blumenfeld is the author of the textbook Neuroanatomy through Clinical Cases. The textbook is used in over half the medical schools in the United States and throughout the world. ^{[16] [17] [18] [19] [20]}

Awards

• 2017 - Javits Neuroscience Investigator Award, National Institute of Neurological Disorders and Stroke ^[21]
• 2017 - Clinical Science Research Award, American Epilepsy Society ^[22]
• 2015 - Graduate Mentor Award, Yale University ^[23]
• 2007 - Francis Gilman Blake Award, Yale University, School of Medicine ^[24]
• 2005 - Dreifuss-Penry Epilepsy Research Award, American Academy of Neurology ^[25]

Publications

Books

• Blumenfeld, H. (2021). Neuroanatomy through Clinical Cases, 3rd Ed. Sinauer Associates/Oxford University Press.
• Cavanna, A.E., Nani, A., Blumenfeld, H., Laureys, S. [Eds.] (2013). Neuroimaging of Consciousness. Springer.
• Faingold, C., Blumenfeld, H. [Eds.] (2014). Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. Elsevier ISBN   9780124158641.

Articles

• X Herman W, Smith RE, Kronemer SI, Watsky RE, Chen WC, M Gober L, Touloumes GJ, Khosla M, Raja A, Horien CL, C Morse E, L Botta K, Hirsch LJ, Alkawadri R, Gerrard JL, Spencer DD, Blumenfeld H:A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cereb Cortex. 2017 Nov. PMID   29194517
• Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H: Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. Lancet Neurol. 2016 Dec. PMID   27839650
• Kundishora AJ, Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Gerrard J, Blumenfeld H: Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cereb Cortex. 2016 Mar 3; 2016 Mar 3. PMID   26941379
• Zhan Q, Buchanan GF, Motelow JE, Andrews J, Vitkovskiy P, Chen WC, Serout F, Gummadavelli A, Kundishora A, Furman M, Li W, Bo X, Richerson GB, Blumenfeld H: Impaired Serotonergic Brainstem Function during and after Seizures. J Neurosci. 2016 Mar 2. PMID   26937010
• Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H: Decreased subcortical cholinergic arousal in focal seizures. Neuron. 2015 Feb 4. PMID   25654258
• Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F: Analysis of time and space invariance of BOLD responses in the rat visual system. Cereb Cortex. 2013 Jan; 2012 Jan 31. PMID   22298731
• Blumenfeld H. (2012). Impaired consciousness in epilepsy. The Lancet Neurology, 11: 814–826.
• Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H: Where fMRI and electrophysiology agree to disagree: corticothalamic and striatal activity patterns in the WAG/Rij rat. J Neurosci. 2011 Oct 19. PMID   22016539
• Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H: Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain. 2010 Dec; 2010 Nov 16. PMID   21081551
• Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, Desalvo M, Novotny EJ, Constable RT, Blumenfeld H: Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging. J Neurosci. 2010 Apr 28. PMID   20427649
• Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F, Blumenfeld H: Cortical deactivation induced by subcortical network dysfunction in limbic seizures. J Neurosci. 2009 Oct 14. PMID   19828814
• Blumenfeld H, Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Zubal IG, Paige AL, Spencer SS: Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures. Brain. 2009 Apr; 2009 Apr 1. PMID   19339252
• Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H: Negative BOLD with large increases in neuronal activity. Cereb Cortex. 2008 Aug; 2007 Dec 5. PMID   18063563
• Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR: Early treatment suppresses the development of spike-wave epilepsy in a rat model. Epilepsia. 2008 Mar; 2007 Dec 6. PMID   18070091
• Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ Jr, Zubal IG, Spencer SS: Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex. 2004 Aug; 2004 Apr 14. PMID   15084494

References

1. http://medfaculty.yale.edu/programs/hal_blumenfeld.profile%5B%5D
2. "Connecticut's Best Doctors 2018". connecticutmag.com.
3. "CNIC Labs > Clinical Neurosciences Imaging Center (CNIC) - Neurology - Yale School of Medicine". cnic.yale.edu.
4. "Home > Blumenfeld Lab - Neurology - Yale School of Medicine". medicine.yale.edu.
5. "Graduate Mentor Awards | Yale Graduate School of Arts & Sciences". Gsas.yale.edu. 2015-05-21. Retrieved 2017-05-03.
6. Curriculum Vitae. Blumenfeld, H. (Accessed 20 May 2021). https://prod.admin.profile.yale.edu/Profiles/Cv/user/hal_blumenfeld
7. "Alumni Directory". columbia.edu. 13 April 2015.
8. Blumenfeld, Hal (1990). Modulation of intracellular calcium in Aplysia sensory neurons (Thesis).
9. "Profile". Yale School of Medicine - Official website. Retrieved 30 September 2021.
10. Guo, Jennifer N.; Kim, Robert; Chen, Yu; Negishi, Michiro; Jhun, Stephen; Weiss, Sarah; Ryu, Jun Hwan; Bai, Xiaoxiao; Xiao, Wendy; Feeney, Erin; Rodriguez-Fernandez, Jorge (December 2016). "Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study". The Lancet. Neurology. 15 (13): 1336–1345. doi:10.1016/S1474-4422(16)30295-2. ISSN   1474-4465. PMC   5504428 . PMID   27839650.
11. Blumenfeld, Hal (2005). "Consciousness and epilepsy: why are patients with absence seizures absent?". The Boundaries of Consciousness: Neurobiology and Neuropathology. Progress in Brain Research. Vol. 150. pp. 271–286. doi:10.1016/S0079-6123(05)50020-7. ISBN   9780444518514. ISSN   0079-6123. PMC   3153469 . PMID   16186030.
12. Bai, Xiaoxiao; Vestal, Matthew; Berman, Rachel; Negishi, Michiro; Spann, Marisa; Vega, Clemente; Desalvo, Matthew; Novotny, Edward J.; Constable, Robert T.; Blumenfeld, Hal (2010-04-28). "Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging". The Journal of Neuroscience. 30 (17): 5884–5893. doi:10.1523/JNEUROSCI.5101-09.2010. ISSN   1529-2401. PMC   2946206 . PMID   20427649.
13. Bai, X.; Guo, J.; Killory, B.; Vestal, M.; Berman, R.; Negishi, M.; Danielson, N.; Novotny, E. J.; Constable, R. T.; Blumenfeld, H. (2011-06-07). "Resting functional connectivity between the hemispheres in childhood absence epilepsy". Neurology. 76 (23): 1960–1967. doi:10.1212/WNL.0b013e31821e54de. ISSN   1526-632X. PMC   3109878 . PMID   21646622.
14. Killory, Brendan D.; Bai, Xiaoxiao; Negishi, Michiro; Vega, Clemente; Spann, Marisa N.; Vestal, Matthew; Guo, Jennifer; Berman, Rachel; Danielson, Nathan; Trejo, Jerry; Shisler, David (2011-06-15). "Impaired attention and network connectivity in childhood absence epilepsy". NeuroImage. 56 (4): 2209–2217. doi:10.1016/j.neuroimage.2011.03.036. ISSN   1095-9572. PMC   3105167 . PMID   21421063.
15. http://medfaculty.yale.edu/about/fahmeed_hyder.profile?source=news ^{[ dead link ]}
16. "Ultimate guide to buying your Neuroscience Textbooks". The Brainworm. Retrieved 2017-05-03.
17. Hal Blumenfeld (2010-02-28). Neuroanatomy Through Clinical Cases (2nd ed.). Booktopia. ISBN   9780878936137 . Retrieved 2017-05-03.
18. "SYLLABUS: MEDICAL NEUROSCIENCE" (PDF). Tulane.edu. Archived from the original (PDF) on 2017-08-13. Retrieved 2017-05-03.
19. "Required and recommended textbook list" (PDF). Medicine.tufts.edu. Archived from the original (PDF) on 2016-07-23. Retrieved 2017-05-03.
20. "Book Review: Neuroanatomy through Clinical Cases". The Neuroradiology Journal. 26 (3): 358–360. June 2013. doi:10.1177/197140091302600319. ISSN   1971-4009. PMC   5278855 .
21. "Blumenfeld receives prestigious award that supports research into seizures - Yale School of Medicine". yale.edu.
22. "2017 Awardees | American Epilepsy Society". Archived from the original on 2018-04-12. Retrieved 2018-04-11.
23. "Graduate Mentor Awards - Yale Graduate School of Arts & Sciences". gsas.yale.edu.
24. "From the inner city to Yale and neurosurgery > Students > Autumn 2007 - Yale Medicine". ymm.yale.edu.
25. "Awards History". www.aan.com. Archived from the original on 2018-06-20. Retrieved 2018-04-11.

External links

• "Home > Blumenfeld Lab | Neurology | Yale School of Medicine". Medicine.yale.edu. Retrieved 2017-05-03.
• "My NCBI Collections : Display Results" (PDF). Ncbi.nlm.nih.gov. Retrieved 2017-05-03.