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The N-methyl-D-aspartatereceptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. Depending on its subunit composition, its ligands are glutamate and glycine (or D-serine). However, the binding of the ligands is typically not sufficient to open the channel as it may be blocked by Mg2+ ions which are only removed when the neuron is sufficiently depolarized. Thus, the channel acts as a "coincidence detector" and only once both of these conditions are met, the channel opens and it allows positively charged ions (cations) to flow through the cell membrane. The NMDA receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions.
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R. Suzanne Zukin is an American neuroscientist and a professor of neuroscience who directs a research lab as a F. M. Kirby Chair in Neural Repair and Protection and director of the Neuropsychopharmacology Center at Albert Einstein College of Medicine. Zukin's areas of research include neurodegenerative disorders, Ischemia, Epigenetics and Autism and uses molecular biology approaches to research these disorders. Zukin has made seminal contributions to the understanding of NMDA and AMPA receptor function and activity.
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References
- 1 2 Hannah Monyer Archived 2008-02-17 at the Wayback Machine , Crossroads in Biology, received 27 May 2010.
- ↑ Why we remember and forget Archived 2012-03-01 at the Wayback Machine , European Molecular Biology Laboratory, retrieved 27 May 2010.
- 1 2 3 4 5 Hannah Monyer receives Leibniz Prize Archived 2016-03-03 at the Wayback Machine , University of Heidelberg, retrieved 27 May 2010.
- 1 2 Phillip Morris Research Prize Archived 2012-02-27 at the Wayback Machine , Biopro, retrieved 27 May 2010.
- ↑ Interdisciplinary Center for Neuroscience, Heidelberg University, retrieved 27 May 2010.
- ↑ Profile of Hannah Monyer Archived 2012-08-14 at the Wayback Machine , Frontiers in Molecular Neuroscience, retrieved 27 May 2010.
- 1 2 DZNE Archived 2012-02-27 at the Wayback Machine , The Senate of the DZNE, retrieved 27 May 2010.
- ↑ Interview with Hannah Monyer, (in German) Siebenbürgische Zeitung, retrieved 27 May 2010.
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