Haplogroup H10e (mtDNA)

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Haplogroup H10e is a human mitochondrial DNA haplogroup. It is defined by mutation C16221T. It is between 5,700 [1] and 7,000 years old. [2]

Contents

Origins

According to Behar et al., the woman who founded this line was estimated to have lived between 2,400 and 7,000 years ago. [2] From a neolithic burial at the Bom Santo cave (near Lisbon/Portugal), however, we know that H10e existed already at 3735 BCE ± 45 years. Hence H10e is at least 5,753 years old. [1]

Almost a thousand years later an H10e find was associated with a Corded Ware Culture burial in Eulau. The site Eulau, Burgenlandkreis, is located in the valley of the Saale river in Germany. What is interesting to note in this context, is that H10e was first found at the Bom Santo cave which is located near the epicenter of the birth of the Bell Beaker culture. Then the find at Eulau was geographically located at the boundary between the Bell Beaker area of influence and the Corded Ware Culture area of influence. Therefore, we may see evidence that some women of Bell Beaker ethnic origin became part of the Corded Ware Culture. [3]

Descendant branches

Haplogroup H10e has currently three descendent branches, namely H10e1, H10e2 and H10e3, that are recognized by PhyloTree. [4] [5] Additional branches, from H10e4 through H10e9, were named by YFull. [6]

Archeological record

Haplogroup H10e has been found at a neolithic site, namely the Bom Santo cave near Lisbon, Portugal. This is the oldest sample of H10 which has ever been found and it has been dated to about 3735 BCE (± 45 years). Out of 14 individuals analyzed there was only a single sample belonging to haplogroup H, namely a migrant male belonging to haplogroup H10e. [2]

In 2008 mitochondrial DNA was extracted from a gravesite in Eulau (2,600 BCE) which has been associated with the Corded Ware Culture. Haplogroup H10e was found in one individual out of nine tested. [7]

Furthermore, H10e has been found in a 10th-century sample from a male individual buried at the Zvonimirovo cemetery site in Croatia. [8]

There is also a strong Viking component with this haplogroup. The following samples from Scandianavia of the Viking age have all been associated with H10e: [9]

Viking era archeological samples of H10e from Scandinavia
CountryAgeRegionSexmtDNA HaplogroupLaboratory ID
Sweden900-1050 ADGotlandMaleH10eGotland_Kopparsvik-212/65
Denmark850-900 ADSealandFemaleH10e1Denmark_Lejre Grav 804
Estonia8th century ADSaaremaaMaleH10eEstonia_Salme_I-7
Estonia8th century ADSaaremaaMaleH10eEstonia_Salme_II-K

H10e has been found twice at the medieval Tuukkala archeological site in Finland. The Tuukkala site is located in north eastern Finland and has been dated to 1200 AD – 1400 AD. Two individuals (TU631 and TU645) both shared the same H10e-haplotype. [10]

H10e has also been found in two individuals from the early 17th century at Jamestown, Virginia. [11]

GenBank samples

The following sequences that are informative of the past and present distributions of haplogroup H10e are among those that are part of the public database GenBank.

HaplogroupGenBank IDPopulationSource
H10e HQ662520 FrenchFamilyTreeDNA
H10e JX153206 FinlandRaule 2014 [12]
H10e JX153631 FinlandRaule 2014 [12]
H10e JX171093 FinlandSoini 2012 [13]
H10e KF161060 DenmarkLi 2014 [14]
H10e KF161301 DenmarkLi 2014 [14]
H10e KF162739 DenmarkLi 2014 [14]
H10e KM576763 SwedishFamilyTreeDNA
H10e KY670894 RussiaMalyarchuk 2017 [15]
H10e MF070512 SwedishFamilyTreeDNA
H10e MG009577 EnglishFamilyTreeDNA
H10e MN540515 ancient FinlandÖversti 2019 [10]
H10e MN540519 ancient FinlandÖversti 2019 [10]
H10e MN888511 GermanyFamilyTreeDNA
H10e MT232751 EnglishYSEQ
H10e OR438625 PolandPiotrowska-Nowak 2023 [16]
H10e1a OM194244 KazakhAskapuli 2022 [17]
H10e1d PP974320 BelarusFamilyTreeDNA
H10e1d KF162232 DenmarkLi 2014 [14]
H10e1d KF162434 DenmarkLi 2014 [14]
H10e2 HM101252 EnglishFamilyTreeDNA
H10e2 KF162694 DenmarkLi 2014 [14]
H10e2 MG646161 PolandPiotrowska-Nowak 2019 [18]
H10e2 OR438506 PolandPiotrowska-Nowak 2023 [16]
H10e3 MF464490 RussianFamilyTreeDNA
H10e3 MZ846245 ShetlandDulias 2022 [19]
H10e3 MZ846248 ShetlandDulias 2022 [19]
H10e3 MZ846250 ShetlandDulias 2022 [19]
H10e3 MZ846346 ShetlandDulias 2022 [19]
H10e3 MZ846703 ShetlandDulias 2022 [19]
H10e3a KF162333 DenmarkLi 2014 [14]
H10e3a MZ846610 ShetlandDulias 2022 [19]
H10e3a MZ846743 OrkneyDulias 2022 [19]
H10e3a MZ846755 OrkneyDulias 2022 [19]
H10e3a MZ846781 OrkneyDulias 2022 [19]
H10e3a MZ847073 OrkneyDulias 2022 [19]
H10e3a MZ847222 OrkneyDulias 2022 [19]
H10e3a MZ847226 OrkneyDulias 2022 [19]
H10e3a MZ847710 OrkneyDulias 2022 [19]
H10e3a MZ847741 OrkneyDulias 2022 [19]
H10e3a MZ847750 OrkneyDulias 2022 [19]
H10e3a MZ847752 OrkneyDulias 2022 [19]

Prominent members of H10e

Pierre Terrail (1473 – 30 April 1524), seigneur de Bayard, the legendary medieval French knight "without fear and beyond reproach", is thought to have carried mtDNA haplogroup H10e. This has been determined by DNA-testing both his exhumed remains and DNA-matching with living relatives on the maternal line. [20]

Marguerite de Baugé, dame de Mirabel (1200–1252), is an ancestor of Pierre Terrail and the presently oldest known member of H10e with an unbroken genealogical tree on the maternal line up the present. [21]

Sir Ferdinando Wenman (abt.1575-1610) and Captain William West (abt.1586-1610), [22] kinsmen of the Virginia colony's first Governor, Thomas West, Third Baron De La Warr. [23]

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References

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  2. 1 2 3 Behar DM, van Oven M, Rosset S, Metspalu M, Loogväli EL, Silva NM, Kivisild T, Torroni A, Villems R (April 2012). "A "Copernican" reassessment of the human mitochondrial DNA tree from its root". American Journal of Human Genetics. 90 (4): 675–84. doi:10.1016/j.ajhg.2012.03.002. PMC   3322232 . PMID   22482806.
  3. ↑ Brotherton P, Haak W, Templeton J, Brandt G, Soubrier J, Jane Adler C, Richards SM, Der Sarkissian C, Ganslmeier R, Friederich S, Dresely V, van Oven M, Kenyon R, Van der Hoek MB, Korlach J, Luong K, Ho SY, Quintana-Murci L, Behar DM, Meller H, Alt KW, Cooper A (2013-04-23). "Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans". Nature Communications. 4 (1): 1764. Bibcode:2013NatCo...4.1764.. doi:10.1038/ncomms2656. PMC   3978205 . PMID   23612305.
  4. ↑ "PhyloTree.org - mtDNA tree Build 17 (18 Feb 2016): subtree R0".
  5. ↑ Canada R (2016-06-06). "H10e". Haplogroup. Archived from the original on 2019-08-03. Retrieved 2018-10-12.
  6. ↑ YFull MTree 1.02.21282 (as of 13 January 2024)
  7. ↑ Haak W, Brandt G, de Jong HN, Meyer C, Ganslmeier R, Heyd V, Hawkesworth C, Pike AW, Meller H, Alt KW (November 2008). "Ancient DNA, Strontium isotopes, and osteological analyses shed light on social and kinship organization of the Later Stone Age". Proceedings of the National Academy of Sciences of the United States of America. 105 (47): 18226–31. Bibcode:2008PNAS..10518226H. doi: 10.1073/pnas.0807592105 . PMC   2587582 . PMID   19015520.
  8. ↑ Csősz A, Szécsényi-Nagy A, Csákyová V, Langó P, Bódis V, Köhler K, Tömöry G, Nagy M, Mende BG (September 2016). "Maternal Genetic Ancestry and Legacy of 10(th) Century AD Hungarians". Scientific Reports. 6 (1): 33446. Bibcode:2016NatSR...633446C. doi:10.1038/srep33446. PMC   5025779 . PMID   27633963.
  9. ↑ Willerslev, Eske; Werge, Thomas; Nielsen, Rasmus; Kristiansen, Kristian; Hedeager, Lotte; Sindbæk, Søren; Bill, Jan; Allentoft, Morten; Gilbert, M. Thomas (2019-07-17). "Population genomics of the Viking world". bioRxiv. 585 (7825): 390–396. doi: 10.1101/703405 . hdl: 10852/83989 . PMID   32939067.
  10. 1 2 3 Översti, Sanni; Majander, Kerttu; Salmela, Elina; Salo, Kati; Arppe, Laura; Belskiy, Stanislav; Etu-Sihvola, Heli; Laakso, Ville; Mikkola, Esa; Pfrengle, Saskia; Putkonen, Mikko (2019-11-15). "Human mitochondrial DNA lineages in Iron-Age Fennoscandia suggest incipient admixture and eastern introduction of farming-related maternal ancestry". Scientific Reports. 9 (1): 16883. Bibcode:2019NatSR...916883O. doi:10.1038/s41598-019-51045-8. ISSN   2045-2322. PMC   6858343 . PMID   31729399.
  11. ↑ Owsley, Douglas W.; Bruwelheide, Karin S.; et al. (2024-08-13). "Historical and archaeogenomic identification of high-status Englishmen at Jamestown, Virginia". Antiquity. doi: 10.15184/aqy.2024.75 .
  12. 1 2 Raule, Nicola; Sevini, Federica; Li, Shengting; Barbieri, Annalaura; Tallaro, Federica; Lomartire, Laura; Vianello, Dario; Montesanto, Alberto; et al. (2014). "The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific". Aging Cell. 13 (3): 401–407. doi:10.1111/acel.12186. PMC   4326891 . PMID   24341918.
  13. ↑ Soini, Heidi K.; Moilanen, Jukka S.; Finnila, Saara; Majamaa, Kari (2012). "Mitochondrial DNA sequence variation in Finnish patients with matrilineal diabetes mellitus". BMC Research Notes. 5: 350. doi: 10.1186/1756-0500-5-350 . PMC   3434112 . PMID   22780954.
  14. 1 2 3 4 5 6 7 Li, Shengting; Besenbacher, Soren; Li, Yingrui; Kristiansen, Karsten; Grarup, Niels; Albrechtsen, Anders; Sparsø, Thomas; Korneliussen, Thorfinn; et al. (2014). "Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population". European Journal of Human Genetics. 22 (8): 1040–1045. doi:10.1038/ejhg.2013.282. PMC   4350597 . PMID   24448545.
  15. ↑ Malyarchuk, Boris; Litvinov, Andrey; Derenko, Miroslava; Skonieczna, Katarzyna; Grzybowski, Tomasz; Grosheva, Aleksandra; Shneider, Yuri; Rychkov, Sergei; Zhukova, Olga (2017). "Mitogenomic diversity in Russians and Poles". Forensic Science International. Genetics. 30: 51–56. doi:10.1016/j.fsigen.2017.06.003. PMID   28633069.
  16. 1 2 Piotrowska-Nowak, Agnieszka; Safranow, Krzysztof; Adamczyk, Jakub G.; Sołtyszewski, Ireneusz; Cięszczyk, Paweł; Tońska, Katarzyna; Żekanowski, Cezary; Borzemska, Beata (2023). "Mitochondrial Genome Variation in Polish Elite Athletes". International Journal of Molecular Sciences. 24 (16): 12992. doi: 10.3390/ijms241612992 . PMC   10454803 . PMID   37629173.
  17. ↑ Askapuli, Ayken; Vilar, Miguel; Garcia-Ortiz, Humberto; Zhabagin, Maxat; Sabitov, Zhaxylyk; Akilzhanova, Ainur; Ramanculov, Erlan; Schamiloglu, Uli; et al. (2022). "Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia". PLOS ONE. 17 (11): e0277771. Bibcode:2022PLoSO..1777771A. doi: 10.1371/journal.pone.0277771 . PMC   9707748 . PMID   36445929.
  18. ↑ Piotrowska-Nowak, Agnieszka; Kosior-Jarecka, Ewa L.; Schab, Aleksandra; Wrobel-Dudzinska, Dominika; Bartnik, Ewa; Zarnowski, Tomasz; Tonska, Katarzyna (2019). "Investigation of whole mitochondrial genome variation in normal tension glaucoma". Experimental Eye Research. 178: 186–197. doi:10.1016/j.exer.2018.10.004. PMID   30312593. S2CID   52974590.
  19. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Dulias, Katharina; Foody, George B.; Justeau, Pierre; Silva, Marina; Martiniano, Rui; Oteo-García, Gonzalo; Fichera, Alessandro; Rodrigues, Simão; et al. (2022). "Ancient DNA at the edge of the world: Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney". Proceedings of the National Academy of Sciences of the United States of America. 119 (8): e2108001119. Bibcode:2022PNAS..11908001D. doi: 10.1073/pnas.2108001119 . PMC   8872714 . PMID   35131896.
  20. ↑ "Chevalier Bayard, une identification ADN et des questions" [Chevalier Bayard, a DNA identification and questions]. FIGARO (in French). 2017-03-02. Retrieved 2018-10-12.
  21. ↑ "Bayard, le chevalier sans peur et sans reproche is Marguerite de Baugé, dame de Mirabel's 8th great grandson!". geni_family_tree. Retrieved 2018-10-13.
  22. ↑ "Captain William West | Historic Jamestowne" . Retrieved 2024-10-14.
  23. ↑ Owsley, Douglas W.; Bruwelheide, Karin S.; Harney, Éadaoin; Mallick, Swapan; Rohland, Nadin; Olalde, Iñigo; Barca, Kathryn G.; Ramsey, Andrew J.; Hull-Walski, Deborah A.; Kelso, William M.; May, Jamie E.; Broomandkhoshbacht, Nasreen; Ferry, Matthew; Lawson, Ann Marie; Michel, Megan (August 2024). "Historical and archaeogenomic identification of high-status Englishmen at Jamestown, Virginia". Antiquity. 98 (400): 1040–1054. doi: 10.15184/aqy.2024.75 . ISSN   0003-598X.
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