Plot
Warren, an alcoholic drifter, learns from a phone call that an ex-girlfriend has died and he has a son in Mexico. Warren writes down the caller's number before travelling to sell Bo Dawg and his associate methamphetamine. Bo Dawg's associate accidentally shoots himself. Warren shoots Bo Dawg dead and flees, pursued by Cal and Robbie.
Warren, after failed attempts to contact the caller, stops at Bedford Flats, an isolated town deep in the American desert near the Mexican border. Warren meets the local liquor store owner Don and local drunk Bob, who is warned that the town is sick of his behavior. Warren attends a sobriety meeting held by Steve Patterson. After the meeting, Steve offers to help Warren become sober. Returning to his motel room, Warren discovers Cal and Robbie have tracked him down. Warren seeks shelter with Steve and his wife Cheryl. Warren takes a horse tranquilizer he finds planted in Steve and Cheryl's bathroom to ease his withdrawal and passes out.
When he awakens, Warren is tied up in the middle of the desert along with Cal, Robbie, Bob and another man, Jim. Sheriff Burnside ignores Bob's pleading and announces the town's annual hunt, where armed townsfolk will hunt and kill the captives. Burnside introduce the hunters, including Steve and Cheryl, Don, and a trio of siblings, Charley, Jessie, and Mickey Wakowski. Burnside frees the captives, who flee through the desert. After a few miles of running, Jim falls over in exhaustion. Warren leaves him the rest of the tranquilizers to ease his suffering. After running several miles further, Bob says he knows what they must do to survive. He knocks Cal unconscious with a rock, forcing Warren and Robbie to flee in different directions. Soon after, the hunters set off to find the men. The Wakowski siblings shoot Jim with an arrow and run him over with a car. When they reach Bob and Cal, Bob attempts to exchange Cal for his survival. Don kills both Cal and Bob with a long range rifle.
Steve and Cheryl ambush Warren, attempting to hit him with their car. Steve accidentally crashes, knocking himself unconscious and killing Cheryl. Warren grabs a gun and a map from the car. When Don arrives, he flees. As night falls, Warren succumbs to his alcohol withdrawal and hallucinates. After bumping into Robbie, the pair discover a service hut, and Warren filters ethanol out of various supplies. Warren contacts a man on a radio and requests help; however, it is revealed to be the Wakowskis. They shoot Robbie through a window, killing him instantly. When the Wakowskis enter the hut, Warren shoots Charley with an arrow through the neck, shoots Mickey multiple times with a gun, and kills Jessie with an axe.
Continuing his hike through the desert, Warren finds a group of Mexicans sneaking into the US and realizes they are tying red ribbons as they go. Warren steps on a bear trap, rendering him immobile. Don catches up to Warren and stabs him, but Warren shoots Don dead. Meanwhile, Steve awakens in Bedford Flats, taken back to receive medical help. Upon learning that Cheryl has died, Steve becomes enraged, murders a townsperson and leaves to locate Warren. Burnside and his son, Junior, set out to help Steve. Burnside explains to Junior that Steve was once a captive in the hunt but escaped, bettered his life, and became sober. Despite Burnside's belief that Steve is a changed man, Steve shoots Junior through the head and beats Burnside to death with a baseball bat.
At night, Warren hallucinates Bo Dawg urging him to take his own life. Warren refuses and frees himself from the bear trap. At the American–Mexican border, he discovers a red ribbon leading to an underground passageway. While traveling through it, Steve attacks Warren. Warren eventually sets Steve on fire with a lighter and a bottle of tequila. Warren reaches the Mexican side of the tunnel and checks his phone for service. As he gets service, he is suddenly shot through the neck by a Mexican gang member. As the gang approach Warren, he laughs.
