IFNG-AS1

IFNG-AS1
Identifiers
Aliases	IFNG-AS1 , GS1-410F4.2, Tmevpg1, NEST, IFNG antisense RNA 1
External IDs	GeneCards: IFNG-AS1; OMA:IFNG-AS1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q15 Start 67,989,445 bp [1] End 68,234,686 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell testicle lymph node epithelium of colon tonsil appendix sural nerve granulocyte urinary bladder skeletal muscle tissue n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100885789 n/a Ensembl ENSG00000255733 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 67.99 – 68.23 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

IFNG antisense RNA 1 is a long non-coding RNA that in humans is encoded by the IFNG-AS1 gene. ^[3] It is a positive regulator of interferon gamma in T and NK cells. ^[4]

IFNG-AS1 (Tmevpg1, NeST) is encoded by a gene near the Ifng locus. Some studies have shown that IFNG-AS1 expression is dependent on T-bet. In fact, transcription of IFNG-AS1 is regulated by T-bet. The upregulation of this LncRNA could enhance the production of IFN-γ from Th1 cells by cooperation of T-bet. In the other hand, in human genomic region, there are some preserved DNase 1 hypersensitivity sites (HS) between Ifng and IFNG-AS1 which induce transcription factors such as NF-κB and ETS proto-oncogene 1 (Ets-1). T-bet could control chromatin remodeling through recruiting These HS. These hypersensitivity sites have transcriptional enhancer activity to enhance or repress transcription of either IFNG or IFNG-AS1. T-bet through this epigenetic mechanism could affect on expression of IFNG-AS1. Also IFNG-AS1 with binding to WD repeat domain 5 (WDR5), stimulates the formation of histone H3 lysine 4 (H3K4) methylation at the IFNG gene and affect on the enhancement of this gene expression. Also, the effective role of IFNG-AS1 in many protective actions, including enhancing the expression of IFN-γ in the immune response in brucellosis patients, suggest a new molecular interaction response to brucella infection. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000255733 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: IFNG antisense RNA 1" . Retrieved 2018-04-09.
4. Stein N, Berhani O, Schmiedel D, Duev-Cohen A, Seidel E, Kol I, et al. (January 2019). "IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells". iScience. 11: 466–473. Bibcode:2019iSci...11..466S. doi:10.1016/j.isci.2018.12.034. PMC   6354656 . PMID   30661002.
5. Gheitasi R, Jourghasemi S, Pakzad I, Hosseinpour Sarmadi V, Samieipour Y, Sekawi Z, et al. (December 2019). "A potential marker in brucellosis, long non coding RNA IFNG-AS1". Molecular Biology Reports. 46 (6): 6495–6500. doi:10.1007/s11033-019-05095-w. PMID   31595441.

Further reading

• Collier SP, Collins PL, Williams CL, Boothby MR, Aune TM (September 2012). "Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells". Journal of Immunology. 189 (5): 2084–2088. doi:10.4049/jimmunol.1200774. PMC   3424368 . PMID   22851706.
• Peng H, Liu Y, Tian J, Ma J, Tang X, Rui K, et al. (December 2015). "The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto's Thyroiditis". Scientific Reports. 5 17702. Bibcode:2015NatSR...517702P. doi:10.1038/srep17702. PMC   4669486 . PMID   26634912.
• Li H, Hao Y, Zhang D, Fu R, Liu W, Zhang X, et al. (November 2016). "Aberrant expression of long noncoding RNA TMEVPG1 in patients with primary immune thrombocytopenia". Autoimmunity. 49 (7): 496–502. doi:10.3109/08916934.2016.1167192. PMID   27050808. S2CID   23831262.