Bipolar disorder, previously known as manic depression or manic depressive disorder, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that each last from days to weeks. If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe and does not significantly affect functioning, it is called hypomania. During mania, an individual behaves or feels abnormally energetic, happy, or irritable, and they often make impulsive decisions with little regard for the consequences; there is usually also a reduced need for sleep during manic phases. During periods of depression, the individual may experience crying, have a negative outlook on life, and demonstrate poor eye contact with others. The risk of suicide is high; over a period of 20 years, 6% of those with bipolar disorder died by suicide, while 30–40% engaged in self-harm. Other mental health issues, such as anxiety disorders and substance use disorders, are commonly associated with bipolar disorder. The global prevalence of bipolar disorder is estimated to be between 1-5% of the world's population.
Bipolar I disorder is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features. Most people also, at other times, have one or more depressive episodes. Typically, these manic episodes can last at least 7 days for most of each day to the extent that the individual may need medical attention, while the depressive episodes last at least 2 weeks.
Schizoaffective disorder is a mental disorder characterized by symptoms of both schizophrenia (psychosis) and a mood disorder - either bipolar disorder or depression. The main diagnostic criterion is the presence of psychotic symptoms for at least two weeks without prominent mood symptoms. Common symptoms include hallucinations, delusions, disorganized speech and thinking, as well as mood episodes. Schizoaffective disorder can often be misdiagnosed when the correct diagnosis may be psychotic depression, bipolar I disorder, schizophreniform disorder, or schizophrenia. This is a problem as treatment and prognosis differ greatly for most of these diagnoses. Many people with schizoaffective disorder have other mental disorders including anxiety disorders.
The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) is a centre for mental health and neuroscience research, education and training in Europe. It is dedicated to understanding, preventing and treating mental illness, neurological conditions, and other conditions that affect the brain. The IoPPN is a faculty of King's College London, England, and was previously known as the Institute of Psychiatry (IoP).
The Maudsley Hospital is a British psychiatric hospital in south London. The Maudsley is the largest mental health training institution in the UK. It is part of South London and Maudsley NHS Foundation Trust, and works in partnership with the Institute of Psychiatry, King's College London. The hospital was one of the originating institutions in producing the Maudsley Prescribing Guidelines. It is part of the King's Health Partners academic health science centre and the National Institute for Health and Care Research (NIHR) Biomedical Research Centre for Mental Health.
Psychiatric genetics is a subfield of behavioral neurogenetics and behavioral genetics which studies the role of genetics in the development of mental disorders. The basic principle behind psychiatric genetics is that genetic polymorphisms are part of the causation of psychiatric disorders.
Mogens Schou was a Danish psychiatrist whose research into lithium led to its utilization as a treatment for bipolar disorder.
Alexander Bogdan ("Bob") Niculescu, III is a Romanian born, San Diego, California, educated and trained scientist and physician. He is a Professor in the Department of Psychiatry at the Indiana University School of Medicine in Indianapolis, Indiana, Director of the Laboratory of Neurophenomics, and an Attending Psychiatrist and R&D Investigator at the Indianapolis VA Medical Center. Considered the inventor of Convergent Functional Genomics (CFG), he is a prominent figure in the field of personalized medicine in psychiatry. His early contributions to the psychiatric genetics field include identification of candidate genes, pathways and mechanisms for bipolar disorder using convergent studies In particular, his work and that of his collaborators has focused attention on circadian clock genes as core components of mood regulation Since these contributions, his research program has expanded to include similar work on schizophrenia alcoholism and stress disorders leading to the identification of panels of DNA and RNA markers for disease risk prediction and severity of illness. Niculescu pioneered early on the view that psychiatric disorders are genetically complex, heterogeneous, and overlapping, requiring gene level integration of data followed by pathway analyses. The cumulative combinatorics of common variants and environment model he described for bipolar and other complex disorders based on empirical data, is being increasingly supported by evidence from other groups working on psychiatric and non-psychiatric disorders. More recently, he has proposed a comprehensive unifying model (Mindscape) for conceptualizing how the mind works. His most recent work has focused on understanding and developing genomic and clinical risk predictors for suicide, a preventable tragedy and increasing public health problem.
The International Society of Psychiatric Genetics (ISPG) is a learned society that aims to "promote and facilitate research in the genetics of psychiatric disorders, substance use disorders and allied traits". To this end, among other things, it organizes an annual "World Congress of Psychiatric Genetics".
The European Society for Primary Immunodeficiencies (ESID) is a Europe-wide medical association for healthcare professionals and researchers who deal with primary immunodeficiency diseases (PID).
Eduard Vieta Pascual is a Catalan psychiatrist from Spain known for his work in the field of mood disorders. His unit is a world reference in clinical care, research and teaching of bipolar disorder and depression.
Augustus John Rush is an internationally renowned psychiatrist. He is a professor emeritus in Duke-NUS Medical School at the National University of Singapore (NUS), and adjunct professor of psychiatry and behavioral sciences at Duke University School of Medicine. He has authored and edited more than 10 books, and over 600 scientific journal articles that are largely focused on the diagnosis and treatment of depressive and bipolar disorders.
Lori Altshuler was a professor at the University of California, Los Angeles (UCLA) Department of Psychiatry and Biobehavioral Sciences and held the Julia S. Gouw Endowed Chair for Mood Disorders. Altshuler was the Director of the UCLA Mood Disorders Research Program and the UCLA Women's Life Center, each being part of the Neuropsychiatric Hospital at UCLA.
Hilary Patricia Blumberg is a medical doctor and the inaugural John and Hope Furth Professor of Psychiatry at the Yale School of Medicine. She is also a professor of Radiology and Biomedical Imaging, and works in the Child Study Center at Yale where she has been a faculty member since 1998. She attended Harvard University as an undergraduate, and completed medical school at Cornell University Medical College (1990). She completed her medical internship and psychiatry residency at Cornell University Medical College/New York Hospital, and her neuroimaging fellowship training at Cornell University, Weill Medical College. She has received the 2006 National Alliance for Research in Schizophrenia and Depression (NARSAD) and the Gerald L. Klerman Award for Clinical Research. Blumberg has authored a number of scientific articles that focus on bipolar disorder, neuroimaging, and effects of specific genetic variations, developmental trajectories and structure-function relationships.
Ellen Frank is a psychologist and Distinguished Professor Emeritus of Psychiatry and Distinguished Professor of Psychology at the University of Pittsburgh. She is known in the field of Psychotherapy as one of the developers of Interpersonal and Social Rhythm Therapy, which aims to treat bipolar disorder by correcting disruptions in the circadian rhythm while promoting increased regularity of daily social routines. Frank is the co-founder and Chief Scientific Officer of HealthRhythms, a company that uses mobile technology to monitor the health and mental health of clients, facilitate the detection of changes in their status, and better manage mental health conditions.
Mary Louise Phillips is a Distinguished Professor in Psychiatry and Clinical and Translational Science, a Pittsburgh Foundation Emmerling Endowed Chair in Psychotic Disorders, Director of the Center for Neural Circuit-Based Technology Interventions in Psychiatry and the Center for Research in Translational and Developmental Affective Neuroscience, Director of the Collaborative on Mood Disorders Research, and Director of the Mood and Brain Laboratory - Department of Psychiatry, University of Pittsburgh. As the director of the Mood and Brain Laboratory, Phillips performs neuroimaging research designed to elucidate the neuropathophysiological basis of bipolar disorders and associated behavioral traits.
Prof. Robert Haim Belmaker, is an Israeli psychiatrist who has had major academic positions in Israeli psychiatry since 1974. He had a formative influence on biological directions in Israeli psychiatry. He was Hoffer-Vickar Professor of Psychiatry at Ben-Gurion University of the Negev, Beersheva Israel until his retirement and is now Emeritus.
Mauricio Tohen is a Mexican American research psychiatrist, Distinguished Professor, and Chairman of the Department of Psychiatry & Behavioral Sciences at the University of New Mexico. Tohen's research has focused on the epidemiology, outcome, and treatment of bipolar and psychotic disorders, and is especially known for innovating the design of clinical trials and the criteria to determine outcome in such diseases. Tohen has edited several books on his specialties. His social awareness has been noted in the promotion of programs to improve mental health care in areas such as substance abuse, bipolar disorder and schizophrenia.
James B. Potash is an American psychiatrist, researcher, and academic leader. He is currently the Henry Phipps Professor and Director (Chair) of the Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine.
Iria Grande is a Spanish physician who is an associate professor of psychiatry at the University of Barcelona, a psychiatrist at Hospital Clínic, and a researcher at the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM). She specializes in bipolar and depressive disorders and is affiliated with the Barcelona Bipolar and Depression Disorders Unit at Hospital Clínic. Since 2022, she has served as one of the councilors on the Executive Committee of the European College of Neuropsychopharmacology (ECNP) for the term 2022-2025.
