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| Abbreviation | ISCBFM |
|---|---|
| Founded | 1981 |
| Type | Learned society |
| Location |
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| Website | www |
The International Society for Cerebral Blood Flow & Metabolism is a professional society based in Rockville, Maryland for physicians and scientists focused on cerebrovascular function. [1]
Technical improvements in the study of cerebral blood flow pioneered by Niels Lassen and David Ingvar in the mid-twentieth century drove demand for meetings dedicated to the discipline. In 1965, the first regional Cerebral Blood Flow (rCBF) symposium was held in Lund, Sweden. In March 1980, following discussions between Bo K. Siesjö and Louis Sokoloff, a steering committee society was formed, including Sokoloff, Siesjö, Konstantin A. Hossman, Igor Klatzo, Eric Mackenzie, Marcus Raichle, MartinReivich, and Fred Plum. The International Society for Cerebral Blood Flow & Metabolism was first announced at the 2021 rCBF meeting in St. Louis, Missouri. [2]
ISCBFM holds an annual meeting called Brain & Brain Pet. The biannual meeting is held in cities throughout the world, with the 2022 meeting taking place in Glasgow. [3]
The Journal of Cerebral Blood Flow & Metabolism has been an important element of the ISCFBM since the organization's founding. Additionally, ISCFBM has published a newsletter titled The Organ since 1990. [2]
A cerebral arteriovenous malformation is an abnormal connection between the arteries and veins in the brain—specifically, an arteriovenous malformation in the cerebrum.
Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain. The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output. Arteries deliver oxygenated blood, glucose and other nutrients to the brain. Veins carry "used or spent" blood back to the heart, to remove carbon dioxide, lactic acid, and other metabolic products. Because the brain would quickly suffer damage from any stoppage in blood supply, the cerebral circulatory system has safeguards including autoregulation of the blood vessels. The failure of these safeguards may result in a stroke. The volume of blood in circulation is called the cerebral blood flow. Sudden intense accelerations change the gravitational forces perceived by bodies and can severely impair cerebral circulation and normal functions to the point of becoming serious life-threatening conditions.
Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion is measured as the rate at which blood is delivered to tissue, or volume of blood per unit time per unit tissue mass. The SI unit is m3/(s·kg), although for human organs perfusion is typically reported in ml/min/g. The word is derived from the French verb "perfuser" meaning to "pour over or through". All animal tissues require an adequate blood supply for health and life. Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary artery disease, cerebrovascular disease, peripheral artery disease, and many other conditions.
Cerebral perfusion pressure, or CPP, is the net pressure gradient causing cerebral blood flow to the brain. It must be maintained within narrow limits because too little pressure could cause brain tissue to become ischemic, and too much could raise intracranial pressure (ICP).
Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Increasingly it is also being used for quantitative studies of brain disease and psychiatric illness. Neuroimaging is a highly multidisciplinary research field and is not a medical specialty.
In image analysis, a resel represents the actual spatial resolution in an image or a volumetric dataset. The number of resels in the image may be lower or equal to the number of pixel/voxels in the image. In an actual image the resels can vary across the image and indeed the local resolution can be expressed as "resels per pixel".
Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. It is a sub-type of stroke along with subarachnoid hemorrhage and intracerebral hemorrhage.
The Organization for Human Brain Mapping (OHBM) is an organization of scientists with the main aim of organizing an annual meeting.
Seymour S. Kety was an American neuroscientist who was credited with making modern psychiatry a rigorous and heuristic branch of medicine by applying basic science to the study of human behavior in health and disease. After Kety died, his colleague Louis Sokoloff noted that: "He discovered a method for measuring blood flow in the brain, was the first scientific director of the National Institute of Mental Health (NIMH) and produced the most-definitive evidence for the essential involvement of genetic factors in schizophrenia."
Niels Alexander Lassen was a Danish nuclear medicine physician, neurologist and pioneer in the fields of neuroimaging, neuropsychiatry and nuclear medicine. He was born and died in Copenhagen.
Autoregulation is a process within many biological systems, resulting from an internal adaptive mechanism that works to adjust that system's response to stimuli. While most systems of the body show some degree of autoregulation, it is most clearly observed in the kidney, the heart, and the brain. Perfusion of these organs is essential for life, and through autoregulation the body can divert blood where it is most needed.
The Journal of Cerebral Blood Flow & Metabolism is a monthly peer-reviewed medical journal the official journal of the International Society for Cerebral Blood Flow & Metabolism and publishes peer-reviewed research and review papers. covering research on experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The editor-in-chief is Jun Chen. According to the Journal Citation Reports, the journal has a 2020 impact factor of 6.200.
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. It has recently been proven to be the only medical intervention which reduces brain damage, and improves an infant's chance of survival and reduced disability.
Albert Gjedde: is a Danish-Canadian neuroscientist. He is Professor of Neurobiology and Pharmacology at the Faculty of Health Sciences and Center of Neuroscience at the University of Copenhagen. He is currently also Adjunct Professor of Neurology and Neurosurgery in the Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, Adjunct Professor of Radiology and Radiological Science in the Division of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, US, Adjunct Professor of Translational Neuropsychiatry Research, University of Southern Denmark, Odense, Denmark, and adjunct professor of psychiatry at Tabriz University of Medical Sciences, Tabriz, East Azerbadjan, Iran.
Gitte Moos Knudsen is a Danish translational neurobiologist and clinical neurologist, and Clinical Professor and Chief Physician at the Department of Clinical Medicine, Neurology, Psychiatry and Sensory Sciences, at Copenhagen University Hospital. She graduated from Lyngby Statsskole, just north of Copenhagen, before gaining entrance to medicine, where she received her MD from University of Copenhagen in 1984, and became a Board certified user of radioisotopes in 1986. She sat the FMGEMS exam (US) in 1989. She became Board certified in neurology in 1994 and received her DMSc (Dr.Med.) from University of Copenhagen in 1994. She currently resides in Copenhagen, and is married to Tore Vulpius. She has 3 children.
Louis Sokoloff was an American neuroscientist. He is considered to be a pioneer in functional imaging of the brain.
Arterial spin labeling (ASL), also known as arterial spin tagging, is a magnetic resonance imaging technique used to quantify cerebral blood perfusion by labelling blood water as it flows throughout the brain. ASL specifically refers to magnetic labeling of arterial blood below or in the imaging slab, without the need of gadolinium contrast. A number of ASL schemes are possible, the simplest being flow alternating inversion recovery (FAIR) which requires two acquisitions of identical parameters with the exception of the out-of-slice saturation; the difference in the two images is theoretically only from inflowing spins, and may be considered a 'perfusion map'. The ASL technique was developed by Alan P. Koretsky, Donald S. Williams, John A. Detre and John S. Leigh, Jr in 1992.
Cerebral blood volume is the blood volume in a given amount of brain tissue.
Martin Johannes Lauritzen is a Danish neuroscientist. He is Professor of Translational Neurobiology at the Department of Neuroscience, University of Copenhagen, Denmark and Professor of Clinical Neurophysiology at the Department of Neurophysiology, Rigshospitalet.
Julie C. Price is an American medical physicist and professor of radiology at Massachusetts General Hospital (MGH), Harvard Medical School (HMS), as well as the director of PET Pharmacokinetic Modeling at the Athinoula A. Martinos Center at MGH. Price is a leader in the study and application of quantitative positron emission tomography (PET) methods. Prior to this, Price worked with Pittsburgh colleagues to lead the first fully quantitative pharmacokinetic evaluations of 11C-labeled Pittsburgh compound-B (PIB), one of the most widely used PET ligands for imaging amyloid beta plaques. As a principal investigator at MGH, Price continues work to validate novel PET methods for imaging biological markers of health and disease in studies of aging and neurodegeneration, including studies of glucose metabolism, protein expression, neurotransmitter system function, and tau and amyloid beta plaque burden.
