The Avenue of the Saints is a 563-mile-long (906 km) highway in the Midwestern United States that connects St. Louis, Missouri and St. Paul, Minnesota.
Interstate 235 (I-235) in Iowa is an auxiliary Interstate Highway that runs just north of downtown Des Moines through the heart of the Des Moines metropolitan area. I-235 runs from the junction of I-35 and I-80 in West Des Moines to the separation of the same two Interstates in Ankeny. The highway is approximately 14 miles (23 km) long.
State Route 90 is a highway in Cochise County, Arizona that runs from the I-10 junction at Benson to a junction with State Route 80 between Bisbee and Tombstone. It is a north–south route north of Sierra Vista, and an east–west route east of the city. It passes through the San Pedro Riparian National Conservation Area at milepost 329; the riparian area makes up a large part of the southern section of the San Pedro Valley.
Iowa Highway 92 (Iowa 92) is a state highway that runs from east to west across the state of Iowa. Iowa 92 is 279 miles (449 km) long. It begins at the Missouri River in Council Bluffs, where it is a continuation of Nebraska Highway 92. It stretches across the state and serves to roughly demarcate the southern one-third of Iowa. It ends at the Mississippi River in Muscatine where it continues into Illinois as Illinois Route 92. In 1939, Iowa 92 replaced the original Iowa 2 in its entirety.
Iowa Highway 28 is a 21.73-mile-long (34.97 km) state highway located in south central Iowa. The route begins at Iowa Highway 92 at Martensdale and ends at Interstate 35 / Interstate 80 in Johnston. It is the first major north–south highway east of Interstate 35 in the Des Moines metropolitan area.
Interstate 680 (I-680) in Nebraska and Iowa is the northern bypass of the Omaha – Council Bluffs metropolitan area. I-680 spans 16.49 miles (26.54 km) from its southern end in western Omaha to its eastern end near Crescent, Iowa. The freeway passes through a diverse range of scenes and terrains – the urban setting of Omaha, the Missouri River and its valley, the rugged Loess Hills, and the farmland of Pottawattamie County, Iowa.
U.S. Highway 6 (US 6) is an east–west U.S. Highway which runs 319 miles (513 km) across the U.S. state of Iowa. The route is signed in places as the Grand Army of the Republic Highway. Like all state highways in Iowa, it is maintained by the Iowa Department of Transportation. The route begins at the Missouri River crossing at Council Bluffs. From there, it travels east through Oakland and Atlantic. North of Atlantic, the highway overlaps Interstate 80 (I-80) until De Soto. Between De Soto and Adel, the highway overlaps US 169 before splitting off to the east towards Des Moines. Through the Des Moines area, the highway runs about one mile (1.6 km) north or south of the I-35 / I-80 corridor.
Iowa Highway 16 is a state highway running from west to east in southeastern Iowa. The highway has a length of 65.18 miles (104.90 km). The western terminus of Iowa Highway 16 is at an intersection with U.S. Highway 34 (US 34) between Agency and Batavia. The eastern terminus is located at Wever at an intersection with US 61.
Iowa Highway 117 is a north–south route in Jasper County. The length of the highway is 18 miles (29 km). In addition to serving several communities directly, Highway 117 also provides a shortcut between U.S. Route 65 and Interstate 80 east of Des Moines.
Iowa Highway 330 is a 47-mile-long (76 km) state highway that runs northeasterly from Altoona past Albion, to just north of Marshalltown in Marshall County. Originally the two-lane, unpaved road was numbered Iowa 88. It became part of Iowa 64 in the 1903s and it received its current route number in 1969. Iowa 330 is mostly a four-lane, divided expressway along much of its length. In conjunction with U.S. Route 65 in Iowa (US 65), Iowa 14 and US 20, Iowa 330 is commonly used as a connector between Des Moines and the Waterloo–Cedar Falls area.
Interstate 35 (I-35) is a north–south Interstate Highway in the United States that runs from Laredo, Texas, to Duluth, Minnesota. In Iowa, the highway runs from south to north through the center of the state, roughly parallel to U.S. Highway 69 (US 69) and US 65. It enters the state near Lamoni from Missouri and continues north through the southern Iowa drift plain. In the Des Moines area, I-35 is overlapped by I-80, and the two routes bypass Des Moines to the west and north. I-235, the only auxiliary route of I-35, serves the suburbs and downtown Des Moines; it begins and ends at the two interchanges where I-35 and I-80 meet. Near Mason City and Clear Lake, US 18 and Iowa Highway 27 (Iowa 27) overlap with I-35. Shortly after, US 18 splits off to the west in Clear Lake, while Iowa 27 runs with I-35 until they reach the Minnesota state line.
Interstate 80 (I-80) is a transcontinental Interstate Highway in the United States, stretching from San Francisco, California, to Teaneck, New Jersey. In Iowa, the highway travels west to east through the center of the state. It enters the state at the Missouri River in Council Bluffs and heads east through the southern Iowa drift plain. In the Des Moines area, I-80 meets up with I-35 and the two routes bypass Des Moines together. On the northern side of Des Moines, the Interstates split and I-80 continues east. In eastern Iowa, it provides access to the University of Iowa in Iowa City. Northwest of the Quad Cities in Walcott is Iowa 80, the world's largest truck stop. I-80 passes along the northern edge of Davenport and Bettendorf and leaves Iowa via the Fred Schwengel Memorial Bridge over the Mississippi River into Illinois.
Iowa Highway 152 (Iowa 152) was a very short route which connected Interstate 35 (I-35) and U.S. Route 69 (US 69) near Osceola, Iowa. Through Iowa, I-35 and US 69 are mostly parallel routes; Iowa 152 connected the two routes at the narrowest location between them. The route was formed in 1980 from a portion of Clarke County Road R35 and did not undergo any changes in alignment while it was designated. The highway was relinquished to Clarke County and the City of Osceola in 2014.
Iowa Highway 415 is a short state highway that runs mostly north-to-south in central Iowa. Iowa 415 begins at U.S. Highway 6 in Des Moines and ends at Iowa Highway 141 east of Granger. Prior to 2003, Iowa 415 extended north from Polk City and ended at Iowa Highway 17 south of Madrid. Now, Iowa 415 turns west at Polk City and crosses the Des Moines River at Saylorville Lake prior to ending at Iowa 141. Since the rerouting in 2003, the northern terminus for Iowa 415 is now farther south than its northernmost point in Polk City.
The bypass around Des Moines, Iowa, is a 25-mile-long (40 km) freeway around the south and east of the Des Moines metropolitan area. The route is made up of two state highways – Iowa Highway 5 (Iowa 5) and U.S. Highway 65 (US 65). The bypass begins in southwestern West Des Moines at Iowa 5's interchange with Interstate 35 (I-35). It heads to the east and then curves to the north near the southeastern side of Des Moines. It ends at the interchange of US 65 and I-80 in Altoona.
U.S. Highway 61 (US 61) is a United States Highway that serves eastern Iowa. It enters the state from Missouri near Keokuk with US 136. North of Keokuk, it is overlapped by US 218 for a few miles. It the follows the course of the Mississippi River past Montrose and Fort Madison. It meets US 34 at Burlington. It passes through Wapello and bypasses Muscatine and Blue Grass on its way toward Davenport. There, it follows Interstate 280 (I-280) and I-80 around the Quad Cities. North of Davenport, it follows a freeway north toward DeWitt where it meets US 30. The highway continues north through Maquoketa and reaches the Dubuque area. There it is joined by US 151 and briefly by US 52. The two highways enter the downtown area on an expressway. Due to the proximity of the Mississippi River and railroad tracks that lie between, the routes have an indirect junction with US 20. The two highways leave the state and enter Wisconsin about one-half mile (800 m) north of the Illinois–Wisconsin state line.
Iowa Highway 46 (Iowa 46) was a state highway in Polk County, Iowa. It began at an intersection with Iowa 5 near Avon. It traveled north and west through the industrial section of southeastern Des Moines. It ended at Iowa 163, also known as E. University Avenue, in Des Moines next to the Iowa State Fairgrounds.
South Dakota Highway 258 is a 2.552-mile-long (4.107 km) state highway in Aurora County, South Dakota. It runs from Interstate 90 (I-90) to U.S. Route 281, and is maintained by the South Dakota Department of Transportation (SDDOT). The route is not a part of the National Highway System.
Interstate 880 (I-880) is an Interstate Highway in Iowa. Its route was created in 2019 from a section of I-680 in order to facilitate the movement of I-29 traffic around Council Bluffs in the event of Missouri River flooding. It follows the same routing as Interstate 80N (I-80N), which originally connected I-29 and I-80 from 1966 to 1973.
U.S. Highway 63 (US 63) is a United States Highway that runs through the eastern third of Iowa. It begins at the Missouri state line southwest of Bloomfield and travels north through Ottumwa, Oskaloosa, Tama, Waterloo, and New Hampton. It ends at the Minnesota state line at Chester. Between Ottumwa and Oskaloosa, the highway is a four-lane controlled-access highway. Through Waterloo and New Hampton, it is partially controlled; that is, the road as both grade-separated interchanges and at-grade intersections. The rest of the highway is largely a two-lane rural highway.
I-80 near Earlham 
I-35 near West Des Moines 
