IsrM small RNA

IsrM sRNA
Predicted secondary structure and sequence conservation of IsrM small RNA
Identifiers
Rfam	RF02763
Other data
Domain(s)	Bacteria
GO	GO:0009405 ,GO:0040033
SO	SO:0000370
PDB structures	PDBe

The IsrM RNA is a small non-coding RNA discovered in Salmonella enterica pathogenicity island, which is not found in E. coli . ^[1] It is important for invasion of epithelial cells, intracellular replication inside macrophages, virulence and colonisation in mice. It targets the SopA and HilE mRNAs, virulence factors essential for bacterial invasion. It is a first pathogenicity island-encoded sRNA shown to be directly involved in Salmonella pathogenesis. ^[2]

References

1. Padalon-Brauch G, Hershberg R, Elgrably-Weiss M, Baruch K, Rosenshine I, Margalit H, Altuvia S (April 2008). "Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence". Nucleic Acids Research. 36 (6): 1913–1927. doi:10.1093/nar/gkn050. PMC   2330248 . PMID   18267966.
2. Gong H, Vu GP, Bai Y, Chan E, Wu R, Yang E, Liu F, Lu S (September 2011). "A Salmonella small non-coding RNA facilitates bacterial invasion and intracellular replication by modulating the expression of virulence factors". PLOS Pathogens. 7 (9): e1002120. doi: 10.1371/journal.ppat.1002120 . PMC   3174252 . PMID   21949647.