Itsik Pe'er

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Itsik Pe'er
Alma mater Tel Aviv University
Scientific career
Fields Systems biology
Human Genetics
Computer Science
Institutions Columbia University
Broad Institute
Weizmann Institute of Science
Thesis Algorithmic Methods for Reconstruction of Biological Sequences, Gene Orders and Maps  (2002)
Doctoral advisor Ron Shamir

Itsik Pe'er is a computational biologist and a Full Professor in the Department of Computer Science at Columbia University.

Contents

Research and career

Pe'er has created computational tools for the analysis of high-throughput DNA sequence data. [1] In particular, he has developed an approach to map copy number variation from whole exome sequencing data. He has published approaches to quantify hidden relatedness and infer population structure using DNA data. [2] He has conducted studies on the genetics of complex traits in Ashkenazi Jews, historically a relatively isolated population [3] enabling identification of genetic risk factors for common disorders in all populations. [4] [5] He is generating a comprehensive resource of genetic variants in the population for precision public health. [6] [7]

Selected publications

Personal life

Itsik Pe'er is married to Dana Pe'er, a computational biologist at Sloan Kettering Institute. [8]

Related Research Articles

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<span class="mw-page-title-main">Alexander Beider</span>

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Nir Friedman is an Israeli Professor of Computer Science and Biology at the Hebrew University of Jerusalem.

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The Khazar hypothesis of Ashkenazi ancestry, often called the Khazar myth by its critics, is a largely abandoned historical hypothesis. The hypothesis postulated that Ashkenazi Jews were primarily, or to a large extent, descended from Khazars, a multi-ethnic conglomerate of mostly Turkic peoples who formed a semi-nomadic khanate in and around the northern and central Caucasus and the Pontic–Caspian steppe. The hypothesis also postulated that after collapse of the Khazar empire, the Khazars fled to Eastern Europe and made up a large part of the Jews there. The hypothesis draws on some medieval sources such as the Khazar Correspondence, according to which at some point in the 8th–9th centuries, a small number of Khazars were said by Judah Halevi and Abraham ibn Daud to have converted to Rabbinic Judaism. The scope of the conversion within the Khazar Khanate remains uncertain, but the evidence used to tie the Ashkenazi communities to the Khazars is meager and subject to conflicting interpretations.

<span class="mw-page-title-main">Dana Pe'er</span>

Dana Pe'er is an Israeli computational biologist and bioinformatician who is currently the Chair and Professor in Computational and Systems Biology Program at Sloan Kettering Institute, and regarded as one of the leading researchers in computational systems biology. She was selected as a Howard Hughes Medical Institute (HHMI) Investigator in September, 2021. Previously, she was a professor at Columbia Department of Biological Sciences. Pe'er's research focuses on understanding the organization, function and evolution of molecular networks, particularly how genetic variations alter the regulatory network and how these genetic variations can cause cancer.

Eran Elhaik is an Israeli-American geneticist and bioinformatician, and an associate professor of bioinformatics at Lund University in Sweden. His research uses computational, statistical, epidemiological and mathematical approaches to fields such as complex disorders, population genetics, personalised medicine, molecular evolution, genomics, paleogenomics and epigenetics.

Yaniv Erlich is an Israeli-American scientist. He is an Associate Professor of Computer Science at Columbia University and the Chief Science Officer of MyHeritage. Erlich's work combines computer science and genomics.

References

  1. "Itsik Pe'er publications indexed by Google Scholar". scholar.google.com. Retrieved 2022-01-02.
  2. "Inference of population structure from time-series genotype data". Banff International Research Station. Retrieved 2022-01-04.
  3. Bray SM, Mulle JG, Dodd AF, Pulver AE, Wooding S, Warren ST (September 2010). "Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population". Proceedings of the National Academy of Sciences. 107 (37): 16222–16227. Bibcode:2010PNAS..10716222B. doi: 10.1073/pnas.1004381107 . PMC   2941333 . PMID   20798349.
  4. "Itsik Pe'er - Overview". Columbia University. Retrieved 2022-01-03.
  5. Lencz T, Yu J, Palmer C, Carmi S, Ben-Avraham D, Barzilai N, Peer I (April 2018). "High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation". Human Genetics. 137 (4): 343–355. doi:10.1007/s00439-018-1886-z. PMC   6954822 . PMID   29705978.
  6. "Mapping the DNA sequence of Ashkenazi Jews". The Jerusalem Post. Retrieved 2022-01-03.
  7. "April 10 Provost's Lecture with Itsik Pe'er". Stony Brook University News. 27 March 2014. Retrieved 2022-01-03.
  8. "Columbia News - Dana Pe'er: Decoding Genetic Variations and Regulatory Networks" (PDF). www.columbia.edu. Retrieved 2022-01-04.