Jacqueline Lees

Last updated
Jacqueline A. Lees
Alma materUniversity of York
University of London
Scientific career
FieldsBiochemistry, cancer biology
InstitutionsKoch Institute for Integrative Cancer Research, MIT

Jacqueline A. Lees is a British biochemist.

Lees is the Virginia and D.K. Ludwig Professor for Cancer Research and associate director of the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology. [1] She received her BSc degree from the University of York in 1986, and her PhD from the University of London in 1990, both in biochemistry. [2] She was a postdoc in the laboratory of Ed Harlow, first at Cold Spring Harbor and then at Massachusetts General Hospital, before joining the faculty at MIT in 1994. [3]

Research

Lees’ research is focused on identifying the proteins and pathways that play a key role in tumorigenicity and establishing the mechanism of their action in both normal and tumor cells. [1] Her lab at MIT uses a combination of molecular and cellular analyses and mutant mouse models. She is also known for her work with Nancy Hopkins on genetic screens in zebrafish. [4] Lees studies how the E2F family of mammalian transcription factors contributes to the regulation of cellular proliferation during normal development and tumorigenesis. [1] Her work has shown that certain E2Fs, despite substantial biochemical similarities, play radically different biological roles. [5]

Related Research Articles

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References

  1. 1 2 3 "The Koch Institute: Jacqueline A. Lees". ki.mit.edu. Retrieved 2020-05-18.
  2. "Corporation awards tenure to 23 faculty members". MIT News. Retrieved 2020-05-18.
  3. "Sizer CD Chair is established". MIT News. Retrieved 2020-05-18.
  4. Zhang, GuangJun; Hoersch, Sebastian; Amsterdam, Adam; Whittaker, Charles A.; Lees, Jacqueline A.; Hopkins, Nancy (2010-09-28). "Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers". Proceedings of the National Academy of Sciences. 107 (39): 16940–16945. doi: 10.1073/pnas.1011548107 . ISSN   0027-8424. PMC   2947874 . PMID   20837522.
  5. Iaquinta, Phillip J; Lees, Jacqueline A (2007-12-01). "Life and death decisions by the E2F transcription factors". Current Opinion in Cell Biology. Cell differentiation / Cell division, growth and death. 19 (6): 649–657. doi:10.1016/j.ceb.2007.10.006. ISSN   0955-0674. PMC   2268988 . PMID   18032011.