Jacqueline A. Lees | |
|---|---|
| Alma mater | University of York University of London |
| Scientific career | |
| Fields | Biochemistry, cancer biology |
| Institutions | Koch Institute for Integrative Cancer Research, MIT |
Jacqueline A. Lees is a British biochemist.
Lees is the Virginia and D.K. Ludwig Professor for Cancer Research and associate director of the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology. [1] She received her BSc degree from the University of York in 1986, and her PhD from the University of London in 1990, both in biochemistry. [2] She was a postdoc in the laboratory of Ed Harlow, first at Cold Spring Harbor and then at Massachusetts General Hospital, before joining the faculty at MIT in 1994. [3]
Lees’ research is focused on identifying the proteins and pathways that play a key role in tumorigenicity and establishing the mechanism of their action in both normal and tumor cells. [1] Her lab at MIT uses a combination of molecular and cellular analyses and mutant mouse models. She is also known for her work with Nancy Hopkins on genetic screens in zebrafish. [4] Lees studies how the E2F family of mammalian transcription factors contributes to the regulation of cellular proliferation during normal development and tumorigenesis. [1] Her work has shown that certain E2Fs, despite substantial biochemical similarities, play radically different biological roles. [5]