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James R. Doty | |
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Nationality | American |
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James R. Doty, M.D., FACS, FICS, FAANS is a clinical professor of neurosurgery at Stanford University and founder and director of the Center for Compassion and Altruism Research and Education, an affiliate of the Stanford Neurosciences Institute. He is the author of a self-help book called Into the Magic Shop: A Neurosurgeon's Quest to Discover the Mysteries of the Brain and the Secrets of the Heart. Doty is also the Senior Editor of the Oxford Handbook of Compassion Science (2017).
This section of a biography of a living person does not include any references or sources .(November 2015) |
Doty is an American neurosurgeon, entrepreneur, and philanthropist. He received his undergraduate training in biological sciences at the University of California, Irvine, leaving in 1977 without a degree following acceptance to Tulane University School of Medicine where he graduated in 1981. He was later awarded his undergraduate degree from Irvine in 1978. He accepted a U.S. Army Health Professions Scholarship completing his internship at Tripler Army Medical Center in Honolulu, HI in 1982 and his neurosurgery residency at Walter Reed Army Medical Center in Washington, D.C. in 1987. He completed pediatric neurosurgery training at Children's Hospital of Philadelphia (CHOP) and completed a research fellowship in neurophysiology. He received board certification by the American Board of Neurological Surgery in 1990. Doty spent 9 years on active duty service in the U.S. Army Medical Department, attaining the rank of major.
Doty's past research interests have focused on the development of technologies using focused beams of radiation in conjunction with robotics and image-guidance techniques to treat solid tumors and other pathologies in the brain and spinal cord. [1] [2] He is recognized as an expert in stereotactic radiosurgery and complex and minimally invasive spine surgery. [3] Additionally, he has multiple patents including a device for spine stabilization and an electrode for monitoring of brain activity. [4] [5] [6]
Following a sabbatical, Doty returned to Stanford University in 2007 and began collaborative research explorations into the neuroscience of compassion and altruism with Stanford colleagues. What had begun as an informal research initiative called "Project Compassion" was later formalized within the School of Medicine by then Dean Phil Pizzo as the Center for Compassion and Altruism Research and Education (CCARE).
As Director of CCARE, Doty has collaborated on a number of research projects [7] focused on compassion and altruism including the use of neuro-economic models to assess altruism, use of the CCARE-developed compassion cultivation training (CCT) in individuals and its effect, assessment of compassionate and altruistic judgment utilizing implanted brain electrodes and the use of optogenetic techniques to assess nurturing pathways in rodents. He also published on the influence of mindful meditation on surgical performance. [8]
He is on the advisory board to the Fogarty Institute of Innovation. Additionally, Doty is on the advisory board of a number of non-profit organizations including the Charter for Compassion of which he is Vice-Chair. He is the former Chairman of the Dalai Lama Foundation. He also writes a blog for the Huffington Post. [9]
In the late 1980s, following a conversation with his colleague, John Adler, M.D., at the time a resident at the Brigham and Women's Hospital in Boston, MA, he was introduced to the concept of the CyberKnife and later invested in the company that manufactures the device, Accuray, Inc. Following development of the prototype device at Stanford University, Doty was so convinced of its potential to change the manner in which radiation therapy was delivered that he convinced an investor to set up the first CyberKnife facility in the U.S. prior to FDA approval under an Investigational Device Exemption. Within one year of the facility opening, Accuray was effectively bankrupt having exhausted all means of raising further capital. Doty then provided ongoing funding to Accuray and became CEO. [10] He ultimately convinced a venture firm in Taiwan to provide an infusion of funds and restructured the company, which soon thereafter received FDA approval for their CyberKnife technology. Accuray went public in 2007 (NASDAQ:ARAY) with a market cap of $1.3bn.
Doty had been successful as an entrepreneur during the dot com heyday acting as an angel investor in a number of start-up companies. [10] Following the dot com crash, he watched his fortune evaporate and became effectively bankrupt having to sell the majority of his assets to live up to his financial obligations. Having made a number of commitments to charitable organizations, Doty donated all of the stock of Accuray ultimately donating $29,000,000 to charity.
Doty remains a consultant and advisor to medical technology and device companies and a variety of venture capital firms. He is an operating partner at Capricorn Health and Special Opportunities Fund (a part of Capricorn Investment Group).
Doty has set up health clinics throughout the world through his donation to Global Healing, and created programs to support AIDS-HIV programs through Family and Children Services.[ citation needed ]
His donation to Stanford University School of Medicine is one of the largest of any graduate or faculty member. [11] He endowed the Chair of the Dean of the School of Medicine at Tulane University following Hurricane Katrina and refurbished its library, in addition to setting up a scholarship for socioeconomically disadvantaged students to commit to a career of service. He remains on the Tulane University School of Medicine Board of Governors.
Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty that focuses on the surgical treatment or rehabilitation of disorders which affect any portion of the nervous system including the brain, spinal cord, peripheral nervous system, and cerebrovascular system. Neurosurgery as a medical specialty also includes non-surgical management of some neurological conditions.
A vestibular schwannoma (VS), also called acoustic neuroma, is a benign tumor that develops on the vestibulocochlear nerve that passes from the inner ear to the brain. The tumor originates when Schwann cells that form the insulating myelin sheath on the nerve malfunction. Normally, Schwann cells function beneficially to protect the nerves which transmit balance and sound information to the brain. However, sometimes a mutation in the tumor suppressor gene, NF2, located on chromosome 22, results in abnormal production of the cell protein named Merlin, and Schwann cells multiply to form a tumor. The tumor originates mostly on the vestibular division of the nerve rather than the cochlear division, but hearing as well as balance will be affected as the tumor enlarges.
Lars Leksell was a Swedish physician and professor of Neurosurgery at the Karolinska Institute in Stockholm, Sweden. He was the inventor of radiosurgery.
Radiosurgery is surgery using radiation, that is, the destruction of precisely selected areas of tissue using ionizing radiation rather than excision with a blade. Like other forms of radiation therapy, it is usually used to treat cancer. Radiosurgery was originally defined by the Swedish neurosurgeon Lars Leksell as "a single high dose fraction of radiation, stereotactically directed to an intracranial region of interest".
Stereotactic surgery is a minimally invasive form of surgical intervention that makes use of a three-dimensional coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery (SRS), etc.
Image-guided surgery (IGS) is any surgical procedure where the surgeon uses tracked surgical instruments in conjunction with preoperative or intraoperative images in order to directly or indirectly guide the procedure. Image guided surgery systems use cameras, ultrasonic, electromagnetic or a combination of fields to capture and relay the patient's anatomy and the surgeon's precise movements in relation to the patient, to computer monitors in the operating room or to augmented reality headsets. This is generally performed in real-time though there may be delays of seconds or minutes depending on the modality and application.
Hypophysectomy is the surgical removal of the hypophysis. It is most commonly performed to treat tumors, especially craniopharyngioma tumors. Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma or Simmond's disease It is also applied in neurosciences to understand the functioning of hypophysis. There are various ways a hypophysectomy can be carried out. These methods include transsphenoidal hypophysectomy, open craniotomy, and stereotactic radiosurgery.
Elekta is a global Swedish company that develops and produces radiation therapy and radiosurgery-related equipment and clinical management for the treatment of cancer and brain disorders. Elekta has a global presence in more than 120 countries, with over 40 offices around the world and about 4,700 employees.
John R. Adler is an American neurosurgeon and medical device entrepreneur.
The CyberKnife system is a radiation therapy device manufactured by Accuray. The system is used to deliver radiosurgery for the treatment of benign tumors, malignant tumors and other medical conditions.
Ablative brain surgery is the surgical ablation by various methods of brain tissue to treat neurological or psychological disorders. The word "Ablation" stems from the Latin word Ablatus meaning "carried away". In most cases, however, ablative brain surgery does not involve removing brain tissue, but rather destroying tissue and leaving it in place. The lesions it causes are irreversible. There are some target nuclei for ablative surgery and deep brain stimulation. Those nuclei are the motor thalamus, the globus pallidus, and the subthalamic nucleus.
Russell A. Brown, an American physician and computer scientist, is the inventor of the N-localizer technology that enables guidance of stereotactic surgery or radiosurgery using medical images that are obtained via computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET).
Griffith Rutherford Harsh IV is an American neurosurgeon, Professor of Neurological Surgery at the University of California, Davis, and former Julian R. Youmans Endowed Chair of the department. Dr. Harsh also led the UC Davis School of Medicine and UC Davis Health faculty as Chair of the Council of Department Chairs. Currently, he maintains his academic appointment at UC Davis and holds visiting professorships at the University of Nairobi and Kenyatta University, while living in Nairobi with his wife, Meg Whitman, the US Ambassador to Kenya.
The N-localizer is a device that enables guidance of stereotactic surgery or radiosurgery using tomographic images that are obtained via computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET). The N-localizer comprises a diagonal rod that spans two vertical rods to form an N-shape and permits calculation of the point where a tomographic image plane intersects the diagonal rod. Attaching three N-localizers to a stereotactic instrument allows calculation of three points where a tomographic image plane intersects three diagonal rods. These points determine the spatial orientation of the tomographic image plane relative to the stereotactic frame.
James Rutka is a Canadian neurosurgeon from Toronto, Canada. Rutka served as RS McLaughlin Professor and Chair of the Department of Surgery in the Faculty of Medicine at the University of Toronto from 2011 – 2022. He subspecializes in pediatric neurosurgery at The Hospital for Sick Children (SickKids), and is a Senior Scientist in the Research Institute at SickKids. His main clinical interests include the neurosurgical treatment of children with brain tumours and epilepsy. His research interests lie in the molecular biology of human brain tumours – specifically in the determination of the mechanisms by which brain tumours grow and invade. He is the Director of the Arthur and Sonia Labatt Brain Tumour Research Centre at SickKids, and Editor-in-Chief of the Journal of Neurosurgery.
Isabelle M. Germano is a neurosurgeon and professor of neurosurgery, neurology, and oncology at the Icahn School of Medicine at Mount Sinai Hospital. She is a Fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Germano works with image-guided brain and spine surgery.
Subramanian Kalyanaraman is an Indian neurosurgeon and a former head of the Department of Neurosurgery at Apollo Hospitals, Chennai. He was known for his pioneering techniques in stereotactic surgery and is an elected fellow of a number of science and medical academies including the National Academy of Medical Sciences and the Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1969.
Konstantin Slavin is a Professor and Head of the Department of Stereotactic and functional neurosurgery at the University of Illinois College of Medicine. He is a former president of the American Society for Stereotactic and functional neurosurgery and current vice-president of the World Society for Stereotactic and Functional Neurosurgery. His specialties include Aneurysm, Brain surgery, Brain Tumor, Cerebrovascular Disorders, Craniotomy, Dystonia, Essential Tremor, Facial Nerve Pain, Facial Pain, Glioblastoma, Headache disorders, Laminectomy, Lower back pain, Movement Disorders, Multiple Sclerosis, Neck Pain, Neurosurgery, Neurosurgical Procedures, Pain, Parkinson Disease, Spinal Cord Injuries, and Stroke.
Accuray is a radiation therapy company that develops, manufactures, and sells radiation therapy systems to deliver treatments including stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). It is the developer of innovative technologies, the CyberKnife and TomoTherapy platforms, including the Radixact System, the latest generation TomoTherapy platform. The company is headquartered in Sunnyvale, CA, the United States. The platforms are installed in leading healthcare centres in approximately 50 countries globally.
Henry Brem, M.D. is an American neurosurgeon, researcher, educator and inventor known for introducing an image guidance computer system to deliver targeted chemotherapy to intraoperative brain tumors. As of 2023, he is the Harvey Cushing Professor, Director of the Department of Neurosurgery, Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering Neurosurgeon-in-Chief, and Director, Hunterian Neurosurgical Research Center and Director at Johns Hopkins in Baltimore, Maryland. Brem has written more than 490 peer-reviewed articles, 50 books and book chapters and holds 11 patents.