Hoeijmakers in 1998
Jan Hendrik Jozef Hoeijmakers (born 15 March in 1951 in Sevenum) is a Dutch molecular biologist, biochemist, and molecular geneticist.
Jan Hendrik Jozef Hoeijmakers (born 15 March in 1951 in Sevenum) is a Dutch molecular biologist, biochemist, and molecular geneticist.
Hoeijmakers studied biology from 1969 at the Radboud University Nijmegen with receiving his MSc degree in molecular biology in 1975 (with a focus on biochemistry and genetics). At the University of Amsterdam he performed his doctoral research from 1975 to 1979 and then was a lecturer at the department of microbiology from 1979 to 1981. He obtained a PhD in molecular medicine in 1981 from the University of Amsterdam [1] under Piet Borst with dissertation Trypanosomes: Kinetoplast DNA and Antigenic Variation. [2] At Erasmus University Rotterdam, as a member of Dirk Bootsma's group in the Institute of Genetics, [3] Hoeijmakers was, in the department of cell biology and genetics, a senior scientist from 1981 to 1985, an associate professor from 1985 to 1993, and a professor of molecular genetics from 1993 to the present. The Royal Netherlands Academy of Arts and Sciences sponsored him as an Academy Professor from 2011 to 2016. [1] He is the author or co-author of over 490 scientific publications. [1] He has served on the editorial boards of five scientific journals. [4]
In 1983 he received the Harold-Quintus-Bosz Prize for his dissertation, in which he clarified the molecular mechanism of the antigen variation of trypanosomes. He uncovered the structure and main function of the network mitochondrial DNA of the parasite. He also clarified the complex genetic mechanism by which trypanosomes constantly change their surface antigens in order to escape the immune system. [3]
In Rotterdam in the early 1980s he achieved the first cloning of human genes responsible for DNA repair and discovered a strong evolutionary stability of the DNA repair system. He clarified the mechanism of nucleotide excision repair (NER) and associated hereditary diseases (xeroderma pigmentosum, Cockayne syndrome, trichothiodystrophy). He found with Jean-Marc Egly that Transcription Factor II H (TFIIH) opens the DNA for the start of the NER. [3]
Hoeijmakers was elected in 2000 a member of the Royal Netherlands Academy of Arts and Sciences (section ‘Medicine’, dept. ‘Physics’). [5] [6] In 2013 he was appointed a Knight in the Order of the Netherlands Lion for important research in cancer and aging. [1]
He received in 1986 the Snoo van t’Hoogerhuys Prize (for the isolation of the first human gene for DNA repair) [1] and in 1995 the Louis-Jeantet Prize for Medicine (jointly with Dirk Bootsma for their research on DNA repair). [7] In 1995 Hoeijmakers was elected a member of the European Molecular Biology Organization (EMBO). He received in 1998 the Spinoza Prize, the highest Dutch science award. [4] He received in 2000 both the Van Gogh award from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) (i.e. Dutch Organization for Science) and the Descartes-Huygens award for French-Dutch scientific collaborations and in 2001 the Josephine Nefkens Prize for Cancer Research. In 2008 the European Research Council awarded him an Advanced Grant. [1] In 2011 he received the Queen Wilhelmina Research Award from the Dutch Society for Cancer Research and, with Bert Vogelstein, the Charles Rodolphe Brupbacher Prize for Cancer Research for research on genome stability and its role in aging and cancer. In 2017 Hoeijmakers received the International Prize of the Olav Thon Foundation. [1]
DAREnet stands for Digital Academic Repositories and is an initiative by the Dutch organisation Surf. The DARE programme is a joint initiative by the Dutch universities and the National Library of the Netherlands, the Royal Netherlands Academy of Arts and Sciences (KNAW) and the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) with the aim to store the results of all Dutch research in a network of so-called repositories, thus facilitating access to them. DAREnet is now integrated into the portal Narcis.nl.
XPB is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
Established in 1986, the Louis-Jeantet Prizes are funded by the Fondation Louis-Jeantet and awarded each year to experienced researchers who have distinguished themselves in the field of biomedical research in one of the member states of the Council of Europe. They are not intended solely as the recognition of work that has been completed, but also to encourage the continuation of innovative research projects. The prizes are awarded to fully active researchers whose scientific efforts are focused on biomedical research. When the research being recognised is close to practical applications for combating illnesses affecting humankind, one of the Louis-Jeantet Prizes converts into a Jeantet-Collen Prize for Translational Medicine, supported by generous donations from the Désiré Collen Stichting.
UV excision repair protein RAD23 homolog B is a protein that in humans is encoded by the RAD23B gene.
DNA excision repair protein ERCC-6 is a protein that in humans is encoded by the ERCC6 gene. The ERCC6 gene is located on the long arm of chromosome 10 at position 11.23.
The Digital Library for Dutch Literature is a website about Dutch language and Dutch literature. It contains thousands of literary texts, secondary literature and additional information, like biographies, portrayals etcetera, and hyperlinks. The DBNL is an initiative by the DBNL foundation that was founded in 1999 by the Society of Dutch Literature.
The Dutch Research Council is the national research council of the Netherlands. NWO funds thousands of top researchers at universities and institutes and steers the course of Dutch science by means of subsidies and research programmes. NWO promotes quality and innovation in science. NWO is an independent administrative body under the auspices of the Dutch Ministry of Education, Culture and Science. NWO directs its approximate budget of 1 billion euros towards Dutch universities and institutes, often on a project basis. Also, NWO has its own research institutes and facilitates international cooperation. Current president of NWO since April 1, 2021 is Marcel Levi. Former NWO presidents include Stan Gielen, Peter Nijkamp and Jos Engelen.
Franklin Gerardus "Frank" Grosveld, FRS is a Dutch molecular biologist whose research interests are in the regulation of transcription during development with a particular emphasis on mammalian erythroid differentiation. He is a professor and former Head of the Department of Cell Biology at the Erasmus MC, Rotterdam.
Stephen Craig West FRS is a British biochemist and molecular biologist specialising in research on DNA recombination and repair. He is known for pioneering studies on genome instability diseases including cancer. West obtained his BSc in 1974, and his PhD in 1977, both from Newcastle University. He is currently a Principal Group Leader at the Francis Crick Institute in London. He is an honorary Professor at University College London, and at Imperial College London. In recognition of his work he was awarded the Louis-Jeantet Prize for Medicine in 2007, is a fellow of the Royal Society, the Academy of Medical Sciences, an International Member of the National Academy of Sciences, and an International Honorary Member of the American Academy of Arts and Sciences. He received the 2022 Royal Medal for 'discovering and determining the functions of key enzymes that are essential for DNA recombination, repair and the maintenance of genomes'.
Johannes (Hans) Carolus Clevers is a Dutch molecular geneticist, cell biologist and stem cell researcher. He became the Head of Pharma, Research and Early Development, and a member of the Corporate Executive Committee, of the Swiss healthcare company Roche in 2022. Previously, he headed a research group at the Hubrecht Institute for Developmental Biology and Stem Cell Research and at the Princess Máxima Center; he remained as an advisor and guest scientist or visiting researcher to both groups. He is also a Professor in Molecular Genetics at the University of Utrecht.
Titia de Lange is the Director of the Anderson Center for Cancer Research, the Leon Hess professor and the head of Laboratory Cell Biology and Genetics at Rockefeller University.
Tjitske Nienke"Cisca"Wijmenga is a Dutch professor of Human Genetics at the University of Groningen and the University Medical Center Groningen. She was Rector Magnificus of the University between September 2019 and September 2023.
Piet Borst CBE is emeritus professor of clinical biochemistry and molecular biology at the University of Amsterdam (UVA), and until 1999 director of research and chairman of the board of directors of the Netherlands Cancer Institute and the Antoni van Leeuwenhoekziekenhuis (NKI-AVL). He continued to work at the NKI-AVL as a staff member and group leader until 2016.
Dirk Bootsma was a Dutch geneticist. He was a professor at the Erasmus University Rotterdam between 1969 and 2002. He and his research group discovered the cause of chronic myelogenous leukemia and furthered the understanding of the nucleotide excision repair.
The Research Foundation – Flanders is a Belgian public research council, based in Brussels. The Flemish research council aims to sponsor ground-breaking research and innovation. Much of this work involves supporting researchers and undertakings in association with the universities and institutes of Flanders, including Ghent University, University of Leuven, University of Antwerp and Free University of Brussels, among others.
Jan Carel Zadoks is a Dutch botanist and a professor emeritus of ecological plant pathology at Wageningen University & Research.
Orlando David Schärer is a Swiss chemist and biologist researching DNA repair, genomic integrity, and cancer biology. Schärer has taught biology, chemistry and pharmacology at various university levels on three continents. He is a distinguished professor at the Ulsan National Institute of Science and Technology (UNIST) and an associate director of the IBS Center for Genomic Integrity located in Ulsan, South Korea. He leads the three interdisciplinary research teams in the Chemical & Cancer Biology Branch of the center and specifically heads the Cancer Therapeutics Mechanisms Section.
Alex Jan"Lex"van der Eb is a Dutch molecular biologist and virologist. He was a professor of fundamental tumor virology and later molecular carcinogenesis at Leiden University from 1979 to 2000. He has performed research in adenoviruses and was fundamental in the creation of the technique of calcium phosphate transfection and the founding of the HEK 293 and PER.C6 cell lines.
Karina Elizabeth de Visser, also named "Karin E. de Visser", is a researcher at the Netherlands Cancer Institute. Her research considers metastatic formation and how the immune system influences how people respond to cancer treatment.
Reuven Agami is a Dutch cancer researcher. He is a professor of Oncogenomics at Erasmus University Rotterdam and head of the section of Oncogenomics at the Netherlands Cancer Institute-Antoni van Leeuwenhoekziekenhuis. Since October 2023 the Royal Netherlands Academy of Arts and Sciences (KNAW) has selected Reuven Agami as a member.
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