Janet K. Yamamoto | |
---|---|
Known for | co-developed a vaccine for the Feline immunodeficiency virus |
Academic background | |
Education | BA, University of California, Davis PhD, Microbiology, 1981, University of Texas Medical Branch |
Academic work | |
Institutions | University of Florida UC Davis School of Veterinary Medicine |
Janet K. Yamamoto is an American immunologist. Yanamoto is a professor of veterinary medicine at the University of Florida where she studies the spread of HIV/AIDS. In 1988,she co-developed a vaccine for the feline version of HIV with Niels C. Pederson and was subsequently elected to the National Academy of Inventors.
Yamamoto is the granddaughter of Sanehiko Yamamoto,who,while serving as the president of publishing house Kaizosha,first translated Albert Einstein's work into Japanese. He subsequently befriended Einstein who,in return,helped her father become the first Japanese person to become an American citizen after World War II. [1] She earned her Bachelor of Arts degree from the University of California,Davis and her PhD in microbiology from the University of Texas Medical Branch. [2]
Upon receiving her PhD,Yamamoto accepted a faculty position at the UC Davis School of Veterinary Medicine where she began research with Niels C. Pederson on the feline version of HIV. [1] She had originally been recruited by the UC Davis School of Medicine after completing postdoctoral work on the Feline Leukemia Virus but remained with their veterinary school until 1993. [3] Yamamoto established the Laboratory of Comparative Immunology and Retrovirology in 1985,where they isolated the feline immunodeficiency virus for the first time in medical history in an effort to create a vaccine. [4] [5] For a one-year term between 1988 and 1989,she also worked as a consultant in the Clinical Division of Bio-Rad Laboratories. [3]
In 1993,Yamamoto moved to the University of Florida where she re-established the Laboratory of Comparative Immunology and Retrovirology and continued researching the vaccine. [4] The immunization,created in 2002 and approved by the U.S. Department of Agriculture,was made from an inactivated form of the FIV virus itself. [6] [7] In recognition of her efforts,Yamamoto was named a Research Foundation Professor of Pathobiology at the University of Florida. [8]
In 2005,Yamamoto conducted a research project in which cats were vaccinated with an experimental strain of the human AIDS virus. The conclusion of the project found that the felines vaccinated with the human strain were similarly protected as those vaccinated by feline strain. [9] In the same year,she received the school's Pfizer Animal Health Award for Research Excellence. [10] Yamamoto later collaborated with AIDS researcher Jay A. Levy to help control the spread of HIV/AIDS in Caribbean and Latin American nations. [11] In a further effort to combat the spread of HIV/AID,Yamamoto donated all of her patient income and parts of her salary to fund her research towards a cure for HIV. [3]
Between 2010 and 2012,Yamamoto served as a consultant to the Idexx Laboratories at Westbrook and served as a member of the Clinical Immunology Society,the International AIDS Society,the American Association of Immunologists,Incorporated,the American Society for Microbiology,the New York Academy of Sciences,the American Association for the Advancement of Science and Phi Zeta Upsilon, [3] In recognition of her academic accomplishments,Yamamoto received a UF Research Foundation professorship at the University of Florida's College of Veterinary Medicine. The University of Florida Research Foundation (UFRF) Professorships are awarded for "a three-year term to tenured faculty campuswide for distinguished research and scholarship that is expected to lead to continuing distinction in their field." [12]
On December 16,2014,Yamamoto was named a fellow of the National Academy of Inventors for her discovery of the feline HIV vaccine. [13] Yamamoto was named to the Florida Inventors Hall of Fame in 2015 for her discovery of the feline immunodeficiency virus. [14] The following year,she was honored by the University of Florida as their "Inventor of the Year" for her achievements. [15]
Feline immunodeficiency virus (FIV) is a Lentivirus that affects cats worldwide,with 2.5% to 4.4% of felines being infected.
The University of California,Davis,School of Veterinary Medicine is the largest veterinary school in the United States. Established in 1948,the school is the primary health resource for California's various animal populations. In 2020,the school was again ranked No. 1 in the United States by U.S. News &World Report and in 2022,ranked No. 2 in the world by QS World University Rankings. The school is located in the southwest corner of the main campus of the University of California,Davis. The current Dean of Veterinary Medicine is Dr. Mark Stetter.
Feline leukemia virus (FeLV) is a retrovirus that infects cats. FeLV can be transmitted from infected cats when the transfer of saliva or nasal secretions is involved. If not defeated by the animal's immune system,the virus weakens the cat's immune system,which can lead to diseases which can be lethal. Because FeLV is cat-to-cat contagious,FeLV+ cats should only live with other FeLV+ cats.
Carnivore protoparvovirus 1 is a species of parvovirus that infects carnivorans. It causes a highly contagious disease in both dogs and cats separately. The disease is generally divided into two major genogroups:FPV containing the classical feline panleukopenia virus (FPLV),and CPV-2 containing the canine parvovirus type 2 (CPV-2) which appeared in the 1970s.
Feline viral rhinotracheitis (FVR) is an upper respiratory or pulmonary infection of cats caused by Felid alphaherpesvirus 1 (FeHV-1),of the family Herpesviridae. It is also commonly referred to as feline influenza,feline coryza,and feline pneumonia but,as these terms describe other very distinct collections of respiratory symptoms,they are misnomers for the condition. Viral respiratory diseases in cats can be serious,especially in catteries and kennels. Causing one-half of the respiratory diseases in cats,FVR is the most important of these diseases and is found worldwide. The other important cause of feline respiratory disease is feline calicivirus.
The health of domestic cats is a well studied area in veterinary medicine.
Feline vaccination is animal vaccination applied to cats. Vaccination plays a vital role in protecting cats from infectious diseases,some of which are potentially fatal. They can be exposed to these diseases from their environment,other pets,or even humans.
The Lange Foundation is a 501(c)(3) non-profit organization founded in 1993 in West Los Angeles,California,by Gillian Lange. The organization is a no-kill shelter committed to rescuing stray and abandoned animals and facilitating adoptions. Animals that are not adopted may remain at the kennel indefinitely without consequence.
Zeda Fran Rosenberg is an American microbiologist and epidemiologist,active in HIV biology and prevention. She is the chief executive officer of the International Partnership for Microbicides (IPM). IPM was founded by Rosenberg in 2002 and is a nonprofit organization dedicated to developing microbicides and other innovative HIV prevention products and making them available for women in developing countries.
SAV001-H is the first candidate preventive HIV vaccine using a killed or "dead" version of the HIV-1 virus.
Julia Beatty is a British-Australian veterinary researcher specialising in feline medicine clinical research and educating students of Veterinary Science.
William "Bill" Fleming Hoggan Jarrett,RCVS,FRCPath,FRCPG,FRS (1928–2011) was a British pathologist.
Tritrichomonas blagburni is a genus of parasite that infects the digestive system of cats.
Melahat Okuyan is a Turkish female veterinary physician,academic and scientist in microbiology. She is an AIDS activist.
Feline foamy virus or Feline syncytial virus is a retrovirus and belongs to the family Retroviridae and the subfamily Spumaretrovirinae. It shares the genus Felispumavirus with only Puma feline foamy virus. There has been controversy on whether FeFV is nonpathogenic as the virus is generally asymptomatic in affected cats and does not cause disease. However,some changes in kidney and lung tissue have been observed over time in cats affected with FeFV,which may or may not be directly affiliated. This virus is fairly common and infection rates gradually increase with a cat's age. Study results from antibody examinations and PCR analysis have shown that over 70% of felines over 9 years old were seropositive for Feline foamy virus. Viral infections are similar between male and female domesticated cats whereas in the wild,more feral females cats are affected with FeFV.
Bette Korber is an American computational biologist focusing on the molecular biology and population genetics of the HIV virus that causes infection and eventually AIDS. She has contributed heavily to efforts to obtain an effective HIV vaccine. She created a database at Los Alamos National Laboratory that has enabled her to design novel mosaic HIV vaccines,one of which is currently in human testing in Africa. The database contains thousands of HIV genome sequences and related data.
Eric Murnane Poeschla is an American infectious disease physician,virologist,and innate immunologist.
Vanessa M. Hirsch is a Canadian-American veterinary pathologist and scientist. She is a senior investigator and chief of the nonhuman primate virology section at the National Institute of Allergy and Infectious Diseases. Hirsch researches AIDS pathogenesis,the evolution and origins of primate lentiviruses,and HIV vaccine development.
Natalie E. Dean is an American biostatistician specializing in infectious disease epidemiology. Dean is currently an assistant professor of Biostatistics at the University of Florida. Her research involves epidemiological modeling of outbreaks,including Ebola,Zika and COVID-19.
Recombinant feline interferon omega (RFeIFN-ω),sold under the brand name Virbagen Omega among others,is a recombinant version of a cat interferon alpha. It is used to treat a range of viral diseases in cats and dogs,including canine parvovirus,feline leukemia virus (FeLV),and feline immunodeficiency virus (FIV) in many countries. It is approved to be used by injection under the skin. RFeIFN-ωis produced in silkworm larvae using a baculovirus vector.