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Tumor protein P53, also known as p53, cellular tumor antigen p53, the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular vertebrates, where it prevents cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
Virgil Craig Jordan,, is a scientist with American and British citizenship specializing in drugs for breast cancer treatment and prevention. Currently, he is Professor of Breast Medical Oncology, and Professor of Molecular and Cellular Oncology at the University of Texas MD Anderson Cancer Center, Houston, Texas. Previously, he was Scientific Director and Vice Chairman of Oncology at the Lombardi Comprehensive Cancer Center of Georgetown University. Jordan was the first to discover the breast cancer prevention properties of tamoxifen and the scientific principles for adjuvant therapy with antihormones. More recently his work has branched out into the prevention of multiple diseases in women with the discovery of the drug group, selective estrogen receptor modulator (SERMs). Currently, he plans to develop a new Hormone Replacement Therapy (HRT) for post-menopausal women that prevents breast cancer and does not increase the risk of breast cancer.
VIB is a research institute located in Flanders, Belgium. It was founded by the Flemish government in 1995, and became a full-fledged institute on 1 January 1996. The main objective of VIB is to strengthen the excellence of Flemish life sciences research and to turn the results into new economic growth. VIB spends almost 80% of its budget on research activities, while almost 12% is spent on technology transfer activities and stimulating the creation of new businesses, in addition VIB spends approximately 2% on socio-economic activities.
Désiré, Baron Collen is a Belgian physician, chemist, biotechnology entrepreneur and life science investor. He made several discoveries in thrombosis, haemostasis and vascular biology in many of which serendipity played a significant role. His main achievement has been his role in the development of tissue-type plasminogen activator (t-PA) from a laboratory concept to a life-saving drug for dissolving blood clots causing acute myocardial infarction or acute ischemic stroke. Recombinant t-PA was produced and marketed by Genentech Inc as Activase and by Boehringer Ingelheim GmbH as Actilyse, and is considered biotechnology's first life saving drug.
Dirk Inzé is a Belgian molecular biologist and professor at Ghent University. In 2002, he succeeded Marc Zabeau as scientific director of the VIB-UGent Center for Plant Systems Biology. His research interest is on the molecular networks underpinning yield and organ growth both under standard as well as mild drought stress conditions in Arabidopsis and the C4 crop maize. He is a member of the European Molecular Biology Organization (EMBO). He was recipient of the 1994 Körber European Science Prize. In 2005, he was awarded the Francqui Prize on Biological and Medical Sciences for his research on plant systems biology.
Marc Guy Albert Marie Lacroix is a biochemist and a researcher who specializes in breast cancer biology, metastasis and therapy.
Frans Van Roy is a Belgian molecular biologist and professor at the University of Ghent. He is head of the VIB Department for Molecular Biomedical Research, UGent. His research interest is on the molecular mechanisms underlying the pathology and the cure of cancer and inflammation-related disorders.
Lode Wyns is a Belgian molecular biologist and professor at the Vrije Universiteit Brussel. He is head of the VIB Department of Molecular and Cellular Interactions, Vrije Universiteit Brussel of the VIB. His research interest is on immunology, with an emphasis on cellular and applied immunology with major ramifications into parasitology and on structural biology such as protein structure, function and design.
Frederic Rousseau is a Flemish Belgian molecular biologist and researcher at the KU Leuven. Together with Joost Schymkowitz he is group leader at the VIB Switch Laboratory, KU Leuven. His research interest is on essential cellular processes where functional regulation is governed by protein conformational switches that have to be actively controlled to ensure cell viability
Bart De Strooper is a Belgian molecular biologist and professor at Vlaams Instituut voor Biotechnologie and KU Leuven and the UK Dementia Research Institute and University College London, UK. His research interests are in Alzheimer's and other neurodegenerative diseases.
Patrick Callaerts is a Belgian molecular biologist and researcher at the Katholieke Universiteit Leuven. He is head of the VIB Laboratory of Developmental Genetics, KU Leuven.
Johan Thevelein is a Belgian molecular biologist and professor at the Katholieke Universiteit Leuven. He is head of the VIB Department of Molecular Biology, KU Leuven.
Hugo Van Heuverswyn is a Belgian molecular biologist, biotech pioneer, entrepreneur and businessman. He has been the chairman of the VIB, Flanders Institute for Biotechnology, since its inception in 1995.
Jurgen Del-Favero is a Belgian scientist working at the VIB Department of Molecular Genetics at the University of Antwerp. His research is directed towards the identification of susceptibility genes for psychiatric disorders and tools for DNA sequence research. His research, in collaboration with the Swedish research group under the direction of Rolf Adolfsson, indicated that the TPH2 protein is involved in the development of depression and manic depression.
Vincent Timmerman is a Belgian scientist working at the VIB Department of Molecular Genetics at the University of Antwerp of Christine Van Broeckhoven. His research is focused on inherited disorders of the peripheral nervous system, classified as hereditary motor and/or sensory neuropathies and the most common inherited peripheral neuropathy is Charcot-Marie-Tooth (CMT) disease or Hereditary Motor and Sensory Neuropathy (HMSN).
Xavier Saelens is a Belgian scientist and currently his main research interest is finding a universal influenza vaccine. He is a lecturer in Virology and Group Leader of the Molecular Virology Unit at the University of Ghent
C. Scott Baker is an American molecular biologist and cetacean specialist. He is Associate Director of the Marine Mammal Institute at Oregon State University. He is also Adjunct Professor of Molecular Ecology and Evolution at the University of Auckland, and Editor of the Journal of Heredity.
Stephen H. Friend is co-founder and director of Sage Bionetworks.
Laurent Susini is a French molecular biologist; his research is in the area of cancer and the genetic basis of tumor reversion.
Curtis. C. Harris is the head of the Molecular Genetics and Carcinogenesis Section and chief of the Laboratory of Human Carcinogenesis at the Center for Cancer Research of the National Cancer Institute, NIH.
References
- ↑ Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA, "Inactivation of the p53 pathway in retinoblastoma", Nature 61–66, 2006
