Jean E. Schaffer

Last updated
Jean Elise Schaffer, MD
Jean Schaffer.jpg
Education Harvard College (A.B.)
Harvard Medical School (M.D.)
Occupationphysician-scientist
Website https://www.schafferlab.org

Jean Elise Schaffer is an American physician-scientist. She is a Senior Investigator at the Joslin Diabetes Center, [1] where she also serves as an Associate Research Director, and she is a Professor of Medicine at Harvard Medical School. [2] Her work focuses on fundamental mechanisms of metabolic stress responses and the pathophysiology of diabetes complications.

Contents

Education

Schaffer studied biochemistry at Harvard College, writing her undergraduate thesis with Richard I. Morimoto in the laboratory of Matthew Meselson. [3] She earned her M.D. from Harvard Medical School. [4] Schaffer completed an internship and residence in medicine at Brigham and Women's Hospital, and clinical and research fellowship in cardiology at Beth Israel Hospital. During her postdoctoral training with Harvey Lodish at the Whitehead Institute at Massachusetts Institute of Technology, she cloned the first member of the fatty acid transport protein family. [5]

Career

In 1995 Schaffer joined the faculty at Washington University School of Medicine in St Louis and in 2008 was appointed as the inaugural Virginia Minnich Distinguished Professor of Medicine. [6] She directed the NIDDK-funded Diabetes Research Center at Washington University from 2008-2019. Her laboratory discovered that disruption of specific small nucleolar RNAs protects against lipid-induced cell death and alters metabolism, work that has provided a new understanding of how nutrient signals influence cellular homeostasis through non-coding RNAs. [7] Schaffer’s contributions to lipid metabolism and metabolic stress have been recognized by American Society for Clinical Investigation, American Association for the Advancement of Science, Association of American Physicians and American Society for Biochemistry and Molecular Biology. [8] In 2019 Schaffer moved to the Joslin Diabetes Center at Harvard Medical School. [9] [10]

Awards and honors

References

  1. ↑ "Schaffer, Jean".
  2. ↑ "Jean Schaffer | Harvard Catalyst Profiles | Harvard Catalyst".
  3. ↑ Washington University Record, November 13, 2008. http://digitalcommons.wustl.edu/record/1160
  4. ↑ Michel, CI; Holley, CL; Scruggs, BS; Sidhu, R; Brookheart, RT; Listenberger, LL; Behlke, MA; Ory, DS; Schaffer, JE (2011). "Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress". Cell Metab. 14: 33–44. doi:10.1016/j.cmet.2011.04.009. PMC   3138526 . PMID   21723502.
  5. ↑ Schaffer, JE; Lodish, HF (1994). "Expression cloning and characterization of a novel adipocyte long-chain fatty acid transport protein". Cell. 79: 427–436.
  6. ↑ Washington University Record, November 13, 2008. http://digitalcommons.wustl.edu/record/1160
  7. ↑ Lee, J; Harris, AN; Holley, CL; Mahadevan, J; Pyles, KD; Lavagnino, Z; Scherrer, DE; Fujiwara, H; Sidhu, R; Zhang, J; Huang, SC; Piston, DW; Remedi, MS; Urano, F; Ory, DS; Schaffer, JE (2016). "Rpl13a small nucleolar RNAs regulate systemic glucose metabolism". J Clin Invest. 126: 4616–4625. doi:10.1172/JCI88069. PMC   5127695 . PMID   27820699.
  8. ↑ "Meet Jean Schaffer".
  9. ↑ "Schaffer, Jean".
  10. ↑ 7. https://www.bizjournals.com/boston/potmsearch/detail/submission/6472448/Jean_Schaffer
  11. ↑ "Louis N. And Arnold M. Katz Basic Science Research Prize for Early Career Investigators".
  12. ↑ "Home".
  13. ↑ "Elected Fellows | American Association for the Advancement of Science (AAAS)".
  14. ↑ https://aap-online.org/
  15. ↑ "Overview | Einstein-Mount Sinai Diabetes Research Center | Albert Einstein College of Medicine". Archived from the original on 2020-12-01. Retrieved 2021-01-28.
  16. ↑ "Robert P. Hebbel Research Day". 14 December 2019.
  17. ↑ "Avanti Award in Lipids".
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