Optical coherence tomography (OCT) is an imaging technique that uses interferometry with short-coherence-length light to obtain micrometer-level depth resolution and uses transverse scanning of the light beam to form two- and three-dimensional images from light reflected from within biological tissue or other scattering media. Short-coherence-length light can be obtained using a superluminescent diode (SLD) with a broad spectral bandwidth or a broadly tunable laser with narrow linewidth. The first demonstration of OCT imaging was published by a team from MIT and Harvard Medical School in a 1991 article in the journal Science. The article introduced the term "OCT" to credit its derivation from optical coherence-domain reflectometry, in which the axial resolution is based on temporal coherence. The first demonstrations of in vivo OCT imaging quickly followed.
Naomi J. Halas is the Stanley C. Moore Professor in Electrical and Computer Engineering, and professor of biomedical engineering, chemistry, and physics at Rice University. She is also the founding director of Rice University Laboratory for Nanophotonics, and the Smalley-Curl Institute. She invented the first nanoparticle with tunable plasmonic resonances, which are controlled by their shape and structure, and has won numerous awards for her pioneering work in the field of nanophotonics and plasmonics. She was also part of a team that developed the first dark pulse soliton in 1987 while working for IBM.
Medical optical imaging is the use of light as an investigational imaging technique for medical applications, pioneered by American Physical Chemist Britton Chance. Examples include optical microscopy, spectroscopy, endoscopy, scanning laser ophthalmoscopy, laser Doppler imaging, and optical coherence tomography. Because light is an electromagnetic wave, similar phenomena occur in X-rays, microwaves, and radio waves.
Bruce J. Tromberg is an American photochemist and a leading researcher in the field of biophotonics. He is the director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) within the National Institutes of Health (NIH). Before joining NIH, he was Professor of Biomedical Engineering at The Henry Samueli School of Engineering and of Surgery at the School of Medicine, University of California, Irvine. He was the principal investigator of the Laser Microbeam and Medical Program (LAMMP), and the Director of the Beckman Laser Institute and Medical Clinic at Irvine. He was a co-leader of the Onco-imaging and Biotechnology Program of the NCI Chao Family Comprehensive Cancer Center at Irvine.
Novacam Technologies Inc. specializes in designing and manufacturing advanced metrology and imaging systems for industrial and bio-medical applications. Novacam's fiber-based optical profilometers and Optical Coherence Tomography (OCT) systems are based on low coherence interferometry. The fiber-based nature of Novacam's detector probes is unique in the optical metrology industry.
Andreas Mandelis FRSC, FCAE, FAPS, FSPIE, FAAAS, FASME, is a Greek - Canadian physicist who is a professor and researcher in the department of Mechanical and Industrial Engineering at the University of Toronto. He is the director of the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT). and of the Institute for Advanced Non-Destructive and Non-Invasive Diagnostic Technologies (IANDIT) at the University of Toronto. He is an internationally recognized expert in thermophotonics. and is considered a pioneer in the fields of diffusion-wave, photothermal, and photoacoustic sciences and related technologies. His research interests encompass studies of physical energy conversion processes in condensed and biological matter as they impact instrumentation science and signal generation technologies with applications spanning the development of a wide spectrum of novel instrumentation, measurement and imaging techniques using optical-to-thermal, thermoelastic, electronic, ultrasonic and/or photonic energy conversion high-dynamic-range and high-sensitivity analytical methodologies, leading to advanced non-destructive / non-invasive diagnostic, inspection and monitoring technologies with major focus on advanced dynamic imaging instrumentation for industrial and biomedical applications. He is the inventor of a photothermal imaging radar which can detect tooth decay at an early stage, can detect the onset of cancerous lesions in soft tissues, cracks in teeth and monitor dental structural integrity over time. His research team also pioneered and patented 22 analytical instrumentation and measurement methodologies and metrologies.
Petra Elfrida Erna Beate Wilder-Smith is a professor and director of dentistry at the Beckman Laser Institute at the University of California, Irvine, and a fellow of the Chao Family Comprehensive Cancer Center at the University of California, Irvine. She is a visiting professor at Aachen University (Germany); and a visiting lecturer at Loma Linda University. Wilder-Smith specializes in the use of light and optics in tracking and treating oral cancer. She has developed innovative noninvasive laser technology used to examine and treat mouth lesions.
Stephen A. Boppart is a principal investigator at the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign, where he holds an Abel Bliss Professorship in engineering. He is a faculty member in the departments of electrical and computer engineering, bioengineering, and internal medicine. His research focus is biophotonics, where he has pioneered new optical imaging technologies in the fields of optical coherence tomography, multi-photon microscopy, and computational imaging.
Tayyaba Hasan is a Professor of Dermatology at the Wellman Center for Photomedicine at Harvard Medical School. She is one of the inventors of Visudyne, a Food and Drug Administration approved treatment for age-related macular degeneration. She received the 2018 SPIE Britton Chance Biomedical Optics Award.
Elizabeth M. C. Hillman is a British-born academic who is Professor of Biomedical Engineering and Radiology at Columbia University. She was awarded the 2011 Adolph Lomb Medal from The Optical Society and the 2018 SPIE Biophotonics Technology Innovator Award.
Muyinatu "Bisi" A. Lediju Bell is the John C. Malone Associate Professor of Biomedical Engineering, Electrical and Computer Engineering, and Computer Science at Johns Hopkins University. She is also the director of the Photoacoustic and Ultrasonic Systems Engineering Laboratory.
Anita Mahadevan-Jansen is a Professor of Biomedical Engineering and holds the Orrin H. Ingram Chair in Biomedical Engineering at Vanderbilt University. Her research considers the development of optical techniques for clinical diagnosis and surgical guidance, particularly using Raman and fluorescence spectroscopy. She serves on the Board of Directors of SPIE, and is a Fellow of SPIE, The Optical Society, Society for Applied Spectroscopy, and the American Society for Lasers in Medicine and Surgery. She was elected to serve as the 2020 Vice President of SPIE. With her election, Mahadevan-Jansen joined the SPIE presidential chain and served as President-Elect in 2021 and the Society's President in 2022.
Jannick Rolland is the Brian J. Thompson Professor of Optical Engineering at the Institute of Optics at the University of Rochester. She is also the co-founder and CTO of LighTopTech, a women-owner business founded in 2013 to create medical imaging technologies with biomimetic noninvasive imaging technology. At the University of Rochester, she is the Director of the NSF I/UCRC Center for Freeform Optics (CeFO). She is also the Director of the R.E. Hopkins Center for Optical Design and Engineering that engages undergraduates in optical design, fabrication, and metrology.
Christine P. Hendon is an electrical engineer and computer scientist and an associate professor in the Department of Electrical Engineering at Columbia University in New York City. Hendon is a pioneer in medical imaging. She develops biomedical optics technologies, using optical coherence tomography and near infrared spectroscopy systems, that enable physicians to perform guided interventional procedures and allow for structure-function dissection of human tissues and organs. Her advances in imaging technologies have led to improved diagnostic abilities and treatments for cardiac arrhythmias as well as breast cancer and preterm birth. She has been recognized for her development of optical imaging catheters for cardiac wall imaging by Forbes 30 under 30, the MIT Technology Review’s 35 Innovators Under 35, and by President Obama with the Presidential Early Career Awards in 2017.
Audrey K. Ellerbee Bowden is an American engineer and Dorothy J. Wingfield Phillips Chancellor's Faculty Fellow at Vanderbilt University, as well as an Associate Professor of Biomedical Engineering and Electrical Engineering. She is a Fellow of Optica, the American Institute for Medical and Biological Engineering and the International Society for Optics and Photonics (SPIE).
Melissa Caroline Skala is an American biomedical engineer who is a professor at the Morgridge Institute for Research. Her research considers photonics-based technologies for personalised medical therapies. She is a Fellow of The Optical Society, SPIE and American Institute for Medical and Biological Engineering.
Irene Georgakoudi is a Greek biophysicist and Professor of Biomedical Engineering at Tufts University, where her work focuses on developing non-invasive medical imaging techniques based on optical spectroscopy for applications in medical diagnostics and therapeutics.
Igor Meglinski is a British, New Zealand and Finnish scientist serving as a principal investigator at the College of Engineering & Physical Sciences at Aston University, where he is a Professor in Quantum Biophotonics and Biomedical Engineering. He is a Faculty member in the School of Engineering and Technology at the Department of Mechanical, Biomedical & Design Engineering, and is also associated with the Aston Institute of Photonic Technologies (AIPT) and Aston Research Centre for Health in Ageing (ARCHA).
Paola Taroni is an Italian engineer and physicist who works at the Polytechnic University of Milan. Her research considers the development of optical approaches for cancer diagnoses. She has held various leadership positions.
Ge Wang is a medical imaging scientist focusing on computed tomography (CT) and artificial intelligence (AI) especially deep learning. He is the Clark & Crossan Chair Professor of Biomedical Engineering and the Director of the Biomedical Imaging Center at Rensselaer Polytechnic Institute, Troy, New York, USA. He is known for his pioneering work on CT and AI-based imaging. He is Fellow of American Institute for Medical and Biological Engineering (AIMBE), Institute of Electrical and Electronics Engineers (IEEE), International Society for Optics and Photonics (SPIE), Optical Society of America (OSA/Optica), American Association of Physicists in Medicine (AAPM), American Association for the Advancement of Science (AAAS), and National Academy of Inventors (NAI).
