Josef Coresh

Last updated
Josef Coresh
Academic background
EducationBS, Mathematics, Princeton University
MHS, PhD, 1992, Johns Hopkins Bloomberg School of Public Health
MD, 1992, Johns Hopkins University
Thesis Genetic epidemiology of Apolipoprotein B (1992)
Academic work
Institutions Johns Hopkins University

Josef Coresh is an American epidemiologist. He is the inaugural George W. Comstock Professor in the Department of Epidemiology at Johns Hopkins University. Coresh serves as the director of both the Cardiovascular Epidemiology Training Program and the George W. Comstock Center for Public Health Research and Prevention at the Johns Hopkins School of Medicine.

Contents

Early life and education

Coresh attended Princeton University for his bachelor's degree in mathematics before enrolling at Johns Hopkins University for his medical degree, master's degree, and PhD. [1]

Career

During his tenure at Johns Hopkins, Coresh studies risk factors for vascular disease across different organs including the heart, kidney and brain with the goal of improving health and research. He developed a population-based longitudinal proteomic study of health in the ARIC (Atherosclerosis Risk in Communities) Study population. He used data of nearly 5000 proteins over three decades to gain insights into novel risk factors and pathways for dementia, heart disease, cancer and aging. [2] [3] Coresh also led the Cardiovascular Epidemiology Training Program at the Bloomberg School since 1997. [4] In this role, he was recognized with the AHA Lifestyle Council Mentorship Award as "a person who has provided exceptional individual and institutional mentoring and advocacy for cardiovascular epidemiology researchers." [5] His mentees included Elizabeth Selvin [6] and Morgan Grams. [7]

In 2007, his paper "Prevalence of chronic kidney disease in the United States" was ranked by Essential Science Indicators as one of the 20 most-cited "Hot Papers" over all fields and a "Highly Cited Paper in Clinical Medicine." [8] The following year, he was appointed both the Cardiovascular Epidemiology Training Program and the George W. Comstock Center for Public Health Research and Prevention at the Johns Hopkins School of Medicine. [9] Later, Coresh was appointed vice-chair of the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative workgroup (for the Clinical Practice Guideline "Chronic Kidney Disease: Evaluation, Classification and Stratification") which has also led to his increased involvement in the international effort to address the public health burden of chronic kidney disease. [8] In 2009, Coresh was the co-author of "Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout" which received the PNAS paper Cozzarelli Prize for outstanding scientific excellence and originality. [10] The following year, the National Kidney Foundation gave Coresh the Garabed Eknoyan Award for his contributions to the field. He was also the recipient of the American Heart Association's Epidemiology and Prevention Mentoring Award. [8]

As the leader of the Chronic Kidney Disease Prognosis Consortium, Coresh analyzed data from 1.7 million participants recruited into 35 cohorts in dozens of countries from 1975 to 2011 and followed for an average of 5 years. He used this data to suggest that new therapies for kidney disease by revising the definition of kidney disease progression used during clinical trials. [11] Due to his overall research, Coresh was the recipient of the 2015 National Kidney Foundation's David Hume Award, their highest honor given to individuals "who exemplifies the high ideals of scholarship and humanism in an outstanding manner." [12]

In Fall 2020, Coresh co-authored a kidney study using international data from over nine million individuals "to develop and validate a risk-scoring calculation that adds blood and urine measures of kidney disease to the current standard method in the United States for assessing cardiovascular disease risk." [13] In October, he was the recipient of the Belding H. Scribner Lifetime Achievement Award from the American Society of Nephrology for his career-long contributions to the practice of nephrology. [14]

Related Research Articles

A saturated fat is a type of fat in which the fatty acid chains have all single bonds. A fat known as a glyceride is made of two kinds of smaller molecules: a short glycerol backbone and fatty acids that each contain a long linear or branched chain of carbon (C) atoms. Along the chain, some carbon atoms are linked by single bonds (-C-C-) and others are linked by double bonds (-C=C-). A double bond along the carbon chain can react with a pair of hydrogen atoms to change into a single -C-C- bond, with each H atom now bonded to one of the two C atoms. Glyceride fats without any carbon chain double bonds are called saturated because they are "saturated with" hydrogen atoms, having no double bonds available to react with more hydrogen.

Chronic kidney disease Progressive loss in kidney function over a period of months or years

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years. Initially there are generally no symptoms; later, symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Complications include an increased risk of heart disease, high blood pressure, bone disease, and anemia.

Johns Hopkins Bloomberg School of Public Health

The Johns Hopkins Bloomberg School of Public Health (JHSPH) is part of Johns Hopkins University in Baltimore, Maryland, United States. As the first independent, degree-granting institution for research in epidemiology and training in public health, and the largest public health training facility in the United States, the Bloomberg School is a leading international authority on the improvement of health and prevention of disease and disability. The school's mission is to protect populations from illness and injury by pioneering new research, deploying its knowledge and expertise in the field, and training scientists and practitioners in the global defense of human life. The school is ranked first in public health in the U.S. News and World Report rankings and has held that ranking since 1994.

JoAnn E. Manson

JoAnn Elisabeth Manson is a physician, best known for her public leadership and advocacy in the field of women's health. She is the Michael and Lee Bell Professor of Women's Health at the Harvard Medical School, a professor of epidemiology in the Harvard School of Public Health, and chief of the Division of Preventive Medicine at Brigham and Women's Hospital.

George W. Comstock

George Wills Comstock was a public health physician, epidemiologist, and educator. He was known for significant contributions to public health, specifically in the fields of micronutrient deficiencies, tuberculosis, and cardiovascular disease. He served as the editor-in-chief for the American Journal of Epidemiology.

Kamyar Kalantar-Zadeh is an Iranian-American physician doing research in nephrology, kidney dialysis, nutrition, and epidemiology. He is best known as a specialist in kidney disease nutrition and chronic kidney disease and for his hypothesis about the longevity of individuals with chronic disease states, also known as reverse epidemiology including obesity paradox. According to this hypothesis, obesity or hypercholesterolemia may counterintuitively be protective and associated with greater survival in certain groups of people, such as elderly individuals, dialysis patients, or those with chronic disease states and wasting syndrome (cachexia), whereas normal to low body mass index or normal values of serum cholesterol may be detrimental and associated with worse mortality. Kalantar-Zadeh is also known for his expertise in kidney dialysis therapy, including incremental dialysis, as well as renal nutrition. He is the brother of Kourosh Kalantar-zadeh, who an Australian scientist involved in research in the fields of materials sciences, nanotechnology, and transducers.

Carmine Zoccali

Carmine Zoccali is an Italian nephrologist and a clinical investigator. He has contributed to research in several fields, most notably hypertension and cardiovascular complications in chronic kidney disease (CKD), CKD progression and clinical epidemiology of kidney diseases at large. He is known for his studies on cardiovascular risk in CKD and dialysis patients. He was among the earliest investigators that focused on the relevance of endothelial dysfunction and inflammation for the high risk of cardiovascular disease in these populations. In this research area, he was the first to link endogenous inhibitors of the nitric oxide system with death and cardiovascular disease. and the first to document a relationship between sympathetic over-activity and these outcomes Dr Zoccali is a practicing specialist in Nephrology, with a national qualification for the full professorship in Nephrology. He is also a specialist in hypertension, certified by the European Society of Hypertension (ESH).

Lawrence J. Appel, MD MPH is the C. David Molina Professor of Medicine and Director of the Welch Center for Prevention, Epidemiology and Clinical Research at Johns Hopkins University, a joint program of the Johns Hopkins University School of Medicine and the Bloomberg School of Public Health. Dr. Appel is a primary care internist who holds a primary appointment in the Department of Medicine with joint appointments in the Department of Epidemiology, International Health, and Nursing. In addition, he directs the ProHealth Clinical Research Unit. The focus of his career is the conduct of clinical, epidemiologic, and translational research pertaining to the prevention and control of high blood pressure, cardiovascular-kidney diseases, and other chronic conditions, primarily through nutrition-based interventions.

Neil R. Powe is an American professor of medicine at the University of California, San Francisco and the chief of medicine at the Zuckerberg San Francisco General Hospital and Trauma Center. Previously he was professor of medicine at the Johns Hopkins University School of Medicine. His research has mainly related to kidney disease, cardiovascular disease and health disparities.

Cheryl Ann Marie Anderson is an American epidemiologist. Anderson is a Professor and Interim chair at the University of California San Diego School of Medicine. Additionally, she acts as the founding Dean at the Herbert Wertheim School of Public Health and Human Longevity Science Department. Anderson's research focus is on nutrition and chronic disease prevention in under-served human populations.

Andrew S. Levey is an American nephrologist who transformed Chronic Kidney Disease (CKD) clinical practice, research and public health by developing equations to estimate glomerular filtration rate (GFR), and leading the global standardization of CKD definition and staging.

Erin D. Michos American cardiologist and researcher

Erin Kathleen Donnelly Michos is an American cardiologist. She is an associate professor of Medicine and Director of Women's Cardiovascular Health at Johns Hopkins School of Medicine. Michos is also an Associate Faculty of the Welch Center for Prevention, Epidemiology and Clinical Research at Johns Hopkins, and has a joint faculty appointment in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health.

Elizabeth Selvin is an American diabetes epidemiologist. She is a Full professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health.

David Wesley Dowdy is an American infectious disease epidemiologist. He is the B. Frank and Kathleen Polk Professor at Johns Hopkins Bloomberg School of Public Health.

Wendy Susan Post is an American cardiologist. She is the Director of Cardiovascular Research for the Division of Cardiology and Director of Research for the Hopkins Cardiovascular Fellowship Training Program.

Michael John Klag is an American internist and epidemiologist. For eight years, he was the Director of the Division of General Internal Medicine and was the first Vice Dean for Clinical Investigation at the Johns Hopkins School of Medicine.

Felicia Hill-Briggs is an American behavioral and social scientist.

Xiaobin Wang is an American molecular epidemiologist. She is the Zanvyl Krieger Professor in Children’s Health at Children’s Memorial Institute and director of the Center on the Early Life Origins of Disease at the Johns Hopkins Bloomberg School of Public Health.

Leigh Ebony Boulware is an American general internist, physician-scientist, and clinical epidemiologist. She is the Eleanor Easley Professor of Medicine and director of the Clinical and Translational Science Institute at the Duke University School of Medicine.

Salvatore Novo is an eminent author, professor and researcher in the field of cardiovascular disease, epidemiology and risk factors of atherosclerosis. He has authored about 550 full papers which were published in many reputed international journals. He is one of the highly cited authors in the field of cardiovascular diseases.

References

  1. ↑ "Josef Coresh, M.D., Ph.D." hopkinsmedicine.org. Retrieved April 7, 2021.
  2. ↑ Alonso, A.; Lopez, F. L.; Matsushita, K.; Loehr, L. R.; Agarwal, S. K.; Chen, L. Y.; Soliman, E. Z.; Astor, B. C.; Coresh, J. (June 28, 2011). "Chronic Kidney Disease is Associated with the Incidence of Atrial Fibrillation: the Atherosclerosis Risk in Communities (ARIC) Study". Circulation . 123 (25): 2946–2953. doi: 10.1161/CIRCULATIONAHA.111.020982 . PMC   3139978 . PMID   21646496.
  3. ↑ "ARIC Neurocognitive Study (ARIC-NCS) 1 of 5". grantome.com. Retrieved April 10, 2021.
  4. ↑ "Josef Coresh". professorships.jhu.edu. Retrieved April 10, 2021.
  5. ↑ "Dr. Josef Coresh Receives National Mentoring Award". hopkinsmedicine.org. 2010. Retrieved April 10, 2021.
  6. ↑ "Elizabeth Selvin a Winner in 2005 Postdoctoral Fellows' Poster Competition". jhsph.edu. 2005. Retrieved April 10, 2021.
  7. ↑ Fischer, Renee (March 19, 2015). "COMSTOCK PROFESSOR JOSEF KORESH ADVANCES EPIDEMIOLOGICAL RESEARCH". giving.jhu.edu. Retrieved April 10, 2021.
  8. 1 2 3 "Coresh Receives Multiple Honors". jhsph.edu. April 12, 2010. Retrieved April 9, 2021.
  9. ↑ Coresh, Josef; Platz, Elizabeth A. (March 1, 2016). "The George W. Comstock Center for Public Health Research and Prevention: A Century of Collaboration, Innovation, and Translation". American Journal of Epidemiology . 183 (5): 362–366. doi:10.1093/aje/kwv261. PMC   4772436 . PMID   26872712 . Retrieved April 10, 2021.
  10. ↑ "PNAS announces six 2009 Cozzarelli Prize recipients". eurekalert.org. Eurekalert. February 23, 2010. Retrieved April 9, 2021.
  11. ↑ "New definition of kidney disease for clinical trials could lead to new treatments". eurekalert.org. Eurekalert. June 3, 2014. Retrieved April 9, 2021.
  12. ↑ "Renowned Kidney Disease Expert to Receive National Kidney Foundation's Highest Honor". kidney.org. National Kidney Foundation. March 19, 2015. Retrieved April 9, 2021.
  13. ↑ "Researchers improve the standard method for assessing cardiovascular disease risk". eurekalert.org. Eurekalert. October 14, 2020. Retrieved April 9, 2021.
  14. ↑ "ASN to Bestow Belding H. Scribner Award on Josef Coresh". kidneynews.org. October 2020. Retrieved April 9, 2021.
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