Jpx (gene)

JPX
Identifiers
Aliases	JPX , DCBALD06, ENOX, LINC00183, NCRNA00183, Jpx, JPX transcript, XIST activator (non-protein coding), JPX transcript, XIST activator
External IDs	OMIM: 300832 GeneCards: JPX
Gene location (Human)
Chr.	X chromosome (human)
End	74,070,408 bp
RNA expression pattern
	Top expressed in
	kidney; ; muscle tissue; ; Achilles tendon; ; stomach; ; peritoneum; ; corpus callosum; ; pituitary gland; ; colon;
	More reference expression data
	n/a
Orthologs
	554203
	n/a
	ENSG00000225470
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated January 13, 2022

In molecular biology, JPX transcript, XIST activator (non-protein coding), also known as Jpx, is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the Xist gene.^[3] Jpx upregulates expression of Xist.^[4]

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In molecular biology, FTX transcript, XIST regulator , also known as FTX, is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the XIST gene. FTX contains several microRNAs within its introns. It upregulates expression of XIST, and inhibits DNA methylation of the XIST promoter.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000225470 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine". Genome Res. 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731 . PMID 12045143.
↑ Tian D, Sun S, Lee JT (2010). "The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation". Cell. 143 (3): 390–403. doi:10.1016/j.cell.2010.09.049. PMC 2994261 . PMID 21029862.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Tsuritani K, Irie T, Yamashita R, et al. (2007). "Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes". Genome Res. 17 (7): 1005–1014. doi:10.1101/gr.6030107. PMC 1899111 . PMID 17567985.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Kolesnikov NN, Elisafenko EA (2010). "[Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]". Genetika. 46 (10): 1386–1391. PMID 21254562.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000225470 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12045143-3] Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine". Genome Res. 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731 . PMID 12045143.

[pmid21029862-4] Tian D, Sun S, Lee JT (2010). "The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation". Cell. 143 (3): 390–403. doi:10.1016/j.cell.2010.09.049. PMC 2994261 . PMID 21029862.

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Jpx (gene)

Contents

See also

Related Research Articles

References

Further reading