U.S. Route 119 (US 119) is a spur of US 19. It is a north–south route that was an original United States highway of 1926. It is Corridor G of the Appalachian Development Highway System (ADHS) east of US 23 and KY 80 in Kentucky to Interstate 64 at Charleston, West Virginia.
U.S. Route 421 is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana. Along its routing, US 421 serves several cities including Wilmington, North Carolina; Greensboro, North Carolina; Bristol, Tennessee and Virginia; Lexington, Kentucky; and Indianapolis, Indiana. US 421 is a spur route of US 21, which it meets west of Yadkinville, North Carolina.
Kentucky Route 876 is a 10-mile-long (16 km) state highway in the Richmond, Kentucky area. The western terminus of the route is at KY 595 southeast of Cottonburg. The eastern terminus is at U.S. Route 25 (US 25) and US 421 in Richmond.
Interstate 75 (I-75) is a part of the Interstate Highway System that runs 1,786.47 miles (2,875.04 km) from Miami Lakes, Florida to the Canada–United States border at Sault Ste. Marie, Michigan. In the U.S. state of Kentucky, I-75 runs through the eastern half of the state, from the Tennessee state line near the city of Williamsburg to the Ohio state line near Covington. The Interstate serves the state's second-most populous city, Lexington. Outside of it, the route is mostly rural or suburban in nature, mainly providing access to other cities via state and U.S. Highways. The major landscapes traversed by I-75 include the rolling hills and mountains of the Cumberland Plateau, the flat Bluegrass region, the urban core of Lexington, and the highly urbanized suburbs of Northern Kentucky; it also very briefly crosses through the Eastern Kentucky Coalfield at its southernmost stretch and passes near the Daniel Boone National Forest in London.
Kentucky Route 21 is a 14.196-mile (22.846 km) west–east highway in Madison County, running from the Garrard County line near Paint Lick to Bighill, east of Berea.
U.S. Route 421 (US 421) in the U.S. state of Kentucky is a 250.536-mile-long (403.199 km) north–south United States highway that traverses twelve counties in the central and eastern parts of the state. It travels in a southeast-to-northwest path from the Virginia state line near Pennington Gap to the Indiana state line, on the Ohio River at Milton, Kentucky and Madison, Indiana.
Kentucky Route 595 is a north- south route running through Madison County, Kentucky, United States. Its northern terminus is at the Kentucky River near Valley View and it southern terminus is at the intersection of Kentucky Route 1617 2 miles south of Berea. From the northern terminus to its intersection with Kentucky Route 876 it follows Silver Creek.
Kentucky Route 192 (KY 192) is a 40.5-mile-long (65.2 km) state highway in the U.S. state of Kentucky. The highway connects the Somerset area and the London areas with mostly rural areas of Pulaski and Laurel counties.
Kentucky Route 330 (KY 330) is a 38.3-mile-long (61.6 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of Owen, Grant, and Pendleton counties with the Corinth and Falmouth areas.
Kentucky Route 371 (KY 371) is a 6.947-mile-long (11.180 km) state highway in the U.S. state of Kentucky. The highway connects urban areas of Kenton County.
Kentucky Route 418 (KY 418) is a 11.736-mile-long (18.887 km) state highway in the U.S. state of Kentucky. The highway is a major connector for Lexington and Interstate 75. It was previously a Fayette County road that was rebuilt and numbered when the interstate was built. East of I-75, it serves the community of Athens and rural areas of Fayette and Clark counties.
Kentucky Route 627 is a 30.367-mile-long (48.871 km) north–south state highway in east-central Kentucky, United States. It traverses portions of northern Madison, Clark, and southern Bourbon counties.
KY 595 north of Berea 
US 25 north of Berea
